ライフサイエンスコーパス: cardiolipin

1 e for the mitochondria-specific phospholipid cardiolipin.

2 ment on the interaction of cytochrome c with cardiolipin.

3 een defined as phosphatidylglycerol (PG) and cardiolipin.

4 cts directly with membrane lipids, including cardiolipin.

5 mitochondrial ADP/ATP carrier, does not bind cardiolipin.

6 eurodegenerative disorders are inactive with cardiolipin.

7 phosphoinositides or sulfatide, but not with cardiolipin.

8 ic molecular form of the mitochondrial lipid cardiolipin.

9 alf as many as observed on membranes without cardiolipin.

10 only partially dependent on the presence of cardiolipin.

11 hat binds to phosphatidylinositol lipids and cardiolipin.

12 rt mitochondrial activities known to require cardiolipin.

13 d membrane tubulation that was stimulated by cardiolipin.

14 mer and tetramer formations were restored by cardiolipin.

15 ells, dsDNA, chromatin, anti-nuclear Abs, or cardiolipin.

16 ion and specifically the mitochondrial lipid cardiolipin.

17 asome through the direct binding of Nlrp3 to cardiolipin.

18 cyclosporin A enhances subsequent binding of cardiolipin.

19 critical step in the de novo biosynthesis of cardiolipin.

20 prevented trimer formation in the absence of cardiolipin.

21 ipin, tetramer formation required additional cardiolipin.

22 than 150 new oxygenated molecular species of cardiolipin.

23 -forming lipids phosphatidylethanolamine and cardiolipin.

24 of the DPPC acyl chain response from that of cardiolipin.

25 iae develop lung injury with accumulation of cardiolipin.

26 t of the mitochondrial membrane phospholipid cardiolipin.

27 of the mitochondrial-specific phospholipid, cardiolipin.

28 on anionic phospholipids and in particular, cardiolipin.

29 ncharacterized adducts, including ammoniated cardiolipins.

30 using perhexiline resulted in a depletion of cardiolipin, a key component of mitochondrial membranes,

31 of FisB binds with remarkable specificity to cardiolipin, a lipid enriched in the engulfing membranes

32 Cardiolipin, a phospholipid specific to the mitochondrio

33 most had high-titer IgG anti-dsDNA and anti-cardiolipin Abs and developed >300 mg/dl proteinuria by

34 Females had only low-titer IgG anti-cardiolipin Abs, and none developed proteinuria by 1 y.

35 ding, where the unfolded form interacts with cardiolipin acyl chains within the bilayer to induce per

36 levels of sphingomyelin and lower levels of cardiolipin, among other phospholipids in the apical pla

37 trate that SS-31 binds with high affinity to cardiolipin, an anionic phospholipid expressed on the in

38 tration of IFN-alpha to females induced anti-cardiolipin and anti-DNA autoantibodies and proteinuria

39 erfering with the mitochondrial phospholipid cardiolipin and causing inefficient electron transfer re

40 2), which also binds the mitochondrial lipid cardiolipin and functions in the assembly of respiratory

41 ant microdomains via direct interaction with cardiolipin and inhibits MAVS protein-mediated apoptosis

42 Lateral segregation of cardiolipin and membrane hemifusion would be critical fo

43 um (ER) and transported to mitochondria, but cardiolipin and phosphatidylethanolamine are produced in

44 The non-bilayer-forming phospholipids cardiolipin and phosphatidylethanolamine are required fo

45 er reports that the abundances of endogenous cardiolipin and phosphatidylethanolamine halve during el

46 n vivo, oxidize the 2'-OH glycerol moiety on cardiolipin and phosphatidylglycerol to produce diacylgl

47 revealed an enrichment of the anionic lipids cardiolipin and phosphatidylglycerol, indicating their c

48 the interaction of 3',6-dinonyl neamine with cardiolipin and phosphatidylglycerol, two negatively cha

49 f mitochondrion-targeted agents that deplete cardiolipin and promote cancer cell death.

50 mitochondrial-targeted peptide that binds to cardiolipin and stabilizes mitochondrial function.

51 by oxidative consumption of polyunsaturated cardiolipin and the accumulation of more than 150 new ox

52 tafazzin cause abnormal molecular species of cardiolipin and the clinical phenotype of Barth syndrome

53 ulate acidic GPL by increasing the levels of cardiolipins and palmitoylated acylphosphatidylglycerols

54 Similar experiments confirm binding of cardiolipins and show that prior binding of the immunosu

55 ycerol (PG), diphosphatidylglycerol (DPG, or cardiolipin), and phosphatidylinositol from Mycobacteriu

56 Complex III contained eight molecules of cardiolipin, and complex IV contained two molecules of c

57 nd in vitro to anionic phospholipids, mainly cardiolipin, and in vivo to the inner mitochondrial memb

58 en species (ROS), oxidation of mitochondrial cardiolipin, and loss of the mitochondrial transmembrane

59 igand cBID, the mitochondrion-specific lipid cardiolipin, and membrane geometrical curvature) all pro

60 ratory complexes and the mitochondrial lipid cardiolipin, and Mic60/Mic19, which assembles independen

61 onic (phosphatidylserine, phosphatidic acid, cardiolipin, and phosphatidylinositol 4,5-bisphosphate (

62 such as ceramides, glycerophosphoglycerols, cardiolipins, and glycerophosphocholines.

63 Labile compounds such as gangliosides and cardiolipins are detected in the negative ion mode direc

64 n, and complex IV contained two molecules of cardiolipin, as determined by electrospray ionization-ma

65 With the addition of the lipid cardiolipin, assembly of these proteins into nanodiscs w

66 the onset of apoptosis, the peroxidation of cardiolipin at the inner mitochondrial membrane by cytoc

67 ipin is functionally distinct from remodeled cardiolipin, at least for the functions examined, sugges

68 reactive oxygen species by removing damaged cardiolipin before it induces apoptosis.

69 ased on molecular modeling to be crucial for cardiolipin binding and transfer mechanism.

70 ended lipid anchorage model for cytochrome c/cardiolipin binding.

71 The final step in cardiolipin biosynthesis is catalyzed by cardiolipin syn

72 erestingly, among yeast mutants deficient in cardiolipin biosynthesis, only the crd1-null mutant, whi

73 Cardiolipin bound to Nlrp3 directly and interference wit

74 terol, tricaprylin, 1,1',2,2'-tetramyristoyl cardiolipin, bradykinin fragment 1-8, and 1-palmitoyl-2-

75 omparable efficiency to generate triacylated cardiolipin by acyltransferase/acyl-acyl carrier protein

76 nd that tafazzin catalyzes the remodeling of cardiolipin by combinations of forward and reverse trans

77 The resulting oxygenation of cardiolipin by cytochrome c provides an early signal for

78 o-damage-associated molecular pattern (DAMP) cardiolipin can be detected in the lungs.

79 s Tim23 membrane attachment, suggesting that cardiolipin can influence preprotein import.

80 tion involving its interaction with membrane cardiolipin (CDL), its peroxidase activity, and the init

81 e, ganglioside GM3, GM2, GM1, GD3 and GD1a), cardiolipin, cholesterol and cholesteryl esters are elev

82 dering along with decreased intensity of the cardiolipin cis-double-bond stretching modes.

83 IMS in imaging high-mass signals from intact cardiolipin (CL) and gangliosides in normal brain and th

84 We investigate the effect of cardiolipin (CL) and phosphatidylglycerol (PG), anionic

85 A binds tightly to the anionic phospholipids cardiolipin (CL) and phosphatidylglycerol (PG).

86 spholipids phosphatidylethanolamine (PE) and cardiolipin (CL) are required for the biogenesis of beta

87 ylation and as a peroxidase that reacts with cardiolipin (CL) during apoptosis.

88 Cardiolipin (CL) is a dimeric phospholipid with critical

89 Cardiolipin (CL) is a key phospholipid in mitochondrial

90 Cardiolipin (CL) is an anionic phospholipid with a chara

91 Cardiolipin (CL) is an atypical, dimeric phospholipid es

92 The unique tetra-acyl phospholipid cardiolipin (CL) is located in the inner mitochondrial m

93 The mitochondrial-specific lipid cardiolipin (CL) is required for numerous processes ther

94 Cardiolipin (CL) is the signature phospholipid of mitoch

95 Cardiolipin (CL) is the signature phospholipid of the mi

96 ding on growth phase and culture conditions, cardiolipin (CL) makes up 5-15% of the phospholipids in

97 Interactions of cytochrome c (cyt c) with cardiolipin (CL) partially unfold the protein, activatin

98 that the prokaryotic-enriched anionic lipid Cardiolipin (CL) plays a key-role in the TFDs delivery t

99 Cardiolipin (CL) plays an important role in OM biogenesi

100 described in humans with genetic defects in cardiolipin (CL) synthesis (Barth syndrome).

101 Cardiolipin (CL) that is synthesized de novo is deacylat

102 1-palmitoyl 2-oleoyl-diphosphatidylglycerol/cardiolipin (CL) to mimic the lipid composition of the b

103 Cardiolipin (CL), a double charged phospholipid composin

104 Cardiolipin (CL), a membrane phospholipid in bacteria an

105 palmitate levels and increases the levels of cardiolipin (CL), a mitochondrial inner membrane-specifi

106 For example, the loss of cardiolipin (CL), a signature non-bilayer-forming phosph

107 s a peroxidase activated by interaction with cardiolipin (CL), and resulting in selective CL peroxida

108 f oxidized mitochondrial phospholipids, e.g. cardiolipin (CL), by excising oxidized polyunsaturated f

109 d from a mitochondria-specific phospholipid, cardiolipin (CL), is oxidized by the intermembrane-space

110 ining the inner mitochondrial membrane lipid cardiolipin (CL), leading to protein conformational chan

111 DHA extensively remodeled the acyl chains of cardiolipin (CL), mono-lyso CL, phosphatidylcholine, and

112 Defective cardiolipin (CL), phosphatidylethanolamine, and phosphat

113 Cardiolipin (CL), the signature phospholipid of mitochon

114 Cardiolipin (CL), the signature phospholipid of mitochon

115 dentify transformations of the heterogeneous cardiolipin (CL)-bound cyt c ensemble with added ATP.

116 operties, stabilities, and interactions with cardiolipin (CL)-containing liposomes.

117 we investigate the interaction of cyt c with cardiolipin (CL)-containing membranes using the innovati

118 les and septa of Escherichia coli cells in a cardiolipin (CL)-dependent manner.

119 ical modification of the mitochondrial lipid cardiolipin (CL).

120 tidylglycerol, phosphatidylethanolamine, and cardiolipin (CL).

121 ms are dependent on the mitochondrial lipid, cardiolipin (CL).

122 s close to the conserved binding location of cardiolipin (CL).

123 Cardiolipins (CL) represent unique phospholipids of bact

124 selected for transmission of doubly charged cardiolipins (CL), for example, detection of 71 differen

125 lly high abundance and chemical diversity of cardiolipins (CL), including many oxidized species.

126 Observations are consistent with variants of cardiolipins (CL), phosphatidylglycerols (PG), phosphati

127 t the diverse species of mitochondria-unique cardiolipins (CLs) in the brain which are essential for

128 LP-2 deficiency was associated with impaired cardiolipin compartmentalization in mitochondrial membra

129 Here we report that the ferric cytochrome c/cardiolipin complex binds nitric oxide tightly through a

130 In addition, the SS-31/cardiolipin complex inhibited cytochrome c peroxidase ac

131 r receptor kinase 1/2 activation; normalized cardiolipin composition in mitochondria; reduced circula

132 h the amount of Bax/BakDeltaC21 but not with cardiolipin concentration.

133 However, compared with cardiolipin-containing giant unilamellar vesicles the tu

134 In this study, we compare the case of cardiolipin-containing giant unilamellar vesicles with t

135 id micro-injection near the external side of cardiolipin-containing giant unilamellar vesicles, leads

136 at cytochrome c can induce pore formation in cardiolipin-containing phospholipid membranes, leading t

137 s work, the interaction of cytochrome c with cardiolipin-containing phospholipid vesicles, serving as

138 rome-correlated leakage was observed only in cardiolipin-containing vesicles.

139 with cBID in a manner adjustable by membrane cardiolipin content and curvature degree.

140 Lipidomic regulation of mitochondrial cardiolipin content and molecular species composition is

141 We postulate that the reduced cardiolipin content in ftsh4 mitochondria leads to pertu

142 This is consistent with the high cardiolipin content in the native tetramer.

143 ver, markers of mitochondrial biogenesis and cardiolipin content were strongly reduced only in males.

144 estimated by citrate synthase [CS] activity, cardiolipin content, and voltage-dependent anion channel

145 that bind to negatively charged lipids like cardiolipin could be promising antibacterial compounds.

146 tidylglycerol, or the tetra-acylated form of cardiolipin could not serve as a competitive inhibitor i

147 Once in a complex with cardiolipin, cytochrome c has been shown to undergo a co

148 ted protein, providing the first view of the cardiolipin/cytochrome c interaction interface at atomic

149 Moreover, its expression restored cardiolipin deficiency and reversed growth impairment in

150 x that may bridge the envelope for regulated cardiolipin delivery.

151 lipin that has been remodeled should promote cardiolipin-dependent mitochondrial processes better tha

152 These two distinct cardiolipin derivatives were both translocated with comp

153 ers and negative intrinsic curvature lipids (cardiolipin, diacylglycerol) facilitating fusion.

154 eter and selected curvature-inducing lipids (cardiolipin, diacylglycerol, and lyso-phosphatidylcholin

155 we used a liposome model to demonstrate that cardiolipin directly inhibits membrane permeabilization

156 DAC oligomerization in the membrane, whereas cardiolipin disrupts VDAC supramolecular assemblies.

157 ned changes in the acyl chain composition of cardiolipin do not alter either mitochondrial morphology

158 parameters, we followed the accumulation of cardiolipin during the reaction from the initial state t

159 xamined the interaction of cytochrome c with cardiolipin embedded in a variety of model phospholipid

160 Cardiolipin enhances Tim23 membrane attachment, suggesti

161 IRF-1 targeting to mDRM possibly by inducing cardiolipin exposure on the outer membrane of mitochondr

162 The dependence on cardiolipin for supercomplex formation suggests that cha

163 elongation, cyclopropanation, and increased cardiolipin formation.

164 -terminal domain binds phosphoinositides and cardiolipin, forms membrane-disrupting pores, and execut

165 thesis that the mitochondrion-specific lipid cardiolipin functions as a first contact site for Bax du

166 Depletion of cardiolipin further affects the stability of the TIM23 c

167 Tightly bound lipids (including cardiolipins) further stabilize interactions between the

168 ontaining transmembrane protein, which binds cardiolipin glycerophospholipids near the inner membrane

169 n between cytochrome c and the anionic lipid cardiolipin has been proposed as a primary event in the

170 arities between different molecular forms of cardiolipin have never been established.

171 leaflet, that is promoted by protonation of cardiolipin headgroups.

172 , cardiolipin oxidation, and accumulation of cardiolipin hydrolysis products, culminating in cell dea

173 We also found a novel cardiolipin hydrolysis reaction by phospholipase A2 to f

174 AqpZ is also stabilized by many lipids, with cardiolipin imparting the most significant resistance to

175 acquire peroxidase activity when it binds to cardiolipin in mitochondrial membranes.

176 ing are consistent with functional roles for cardiolipin in stabilizing and lubricating the rotor, an

177 her anionic phospholipid was as effective as cardiolipin in supporting tetramer formation.

178 have indicated that an increased content of cardiolipin in the bacterial membrane may contribute to

179 ot significantly disturbed by the binding of cardiolipin in the context of the reverse micelle.

180 correlated tightly with the concentration of cardiolipin in the equilibrium state (lipid-dependent pa

181 enzyme, selectively increased the content of cardiolipin in the outer mitochondrial membrane, but the

182 y of cyt c gained upon its complexation with cardiolipin in the presence of reactive oxygen species.

183 ndance of the mitochondrial-specific lipids, cardiolipins, in normoxic conditions.

184 similar way, which can also be prevented by cardiolipin, indicating that they interact like transpor

185 Cardiolipin induces PPARgamma SUMOylation, which causes

186 Cardiolipin inhibits resolution of inflammation by suppr

187 in the presence of phosphatidic acid, or of cardiolipin, interaction is detected by different method

188 gy at the final stage of engulfment and FisB-cardiolipin interactions ensure that the mother cell mem

189 Cardiolipin interacts with protein complexes and plays p

190 Incorporation of cardiolipin into the reverse micelle surfactant shell ca

191 n and/or remodeling of lipids, in particular cardiolipin, into complex IV and.

192 Cardiolipin is a glycerophospholipid found predominantly

193 We show that the mitochondria-specific lipid cardiolipin is a potent stimulator of Drp1 GTPase activi

194 When cardiolipin is added at molar fractions of 10 or 20% to

195 The anionic lipid cardiolipin is an essential component of active ATP synt

196 t the prevailing hypothesis that unremodeled cardiolipin is functionally distinct from remodeled card

197 paradigm that the acyl chain composition of cardiolipin is matched to the unique mitochondrial deman

198 s drastically reduced and the composition of cardiolipin is modified like in mutants lacking tafazzin

199 has been shown that the dimeric phospholipid cardiolipin is required for the stability of TOM and SAM

200 mitochondrial ADP/ATP carrier (yAAC3) toward cardiolipins is preserved in DPC, thereby suggesting tha

201 leic acid pattern of mammalian mitochondrial cardiolipin, is necessary for maintaining normal mitocho

202 Overexpression of wild-type SIRT3 increased cardiolipin levels and rescued mitochondrial respiration

203 ed manipulations of cardiolipin synthase and cardiolipin levels conferred resistance to mechanical st

204 ercomplex formation suggests that changes in cardiolipin levels resulting from changes in physiologic

205 cardiolipin synthesis, reduction in cellular cardiolipin levels, alterations in mitochondrial morphol

206 Measurements of renal cardiolipin levels, citrate synthase activity, rotenone-

207 E. coli ClsB significantly increased PG and cardiolipin levels, with the growth deficiency of pgsA n

208 on studies confirm that MgtA is found in the cardiolipin lipid domains in the membrane.

209 branes but also phosphatidylethanolamine and cardiolipin, lipids with high spontaneous negative curva

210 ate that the mitochondrial failure rescue by cardiolipin manipulation may be a new intriguing target

211 pathy biochemically characterized by reduced cardiolipin mass and increased monolysocardiolipin level

212 r role in activation of MgtA suggesting that cardiolipin may act as a Mg(2+) chaperone for MgtA.

213 ndings suggest a possible mechanism by which cardiolipin may mediate resistance to daptomycin, and th

214 lycero-3-phosphocholine (DPPC) or mixed-DPPC/cardiolipin membrane and containing a membrane-impermeab

215 However, the mechanisms controlling cardiolipin metabolism during health or disease progress

216 deletion of liaR altered the localization of cardiolipin microdomains in the cell membrane.

217 ntly, through functional assays we show that cardiolipin modulates AqpZ function.

218 marked changes in the temporal maturation of cardiolipin molecular species during development.

219 rall imbalance with most prominent effect on cardiolipin molecular sub-species.

220 ith c10- and c11-rings, the density of bound cardiolipin molecules at this site increased, but reside

221 terial c10- or c11-rings, the head-groups of cardiolipin molecules became associated selectively with

222 Hence, cardiolipin molecules in different organisms, and even d

223 Evidence suggests that cardiolipin molecules segregate into such microdomains,

224 For this hypothesis to be correct, cardiolipin molecules with different acyl chain composit

225 However, the residence times of cardiolipin molecules with the ring were brief and suffi

226 s, of the mitochondrial structural component cardiolipin, of the mitochondrial DNA content, and of th

227 ts mitochondrial cristae by interacting with cardiolipin on the inner mitochondrial membrane.

228 the membrane and demonstrated the effect of cardiolipin on the stabilization of the binding.

229 ia-targeted electron scavenger, we prevented cardiolipin oxidation in the brain, achieved a substanti

230 ages is linked to enhanced mtROS generation, cardiolipin oxidation, and accumulation of cardiolipin h

231 o-apoptotic conditions, however, cyt c gains cardiolipin peroxidase activity, translocates into the c

232 hrome c peroxidase activity, which catalyzes cardiolipin peroxidation and results in mitochondrial da

233 This unfolding mechanism may play a role in cardiolipin peroxidation by cyt c during apoptosis.

234 Non-bilayer-forming lipids such as cardiolipin, phosphatidic acid, and phosphatidylethanola

235 P activity was stimulated by anionic lipids (cardiolipin, phosphatidylglycerol, phosphatidylserine, a

236 a unique assemblage of features, including: cardiolipin, phosphonolipid, amino acid, and fatty acid

237 The head group of cardiolipin plays major role in activation of MgtA sugge

238 cted to the cell membrane inner leaflet) and cardiolipin (present in the inner and outer leaflets of

239 gned tetramers in opposite leaflets and that cardiolipin prevents the translocation of tetramers to t

240 drial respiration and enzyme activities, and cardiolipin profile with no change in mitochondrial cont

241 ction by phospholipase A2 to form diacylated cardiolipin progressing to the completely deacylated hea

242 eta secretion, suggesting that mitochondrial cardiolipin release may trigger abacavir-induced inflamm

243 cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in

244 that these alterations result from increased cardiolipin remodeling by sequential phospholipase and t

245 thetase, demonstrating the first evidence of cardiolipin remodeling in bacteria.

246 Importantly, preventing cardiolipin remodeling initiation in yeast lacking TAZ1,

247 rated that LYCAT modulated bleomycin-induced cardiolipin remodeling, mitochondrial membrane potential

248 We studied the LYCAT action on cardiolipin remodeling, mitochondrial reactive oxygen sp

249 enhances mitochondrial respiration, induces cardiolipin remodeling, reduces specific sphingolipids,

250 Lysocardiolipin acyltransferase (LYCAT), a cardiolipin-remodeling enzyme regulating the 18:2 linole

251 h selective interaction of cytochrome c with cardiolipin, resulting in protein unfolding, where the u

252 Cardiolipin reverses destabilizing effects of ADP and bo

253 cid, the most common fatty acid component of cardiolipin, show that C11 of linoleic acid can sit adja

254 affected by cytochrome c accumulation, while cardiolipin showed major changes in acyl chain structure

255 Finally, pharmacological cardiolipin stabilization reverted the energetic impairm

256 In addition, the mitochondrial lipid cardiolipin stabilized the structure of associated UCP1

257 g the associated detergent micelle size, but cardiolipin stabilizes by direct interactions as well.

258 Cardiolipin stabilizes UCP1, as demonstrated by reconsti

259 amine the subcellular distribution of CL and CARDIOLIPIN SYNTHASE (CLS) and analyzed loss-of-function

260 he last step of CL synthesis is catalyzed by CARDIOLIPIN SYNTHASE (CLS), encoded by a single-copy gen

261 e discovered that M. catarrhalis expresses a cardiolipin synthase (CLS), termed MclS, that is respons

262 Instead, depletion of cardiolipin synthase 1 abolished abacavir-induced IL-1be

263 RNAi-based manipulations of cardiolipin synthase and cardiolipin levels conferred re

264 in cardiolipin biosynthesis is catalyzed by cardiolipin synthase and differs mechanistically between

265 under metabolic stress, thereby identifying cardiolipin synthase as a novel therapeutic target to at

266 Furthermore, transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin

267 esults demonstrate the unanticipated role of cardiolipin synthase in maintaining physiologic membrane

268 gh resolution respirometry demonstrated that cardiolipin synthase transgene expression resulted in im

269 Moreover, cardiolipin synthase transgene expression results in alt

270 During the postnatal period, cardiolipin synthase transgene expression results in mar

271 During depletion of cardiolipin synthase, the levels of cytochrome oxidase s

272 is catalyzed by ClsB, a phospholipase D-type cardiolipin synthase.

273 It was impossible to delete clsA (cardiolipin synthase; SCO1389) unless complemented by a

274 e and anucleate spores and demonstrates that cardiolipin synthesis is a requirement for morphogenesis

275 ound to Nlrp3 directly and interference with cardiolipin synthesis specifically inhibited Nlrp3 infla

276 expression resulted in inhibition of de novo cardiolipin synthesis, reduction in cellular cardiolipin

277 dic acid from the ER to the mitochondria for cardiolipin synthesis.

278 (glucosylceramide) and glycerophospholipid (cardiolipin) synthesis.

279 ion occurred dependent only on tightly bound cardiolipin, tetramer formation required additional card

280 uld have distinct functional capacities, and cardiolipin that has been remodeled should promote cardi

281 t the levels of phosphatidylethanolamine and cardiolipin, the two key inner membrane phospholipids.

282 selective interactions of cytochrome c with cardiolipin, these experiments were repeated where the D

283 nner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function.

284 Further addition of cardiolipin to the proteoliposome reconstitution mixture

285 tions to investigate the specific binding of cardiolipins to yAAC3.

286 ydrated phospholipids, including tetraoleoyl cardiolipin (TOCL) and several phosphatidylcholine lipid

287 for pathogenesis, suggesting that increased cardiolipin trafficking to the OM is necessary for Salmo

288 In addition, the level of tafazzin, a cardiolipin transacylase, is drastically reduced and the

289 phosphotransfer serving local GTP supply and cardiolipin transfer for apoptotic signaling and putativ

290 Here, SIRT5 was observed to bind to cardiolipin via an amphipathic helix on its N terminus.

291 s lost when the mitochondrial specific lipid cardiolipin was present, as Drp1 directly interacted wit

292 ver, the mitochondria-specific phospholipid, cardiolipin, was significantly reduced in both strains c

293 Increased levels of cardiolipin were associated with tubular mitochondria an

294 to the lipoidal antigen used in RPR testing (cardiolipin) were not detected in the MBA.

295 s, such as reactive oxygen species, DNA, and cardiolipin, which can cause NLRP3 inflammasome activati

296 are the ability of unremodeled and remodeled cardiolipin, which differ markedly in their acyl chain c

297 lipids including glycosylated ceramides and cardiolipins, which have no direct connection to ether l

298 HSD10 exhibits a strong preference for cardiolipin with oxidized fatty acids.

299 Drosophila Sniffer and human HSD10, oxidize cardiolipin with similar kinetic parameters.

300 pholipids to monolysocardiolipin to generate cardiolipin with unsaturated fatty acids.

301 y TLC reveal that UCP1 retains tightly bound cardiolipin, with a lipid phosphorus content equating to