ライフサイエンスコーパス: cardioprotective

1 s were not restricted to the kidney but were cardioprotective.

2 tion of O-GlcNAcylation has been shown to be cardioprotective.

3 r, evidence suggests that sirolimus might be cardioprotective.

4 s similar suggests that sirolimus is in fact cardioprotective.

5 te as to whether light-to-moderate intake is cardioprotective.

6 on, which we initially hypothesized would be cardioprotective.

7 uggested that HRT may be neuroprotective and cardioprotective.

8 ) and/or endurance exercise training (EX) is cardioprotective.

9 ported by a perception that modest intake is cardioprotective.

10 The cardioprotective action of HDL and its major protein, ap

11 This cardioprotective action of HSPA12B was mediated, at leas

12 GLP-1R agonists and DPP-4 inhibitors exhibit cardioprotective actions in animal models of myocardial

13 schaemic insults in vitro, but its long-term cardioprotective actions in vivo are largely unknown.

14 The cardioprotective actions of the fish oil (FO)-derived lo

15 rats and healthy volunteers, evaluate their cardioprotective actions, and identify the molecular mec

16 ectin, an adipocyte-derived cytokine, exerts cardioprotective actions, and its deficiency is implicat

17 nzyme that inactivates peptides that possess cardioprotective actions, correlates with adverse outcom

18 t containing olive pomace (OP), that exhibit cardioprotective activities.

19 , anti- inflammatory, anti-proliferative and cardioprotective activities.

20 f both pharmacophores results in synergistic cardioprotective activity through the combination of bot

21 total protein carbonylation corresponded to cardioprotective activity.

22 an target of rapamycin inhibitors may confer cardioprotective advantages, but clinical data are limit

23 ge, that drugs targeting the IKK complex are cardioprotective against cancer cachexia-induced cardiac

24 PC of the arm identified plasma nitrite as a cardioprotective agent in isolated Langendorff mouse hea

25 NN is a cardioprotective agent that promotes cardiomyocyte survi

26 The most promising pharmaceutical cardioprotective agents at this time appear to be adenos

27 chemotherapy, development and application of cardioprotective agents for prevention of cardiotoxicity

28 osages of anthracyclines and coadministering cardioprotective agents may prevent some of these cardio

29 iotoxicity should receive closer monitoring, cardioprotective agents, dose adjustment or alternative

30 patients was observed despite treatment with cardioprotective agents.

31 ester transfer protein (CETP) inhibitors as cardioprotective agents.

32 (EPA) and docosahexaenoic acid (DHA), elicit cardioprotective and anti-inflammatory effects through u

33 HDL exhibits cardioprotective and anti-inflammatory properties though

34 ediated arrhythmias in T2DM via its putative cardioprotective and antidiabetic property.

35 ropaea L., exerts hypoglycemic, antioxidant, cardioprotective and antitumoral activities.

36 e STAT3 transcription factor in the heart is cardioprotective and decreases the levels of reactive ox

37 Dexrazoxane was cardioprotective and did not compromise antitumor effica

38 acid (DHA) has been demonstrated to possess cardioprotective and immune-enhancing effects.

39 des a novel mechanism by which HN exerts its cardioprotective and neuroprotective effects.

40 Furthermore, the observed cardioprotective and other health effects of ALA have be

41 unction, and heart disease with focus on the cardioprotective and sensitizing effect of growth factor

42 ypoxic stress is essential to maximize their cardioprotective and therapeutic potential.

43 NO3(-)) and nitrite (NO2(-)) are known to be cardioprotective and to alter energy metabolism in vivo

44 ld uncoupling of mitochondria is known to be cardioprotective, and adenine nucleotide translocase 1 (

45 ral products that display potent anticancer, cardioprotective, and neuroprotective activities.

46 sociated peptide that offers cytoprotective, cardioprotective, and neuroprotective effects in vivo an

47 The recognition that cell therapy may be cardioprotective, and not just regenerative, merits furt

48 Exenatide has been demonstrated to be cardioprotective as an adjunct to primary percutaneous c

49 uch speculation with regard to the potential cardioprotective benefits of equol, a microbial-derived

50 ition, they have long been debated to confer cardioprotective benefits.

51 might limit mitochondrial Ca(2+) load and be cardioprotective, but direct evidence for tPTP in cells

52 that fully functional adipose tissue can be cardioprotective by reducing lipotoxic effects in other

53 activated kinase that has been shown to have cardioprotective capabilities against myocardial ischemi

54 some of the newest agents that seem to have cardioprotective capabilities.

55 heart failure by potentially activating this cardioprotective channel.

56 Although natriuretic peptides are considered cardioprotective, clinical heart failure trials with rec

57 Moderate alcohol consumption is known to be cardioprotective compared with either heavy drinking or

58 To address the cardioprotective contribution of PGI2, we generated mice

59 n provides ultrafast and potently neuro- and cardioprotective cooling after shockable cardiac arrest

60 e endpoints, and in some cases initiation of cardioprotective drug therapy in asymptomatic women.

61 nate), which is an approved, clinically used cardioprotective drug, is a relatively poor BBOX inhibit

62 nhanced by widely used anti-inflammatory and cardioprotective drugs (aspirin and statins) via the mod

63 nsiderable efforts have been made to exploit cardioprotective drugs and gene delivery systems for myo

64 comprehensive prescription of evidence-based cardioprotective drugs.

65 s of the beta1AR transduction cascade and is cardioprotective during heart failure.

66 s, although short-term Akt activation may be cardioprotective during ischemia by reducing mitochondri

67 Hence, modulation of this axis may be cardioprotective during ischemia.

68 ac function in control animals, leptin had a cardioprotective effect following TAC, normalizing cardi

69 us on cardiac function in sham, leptin had a cardioprotective effect following TAC.

70 patients with short system delay, whereas no cardioprotective effect in patients with long system del

71 stromal cells to TLR3-/- mice abolished the cardioprotective effect in sepsis.

72 This study sought to determine how this cardioprotective effect is influenced by the timing of m

73 cardiac-specific GRK2 knockdown restored the cardioprotective effect of adiponectin.

74 A cardioprotective effect of cGMP/cGKI has been reported i

75 However, the cardioprotective effect of cyclosporine in neonates has

76 In addition, whether the cardioprotective effect of exenatide, a glucose-lowering

77 ay significantly contributes to the observed cardioprotective effect of FTY720.

78 The cardioprotective effect of HDL is thought to be largely

79 njury, siRNA knockdown of ANT1 inhibited the cardioprotective effect of LNO(2).

80 n of cardiovascular risk in diabetes and the cardioprotective effect of metformin.

81 ective of this study was to determine if the cardioprotective effect of PAI-1 is mediated through its

82 amelioration of pathological remodeling, the cardioprotective effect of this drug was not significant

83 genetic evidence to demonstrate a long-term cardioprotective effect of TOR signaling inhibition on a

84 The cardioprotective effect of ultrasound targeted hs-MB des

85 This was predominantly because of a cardioprotective effect on ischemic segments (strain rat

86 Mechanistically, TAK1 exerts its cardioprotective effect through activation of NFAT/NFkap

87 This cardioprotective effect was associated with alleviation

88 tration of DNase I and rhADAMTS13 revealed a cardioprotective effect, resulting in subsequent improve

89 thus, RAS activation, ultimately exerting a cardioprotective effect.

90 se-derived stem cells (ADSCs) enhances their cardioprotective effects after transplantation into infa

91 se results strongly indicate that Myr exerts cardioprotective effects against DCM through the blockag

92 Mechanistically, these cardioprotective effects are conveyed by the antihypertr

93 The remarkable cardioprotective effects ascribed to heme oxygenase-1 ar

94 ciation could explain, at least in part, the cardioprotective effects attributed to fiber intake.

95 or, beyond its antiplatelet efficacy, exerts cardioprotective effects by reducing necrotic injury and

96 oglia at the level of the spinal cord elicit cardioprotective effects during seizure.

97 e, a representative prodrug exhibited potent cardioprotective effects in a murine model of myocardial

98 n-like peptide 1 (GLP-1) agonists have shown cardioprotective effects in early clinical studies of pa

99 thesis that apoptosis imaging can detect the cardioprotective effects of a conditioned MSC patch graf

100 ew evaluates the current evidence behind the cardioprotective effects of a Mediterranean dietary patt

101 the mobilization of CXCR4(+) cells, and the cardioprotective effects of AMD3100 were retained in eNO

102 The cardioprotective effects of autophagy deficiency were re

103 Furthermore, the cardioprotective effects of beta(3)-AR agonists are medi

104 -secreted exosomes (CDCexo) recapitulate the cardioprotective effects of CDC therapy known as cellula

105 PKCdelta transcript levels and underlies the cardioprotective effects of CDCs administered after repe

106 at epicatechin may in part contribute to the cardioprotective effects of cocoa and tea by improving i

107 Cardioprotective effects of cyclosporine have been obser

108 The sustained cardioprotective effects of exercise are mediated by alt

109 iochemical changes have been linked with the cardioprotective effects of exercise, including increase

110 e objective of this study was to compare the cardioprotective effects of fresh vs. stored blood when

111 Cardioprotective effects of FTY720 were abolished follow

112 Cardioprotective effects of FTY720 were confirmed in pol

113 This novel mechanism might contribute to the cardioprotective effects of ghrelin in HF.

114 s largely in ventricles and is vital for the cardioprotective effects of Hsp20.

115 The aim of this study was to confirm the cardioprotective effects of hypothermia using a combinat

116 Previous studies have indicated that the cardioprotective effects of long-chain (LC) n-3 (omega-3

117 Although studies have demonstrated the cardioprotective effects of matrix metalloproteinase inh

118 The cardioprotective effects of mesenchymal stem cells (MSCs

119 Furthermore, the cardioprotective effects of NaHS were enhanced by inhibi

120 esses are putative mechanisms underlying the cardioprotective effects of physical activity.

121 The promising cardioprotective effects of recombinant human erythropoi

122 indings provide new insights into the remote cardioprotective effects of RF-RDN acting directly on ca

123 The cardioprotective effects of SAHA during ischemia/reperfu

124 uding HF, the mechanisms responsible for the cardioprotective effects of SGLT2 inhibitors remain inco

125 ADSCs, and depletion of IGF-1 attenuated the cardioprotective effects of shPHD2-ADSC-conditioned medi

126 inhibition may partially explain the robust cardioprotective effects of statins are warranted.

127 hat quercetin plays an important role in the cardioprotective effects of tea.

128 ular targeting of Pim1 bolsters the distinct cardioprotective effects of this kinase in hCPCs to incr

129 yl)theophylline administration abolished the cardioprotective effects of ticagrelor over clopidogrel.

130 The cardioprotective effects of TNF-alpha are a consequence

131 ed by our bioreducible polymer might produce cardioprotective effects on post-infarct cardiac remodel

132 ter increase in aerobic capacity and greater cardioprotective effects than exercise at moderate inten

133 Na2S induces cardioprotective effects through miR-21-dependent attenu

134 These cardioprotective effects were associated with a signific

135 ke peptide-1, an incretin hormone with known cardioprotective effects, alongside MSC endogenous parac

136 MPCs exert extensive cardioprotective effects, and are considered to be immun

137 ncluding positive fluid balance), along with cardioprotective effects, modulation of circulatory infl

138 dine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy a

139 g was followed by significant angiogenic and cardioprotective effects.

140 sential autophagy proteins, abolished SAHA's cardioprotective effects.

141 roviding a novel potential mechanism for its cardioprotective effects.

142 in is widely used for relief of pain and for cardioprotective effects.

143 ntribute to ACE inhibitors' (ACEi) reno- and cardioprotective effects.

144 imental and clinical research supporting its cardioprotective effects.

145 MPO) has been proposed to deprive HDL of its cardioprotective effects.

146 c hypertrophy, and blunts metformin-mediated cardioprotective effects.

147 known free radical scavengers and have shown cardioprotective effects.

148 systemic metabolism and exerts also relevant cardioprotective effects; hence, it has been proposed fo

149 miR-181b alter Mvarphi phenotype and confer cardioprotective efficacy in a rat model of myocardial i

150 abolites, including a marked increase in the cardioprotective eicosanoid 14,15-epoxyeicosatrienoic ac

151 sion and activity of superoxide dismutase, a cardioprotective enzyme.

152 g in increased plasma EPA composition may be cardioprotective, especially in minor allele homozygotes

153 Follistatin-like1 (FSTL1) is a cardioprotective factor against ischemic injury and is i

154 )GPI in the fetal circulation may be a novel cardioprotective factor in anti-Ro60-exposed pregnancies

155 ectors (AAVs) encoding anti-inflammatory and cardioprotective factors appears to be a promising thera

156 pressive and prosurvival agents, delivery of cardioprotective factors packaged in exosomes rather tha

157 other toxicants at the cost of reduction in cardioprotective fatty acids.

158 eptide with a short circulating-half life is cardioprotective following MI but its clinical use is li

159 Long-term HAART appears to be cardioprotective for HIV-infected children and adolescen

160 duced intermediate filament cytoskeleton has cardioprotective function in mice and potentially in hum

161 gest that the novel mechanism underlying the cardioprotective function of H2S is secondary to a combi

162 ciated proteins and, ultimately, improve the cardioprotective function of HDL.

163 phosphorylation of Ser96 is critical for the cardioprotective function of HRC.

164 Here we provide evidence for a cardioprotective function of TNF-alpha in a genetic hear

165 odel, whether the reported impairment of HDL cardioprotective function was associated with alteration

166 trin-1, is critical for mediating netrin-1's cardioprotective function.

167 tion of SIAH1/2 further augmented netrin-1's cardioprotective function.

168 t regulation of miRNA function could serve a cardioprotective function.

169 tress resistance in multiple cell types, but cardioprotective functions have not been reported previo

170 Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homo

171 calcineurin (CN) to potentiate induction of cardioprotective gene expression while suppressing expre

172 laborate a spatial- and chronologic model of cardioprotective gene networks to prevent left ventricul

173 ega-3 Fatty acids continue to be promoted as cardioprotective, generating an increased demand for the

174 ur data demonstrate that Dusp1 and Dusp4 are cardioprotective genes that play a critical role in the

175 Cardioprotective GRK2 inhibition required an intact ERK

176 prescribed antagonists that promote slower, cardioprotective heart rates during heightened vigilant

177 est that B-type natriuretic peptide (BNP) is cardioprotective; however, in clinical studies, higher p

178 arious kinases, leading to activation of the cardioprotective HSP27.

179 dium by a pathway involving TLR4 and classic cardioprotective HSPs.

180 cellular regenerative products, interesting cardioprotective, immunoregulatory, and cardioregenerati

181 tigate whether gene transfer of Ang-(1-9) is cardioprotective in a murine model of myocardial infarct

182 Monomeric CXCL12, but not dimeric CXCL12, is cardioprotective in a number of experimental models of c

183 The exosome-rich fraction was powerfully cardioprotective in all tested models of cardiac ischemi

184 ibrate is well tolerated, and is potentially cardioprotective in patients with atherogenic 'mixed' dy

185 sed for the treatment of type 2 diabetes are cardioprotective in preclinical studies; however, some c

186 Helium proved neuroprotective in rodents and cardioprotective in rabbits, and there were too few data

187 t effects, being neuroprotective in rodents, cardioprotective in rodents and pigs, and renoprotective

188 of enhanced catabolism or adipose tissue is cardioprotective in the context of HF.

189 inhibition initiated 1 week post-injury was cardioprotective in the I/R model of chronic HF, includi

190 (mRQ) when co-administered with ADR, will be cardioprotective in vitro and in vivo, while maintaining

191 eperfusion phase of myocardial infarction is cardioprotective in vivo in mice.

192 s deserves attention because Pim-1 kinase is cardioprotective, in part, by preservation of mitochondr

193 ation in neonatal hearts may present a novel cardioprotective intervention to limit post-ischemic con

194 onditioning procedures are the most powerful cardioprotective interventions in animal experiments.

195 The translation of cardioprotective interventions to clinical practice has

196 sed risk of heart failure; whether Klotho is cardioprotective is unknown.

197 Cardioprotective kinase Pim-1 increases asymmetric cell

198 Our studies identify a cardioprotective lncRNA, define a new targeting mechanis

199 odification of a cysteine switch is a robust cardioprotective mechanism and hence a rational therapeu

200 f cAMP from cardiac myocytes is an intrinsic cardioprotective mechanism in response to cardiac stress

201 antioxidative activity, representing two key cardioprotective mechanisms of HDL, were profoundly supp

202 We aimed to identify novel Nox4-driven cardioprotective mechanisms that promote adaptive cardia

203 ling pathways also are capable of activating cardioprotective mechanisms.

204 Use of cardioprotective medication after coronary revasculariza

205 n with patients regarding their adherence to cardioprotective medication.

206 y prevention; however, changes in the use of cardioprotective medications after incident diagnosis of

207 data are available on the use of potentially cardioprotective medications among U.S. kidney transplan

208 per was to examine disparities in the use of cardioprotective medications in the treatment of periphe

209 Adherence to cardioprotective medications in the year after acute cor

210 Despite improvement in the use of cardioprotective medications over time, patients with PA

211 tential gains from expanding indications for cardioprotective medications will not be realized.

212 ered intervention could improve adherence to cardioprotective medications.

213 essed temporal trends and comparative use of cardioprotective medications.

214 process and remind patients to refill their cardioprotective medications.

215 ithin this cluster the cancer-associated and cardioprotective miR-22 was shown to repress fatty acid

216 The cardioprotective miRNA-133a (miR-133a) is downregulated,

217 nal nerves participate in the degradation of cardioprotective NP.

218 ide levels with the previously reported R19X cardioprotective null mutation (beta = -1.09,sigma = 0.1

219 cal studies suggest that these cells release cardioprotective paracrine factors that activate endogen

220 es to H-H, resulting in diminished levels of cardioprotective parasympathetic activity to the heart a

221 mTOR complex 2 and activation of the Akt/SGK cardioprotective pathway in a PI3K-independent manner.

222 Animal studies have identified many cardioprotective pathways that have the potential to red

223 myocardial infarction, activating different cardioprotective pathways without inducing maladaptive h

224 agon-like peptide-1 analog activates several cardioprotective pathways, prevents HFD-induced insulin

225 e for ACE2 and functions as an inotropic and cardioprotective peptide.

226 elial function and blood flow and serve as a cardioprotective peptide.

227 Increased expression of the EGR1-regulated cardioprotective peptides atrial natriuretic peptide (AN

228 Myocardial conditioning is an endogenous cardioprotective phenomenon that profoundly limits infar

229 ating macrophages can be primed to acquire a cardioprotective phenotype in ischemic heart and exert t

230 t polarized macrophages toward a distinctive cardioprotective phenotype that was not M1 or M2.

231 n, the ischemia-injured heart elaborates the cardioprotective polypeptide, insulin-like growth factor

232 e which actions of HDL may contribute to its cardioprotective potential and how they can be quantifie

233 In this investigation, we demonstrated a cardioprotective process involving FGF21 from the liver

234 y, little is known about how CDCs confer the cardioprotective process known as cellular postcondition

235 The MAPK cascade contributed to the cardioprotective profile of GRK2 inhibition by preventin

236 iated with facilitation of Th2 responses and cardioprotective properties in rodent models.

237 t the remodeling of HDLs may impact on their cardioprotective properties is beginning to emerge.

238 the design, synthesis, and evaluation of the cardioprotective properties of a number of novel hybrid

239 Studies in healthy animals suggest cardioprotective properties of GLP-1 receptor agonists,

240 This study asks if the cardioprotective properties of niacin involve the induct

241 The in vitro cardioprotective properties of the polar lipid fractions

242 n for polar lipid HPLC fractions with strong cardioprotective properties.

243 Exosomes can be proangiogenic and may have cardioprotective properties.

244 urface charge, as well as in their potential cardioprotective properties.

245 its reduced form may optimize its intrinsic cardioprotective properties.

246 eMSCs enable sustained local delivery of cardioprotective proteins to the heart, thereby enhancin

247 myocardial biopsies, an array of established cardioprotective proteins was analyzed by Western immuno

248 sters, and proteomic changes, with losses in cardioprotective proteins.

249 C3 provides robust evidence for a replicable cardioprotective rare variant aggregation (P = 3.2 x 10(

250 eriments, fingolimod treatment activated the cardioprotective reperfusion injury salvage kinase and s

251 Young euglycemic Dpp4(-/-) mice exhibited a cardioprotective response after TAC surgery or doxorubic

252 Intriguingly, a very similar cardioprotective response of IL-10 was found in transver

253 A cardioprotective response that alters ventricular contra

254 Because HIF-1alpha mediates the cardioprotective response to ischemic injury, its upregu

255 Mitophagy functions as an early cardioprotective response, favoring adaptation to stress

256 hese studies suggest that iPLA2gamma plays a cardioprotective role during the acute stage of Chagas'

257 Our data strongly support a cardioprotective role for sphingosine-1-phosphate recept

258 PKA inhibition revealed a cardioprotective role of beta-adrenergic signaling via c

259 Our results suggest that the cardioprotective role of DeltaPDZ nNOS is likely through

260 e findings, coupled with the well-recognized cardioprotective role of Hsp20, suggest a dual benefit o

261 over-expression studies have established the cardioprotective role of neuronal nitric oxide synthase

262 proteins (HDLs) contribute to explaining the cardioprotective role of the lipoprotein beyond quantita

263 PK terminal effectors, potentially serving a cardioprotective role.

264 beneficial effects, including its potential cardioprotective role.

265 The cardioprotective roles of miR-214 during IR injury were

266 Cardioprotective signal transduction appears as a highly

267 access a pharmacological profile stimulating cardioprotective signaling and inotropic effects through

268 Cardioprotective signaling has been extensively characte

269 ccessful, the pharmacological recruitment of cardioprotective signaling has been largely disappointin

270 ST2 is involved in cardioprotective signaling in the myocardium and has bee

271 Thus, cardioprotective signaling induced by GRK2 inhibition is

272 Hydrogen sulfide is a cardioprotective signaling molecule but is toxic at elev

273 may engage reactive oxygen species-dependent cardioprotective signaling.

274 Pharmacological recruitment of cardioprotective signalling has also been used to reduce

275 een beta1-adrenergic receptors (ARs) and the cardioprotective sphingosine-1-phosphate (S1P) receptor-

276 RATIONALE: The impact of cardioprotective strategies and ischemia duration on pos

277 at predicting cardiotoxicity and developing cardioprotective strategies may lead to changes in the a

278 earch is needed to further investigate newer cardioprotective strategies to continue the current tren

279 d remote conditioning as clinically relevant cardioprotective strategies.

280 ern in all 40-minute I/R pigs, regardless of cardioprotective strategy and the degree of intramyocard

281 n of their function could be used as a novel cardioprotective strategy.

282 ording to CMR timing, ischemia duration, and cardioprotective strategy.

283 of CAD and apoD may be part of an intrinsic cardioprotective system, possibly as a consequence of it

284 pective focuses on P2X(4) receptors as a new cardioprotective target in heart failure.

285 f apoA-I that resist oxidation might be more cardioprotective than the native form.

286 l ischemia, 2) evaluation and development of cardioprotective therapeutic strategies, and 3) decision

287 the Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR), based on the princi

288 Cardioprotective therapies, duration of index ischemia,

289 een used to assess myocardial salvage by new cardioprotective therapies.

290 rrogate cardiac biomarkers, and prophylactic cardioprotective therapy in asymptomatic women with limi

291 eeded to determine the effect of combination cardioprotective therapy on event-free survival in Duche

292 Post-conditioning is a cardioprotective therapy that reduces infarct size after

293 ho may benefit the most from early reno- and cardioprotective therapy.

294 d mortality by allowing early instigation of cardioprotective therapy.

295 hondrial function, which may present a novel cardioprotective treatment that inhibits the progress of

296 .8% of individuals are heterozygous for this cardioprotective variant, which was previously thought t

297 To determine if MICU2 expression was cardioprotective, we produced and characterized Micu2(-/

298 n of autophagy is generally considered to be cardioprotective, whereas excessive autophagy can lead t

299 hat a newly formulated, covalent NN would be cardioprotective with reduced proneoplastic effects in c

300 egulate fibrosis and induce transcription of cardioprotective wound healing genes, including COX-2.