ライフサイエンスコーパス: cardiotonic steroid

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1 ically used for patients with heart failure (cardiotonic steroids).

2 ciated signaling function of Na/K-ATPase and cardiotonic steroids.

3 In this report, we demonstrate that two cardiotonic steroids already in use in humans, digoxin a

4 Plasma levels of cardiotonic steroids are elevated in volume-expanded sta

5 Our results identify currently prescribed cardiotonic steroids as modulators of alternative splici

6 The expedient and scalable approach to cardiotonic steroids carrying oxygenation at the C11- an

7 of Na/K-ATPase in combination with increased cardiotonic steroids causes cardiac myocyte death and ca

8 A synthetic derivative of the cardiotonic steroid convallotoxin was even more potent t

9 Cardiotonic steroids (CTS) are clinically important drug

10 Cardiotonic steroids (CTSs) are specific and potent inhi

11 The Na,K-ATPase is specifically inhibited by cardiotonic steroids (CTSs) like digoxin and is of signi

12 'Classic' cardiotonic steroids (CTSs) such as digoxin and ouabain

13 Several cardiotonic steroids (CTSs), including ouabain and digox

14 Cardiotonic steroids (CTSs), widely used in the clinic a

15 ng junction, as found in naturally occurring cardiotonic steroids derived from digitalis.

16 Cardiotonic steroids (digitalis) inhibit this activity a

17 Endogenous cardiotonic steroids (ECS) are putative ligands of the i

18 logical significance of ring flection in the cardiotonic steroids has not been described.

19 We demonstrate that the cardiotonic steroids in the nuchal glands of R. tigrinus

20 nobufagenin (MBG) is an endogenous mammalian cardiotonic steroid involved in the inhibition of Na(+)/

21 e and its regulation by potential endogenous cardiotonic steroid-like compounds.

22 ught to determine the prognostic role of the cardiotonic steroids marinobufagenin (MBG) in HF, partic

23 There is growing evidence that cardiotonic steroids may promote the growth of cardiac a

24 enzyme is highly sensitive to inhibition by cardiotonic steroids, most notably the digitalis/ouabain

25 a method for mapping the footprint of bound cardiotonic steroid on the extracellular surface of the

26 veral biologically active derivatives of the cardiotonic steroid ouabain have been made containing NM

27 hesis of the AB ring system of the important cardiotonic steroid ouabain, have been synthesized from

28 promoting effects of 2 sodium pump-selective cardiotonic steroids, ouabain and marinobufagenin, on cu

29 ncentration-dependent manner, reflecting the cardiotonic steroid sensitivity of the specific alpha1 s

30 Similarly, nanomolar concentrations of cardiotonic steroids such as ouabain and digoxin switche

31 erved that, in renal proximal tubular cells, cardiotonic steroids such as ouabain in vitro signal thr

32 Cardiotonic steroids (such as ouabain) signaling through

33 Cardiotonic steroids, such as ouabain, are specific inhi

34 d alpha1 Na/K-ATPase works as a receptor for cardiotonic steroids, such as ouabain, to regulate cellu

35 oups on the beta-side of the steroid core of cardiotonic steroids were investigated by comparing vari

36 a subunit of Na,K-ATPase is the receptor for cardiotonic steroids, which act through the ouabain-bind

37 dence of alpha2 pumps also helps explain how cardiotonic steroids, which block NKA pumps, can be a be

38 The natural product ouabagenin is a complex cardiotonic steroid with a highly oxygenated skeleton.

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