ライフサイエンスコーパス: cardiac ryanodine receptor

1 current amplitude or open probability of the cardiac ryanodine receptor.

2 body MA3-916, also raised against the canine cardiac ryanodine receptor.

3 es and regulation by CaM of the skeletal and cardiac ryanodine receptors.

4 alcium release activity of both skeletal and cardiac ryanodine receptors.

5 Mutations in the cardiac ryanodine receptor 2 (RyR2) have been associated

6 rm a protein complex that is associated with cardiac ryanodine receptor 2 (RyR2) SR Ca(2+) release ch

7 ired beta-agonist-induced denitrosylation of cardiac ryanodine receptor 2 (RyR2), resulting in calciu

8 Moreover, SERCA2a, cardiac ryanodine receptor 2, and sodium-calcium exchang

9 2+-binding protein that associates with both cardiac ryanodine receptors and L-type Ca2+ channels and

10 Ca(2+)-ATPase [SERCA2a], phospholamban, and cardiac ryanodine receptor), and contractile function (m

11 nteract with and disrupt the function of the cardiac ryanodine receptor Ca(2+) release channel (RyR2)

12 ith PKA-mediated hyperphosphorylation of the cardiac ryanodine receptor/Ca(2+)-release channel, which

13 arcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine receptor/calcium release channel (RyR2

14 ple targets in cardiac muscle, including the cardiac ryanodine receptor/calcium release channel (RyR2

15 The cardiac ryanodine receptor/calcium release channel (RyR2

16 constructed models of the pore region of the cardiac ryanodine receptor channel (RyR2) monomer and te

17 study, we addressed whether Zn(2+) modulates cardiac ryanodine receptor gating and Ca(2+) dynamics in

18 RATIONALE: Mutations in the cardiac Ryanodine Receptor gene (RYR2) cause dominant ca

19 ia syndrome associated with mutations in the cardiac ryanodine receptor gene (Ryr2) in the majority o

20 prevalence of mutations in the RYR2-encoded cardiac ryanodine receptor in cases with exertional sync

21 These results appear to indicate that the cardiac ryanodine receptor is capable of being activated

22 hmias in a mouse model of CPVT by inhibiting cardiac ryanodine receptor-mediated Ca(2+) release and t

23 including voltage-gated Na and Ca channels, cardiac ryanodine receptors, Na/Ca-exchanger, and SR Ca-

24 hypothesis for elevated Ca(2+) leak through cardiac ryanodine receptors (ryanodine receptor 2 [RyR2]

25 The peripheral distributions of the cardiac ryanodine receptor (RyR) and a junctional protei

26 ion to determine whether Ca(2+) can regulate cardiac ryanodine receptor (RyR) channel gating from wit

27 Cardiac ryanodine receptor (RyR) gating in rats and shee

28 studied the effect of a peptide (Ac-10C) on cardiac ryanodine receptor (RyR) opening.

29 Increased phosphorylation of the cardiac ryanodine receptor (RyR)2 by protein kinase A (P

30 with mutations in the genes encoding for the cardiac ryanodine receptor (RyR2) and cardiac calsequest

31 Mutations in cardiac ryanodine receptor (RYR2) and cardiac calsequest

32 ic disorder associated with mutations in the cardiac ryanodine receptor (RyR2) and cardiac calsequest

33 determine the CaM binding properties of the cardiac ryanodine receptor (RyR2) and to identify potent

34 d its metabolite, doxorubicinol, bind to the cardiac ryanodine receptor (RyR2) and to the sarco/endop

35 Activation of the cardiac ryanodine receptor (RyR2) by elevating cytosolic

36 Phosphorylation of the cardiac ryanodine receptor (RyR2) by protein kinase A (P

37 Cardiac ryanodine receptor (Ryr2) Ca(2+) release channel

38 a widely used pharmacological agonist of the cardiac ryanodine receptor (RyR2) Ca(2+) release channel

39 To study the function and regulation of the cardiac ryanodine receptor (RyR2) Ca(2+) release channel

40 CPVT) require spontaneous Ca(2+) release via cardiac ryanodine receptor (RyR2) channels affected by g

41 e crossing region (the proposed gate) of the cardiac ryanodine receptor (RyR2) completely abolishes l

42 pryn co-purifies with myospryn and the major cardiac ryanodine receptor (RyR2) from heart.

43 show that PC2 coimmunoprecipitates with the cardiac ryanodine receptor (RyR2) from mouse heart.

44 Abnormal cardiac ryanodine receptor (RyR2) function is recognized

45 NH2-terminal region (residues 1-543) of the cardiac ryanodine receptor (RyR2) harbors a large number

46 Deficient S-nitrosylation of the cardiac ryanodine receptor (RyR2) has a variable effect

47 m the sarcoplasmic reticulum mediated by the cardiac ryanodine receptor (RyR2) is a fundamental event

48 Cardiac ryanodine receptor (RyR2) is a homotetramer of 5

49 t the single-channel level, oxidation of the cardiac ryanodine receptor (RyR2) is known to activate a

50 Calstabin2 is a component of the cardiac ryanodine receptor (RyR2) macromolecular complex

51 Ca from sarcoplasmic reticulum (SR) via the cardiac ryanodine receptor (RyR2) may contribute to cont

52 s a hetero-oligomer with FKBP12, whereas the cardiac ryanodine receptor (RyR2) more selectively assoc

53 Arrhythmogenic cardiac ryanodine receptor (RyR2) mutations are associat

54 Most cardiac ryanodine receptor (RyR2) mutations associated w

55 tachycardia (CPVT) is caused by mutations in cardiac ryanodine receptor (RyR2) or calsequestrin (Casq

56 n kinase A (PKA) hyperphosphorylation of the cardiac ryanodine receptor (RyR2) resulting in dissociat

57 riments we characterized another site on the cardiac ryanodine receptor (RyR2) with which ryanoids in

58 rdiac death due to missense mutations in the cardiac ryanodine receptor (RyR2), an intracellular Ca2+

59 lation of the calcium (Ca2+) release channel/cardiac ryanodine receptor (RyR2), required for cardiac

60 cytes with a functional knockout (KO) of the cardiac ryanodine receptor (RyR2).

61 of FKBP, is selectively associated with the cardiac ryanodine receptor (RyR2).

62 Defective regulation of the cardiac ryanodine receptor (RyR2)/calcium release channe

63 The cardiac ryanodine receptor (RyR2)/calcium release channe

64 sphodiesterase 4D3 (PDE4D3) was found in the cardiac ryanodine receptor (RyR2)/calcium-release-channe

65 ssible for flecainide to directly affect the cardiac ryanodine receptor (RyR2); however, an extracell

66 lasmic reticulum (SR) Ca(2+) release through cardiac ryanodine receptors (RyR2) aggravate cardiac rem

67 Diffusion of cardiac ryanodine receptors (RyR2) in lipid bilayers was

68 kinase A (PKA)-dependent phosphorylation of cardiac ryanodine receptors (RyR2) is linked to the deve

69 eins FKBP12.6 and FKBP12 are associated with cardiac ryanodine receptors (RyR2), and cAMP-dependent p

70 ses sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or ca

71 r tachyarrhythmias (VTs) in a mouse model of cardiac ryanodine-receptor (RyR2)-linked catecholaminerg

72 In contrast, the cardiac ryanodine receptor, RyR2, appears to bind select

73 rhythmogenesis through redox modification of cardiac ryanodine receptors (RyR2s).

74 nels is a critical step in the activation of cardiac ryanodine receptors (RyRs) and release of Ca2+ v

75 We have previously shown that cardiac ryanodine receptors (RyRs) are protein kinase A-

76 cytes and single channel recordings from rat cardiac ryanodine receptors (RyRs) incorporated into pla

77 ein kinase A-mediated phosphorylation of the cardiac ryanodine receptor (the Ca(2+) release channel o

78 rdia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestri

79 Cardiac ryanodine receptor type 2 plays a key role in ex

80 ised against a peptide sequence from the dog cardiac ryanodine receptor was employed.

81 The cardiac ryanodine receptor was not altered in transcript

82 tabolic labeling experiments showed that the cardiac ryanodine receptor was phosphorylated at additio