ライフサイエンスコーパス: cardiac regeneration

1 ivities of natural stem cells in therapeutic cardiac regeneration.

2 rogenitor cell differentiation to facilitate cardiac regeneration.

3 e the number and function of these cells for cardiac regeneration.

4 a unique yet poorly understood capacity for cardiac regeneration.

5 borate in an Fgf-dependent manner to achieve cardiac regeneration.

6 may be delivered therapeutically to enhance cardiac regeneration.

7 cally dissecting the molecular mechanisms of cardiac regeneration.

8 vivo and provide a more robust platform for cardiac regeneration.

9 ight be exploited therapeutically to enhance cardiac regeneration.

10 rve as a promising therapeutic for pediatric cardiac regeneration.

11 ming has enabled exciting new strategies for cardiac regeneration.

12 V vectors may serve as a powerful system for cardiac regeneration.

13 nd experimental research in animal models of cardiac regeneration.

14 e the key mechanism responsible for neonatal cardiac regeneration.

15 ownstream from Pim-1 signaling that enhances cardiac regeneration.

16 s and Hippo signaling-a central regulator of cardiac regeneration.

17 Promising progress has been made in studying cardiac regeneration.

18 in situ represents a promising strategy for cardiac regeneration.

19 on of critical controversies in experimental cardiac regeneration.

20 ure has stimulated interest in understanding cardiac regeneration.

21 in the scar of treated pigs, consistent with cardiac regeneration.

22 rial-to-ventricular transdifferentiation and cardiac regeneration.

23 ture development of cell-based therapies for cardiac regeneration.

24 t injury, providing a platform for enhancing cardiac regeneration.

25 ent and future studies directed at enhancing cardiac regeneration.

26 and advance translational implementation of cardiac regeneration.

27 on required to realize the goal of effective cardiac regeneration.

28 sist at least 1 year and are consistent with cardiac regeneration.

29 have not been fully utilized in the field of cardiac regeneration.

30 thood and their implications for therapeutic cardiac regeneration.

31 ESC exosomes possess cardiac regeneration ability and modulate both cardiomyo

32 nhibited sympathetic regrowth and subsequent cardiac regeneration after apical resection significantl

33 n of this pathway is also essential to drive cardiac regeneration after injury.

34 onatal and adult hearts as a means to induce cardiac regeneration after myocardial infarction in mice

35 the mouse heart using viral vectors, induce cardiac regeneration after myocardial infarction.

36 ramming as a therapeutic approach to promote cardiac regeneration after myocardial injury.

37 l cardiomyogenic differentiation and role in cardiac regeneration after myocardial injury.

38 This allows for the analysis of cardiac regeneration after surgical amputation of the le

39 ipheral nervous system, we hypothesized that cardiac regeneration also requires reinnervation.

40 ight be potential therapeutic candidates for cardiac regeneration and congenital heart diseases.

41 to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contract

42 growth factor receptor inhibition to arrest cardiac regeneration and enable scar formation, experime

43 eview of techniques currently used to assess cardiac regeneration and functional integration of de no

44 g limits CSP cell renewal, blocks endogenous cardiac regeneration and impairs cardiac performance, hi

45 CDCs are cardiogenic in vitro; they promote cardiac regeneration and improve heart function in a mou

46 itor cells (CPCs) have been shown to promote cardiac regeneration and improve heart function.

47 ve form of Yap in the adult heart stimulates cardiac regeneration and improves contractility after my

48 ession of Notch signaling profoundly impairs cardiac regeneration and induces scar formation at the a

49 ry size, does not induce known mechanisms of cardiac regeneration and leads to a sustained reduction

50 demonstrates synergistic effects to enhance cardiac regeneration and left ventricular functional rec

51 Cardiac regeneration and neovascularization were not obs

52 ing and improves LV performance by promoting cardiac regeneration and probably also by exerting other

53 gs identify Yap as an important regulator of cardiac regeneration and provide an experimental entry p

54 the transcriptional regulation of mammalian cardiac regeneration and provides the founding circuitry

55 This may allow percutaneous cardiac regeneration and repair approaches, or injectabl

56 he microenvironment that may be required for cardiac regeneration and repair.

57 rdiogenic potential of these progenitors for cardiac regeneration and repair.

58 hat these ligands mediate inverse effects on cardiac regeneration and specifically on cardiomyocyte (

59 The results establish CSCs as candidates for cardiac regeneration and support an approach in which th

60 without immunosuppression is safe, promotes cardiac regeneration, and improves heart function in a r

61 c function, and the implications of this for cardiac regeneration are causing great excitement.

62 Stem cell-based approaches to cardiac regeneration are increasingly viable strategies

63 suggest a mechanism underlying the improved cardiac regeneration associated with combination therapy

64 tions of this finding may be significant for cardiac regeneration biology and therapeutics.

65 nic stem cells (ESCs) hold great promise for cardiac regeneration but are susceptible to various conc

66 tion is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited

67 hypothesis that HASF can also contribute to cardiac regeneration by stimulating cardiomyocyte divisi

68 There was no evidence of cardiac regeneration by the infused MSC or endogenous ca

69 on effect of the micromatrix and the in situ cardiac regeneration by the injected cells.

70 ropriate number of cardiomyocytes; likewise, cardiac regeneration following injury relies upon the re

71 fate of transplanted cells participating in cardiac regeneration, given its ability to observe livin

72 Recently, cardiac regeneration has been demonstrated in fish and n

73 Cell-based cardiac regeneration has been the focus of intensive eff

74 er, the potential utility of platelet gel in cardiac regeneration has yet to be tested.

75 nscriptional changes that underpin mammalian cardiac regeneration have not been fully characterized a

76 o, a single administration of agrin promotes cardiac regeneration in adult mice after myocardial infa

77 nesis suggested that hand2 could also impact cardiac regeneration in adult zebrafish; indeed, we find

78 fe, but it is largely ineffective in driving cardiac regeneration in adults, because of permanent epi

79 cell-based manufactured products to promote cardiac regeneration in congenital heart disease has dem

80 an, the heart, and can longitudinally follow cardiac regeneration in individual animals after major i

81 The most-cited basis of this ineffective cardiac regeneration in mammals is the low proliferative

82 as accelerated research on the mechanisms of cardiac regeneration in mammals.

83 resent an alternative model for the study of cardiac regeneration in neonatal mice in which cryoinjur

84 gy to both prevent remodeling and to promote cardiac regeneration in pathological states.

85 l trials, and we suggest that achieving true cardiac regeneration in patients may ultimately require

86 injury; however, the factors that facilitate cardiac regeneration in the neonatal heart are not known

87 Innate cardiac regeneration in the pediatric setting is measura

88 A focus on preemptive cardiac regeneration in the pediatric setting may offer

89 cells (MSCs) produce and/or stimulate active cardiac regeneration in vivo after myocardial infarction

90 Cs), have been shown to be capable of direct cardiac regeneration in vivo.

91 Here, we report that cardiac regeneration in zebrafish relies on Notch signal

92 ate with cardiomyocytes will be critical for cardiac regeneration, in which the ultimate goal is not

93 ies in humans: what is the mechanism and can cardiac regeneration indeed occur in newborn humans?

94 Cardiac regeneration is a rapidly evolving and controver

95 Whether the capacity for cardiac regeneration is absent in mammals or whether it

96 Efficient cardiac regeneration is closely associated with the abil

97 Success of stem cell transplantation for cardiac regeneration is partially limited by low retenti

98 g the optimal stem cell type best suited for cardiac regeneration is the key toward improving clinica

99 Successful strategies for cardiac regeneration may therefore depend on establishin

100 may be feasible for large animal preclinical cardiac regeneration paradigms.

101 tion, new studies indicate that mammals have cardiac regeneration potential during development and ve

102 all adult mammals appear to lack significant cardiac regeneration potential, some vertebrates can reg

103 genetic and cellular determinants of natural cardiac regeneration remain incompletely characterized.

104 one marrow (BM)-derived cells participate in cardiac regeneration remains highly controversial and th

105 scientific discoveries related to intrinsic cardiac regeneration, renewal factors that can trigger r

106 Cardiac regeneration strategies and de novo generation o

107 is of congenital heart defects and to derive cardiac regeneration strategies.

108 a signaling has been implicated in zebrafish cardiac regeneration, the role of its individual ligands

109 eviews and meta-analyses of human cell-based cardiac regeneration therapies are still valid to inform

110 ation-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myo

111 For example, miR-590 promotes cardiac regeneration through activating cardiomyocyte pr

112 and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is no

113 on of TEAD-YAP activity in applications from cardiac regeneration to cancer.

114 For heart failure, recent work suggests that cardiac regeneration using stem/progenitor cells, gene t

115 Cardiac regeneration was via endogenous cKit(+) cardiac

116 investigate the role of immune responses in cardiac regeneration, we delayed macrophage recruitment

117 factors, and some tantalizing insights into cardiac regeneration were some of the highlights of what

118 ypothesis that ACCT synergistically promotes cardiac regeneration without provoking immunologic react