ライフサイエンスコーパス: cardioprotection

1 dation markers and autophagic mechanisms for cardioprotection.

2 onist can restore this aging-related loss of cardioprotection.

3 s also required for autophagy activation and cardioprotection.

4 simultaneously study antitumor activity and cardioprotection.

5 f transcription 5 was associated with RIPC's cardioprotection.

6 that PI3K is necessary for exercise-induced cardioprotection.

7 acilitate the development of pharmacological cardioprotection.

8 g may be a mechanism for nitroalkene-induced cardioprotection.

9 an important role in energy homeostasis and cardioprotection.

10 genes by HDL might link innate immunity and cardioprotection.

11 or understanding the underlying mechanism of cardioprotection.

12 ocardial I/R injury with betaARKct imparting cardioprotection.

13 gesting a novel pharmacological strategy for cardioprotection.

14 ation of proteins plays an important role in cardioprotection.

15 andling and play an important role in female cardioprotection.

16 phagy may provide a novel strategy to confer cardioprotection.

17 uce greater amounts of NO, thereby affording cardioprotection.

18 application of topical capsaicin, to elicit cardioprotection.

19 -sensitive conductance and may contribute to cardioprotection.

20 e show involvement of the K(ATP) channels in cardioprotection.

21 et for sustainable prophylactic induction of cardioprotection.

22 caveolae have been found to be critical for cardioprotection.

23 cancer, although these drugs do not provide cardioprotection.

24 vascular nitric oxide species accounting for cardioprotection.

25 gulation of heme oxygenase (HO-1) to provide cardioprotection.

26 osphorylation at its Ser16 site enhances its cardioprotection.

27 ricted expression of iNOS provides sustained cardioprotection.

28 ng ribosome biosynthesis, cell survival, and cardioprotection.

29 nts an endogenously recruitable mechanism of cardioprotection.

30 essential role of PKG in sildenafil-induced cardioprotection.

31 ther sex differences exist in TNFR2-mediated cardioprotection.

32 ng eNOS activation, which ultimately lead to cardioprotection.

33 properties that contribute to their role in cardioprotection.

34 plays critical roles in atheroprevention and cardioprotection.

35 icits similar effects on S-nitrosylation and cardioprotection.

36 athway, the putative mechanism for aspirin's cardioprotection.

37 n pore is emerging as a central mechanism in cardioprotection.

38 examining mechanisms of volatile anesthetic cardioprotection.

39 cogen synthase kinase-3beta (GSK-3beta), and cardioprotection.

40 ibition of both may achieve further enhanced cardioprotection.

41 ucidating the signaling pathways involved in cardioprotection.

42 t hypercholesterolemia abolishes HDL-related cardioprotection.

43 the beta2-adrenergic receptor (beta2-AR) in cardioprotection.

44 strate Akt but had no effect on EPO-mediated cardioprotection.

45 of PKCdelta-suppressed Mvarphi recapitulates cardioprotection.

46 in vivo would represent a novel approach of cardioprotection.

47 tin-1 on cardiac myocytes contribute to this cardioprotection.

48 nase (ERK) but had no effect of EPO-mediated cardioprotection.

49 e completely eradicated the training-induced cardioprotection.

50 t might translate into long-term nephro- and cardioprotection.

51 p in developing novel therapeutics for acute cardioprotection.

52 inhibition of cell death, thus resulting in cardioprotection.

53 act of using NANSAIDs along with aspirin for cardioprotection.

54 during ischemia contributed to EPO-mediated cardioprotection.

55 eraction with the proteasome, still promoted cardioprotection.

56 re act as humoral transfer factors of RIPC s cardioprotection.

57 tion, and the development of hypertrophy and cardioprotection.

58 important but previously undescribed role in cardioprotection.

59 tion of both molecular pathways that trigger cardioprotection.

60 ct size, it would be premature to give up on cardioprotection.

61 e IAE was more effective than that of MVT in cardioprotection.

62 nnels play crucial roles in excitability and cardioprotection.

63 SM, yet there are no reports that it confers cardioprotection.

64 ve stimulation (VNS) has been shown to exert cardioprotection.

65 xplored role of S-nitrosylated hemoglobin in cardioprotection.

66 ricular myocardium is associated with RIPC s cardioprotection.

67 tribution of adenosine in ticagrelor-related cardioprotection.

68 y partially account for the nitrite-mediated cardioprotection.

69 as a critical component in exosome-mediated cardioprotection.

70 have truly a chance to benefit from adjunct cardioprotection.

71 hages with clodronate abolished CDC-mediated cardioprotection.

72 n nitric oxide (NO) production to potentiate cardioprotection.

73 This is a revolutionary new approach to cardioprotection.

74 ophagy induction might underlie the observed cardioprotection.

75 on how the citric acid cycle is involved in cardioprotection.

76 se 2beta as the primary molecular target for cardioprotection.

77 s a potential therapeutic target for post-MI cardioprotection.

78 nism of endothelial lipase function improves cardioprotection.

79 n lieu of postconditioning caused equivalent cardioprotection (15.0+/-2.6% infarction), whereas 1 min

80 on and reperfusion has been shown to produce cardioprotection, a phenomenon termed anesthetic-induced

81 ineered mice to test the hypothesis that the cardioprotection afforded by iNOS gene transfer is media

82 examine the involvement of KATP channels in cardioprotection afforded by preconditioning.

83 The cardioprotection afforded by RhoA was reversed by PKD in

84 100 g/L hemoglobin in anemic animals offers cardioprotection after acute myocardial infarction.

85 Although efficient cardioprotection after HO-1 overexpression has been repo

86 on into the signaling mechanisms involved in cardioprotection after IPC was performed in both uremic

87 t and necessary for the resulting late phase cardioprotection against a subsequent ischemia/reperfusi

88 spholipase C-delta1 in TNF receptor-mediated cardioprotection against adriamycin-induced injury was e

89 PHLPP-1 knockdown enhances LIF-mediated cardioprotection against doxorubicin and also protects c

90 on a panel of human cancer cell lines, their cardioprotection against doxorubicin-induced apoptosis i

91 ng sufficient endothelial BH4 is crucial for cardioprotection against hypoxia/reoxygenation injury.

92 Thus, Sestrin2 plays an important role in cardioprotection against I/R injury, serving as an LKB1-

93 PKD as a downstream mediator of RhoA and in cardioprotection against I/R.

94 yocardial hypertrophy and heart failure, and cardioprotection against ischaemia-reperfusion.

95 of vasodilation and platelet aggregation, in cardioprotection against ischemia injury.

96 livery of psi(epsilon)RACK confers sustained cardioprotection against ischemia-reperfusion in isolate

97 kinase C (PKC), psi(epsilon)RACK, conferred cardioprotection against ischemia-reperfusion when deliv

98 il, a phosphodiesterase-5 inhibitor, induces cardioprotection against ischemia/reperfusion injury via

99 treatment leads to increased protein SNO and cardioprotection against ischemia/reperfusion injury, su

100 e ischemic stimuli have been shown to elicit cardioprotection against ischemia/reperfusion injury, th

101 ential factor produced by EC, which promotes cardioprotection against ischemic injury.

102 RCS induces cardioprotection against lethal myocardial ischemia that

103 bition of PI3K abolished the HSPA12B-induced cardioprotection against myocardial I/R injury.

104 lae and Cav-3 are essential for AS-1-induced cardioprotection against myocardial I/R injury.

105 odulation of Ca(2)(+) handling provides some cardioprotection against the paradoxical effects of rest

106 This review focuses on mechanisms by which cardioprotection alters mitochondrial proteins and chann

107 nt bioactive molecule, capable of conferring cardioprotection and a variety of other benefits in the

108 p110alpha) is essential for exercise-induced cardioprotection and delivery of caPI3K vector can impro

109 idate possible mechanisms of nitrite-induced cardioprotection and have implications for nitrite dosin

110 antisense PGC-1alpha prevented DPN-mediated cardioprotection and increase in ATP levels and Tfam but

111 heightened sympathetic activity to aberrant cardioprotection and increased ischemic vulnerability in

112 In addition, the DPN-induced cardioprotection and increased SNO were abolished by tre

113 The importance of the PKCepsilon isozyme in cardioprotection and its relationship to cardioprotectio

114 ects at mitochondria have been implicated in cardioprotection and mitochondria/cytosol fractionation

115 tion occurs in vivo and on its mechanisms of cardioprotection and modulation of energy metabolism.

116 her show that meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-re

117 consistently reduced infarct size indicating cardioprotection and PDE5Is also promote reverse remodel

118 bition of Arg1 in wild-type mice had similar cardioprotection and reduced inflammation after MI as Fo

119 vivo from cardiac biopsies; they confer both cardioprotection and regeneration in acute myocardial in

120 tor mechanism(s) mediating annexin 1-induced cardioprotection and shows a pivotal role for ALX and ci

121 -independent effectors are required for full cardioprotection and suggest a mechanism by which chroni

122 data show an important role for beta2-AR in cardioprotection and support the novel hypothesis that p

123 gatory downstream effector of iNOS-dependent cardioprotection and that NF-kappaB is a critical link b

124 ct relationship of PKG in sildenafil-induced cardioprotection and the downstream targets of PKG remai

125 ion puncture to assess hemodynamic efficacy, cardioprotection, and biomechanics under acute or contin

126 injection (10 mg/kg), hemodynamic efficacy, cardioprotection, and biomechanics were assessed under I

127 is essential for mediating exercise-induced cardioprotection, and if so, whether its activation inde

128 , generates reproducible results, can detect cardioprotection, and provides a mechanism for assessing

129 ling, contributing to extension of lifespan, cardioprotection, and tumor inhibition.

130 1 as well as 8 paracrine factors involved in cardioprotection, angiogenesis, and stem cell function.

131 During the late phase of cardioprotection, antigen immunomodulatory pathways were

132 Outcomes of cardioprotection are affected by age, sex, comorbidities

133 ional control of pathological remodeling, to cardioprotection arising from caloric restriction.

134 active transdifferentiation, resulting into cardioprotection as indicated by diminished scar formati

135 r activation with apelin peptides results in cardioprotection as noted through positive ionotropy, an

136 s which have previously been associated with cardioprotection, before (baseline)/after RIPC or placeb

137 a qualitatively different genomic profile of cardioprotection between ischemic preconditioning induce

138 dies addressing long-term effects of adjunct cardioprotection beyond infarct size reduction, that is,

139 om numerous successful animal experiments on cardioprotection beyond that by reperfusion to clinical

140 Therefore, cardioprotection beyond that by timely reperfusion is ne

141 Therefore, cardioprotection beyond timely reperfusion is needed.

142 psilonPKC activator psi(epsilon)RACK induced cardioprotection both in vivo and ex vivo, reduced the i

143 ed the involvement of Cav-3 in AS-1 mediated cardioprotection both in vivo and in vitro.

144 ivates cell signaling pathways and generates cardioprotection but has not been linked to LMP-2 functi

145 nly provide a potential new target for acute cardioprotection but it may also act as an anti-diabetic

146 ssential downstream effector of AKT-mediated cardioprotection but the mechanistic basis for maintenan

147 naproxen, may provide some lesser degree of cardioprotection, but conclusive evidence is lacking.

148 PCR (A1AR) is a major therapeutic target for cardioprotection, but current agents acting on the recep

149 These results suggest that MnSOD provides cardioprotection by attenuating IR-induced oxidation and

150 cise-induced increase in MnSOD would provide cardioprotection by attenuating IR-induced oxidative mod

151 sitive potassium channel in the mechanism of cardioprotection by DZX.

152 Postischemia cardioprotection by EPO required the PI3K pathway but wa

153 Also, cardioprotection by exenatide treatment is independent o

154 vectors available for this emerging field of cardioprotection by gene-based therapy.

155 Recent experiments suggest that cardioprotection by hypoxic preconditioning or exposure

156 Myocardial ischemia and cardioprotection by ischemic pre-conditioning induce sig

157 potassium channel (mK(ATP)) is implicated in cardioprotection by ischemic preconditioning (IPC), but

158 c function, ischemia-reperfusion injury, and cardioprotection by ischemic preconditioning.

159 Cardioprotection by Klotho in normal mice is mediated by

160 ly at intercalated discs (IDs) and conferred cardioprotection by maintaining normal ID structure and

161 Perioperative cardioprotection by means of gene therapy might improve

162 mechanism of DOX-induced cardiomyopathy and cardioprotection by mitoquinone (Mito-Q), a triphenylpho

163 duration of ischemia can be so that adjunct cardioprotection by postconditioning at reperfusion stil

164 diac mast cells, contributing to IPC-induced cardioprotection by preventing mast cell renin release a

165 Cardioprotection by RIPC in pigs causally involves activ

166 globin within the target organ abrogated the cardioprotection by rIPC.

167 thesis that IPC-induced protein SNO provides cardioprotection by shielding cysteine residues from rea

168 The loss of cardioprotection by the mutant Hsp20 was associated with

169 ompound C (AMPK inhibitor) partially blocked cardioprotection by TP, suggesting that both PKC and AMP

170 This loss of cardioprotection by Ucn was also seen in whole hearts fr

171 Cx43 C-terminal binding peptide RRNYRRNY for cardioprotection, circumventing further upstream pathway

172 studies showed that they conferred enhanced cardioprotection compared to adenine or 4-hydroxythioben

173 ense oligonucleotides greatly attenuated the cardioprotection conferred by exercise.

174 on (p < .05), NO increase (p < .05), and the cardioprotection conferred by hypercarbic reperfusion (i

175 s compared to wild-type mice and loss of the cardioprotection conferred by ischemic preconditioning.

176 nce has indicated that it provides long-term cardioprotection; continuous infusions should be elimina

177 dence showing PostC-induced infarct-limiting cardioprotection could be triggered by activation of mul

178 a novel therapeutic strategy for neuro- and cardioprotection, disorders of smooth muscle hyperactivi

179 ata suggest that Pim-1 is a crucial facet of cardioprotection downstream of Akt.

180 reventing no-reflow and conferring secondary cardioprotection during AMI.

181 f the METOCARD-CNIC (effect of METOprolol of CARDioproteCtioN during an acute myocardial InfarCtion)

182 The METOCARD-CNIC (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction)

183 epsilon (PKCepsilon) plays a pivotal role in cardioprotection during cardiac ischemia and reperfusion

184 se at the remote site of rIPC contributes to cardioprotection during I/R.

185 H2S therapy with SG-1002 resulted in cardioprotection during transverse aortic constriction v

186 yloidogenic protein and the first conferring cardioprotection even in the unfavourable context of ren

187 the PI3K/Akt signaling pathway in TLR4(-/-) cardioprotection following I/R injury.

188 icate ankyrin-B as a molecular component for cardioprotection following ischemia.

189 receptor-beta and consequently contribute to cardioprotection following trauma hemorrhage.

190 We evaluated metallothionein (MT)-mediated cardioprotection from angiotensin II (Ang II)-induced pa

191 e discuss the difficulties in translation of cardioprotection from animal experiments and proof-of-co

192 Dexrazoxane provides long-term cardioprotection from doxorubicin-associated cardiotoxic

193 Thus, TP508 may offer a novel approach in cardioprotection from ischemia-reperfusion injury in dia

194 ion of glycolytic enzymes and Per2-dependent cardioprotection from ischemia.

195 ck proteins (Hsps) have been shown to render cardioprotection from stress-induced injury; however, li

196 igh-density lipoprotein (HDL) cholesterol in cardioprotection has been questioned by genetic and rand

197 he effect of fluoxetine on mK(ATP)-dependent cardioprotection has implications for the growing use of

198 otein important in insulin sensitization and cardioprotection, has a strong genetic component.

199 Several methods of cardioprotection have shown the ability to limit myocard

200 t contribute to ischemic preconditioning and cardioprotection, high levels of ROS induce structural m

201 us wave was ameliorated only in pigs showing cardioprotection (ie, those undergoing short-duration is

202 Regional hHO-1 gene therapy provides cardioprotection in a pre-clinical porcine ischemia/repe

203 investigated the use of sildenafil-mediated cardioprotection in a rat model of heterotopic cardiac t

204 Cardiosphere-derived cells (CDCs) confer cardioprotection in acute myocardial infarction by disti

205 n of CRP is thus a promising new approach to cardioprotection in acute myocardial infarction, and may

206 We tested the hypothesis that cardioprotection in females is mediated by altered mitoc

207 emic preconditioning (PC) is known to confer cardioprotection in healthy animal models, it is unknown

208 Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related

209 localization suggest possible mechanisms of cardioprotection in MKK6 TG mouse hearts.

210 heart by ischemia/reperfusion confers robust cardioprotection in part through induction of the HBP.

211 the safety of one glass of wine per day for cardioprotection in patients at risk for both coronary h

212 rsus NRG, NN has translational potential for cardioprotection in patients with cancer receiving anthr

213 is a potential mediator of exercise-induced cardioprotection in post-MI rats.

214 viable therapeutic approach to enhance late cardioprotection in postischemic heart disease.

215 rresponding to cytotoxicity in the tumor and cardioprotection in the heart.

216 ressing an elusive clinical goal: meaningful cardioprotection in the postreperfusion time period.

217 unique capacity of (-)-epicatechin to confer cardioprotection in the setting of a severe form of myoc

218 The Working Group concluded that cardioprotection in the setting of acute myocardial infa

219 the presence of mRQ with ADR conferred full cardioprotection in these mice.

220 A and EPA omega-3 PUFA that provides maximal cardioprotection in those at risk of CV disease as well

221 onse to ischemia and is sufficient to confer cardioprotection in vivo equally potent to preconditioni

222 tective or a central mediator of adiponectin cardioprotection in vivo remains unknown.

223 tide and a stable lipoxin A4 analog) exerted cardioprotection in wild-type and FPR null mice to an eq

224 yocardial IPC, and SNO is thought to provide cardioprotection, in part, by reducing cysteine oxidatio

225 e of glycogen synthase kinase (GSK)-3beta in cardioprotection, including pre- and postconditioning.

226 opropionyl) glycine during TP also abolished cardioprotection, indicating an involvement of free radi

227 mice; genetic deletion of eNOS abrogated the cardioprotection induced by late PC.

228 (1) unlike all other known forms of delayed cardioprotection, infarct sparing following chronic exer

229 The conditioning phenomena provide such cardioprotection, insofar as brief episodes of coronary

230 This cardioprotection is associated with a decrease in reperf

231 f failure has led us and others to wonder if cardioprotection is dead.

232 However, PDGF-AB cardioprotection is diminished in older animals, suggest

233 e tested the hypothesis that ERbeta-mediated cardioprotection is induced via up-regulation of PGC-1al

234 er women generally being protected, but this cardioprotection is lost later in life, suggesting a rol

235 uestion of whether post-conditioning-induced cardioprotection is maintained in aging cohorts is unkno

236 One proposed mechanism of cardioprotection is mitochondrial matrix swelling.

237 (eNOS) in ischemic preconditioning (PC) and cardioprotection is poorly understood.

238 Receptor-mediated cardioprotection is triggered by an intracellular signal

239 eutic strategy to target mTORC1 and increase cardioprotection is under intense investigation.

240 Whereas psi(epsilon)RACK-induced cardioprotection lasted 1 hour after a single intraperit

241 novel 5HT2R antagonists, with potential for cardioprotection, liver protection, or central nervous s

242 nd Col14a1, with concomitant upregulation of cardioprotection markers, including COX-2 itself, lipoca

243 These results suggest a novel cardioprotection mechanism by Mito-Q during DOX-induced

244 ts reveal a novel gender-specific pathway of cardioprotection mediated by ERalpha and its regulation

245 optimization of tissue-level perfusion, and cardioprotection must be addressed to improve patient ou

246 ferences in the mechanisms of TNFR2-mediated cardioprotection occur by increasing STAT3, SOCS3, and v

247 ockout mice, indicating that the DPN-induced cardioprotection occurs through the activation of ER-bet

248 However, a significant portion of the cardioprotection of adiponectin against MI/R injury was

249 However, the mechanism underlying cardioprotection of Hsp20 and especially the role of its

250 gulation of cyclooxygenase-2 (COX-2) and the cardioprotection of late preconditioning (PC), the role

251 c targets in cardiovascular diseases such as cardioprotection of murine hearts after myocardial infar

252 and XI), we investigated the role of PKB in cardioprotection of the rat and human myocardium, the lo

253 refore, we determined whether opioid-induced cardioprotection (OIC) occurs during reperfusion by alte

254 18BP genetically modified stem cells improve cardioprotection over that observed with unmodified stem

255 hol intake can actually provide a measure of cardioprotection, particularly against coronary heart di

256 y-ligated rat heart, suggests that AA-driven cardioprotection primarily arises from PPARalpha agonism

257 ent with leptin (0.12 mug/kg i.v.) abolished cardioprotection produced by Goodbelly.

258 in cardioprotection and its relationship to cardioprotection produced by Ucn was assessed using PKCe

259 ) 24 h before ischemia/reperfusion abolished cardioprotection produced by vancomycin treatment.

260 of the mechanistic basis for Pim-1 mediated cardioprotection provides important insights for designi

261 animal MI models, TG100-115 provided potent cardioprotection, reducing infarct development and prese

262 Red wine may offer increased cardioprotection related to its antioxidant properties.

263 ion in organs remote from the heart provides cardioprotection (remote ischemic conditioning).

264 ly modify ANT1 and that nitroalkene-mediated cardioprotection requires ANT1.

265 Cardioprotection resulting from the absence of HDAC5 or

266 Thus, the cardioprotection seems to correlate to antagonism to het

267 We conclude that IPC-induced miRNAs trigger cardioprotection similar to the delayed phase of IPC, po

268 sue injury, a phenomenon termed sex-specific cardioprotection (SSC).

269 m of beta(2)ARs abolished betaARKct-mediated cardioprotection, suggesting that enhanced GRK2 activity

270 unique endogenously recruitable mechanism of cardioprotection that may involve direct modification of

271 is review addresses the role of autophagy in cardioprotection, the balance of catabolism and anabolis

272 rease, and there is a need to provide better cardioprotection (therapy that reduces the amount of nec

273 Adenosine elicits cardioprotection through A1-receptor activation.

274 or mitochondrial STAT3 activation to mediate cardioprotection through better mitochondrial function.

275 ell death through PKA-dependent pathways and cardioprotection through PKA-independent pathways.

276 contributed to the failure of translation of cardioprotection to clinical practice.

277 Fluoxetine also blocked cardioprotection triggered by IPC, but did not block pro

278 uated potential mechanisms of H(2)S-mediated cardioprotection using an in vivo model of pharmacologic

279 f SIAH in facilitating NO/netrin-1-dependent cardioprotection, using the DCC receptor.

280 ergic receptor (beta1AR) stimulation confers cardioprotection via beta-arrestin-de pend ent transacti

281 Delayed ischemic preconditioning promotes cardioprotection via genomic reprogramming.

282 w the importance of L-arginine and BH(4) for cardioprotection via regulation of mitochondrial oxidati

283 )ATSM may provide a therapeutic strategy for cardioprotection via upregulation of antioxidant defense

284 as a Kcnma1 product because NS1619-mediated cardioprotection was absent in Kcnma1 knockout mice.

285 hways, demonstrating that fingolimod-induced cardioprotection was mediated by reperfusion injury salv

286 iNOS-mediated cardioprotection was not abolished by atractyloside.

287 Similar cardioprotection was observed in guinea pig hearts treat

288 Cardioprotection was prevented by a neutralizing antibod

289 d continued during reperfusion, EPO-mediated cardioprotection was significantly inhibited.

290 he potential mechanisms of O-GlcNAc-mediated cardioprotection, we discuss technical issues related to

291 n kinase (PKG) signaling plays a key role in cardioprotection, we hypothesized that PKG activation wi

292 H) and remarkably concordant nitrite-induced cardioprotection, which both followed a complex dose-res

293 lso post-I/R) still demonstrated significant cardioprotection, which suggested a potential protective

294 ting protein S-nitrosylation and its role in cardioprotection will provide us new therapeutic opportu

295 represents a novel therapeutic strategy for cardioprotection with great potential clinical utility.

296 R injury demonstrated significant functional cardioprotection with reduced myofibroblast transformati

297 Additionally, we contemplated that cardioprotection with tadalafil is mediated by hydrogen

298 ncy of heart-targeted delivery and effective cardioprotection with this combination approach.

299 Dexrazoxane provides long-term cardioprotection without compromising oncological effica

300 emical changes in isolation, to suggest that cardioprotection would necessarily follow; rather, direc