ライフサイエンスコーパス: cardiac progenitor cell

1 and the self-renewal and differentiation of cardiac progenitor cells).

2 tion of dmiR-1 in regulating the polarity of cardiac progenitor cells.

3 s, suggesting that GSK-3beta-MSCs upregulate cardiac progenitor cells.

4 tly higher activation of endogenous c-kit(+) cardiac progenitor cells.

5 fied disease of disrupted differentiation of cardiac progenitor cells.

6 protein (Bmp) signaling regulates miRNAs in cardiac progenitor cells.

7 fied a family of closely related multipotent cardiac progenitor cells.

8 ain survival of proliferating populations of cardiac progenitor cells.

9 cted intramyocardially to stimulate resident cardiac progenitor cells.

10 ymmetry, cardiac evolution, and isolation of cardiac progenitor cells.

11 nd heart field (SHF), an important source of cardiac progenitor cells.

12 ften result from improper differentiation of cardiac progenitor cells.

13 reMer and the MLC-2v promoters are active in cardiac progenitor cells.

14 cell [FhCPC]) and adult failing (adult human cardiac progenitor cell [AhCPC]) hearts, as well as youn

15 hat the local trophic effects of MSC require cardiac progenitor cell and CM-CXCR4 expression and are

16 it(+) cell populations yielding a mixture of cardiac progenitor cells and endothelial progenitor cell

17 ISL1 is expressed in cardiac progenitor cells and plays critical roles in car

18 eacetylation of Gata4, which is expressed by cardiac progenitor cells and plays critical roles in the

19 ine the transcriptional profile of mammalian cardiac progenitor cells and provide insight into the mo

20 can improve the engraftment of transplanted cardiac progenitor cells and therapeutic efficacy for tr

21 Nkx2-5 marks the earliest recognizable cardiac progenitor cells, and is activated in response t

22 After cardiac injury, cardiac progenitor cells are acutely reduced and are rep

23 RATIONALE: Cardiac progenitor cells are an attractive cell type for

24 Cardiac progenitor cells are an attractive cell type for

25 Multipotent cardiac progenitor cells are found in the fetal and adul

26 Cardiac progenitor cells are multipotent and give rise t

27 From a clinical perspective, the ideal cardiac progenitor cells are those that can proliferate,

28 cessary and sufficient to specify a field of cardiac progenitor cells as the heart-valve-inducing reg

29 smooth muscle alpha-actin gene expression in cardiac progenitor cells, as an agonist of myofibroblast

30 Remarkably, ablation of up to 60% of cardiac progenitor cells at embryonic day 7.5 was well t

31 rentiation of a subset of second heart field cardiac progenitor cells at the epicardium to adipocytes

32 at therapies targeting this axis may enhance cardiac-progenitor cell-based regenerative therapy.

33 ription factor gene Six1, which functions in cardiac progenitor cells but is stably silenced upon car

34 Percentages of cardiac progenitor cells (c-kit+ cells) and mononucleate

35 humans has identified the presence of adult cardiac progenitor cells, capable of cardiomyogenic diff

36 on of freshly isolated, c-kit-enriched human cardiac progenitor cells confirmed frequent coexpression

37 During mammalian embryogenesis, cardiac progenitor cells constituting the second heart f

38 Endogenous cardiac progenitor cell (CPC) activation may partially o

39 ction and mechanisms of SWI/SNF in mediating cardiac progenitor cell (CPC) differentiation during car

40 with diabetes and oxygen toxicity may alter cardiac progenitor cell (CPC) function resulting in defe

41 ) mice arises as a consequence of defects in cardiac progenitor cell (CPC) function, and that neonata

42 aging myopathy dictated by depletion of the cardiac progenitor cell (CPC) pool is unknown.

43 diac-specific Pim-1 kinase expression on the cardiac progenitor cell (CPC) population were examined t

44 KEY POINTS: Autologous cardiac progenitor cell (CPC) therapy is a promising app

45 of donor age and hypoxia of human pediatric cardiac progenitor cell (CPC)-derived exosomes in a rat

46 both neonatal rat cardiomyocytes (NRCM) and cardiac progenitor cells (CPC) upon exposure to doxorubi

47 Administration of cardiac progenitor cells (CPCs) 4 hours after reperfusio

48 We report that c-kit-positive cardiac progenitor cells (CPCs) activated with insulin-l

49 and perform side-by-side comparison between cardiac progenitor cells (CPCs) and cardiomyocytes (CMs)

50 An analysis of the clonality of cardiac progenitor cells (CPCs) and myocyte turnover in

51 Cardiac progenitor cells (CPCs) and other stem cell type

52 Cardiac progenitor cells (CPCs) and skin fibroblasts fro

53 Autologous c-kit(+) cardiac progenitor cells (CPCs) are currently used in th

54 Cardiac progenitor cells (CPCs) are thought to different

55 s in the mouse heart tube are hypoxic, while cardiac progenitor cells (CPCs) expressing islet 1 (ISL1

56 rived from mouse ES (mES) cells, we isolated cardiac progenitor cells (CPCs) from differentiating mES

57 of ischemic myocardium and whether c-kit(+) cardiac progenitor cells (CPCs) function can be enhanced

58 However, the role of CaMKIIdelta in cardiac progenitor cells (CPCs) has not been previously

59 Cardiac progenitor cells (CPCs) have been shown to promo

60 We tested whether cardiac progenitor cells (CPCs) implanted in proximity o

61 Transfer of cardiac progenitor cells (CPCs) improves cardiac functio

62 Cardiac progenitor cells (CPCs) in the niches express No

63 We recently identified a population of cardiac progenitor cells (CPCs) in zebrafish expressing

64 e a versatile population of Sca-1(+)/CD45(-) cardiac progenitor cells (CPCs) into endothelial cells a

65 ABSTRACT: Therapeutic use of c-kit(+) cardiac progenitor cells (CPCs) is being evaluated for r

66 T) and PG(TR) were expressed in c-Kit+:Sca1+ cardiac progenitor cells (CPCs) isolated from the hearts

67 Cardiac progenitor cells (CPCs) must control their numbe

68 Cardiac progenitor cells (CPCs) possess the insulin-like

69 In vertebrate embryos, cardiac progenitor cells (CPCs) undergo long-range migra

70 nerative potential of adoptively transferred cardiac progenitor cells (CPCs) via genetic engineering

71 Cardiac progenitor cells (CPCs) were isolated from trans

72 Here, we hypothesize that codelivery of cardiac progenitor cells (CPCs) with a nonviral minicirc

73 teome of human embryonic stem cells (hESCs), cardiac progenitor cells (CPCs), and cardiomyocytes duri

74 tent stem cells (hPSCs), adult heart-derived cardiac progenitor cells (CPCs), and reprogrammed fibrob

75 c characteristics and the secretome of human cardiac progenitor cells (CPCs), and their potential to

76 f aged stem cells and in particular c-kit(+) cardiac progenitor cells (CPCs).

77 tential mechanisms by which diabetes affects cardiac progenitor cells (CPCs).

78 ssociated with cellular senescence in c-kit+ cardiac progenitor cells (CPCs).

79 the transition from mesodermal precursors to cardiac progenitor cells (CPCs).

80 d recent therapeutic application of resident cardiac progenitor cells (CPCs).

81 from the second heart field, a population of cardiac progenitors cells (CPCs).

82 Human cardiac progenitor cells, cultured as cardiospheres (CSp

83 yoblasts, HL-1 atrial myocytes, and c-kit(+) cardiac progenitor cells demonstrated higher expression

84 Although transcription factors involved in cardiac progenitor cell differentiation have been descri

85 in a Notch1-independent manner, and regulate cardiac progenitor cell differentiation in an endocytosi

86 Numb regulated cardiac progenitor cell differentiation in an endocytosi

87 itional depletion of JMJD3 leads to impaired cardiac progenitor cell differentiation, phenocopying th

88 MiRNAs have also been implicated in resident cardiac progenitor cell differentiation.

89 mammalian heart develops from two fields of cardiac progenitor cells distinguished by their spatiote

90 By arresting the cardiac progenitor cell divisions at different developin

91 CHES-1-like) and Jumeau (Jumu), which govern cardiac progenitor cell divisions by regulating Polo kin

92 khead domain TFs and Polo kinase to regulate cardiac progenitor cell divisions.

93 olved image data show that a subset of these cardiac progenitor cells do not overlap with the express

94 In the absence of SHP-2 signaling, cardiac progenitor cells downregulate genes associated w

95 alized phenotypic properties consistent with cardiac progenitor cells, endothelial progenitor cells,

96 ying enzyme histone deacetylase 3 (Hdac3) in cardiac progenitor cells exhibit precocious cardiomyocyt

97 erived CDCs demonstrated increased number of cardiac progenitor cells expressing c-kit(+), flk-1, and

98 rt-derived cell subpopulations that included cardiac progenitor cells expressing c-kit(+), Islet-1, a

99 report the existence of adult heart-derived cardiac progenitor cells expressing stem cell antigen-1.

100 CPCs isolated from human fetal (fetal human cardiac progenitor cell [FhCPC]) and adult failing (adul

101 differentiation of mouse and human PSCs into cardiac progenitor cells, followed by intramyocardial de

102 ppearing to be more suitable than c-kit(POS) cardiac progenitor cells for widespread clinical therape

103 Primary cardiac progenitor cells formed new human cardiac myocyt

104 tly by a strategy that implements the use of cardiac progenitor cells from the recipient to repopulat

105 elivery, engraftment, and differentiation of cardiac progenitor cells from the recipient.

106 d enhancer with genes that play key roles in cardiac progenitor cell function and cardiovascular deve

107 ic link between this surface transporter and cardiac progenitor cell function.

108 The isolation and culturing of cardiac progenitor cells has demonstrated that growth fa

109 c-kit-expressing cardiac progenitor cells have been reported as the prima

110 Human cardiac progenitor cells have demonstrated great potenti

111 , the mechanisms underlying ISL1 function in cardiac progenitor cells have not been fully elucidated.

112 was to demonstrate the enhancement of human cardiac progenitor cell (hCPC) reparative and regenerati

113 ) reporter gene imaging for monitoring human cardiac progenitor cell (hCPC) transplantation in a mous

114 Human cardiac progenitor cells (hCPC) improve heart function a

115 2+ initiate division of c-kit-positive human cardiac progenitor cells (hCPCs) and determine their fat

116 Human cardiac progenitor cells (hCPCs) are a promising cell so

117 harmacological/genetic modification of human cardiac progenitor cells (hCPCs) are necessary intervent

118 on is enhanced by adoptive transfer of human cardiac progenitor cells (hCPCs) into a pathologically c

119 ogous stem cell therapy using human c-Kit(+) cardiac progenitor cells (hCPCs) is a promising therapeu

120 Human cardiac progenitor cells (hCPCs) may promote myocardial

121 Cardiac progenitor cells hold great potential for clinic

122 generate expandable and multipotent induced cardiac progenitor cells (iCPCs) from mouse adult fibrob

123 er, reprogramming into proliferative induced cardiac progenitor cells (iCPCs) remains to be accomplis

124 ons for proliferation and differentiation of cardiac progenitor cells, implicate Su(H) in regulating

125 c positional fate maps resolve the origin of cardiac progenitor cells in amniotes.

126 kx2.5, an evolutionarily conserved marker of cardiac progenitor cells in both fields.

127 d abundance and cardiac myogenic capacity of cardiac progenitor cells in failing human hearts, the ne

128 The identification of cardiac progenitor cells in mammals raises the possibili

129 naling leads to premature differentiation of cardiac progenitor cells in mice.

130 muscles share a gene regulatory network with cardiac progenitor cells in pharyngeal mesoderm of the s

131 Resident cardiac progenitor cells in ScaKI mice do not respond to

132 on factor essential for the specification of cardiac progenitor cells in the second heart field, as a

133 ons of impaired growth and survival of ScaKI cardiac progenitor cells in vitro.

134 The molecular basis of the defect in ScaKI cardiac progenitor cells is associated with increased ca

135 Understanding the origins and roles of cardiac progenitor cells is important for elucidating th

136 enitor cells, but the expression of CXCR4 in cardiac progenitor cells is very low.

137 s, with selective increases in expression of cardiac progenitor cell markers and reduced differentiat

138 apparently distinct populations of resident cardiac progenitor cells may have the potential to regen

139 ac progenitor cell [YCPC]) and old mice (old cardiac progenitor cell [OCPC]), were studied for senesc

140 t the cXin gene is specifically expressed in cardiac progenitor cells of chick embryos as early as st

141 ), which profoundly reduces FGF signaling in cardiac progenitor cells of the second heart field.

142 influence of hypoxia on CXCR4 expression in cardiac progenitor cells, on the recruitment of intraven

143 rine embryos that exhibit a full spectrum of cardiac progenitor cell or cardiomyocyte ablation.

144 congenital malformation, the consequences of cardiac progenitor cell or embryonic cardiomyocyte loss

145 rnative strategies using autologous resident cardiac progenitor cells or embryonic stem cell-derived

146 d the cellular mechanisms that maintain this cardiac progenitor cell pool in vivo remain unknown.

147 l infarction rapidly depletes the endogenous cardiac progenitor cell pool, and the inefficient recrui

148 of Akt promotes expansion of the presumptive cardiac progenitor cell population as assessed by immuno

149 /Sca1+ cardiac SP cells represent a distinct cardiac progenitor cell population, capable of cardiomyo

150 -population (CSP) cells represent a distinct cardiac progenitor cell population, capable of in vitro

151 es exhibiting differential expression in the cardiac progenitor cell population.

152 the molecular identities of these different cardiac progenitor cell populations appear to be distinc

153 , conclude that following myocardial injury, cardiac progenitor cell populations are acutely depleted

154 ebrafish embryos, Bmp signaling is active in cardiac progenitor cells prior to their differentiation

155 ion via proliferation and differentiation of cardiac progenitor cells, proliferation of pre-existing

156 epair consistent with impairment of resident cardiac progenitor cell proliferative capacity associate

157 beling positive CM (-44%, P<0.01), increased cardiac progenitor cell recruitment (100.9%, P<0.01), an

158 Infarct size, cardiac function, cardiac progenitor cells recruitment, fibrosis, and card

159 Deletion of Hdac3 in cardiac progenitor cells releases genomic regions from t

160 regeneration by differentiation of recipient cardiac progenitor cells restored a significant portion

161 re we uncover a hierarchical role of ISL1 in cardiac progenitor cells, showing that ISL1 directly reg

162 scored the importance of Gata4 in regulating cardiac progenitor cells specification and differentiati

163 se studies suggest that ISO injury activates cardiac progenitor cells that can differentiate into new

164 ), Fgf10 promotes the proliferation of these cardiac progenitor cells that form the arterial pole of

165 whether the heart in large mammals contains cardiac progenitor cells that regulate organ homeostasis

166 ABSTRACT: Autologous cardiac progenitor cell therapy is a promising alternati

167 Among cardiac progenitor cells, there is a distinct subpopulat

168 s reveal that Hdac3 plays a critical role in cardiac progenitor cells to regulate early cardiogenesis

169 nger transcription factor expressed in early cardiac progenitor cells, to activate the alphaCA promot

170 The abundance of these cardiac progenitor cells was increased nearly 4-fold in

171 cKit+ cardiac progenitor cells were BrdU labeled during injury

172 Pure populations of cardiac progenitor cells were isolated from the cardiac

173 central regulator of genome organization in cardiac progenitor cells, which is crucial for cardiac l

174 n hearts contain myocytes derived from extra-cardiac progenitor cells, which may have originated from

175 rotein 3 (ltbp3) transcripts mark a field of cardiac progenitor cells with defining characteristics o

176 ell [AhCPC]) hearts, as well as young (young cardiac progenitor cell [YCPC]) and old mice (old cardia