ライフサイエンスコーパス: cardiotonic

1 Phosphodiesterase III inhibitors are cardiotonic agents that increase myocardial contractilit

2 have tested the inhibitory properties of 47 cardiotonic and hormonal steroids and developed a three-

3 esults of competition binding studies for 56 cardiotonic and hormonal steroids were employed to devel

4 nd reveal the multi-modal role played by the cardiotonic and scavenging actions of the triglyceride s

5 p) and, via Na+ / Ca2+ exchange (NCX), exert cardiotonic and vasotonic effects.

6 Members of this class of cardiotonic drugs could be repositioned for retinoblasto

7 ncludes both transient drug scavenging and a cardiotonic effect that couple to accelerate movement of

8 e mode of the Na/Ca exchanger, abolished the cardiotonic effects of ouabain in isolated wild type and

9 The cardiotonic effects of thiadiazinone derivative EMD 5703

10 pe Na,K-ATPase, while the sensitivity to the cardiotonic inhibitor, ouabain, was unchanged.

11 A synthetic derivative of the cardiotonic steroid convallotoxin was even more potent t

12 nobufagenin (MBG) is an endogenous mammalian cardiotonic steroid involved in the inhibition of Na(+)/

13 a method for mapping the footprint of bound cardiotonic steroid on the extracellular surface of the

14 veral biologically active derivatives of the cardiotonic steroid ouabain have been made containing NM

15 hesis of the AB ring system of the important cardiotonic steroid ouabain, have been synthesized from

16 ncentration-dependent manner, reflecting the cardiotonic steroid sensitivity of the specific alpha1 s

17 The natural product ouabagenin is a complex cardiotonic steroid with a highly oxygenated skeleton.

18 e and its regulation by potential endogenous cardiotonic steroid-like compounds.

19 Cardiotonic steroids (CTS) are clinically important drug

20 Cardiotonic steroids (CTSs) are specific and potent inhi

21 The Na,K-ATPase is specifically inhibited by cardiotonic steroids (CTSs) like digoxin and is of signi

22 'Classic' cardiotonic steroids (CTSs) such as digoxin and ouabain

23 Several cardiotonic steroids (CTSs), including ouabain and digox

24 Cardiotonic steroids (CTSs), widely used in the clinic a

25 Cardiotonic steroids (digitalis) inhibit this activity a

26 Endogenous cardiotonic steroids (ECS) are putative ligands of the i

27 Cardiotonic steroids (such as ouabain) signaling through

28 In this report, we demonstrate that two cardiotonic steroids already in use in humans, digoxin a

29 Plasma levels of cardiotonic steroids are elevated in volume-expanded sta

30 Our results identify currently prescribed cardiotonic steroids as modulators of alternative splici

31 The expedient and scalable approach to cardiotonic steroids carrying oxygenation at the C11- an

32 of Na/K-ATPase in combination with increased cardiotonic steroids causes cardiac myocyte death and ca

33 ng junction, as found in naturally occurring cardiotonic steroids derived from digitalis.

34 logical significance of ring flection in the cardiotonic steroids has not been described.

35 We demonstrate that the cardiotonic steroids in the nuchal glands of R. tigrinus

36 ught to determine the prognostic role of the cardiotonic steroids marinobufagenin (MBG) in HF, partic

37 There is growing evidence that cardiotonic steroids may promote the growth of cardiac a

38 Similarly, nanomolar concentrations of cardiotonic steroids such as ouabain and digoxin switche

39 erved that, in renal proximal tubular cells, cardiotonic steroids such as ouabain in vitro signal thr

40 oups on the beta-side of the steroid core of cardiotonic steroids were investigated by comparing vari

41 ically used for patients with heart failure (cardiotonic steroids).

42 enzyme is highly sensitive to inhibition by cardiotonic steroids, most notably the digitalis/ouabain

43 promoting effects of 2 sodium pump-selective cardiotonic steroids, ouabain and marinobufagenin, on cu

44 Cardiotonic steroids, such as ouabain, are specific inhi

45 d alpha1 Na/K-ATPase works as a receptor for cardiotonic steroids, such as ouabain, to regulate cellu

46 a subunit of Na,K-ATPase is the receptor for cardiotonic steroids, which act through the ouabain-bind

47 dence of alpha2 pumps also helps explain how cardiotonic steroids, which block NKA pumps, can be a be

48 ciated signaling function of Na/K-ATPase and cardiotonic steroids.