ライフサイエンスコーパス: cargo

1 itate release of an encapsulated hydrophilic cargo.

2 sions that ultimately depend upon the target cargo.

3 ial in determining the fate of ubiquitinated cargo.

4 oteins linked to nuclear import of selective cargo.

5 core autophagy machinery, as a specific AP-4 cargo.

6 role assumes unique protein and nucleic acid cargo.

7 that ATMs secrete exosomes containing miRNA cargo.

8 s energy production or delivery of molecular cargo.

9 lin or anti-nuclear pore complex antibody as cargo.

10 rotubule and actin motors acting on the same cargo.

11 in shell of the carboxysome and its internal cargo.

12 acilitating the autophagic engulfment of the cargo.

13 and much of the peptide is released from the cargo.

14 ases into phagosomes and in digestion of the cargo.

15 mately organelle closure around a particular cargo.

16 hich cytosolic PEX5 can enter to release its cargo.

17 ved protection and controlled release of DNA cargo.

18 that LDLR-R410S recycles loaded with its LDL-cargo.

19 ests that each dynein activator has multiple cargos.

20 hand domain for picking up and dropping off cargos.

21 otype-specific targeting of NPC pathways and cargos.

22 that can harbor genomic, proteomic and lipid cargos.

23 a single robot can repeatedly sort multiple cargos.

24 ticles encapsidating nonnative RNAs or other cargoes.

25 d to cell penetrating peptides and d-peptide cargoes.

26 romise for storage and transport of chemical cargoes.

27 ng the biogenesis and transport of vesicular cargoes.

28 targeted delivery and controlled release of cargoes.

29 lained by the lack of transport of any known cargoes.

30 utophagy upon the accumulation of autophagic cargoes.

31 ans to translocate membrane-impermeable drug cargoes across the plasma membrane of cancer cells.

32 Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capab

33 ODA16, a cargo adaptor specific for outer arm dynein, also fails

34 ted by complex formation with dynactin and a cargo adaptor.

35 ases, CBH-1 and CBH-2, depend on distinct ER cargo adaptors for efficient exit from the ER.

36 interaction properties of the p24 and ERV-29 cargo adaptors, as well as their role in cellulase enzym

37 gatively affect the activity of the appended cargo against its cellular target.

38 f-propelled motion and an ability to carry a cargo along a pre-defined path.

39 ade intraflagellar transport (IFT), ferrying cargo along microtubules (MTs) toward the tips of cilia.

40 ins hydrolyse ATP to transport intracellular cargoes along microtubules.

41 -whereas conditional knockout of another RCP cargo, alpha5 integrin, does not suppress pancreatic can

42 Removal of blocking cargo also restores cell morphology and attenuates the E

43 Understanding how MkMPs target, deliver cargo and alter the fate of HSPCs is important for explo

44 hey are able to encapsulate specific protein cargo and are proposed to be involved in redox-related p

45 drug-use and duration of semen storage on SE cargo and bioactivity will advance our understanding of

46 rane-localizing peptide with a toxic peptide cargo and discovers a tandem peptide that displays syner

47 n to the motility of an endogenous dendritic cargo and found that dynein inhibition eliminates the re

48 The structural mechanisms for the GIPC/cargo and GIPC/myosin VI interactions remained unclear.

49 Interestingly, these cargo and PIP2 interactions are not conserved in yeast.

50 tors work as scaffolds that selectively bind cargo and tether substrates to their cognate proteases t

51 ot determined the impact of both the genetic cargo and the donor and recipient species on the rate of

52 imple algorithm encoding recognition between cargos and their destinations allows for a simple robot

53 th distinct mutations or linked to different cargos) and filaments (e.g., in distinct nucleotide stat

54 o degradation of the delivery vector and DNA cargo, and subsequent inefficient delivery to target cel

55 d the accompanying rotational motions of the cargoes are resolved accurately to render the intracellu

56 Ubiquitinated plasma membrane proteins (cargo) are delivered to endosomes and sorted by endosoma

57 os like Dumpy, which we identify as a Tango1 cargo, are removed from the cell, nonbulky proteins reen

58 lso identify the IGF1R, among more potential cargo, as another SNX5 and SNX6 binding receptor that re

59 cates that receptor engagement by phagosomal cargo, as well as inflammatory mediators and cellular ac

60 Our results suggest that RZZ is dynein's cargo at human kinetochores.

61 During CME, endocytic adaptor proteins bind cargoes at the cell surface and link them to the PM and

62 for how molecular motors accurately deposit cargoes at the correct locations.

63 e a primary mechanical anchor for the KIF16B-cargo attachment, we measured the adhesion forces and de

64 inding partner, J-domain protein RME-8, sort cargo away from degradation, promoting cargo recycling t

65 r solubilizers that envelope their insoluble cargo before transporting it to destination sites.

66 echanism to exchange non-specialized genetic cargo between bacterial species.

67 radation, thereby impairing its functions in cargo binding and PTS protein import in human cells.

68 phatidylinositol-4,5-bisphosphate (PIP2) and cargo binding at multiple sites.

69 We reveal the 3D structure of the cargo binding dynein tail and show how self-dimerization

70 ClpXP protease are readily degraded but that cargo binding inhibits this degradation.

71 radation tags were not protected even though cargo binding is unaffected.

72 nd 4.1, ezrin, radixin, moesin; MF) in their cargo binding tails and are essential for the growth and

73 mization of inherent adaptor degradation and cargo binding that ensures that robust adaptor activity

74 icrotubule motor kinesin-1 interacts via its cargo-binding domain with both microtubules and organell

75 ammalian structure, but additionally reveals cargo bound beneath beta'-COP.

76 e-active SNX-BAR complex displaces Ypt7 from cargo-bound CSC during formation of recycling tubules.

77 tegy demands not only good protection of the cargo but also reversibility in conjugation and activity

78 g, including the capture of diverse membrane cargo by the tubby domain in a phosphoinositide 4,5-bisp

79 ansporter of mitochondria and other cellular cargoes by attaching them to dynamic microtubule ends du

80 orting signals in the cytosolic tails of the cargos by adaptor proteins, leading to cargo packaging i

81 The velocity and final peak location of the cargo can be tuned independently.

82 However, current systems have a small cargo capacity and have mostly been used for gene silenc

83 y stripe mosaic virus-based system with high cargo capacity was constructed for the rapid and stable

84 Enhanced stability, larger cargo capacity, non-toxicity, ease of surface modificati

85 r 5 (PEX5) followed by insertion of the PEX5-cargo complex into the peroxisomal membrane at the docki

86 mediated by dynamic assembly/disassembly of cargo complexes followed by short-range vectorial transi

87 Motor-cargo complexes that interact with the intersecting fila

88 dynamically clusters cytosolic proteins into cargo complexes, allowing transport.

89 hesis for the architecture and action of the cargo-conducting part of the type-III secretion apparatu

90 ions for assessing the translocation of drug cargoes conjugated to pHLIP.

91 Ptr2 and the ammonium permease Mep3 as Syp1 cargoes containing DxY motifs.

92 Our data establish that cargoes containing Yxxphi motif, but not dileucine motif

93 Our data suggest that protein and lipid cargoes cooperate to activate myosin VI, allowing myosin

94 adjuvant activity of the accompanying lipid cargo could be a general essential feature of the mechan

95 This process induces cargo crowding and inward membrane buckling, followed by

96 promoting autophagosome-lysosome fusion and cargo degradation.

97 e-molecule level has the potential to impair cargo delivery at locations of microtubule defect sites

98 nspired by the secretion process and natural cargo delivery functions of natural exosomes, biomimetic

99 sses a major shortcoming in plasmon actuated cargo delivery systems.

100 as a key factor for autophagic and endocytic cargo delivery to and degradation in lysosomes.

101 After cargo delivery, a complex of the PEX1 and PEX6 ATPases a

102 laterally targeted but not apically targeted cargo delivery, for both PM-destined and secretory cargo

103 demonstrates endocytosis as one mechanism of cargo delivery.

104 pose a mechanism to prevent the onset of ILV cargo deubiquitination at the initiation of ESCRT-III co

105 s of individual exocytotic events, promoting cargo discharge and reducing pore closure ('kiss-and-run

106 dynein heavy chain, in maintaining neuronal cargo distribution.

107 it as a substratum to deliver ParB-attached cargo DNA, and ParB drives ParA dynamics, allowing ParA

108 cteria, and that the identity of the genetic cargo, donor strain, and recipient strain all influence

109 een ciliary gating components and transiting cargoes during ciliary entry.

110 The molecular basis of how cargo engagement affects the balance between kinesin-1's

111 p1 at the phagophore-assembly site, Atg24 in cargo engulfment, Atg26 in cytoplasm-to-vacuole targetin

112 ent complexes formed between the peptide and cargo enter the cell via an endosomal pathway where the

113 These short cargo escape times predict the need for strong diffusion

114 esis, which was important for uptake of most cargos, except the IgG-coated ones.

115 inal mu-homology domain (muHD); however, few cargoes exhibiting muniscin-dependent endocytosis have b

116 Because LC3-associated phagocytosis delivers cargo for degradation, the contribution of ELMO1 to the

117 lasm, respectively, inside autophagosomes as cargo for delivery to lysosomes.

118 s in flagella and demonstrate that PRMTs are cargo for translocation within flagella by the process o

119 non-covalent self-assembly with therapeutic cargo, forming HER3-homing nanobiologics.

120 coat machinery to actively sort biosynthetic cargo from diffusible misfolded and resident ER proteins

121 etromer complex, which mediates recycling of cargo from endosomes to the Golgi.

122 ssential for recycling numerous cell-surface cargoes from endosomes and is structurally and functiona

123 the direct transport of a selected number of cargoes from the trans-Golgi network (TGN) to the plasma

124 ed, and sustained release of their entrapped cargoes have been demonstrated over time.

125 lls show unimpaired degradation of endocytic cargo, have intact BCR signaling, and do not exhibit any

126 ieve maximal motile activity and to bind its cargos, human dynein/dynactin requires 'activators', of

127 e prototypical cytosolic secretory autophagy cargo IL-1beta is recognized by specialized secretory au

128 igand, the dinucleotide CpG, were present as cargo in IRAP(+) endosomes.

129 ore, degradation of endocytic and autophagic cargo in lysosomes.

130 ated the cellular localization of US9-driven cargo in neurons and created a US9-driven functional ass

131 enetic approach to recruit motor proteins to cargo in real time within axons or dendrites in hippocam

132 They egressed as cargo in residual bodies and maintained Treg-dependent p

133 iggered to release an encapsulated molecular cargo in response to an external control signal by emplo

134 been used as a shuttle to pack biomolecular cargo in the vault lumen.

135 les released by many eukaryotic cells; their cargo includes proteins, mRNA and microRNA (miR) that ca

136 vesicles released from cells that transport cargo including DNA, RNA, and proteins, between cells as

137 xogenous atherogenic material and endogenous cargo including dysfunctional proteins and organelles.

138 nbiased characterization of the complete RNA cargo, including both small- and long-RNAs, in a single

139 ng of structurally diverse integral membrane cargo, including multiple reported and novel rhodopsin f

140 ion both of secretory pathway components and cargoes, including apolipoproteins ApoA-IV and ApoC-II,

141 s can be used as smart carriers for multiple cargos, including both naked and nanoparticle-encapsulat

142 and energy resources and transports specific cargos, including damaged mitochondria, other broken org

143 ssential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruse

144 ilin via a new class of mitochondria-derived cargos independent of Parkin, Drp1, and autophagy.

145 Transferrin-coated endocytic gold nanorod cargoes initially undergo active rotational diffusion an

146 ected movement while retaining physiological cargo interactions in the tail.

147 a proof-of-concept that a microtubule motor-cargo interface and associated autoregulatory mechanism

148 proteins, indicating capsids are packaged as cargo into eHAV vesicles via a highly specific sorting p

149 translocation and delivery of the enzymatic cargo into the host cell.

150 ar vehicle capable of delivering therapeutic cargo into the neuronal cytosol.

151 endocytic receptor on human MoDC that routes cargo into unusual Ag processing pathways, which reduces

152 iquitinates transmembrane proteins sorted as cargoes into ILVs.

153 By transferring their cargoes into target cells and tissues, they now emerge a

154 alization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.

155 Moreover, the cargo is defined.

156 Consequently, the cargo is deposited around a specific position on the sur

157 of how the IFT subunits interact with their cargo is of critical importance for understanding how th

158 How dynein motors accurately move cargoes is an important question.

159 We further show that deubiquitination of ILV cargoes is inhibited via Doa4 binding to Vps20, which is

160 hanical linkage of microtubule tips to their cargoes is poorly understood.

161 ere a clathrin-coated pit will form and what cargo it will contain are difficult to foresee.

162 mic reticulum (ER) in two layers to generate cargo-laden transport carriers that ultimately fuse with

163 Kinesin-1, a robust axonal motor, moves cargo less efficiently in dendrites.

164 If large cargos like Dumpy, which we identify as a Tango1 cargo,

165 actions, suggesting no direct involvement in cargo loading/unloading.

166 atility in terms of identity of the enclosed cargo, makes these hierarchical microshells suitable for

167 tation and profiling of donor intra-exosomal cargoes may constitute a biomarker platform for monitori

168 eLa cell lines were created with fluorescent cargos (mCherry) for the importin alpha/beta, transporti

169 nalization by active pathways, attachment of cargo molecules to CPPs invariably reduces their cellula

170 ptide-mediated translocation and delivery of cargo molecules to specific cellular destinations.

171 he channel, which might form a gasket around cargo molecules undergoing export.

172 s a Brownian ratchet that directs persistent cargo movement with a ParA-depletion zone trailing behin

173 ionally adaptive dimer can drive large-scale cargo movement without the requirement for polymers and

174 isolated from its environment; the molecular cargo must be removed to a separate physical space.

175 s nuclear localization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.

176 haracteristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstr

177 mmunication and potentially present a potent cargo of disease biomarkers to an assay.

178 the Och1 mannosyltransferase, an established cargo of intra-Golgi retrograde transport.

179 In CEM cilia, tba-6 regulates velocities and cargoes of intraflagellar transport (IFT) kinesin-2 moto

180 effects can be attributed to the transfer of cargos of diverse types of RNAs, which are promising dia

181 identifying the protein composition and mRNA cargos of the ribonucleoprotein particles (RNPs) that fo

182 carried to the tip by kinesin-II as inactive cargo on anterograde trains.

183 he previously observed dependence of smaller cargos on Tango1 is a secondary effect.

184 rt mitochondria and CENP-F-coated artificial cargoes over micrometer-long distances during both growi

185 eration (Ki67), nuclear localization of XPO1 cargos (p53, PTEN), and increased apoptosis after treatm

186 f the cargos by adaptor proteins, leading to cargo packaging into coated vesicles destined for the en

187 nding of the mechanisms surrounding exosomal cargo packaging, including viral proteins.

188 ted vesicles that completely encapsulate the cargo PC1 and are physically separated from ER.

189 Here, we show that cargo processing and transport continue-even when indivi

190 cancer and inflammation makes EVs and their cargo promising biomarkers of disease and cell-free ther

191 eads to the inability of the apical exosomal cargo protein GPRC5B to enter the ILV/exosomal pathway.

192 , HBB2 increases the levels of the autophagy-cargo protein p62/sequestosome 1, and the lipidated form

193 leviate the steric hindrance produced by the cargo protein, by functioning as a spacer to which cytos

194 ired for the correct sorting of another Snx3 cargo protein, suggesting that the incorporation of Neo1

195 to a peptide from Dab2 (LOVDab), a myosin VI cargo protein.

196 Native cargo proteins exit the endoplasmic reticulum (ER) in CO

197 E) is used to internalize a diverse range of cargo proteins from the cell surface, often in response

198 ins including PEX5, a receptor that delivers cargo proteins from the cytosol to the peroxisomal matri

199 ealed that the N-terminal unfolded region of cargo proteins is critical for their localization capabi

200 Altered cargo proteins of human plasma endothelial cell-derived

201 ecific absorption procedures for analyses of cargo proteins relevant to atherosclerosis.

202 or proteins mediate endocytosis by tethering cargo proteins to the myosin VI motor.

203 mational change favoring an interaction with cargo proteins.

204 delivery, for both PM-destined and secretory cargo, providing the first evidence of selectivity in te

205 After endocytosis, transmembrane cargo reaches endosomes, where it encounters complexes d

206 y autophagy utilizes a specialized cytosolic cargo receptor and a dedicated SNARE system.

207 bidopsis thaliana We show that the autophagy cargo receptor NEIGHBOR OF BRCA1 (NBR1) targets nonassem

208 tivates autophagy through recruitment of the cargo receptor nuclear dot protein 52 (NDP52).

209 osome membrane and are thought to facilitate cargo receptor recruitment, vesicle maturation, and lyso

210 interface with the outer COPII coat and the cargo receptor Tango1/cTAGE5.

211 ecognized by specialized secretory autophagy cargo receptor TRIM16 and that this receptor interacts w

212 rotein directing autophagosome formation and cargo recruitment.

213 sort cargo away from degradation, promoting cargo recycling to the Golgi.

214 ndent manner that is directly coupled to NLS-cargo release and NPC barrier function.

215 Cargo release and vesicle recycling depend on the fate o

216 C) barrier selectivity, Kap traffic, and NLS-cargo release are systematically linked and simultaneous

217 roof-of-concept for highly pathogen-specific cargo release from mesoporous silica nanoparticles is de

218 nts of the NPC whose barrier, transport, and cargo release functionalities establish a continuum unde

219 with LC/MS analytics that the intracellular cargo release is controlled by the sequence of the pepti

220 Moreover, a consequence of MA vaccine cargo release was the generation of long-lived antigen-s

221 ovides a real time analysis of the amount of cargo remaining.

222 ol signal, the catalyst is inactive, and the cargo remains encapsulated within the vesicle.

223 e binding affinities of Vps26 for a retromer cargo, resulting in corresponding changes in cargo sorti

224 in membrane remodeling, cargo selection, and cargo retention, which act repetitively to maximize the

225 rphology are secondary consequences of bulky cargo retention.

226 onserved retromer complex has been linked to cargo retrieval from endosomes to the trans-Golgi networ

227 Cargo secretion is unaffected by downregulation of synta

228 n 4 as well as SNAP-23 and SNAP-29 completes cargo secretion.

229 sphorylation-based gating mechanism controls cargo selection by yeast retromer, and they establish a

230 ctions for ESCRT-III in membrane remodeling, cargo selection, and cargo retention, which act repetiti

231 roteins, SNX1, SNX2, SNX5, and SNX6, are the cargo-selective elements that mediate the retrograde tra

232 We further showed that the cargo-selective sorting nexin Snx3 is required for Neo1

233 In VAMP-3(-/-) platelets, the 2 cargoes showed limited colocalization with Rab4, Rab11,

234 pleted cells persist in the absence of bulky cargo, showing that they are due to a secretion-independ

235 n VI to integrate Ca(2+), lipid, and protein cargo signals in the cell to deploy in a site-specific m

236 ocytosis, an essential function that aids in cargo sorting and degradation.

237 chieved and is it related to its function in cargo sorting and export?

238 endosome and the vacuole membrane to mediate cargo sorting and intra-luminal vesicle formation.

239 cargo, resulting in corresponding changes in cargo sorting at the endosome.

240 uilding blocks for a DNA robot that performs cargo sorting at the molecular level.

241 of extracellular vesicle biology, including cargo sorting, release, and bioactivity.

242 We propose that PICK1 is a cargo-specific endocytic accessory protein required for

243 zone progressively increases relative to the cargo speed, evolving from diffusion to pole-to-pole osc

244 e(II)4L4 coordination cage 1 can transport a cargo spontaneously and quantitatively from water across

245 TNPO3) is responsible for shuttling specific cargoes such as serine/arginine-rich splicing factors fr

246 PII) is essential for the transport of large cargo, such as 300-nm procollagen I (PC1) molecules, fro

247 NS and the major anterograde transporters of cargos, such as mitochondria, synaptic vesicle precursor

248 for methods to propel and steer microscopic cargo that do not require modifying these particles.

249 r ensemble transporting a 350 nm lipid-bound cargo that encounters a suspended 3D actin filament inte

250 eted from astrocytes contain neuroprotective cargoes that could support the survival of neighboring n

251 r, delivering toxin and acquiring beneficial cargo, thereby maximally exploiting potential niche reso

252 self-interactions but also interact with the cargo they encapsulate.

253 ryopherins) when trafficking large molecular cargos through the NPC, the processing preferences of in

254 tein has a relevant role in the transport of cargos throughout neurons.

255 utophagosomes and ubiquitinated molecules on cargos, thus facilitating the autophagic engulfment of t

256 ple ParA-ParB bonds can bridge a parS-coated cargo to a DNA carpet, and they can work collectively as

257 that Stx3 plays a role in the recruitment of cargo to exosomes, and that the Stx3-5R mutant acts as a

258 in vitro and subsequently deliver the dCas9 cargo to live cells.

259 n the tissue, and ii) a novel tandem peptide cargo to localize payload to bacterial membranes.

260 We also found that the ability of a cargo to protect its adaptor is adaptor substrate-specif

261 interacts with the R-SNARE Sec22b to recruit cargo to the LC3-II(+) sequestration membranes.

262 g appropriate delivery of specific organelle cargoes to selected subcellular domains.

263 t ESCRT-III complexes surround ubiquitinated cargoes to trap them at the site of ILV budding while th

264 ytokines, and nucleic acids, transport these cargos to adjacent or distant specific recipient cells,

265 e therefore expected to result in linkage of cargos to dynein-dynactin complexes that have defective

266 c sorting of newly synthesized transmembrane cargos to endosomes and lysosomes is thought to occur at

267 stems, with rapid transporting and efficient cargo towing abilities, are expected to open up new hori

268 discrete functions as specialized tracks for cargo trafficking.

269 osttranslationally modified microtubules for cargo transport and thereby spatially restrict focus for

270 tion and point to a possible role for SGs in cargo transport and/or protein targeting to the plasma m

271 H and salt concentration, and selectivity in cargo transport can be simultaneously achieved by grafti

272 whereas Golgi-recruited GRK2ct-KERE inhibits cargo transport from the TGN to the PM.

273 LIS1 promotes the plus-end localisation and cargo transport functions of dynein in vivo.

274 he first evidence of selectivity in terms of cargo transport regulated by betagamma.

275 Intracellular cargo transport relies on myosin Va molecular motor ense

276 Inhibition of ubiquitinated cargo transport through the multivesicular body (MVB) pa

277 volve dynein's role as a retrograde motor in cargo transport, hinging instead on its ability to inhib

278 opathy-associated KIF1Bbeta mutations impede cargo transport, providing a direct link between neurobl

279 central role in microtubule organisation and cargo transport.

280 based kinesin-2 KIF3AC motor, an anterograde cargo transporter in neurons.

281 Among a number of cargo transporting kinesins, KIF5A was notably upregulat

282 mechanism by which proteins and other large cargo traverse epithelial barriers in normal tissue.

283 he E2 ubiquitin-conjugating enzyme and IPO11 cargo, UBE2E1, is a limiting factor for PTEN degradation

284 ap them at the site of ILV budding while the cargoes undergo deubiquitination.

285 Phagocytic cargo, upon internalization, follows a defined trafficki

286 a ubiquitous molecular motor that transports cargo vesicles of the endomembrane system in intracellul

287 s plate requires the coordinated movement of cargo vesicles whose size is below the diffraction-limit

288 These adaptors bind cargo via a C-terminal mu-homology domain (muHD); howeve

289 critical function of REEP6 in trafficking of cargo via a subset of Clathrin-coated vesicles to select

290 KIF16B attaches to lipid cargoes via a PX motif at its C-terminus, which has nano

291 As pathogenic cargos, viruses require MTs to transport to and from the

292 ibited histamine-evoked secretion of the WPB cargos von Willebrand factor and P-selectin.

293 lly, we demonstrate that the fluorescent dye cargo was able to penetrate intra-tumorally.

294 ppeared to enhance binding, as many of these cargoes were not bound in non-aqueous media.

295 em that is not only capable of releasing its cargo when stimulated by light but also provides a real

296 ce are a key EV source with a specific miRNA cargo, which are specific for ASH-related liver injury.

297 tion imaging show the budding of syntaphilin cargos, which then share a ride on late endosomes for tr

298 The efficient transport of cargoes within axons and dendrites is critical for neuro

299 Notably, this strategy allowed cargoes within capsules, including polycyclic aromatic c

300 widespread mechanism to distribute sizeable cargos within prokaryotic cells.