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1 an extended beta-ketoacyl chain (ACP = acyl carrier protein).
2 gnition of peptides derived from the coupled carrier protein.
3 vaccine that used SIIL tetanus toxoid as the carrier protein.
4 shear conditions FVIII is released from its carrier protein.
5 surrogate of BDE-47 covalently attached to a carrier protein.
6 exclusive of the native substrate, acyl-acyl carrier protein.
7 harides of varying chain length to CRM197 as carrier protein.
8 ozoite surface protein 8 (MSP8) as a vaccine carrier protein.
9 alamin II receptor and the transcobalamin II carrier protein.
10 entified as proteolytic products of the acyl carrier protein.
11 via the synthesis of [(14)C]linolenoyl-acyl carrier protein.
12 ons ready for activation and coupling to the carrier protein.
13 a chain linker to a diphtheria toxin mutant carrier protein.
14 array of tertiary and heteroaryl amines to a carrier protein.
15 th siderophores conjugated to an immunogenic carrier protein.
16 l length polysaccharide for conjugation to a carrier protein.
17 sence of a prior immune response against the carrier protein.
18 h CD45 expression, were examined for SC-PNAL carrier proteins.
19 along with a reduction in mitochondrial acyl carrier proteins.
20 ting functional overlap between BSH and Fe-S carrier proteins.
21 of B. pseudomallei and covalently linked to carrier proteins.
22 ately being incorporated into essential acyl carrier proteins.
23 antigens were coupled to immune stimulating carrier proteins.
24 protein-protein interactions with noncognate carrier proteins.
25 glycopeptide antibiotics to three different carrier proteins.
26 6-aminohexyl glycosides to be conjugated to carrier proteins.
27 to the target molecule or additional sulfur carrier proteins.
28 immunization strategies based on the use of carrier proteins.
29 other mitochondrial proteins such as ADP/ATP carrier proteins.
30 supercomplex (termed III-IV) and the ADP/ATP carrier proteins.
31 sponses to Pfs25 when coupled to immunogenic carrier proteins.
32 f genes encoding mitochondrial dicarboxylate carrier proteins.
35 t function in vivo, we focused on the Sterol Carrier Protein 2 (scp2), a multifunctional protein that
38 H-Asn-Phe-Gly-Ala-Ile-Leu-Gly-NH2) and acyl carrier protein (65-74) fragment (H-Val-Gln-Ala-Ala-Ile-
39 initial cluster assembly and transfer to FeS carrier proteins, accessory factors such as monothiol gl
41 ucing polyketide synthases (NR-PKS) the acyl-carrier protein (ACP) carries the growing polyketide int
43 an acyl-adenylate and ligation onto the acyl carrier protein (ACP) domain of MbtB to form covalently
45 a reaction chamber for the intramodule acyl carrier protein (ACP) domain that carries building block
47 s DSF by dehydration of a 3-hydroxyacyl-acyl carrier protein (ACP) fatty acid synthetic intermediate
49 le for the C2-methylation of 3-ketoacyl-acyl carrier protein (ACP) intermediates to give the correspo
50 pical primer is transformed to pimeloyl-acyl carrier protein (ACP) methyl ester by two cycles of fatt
55 ze the reduction of 2-methyl-3-ketoacyl acyl carrier protein (ACP) substrates and in certain cases ep
56 ia esterification by the bacterial acyl-acyl carrier protein (ACP) synthase AasC but inhibitors of th
59 parate domains of the bifunctional acyl-acyl carrier protein (ACP) synthetase/2-acylglycerolphosphoet
61 fatty acid synthetic intermediate, the acyl carrier protein (ACP) thioester of 3-hydroxydodecanoic a
62 d for the Umbellularia californica acyl-acyl carrier protein (ACP) thioesterase was shown to have hig
63 specialized acyl-transferase that uses acyl carrier protein (ACP) to covalently link fatty acids, vi
64 yl coenzyme A (acetyl-CoA) with malonyl-acyl carrier protein (ACP) to make the FAS primer beta-acetoa
65 We reveal that subunit B22 anchors an acyl carrier protein (ACP) to the complex, replicating the LY
67 ype I PKS module minimally contains AT, acyl carrier protein (ACP), and ketosynthase (KS) domains.
68 he PKS and NRPS modules mediated by the acyl carrier protein (ACP), condensation (C) and ketoreductas
69 on a thioesterase specific for butyryl-acyl carrier protein (ACP), which allows native fatty acid bi
70 , we demonstrate that the mitochondrial acyl carrier protein (ACP), which has a well-known role in FA
71 enosyl-l-methionine and either cellular acyl carrier protein (ACP)-coupled fatty acids or CoA-aryl/ac
72 both acyltransferases catalyze an acyl-acyl carrier protein (ACP)-dependent transfer of a fatty acyl
80 l transcriptional regulator Fis and the acyl carrier protein AcpP, were identified in P. aeruginosa.
82 ratory has developed methods to prepare acyl carrier proteins (ACPs) loaded with substrate mimetics a
83 Prior work showed that expression of acyl carrier proteins (ACPs) of a diverse set of bacteria rep
85 is highly selective for two specialized acyl carrier proteins (ACPs) that deliver the donor and accep
86 tics are positioned on the actinorhodin acyl carrier protein (actACP) to probe the underpinnings of s
87 n is laid for defining the dynamic action of carrier-protein activity in primary and secondary metabo
89 generally consists of an integrated peptidyl carrier protein, an amino acid-loading adenylation domai
90 terase-mediated offloading reaction from the carrier protein and activates the biosynthetic intermedi
92 only when present at the amino-terminus of a carrier protein and even conservative peptide amino acid
93 ocking crosslinking of Escherichia coli acyl carrier protein and FabA, a direct mimic of the biologic
94 g (SAXS), the positions of the flanking acyl carrier protein and ketosynthase domains have been ident
95 cular level and is performed by at least one carrier protein and two channels in Arabidopsis (Arabido
96 dent tailoring enzymes, a free-standing acyl carrier protein and two hypothetical proteins in oocydin
97 ng to transfer clusters between scaffold and carrier proteins and in the final stages of FeS protein
98 nslocase, which is involved in the import of carrier proteins and other, hydrophobic membrane protein
99 g enzyme can adenylate each of these sulphur-carrier proteins and probably also catalyses the subsequ
100 ol-linker to serve as a conjugation point to carrier proteins and surfaces for immunological experime
101 me this limitation, including conjugation to carrier proteins and/or formulation with potent adjuvant
102 ed around novel emerging cofactors (tRNA and carrier proteins) and then more complex cofactor structu
104 oesterase that hydrolyzes beta-ketoacyl acyl-carrier protein, and ShMKS1 is a decarboxylase that conv
105 olysaccharides were conjugated to the CRM197 carrier protein, and the resulting glycoconjugates were
107 specificities and can employ acyl-CoAs, acyl carrier proteins, and galactolipids as acyl donors.
108 osphate (S1P) is present in plasma, bound to carrier proteins, and involved in many physiological pro
109 h we covalently link the target molecules to carrier proteins, and then crystallize the entire carrie
114 e reaction is an acyl chain bound to an acyl carrier protein, are classified so that unusual reaction
116 rboxyl of either malonyl-CoA or malonyl-acyl carrier protein based on the ability of O-methylated (bu
118 of the vitamin biotin to the biotin carboxyl carrier protein (BCCP) domain of five biotin-dependent c
119 oforms interact with the two biotin carboxyl carrier protein (BCCP) isoforms of A. thaliana ACCase.
120 ion reaction of the acceptor biotin carboxyl carrier protein (BCCP), through the expected biotinoyl-A
124 oduced, to our knowledge, a novel carotenoid carrier protein, COCP, which consists of dimerized C-dom
126 al description of transport by mitochondrial carrier proteins, consistent with an alternating-access
130 njugate vaccines, consisting of an antigenic carrier protein coupled to the capsular polysaccharide o
131 on the chemical equilibrium of Fa binding to carrier proteins Cp, like albumin in plasma and intersti
132 ction of these compounds via functionalizing carrier proteins (CPs) of biosynthetic megaenzymes.
134 lease and analysis of intermediates bound to carrier proteins (CPs), providing access to these specie
136 es consisting of hexasaccharide 2 coupled to carrier protein CRM197 stimulates a T-cell-dependent B-c
138 is of either FabZ (3-R-hydroxymyristoyl acyl carrier protein dehydratase), slrA (novel RpoE-regulated
139 ABC genes encoding the (3R)-hydroxyacyl-acyl carrier protein dehydratases resulted in more than a 16-
145 ation of the soluble castor Delta9-18:0-acyl carrier protein desaturase, specifically, the hypothesis
147 trait loci to a region containing ACYL-ACYL CARRIER PROTEIN DESATURASE1 (AAD1) and AAD3 We found tha
148 obo H antigens were then conjugated with the carrier protein diphtheria toxoid cross-reactive materia
149 itope fragment) conjugated to an immunogenic carrier protein, diphtheria toxoid (DT), and formulated
150 is governed by interactions between the acyl carrier protein domain and the ketosynthase domain plus
152 -shaped structure capable of caging the acyl carrier protein domain proximal to each active site.
153 es that are ready for transfer from its acyl carrier protein domain to its ketosynthase domain and as
154 malonyl group can be transferred to the acyl carrier protein domain, transfer of the acetyl group to
155 s from isochorismic acid, but lacks the aryl carrier protein domain, which is needed for tethering ac
156 n, suggesting that chemical modifications to carrier proteins during NRPS synthesis may impart direct
158 ubiquitin-activating enzymes), E2 (ubiquitin-carrier proteins), E3 (ubiquitin-protein ligases), and E
159 ures of three forms of Escherichia coli acyl carrier protein engaging LpxD, which represent stalled s
161 ber of the LDL receptor family, as a new LeX carrier protein expressed by mouse neural stem cells.
162 iosynthesis of the unusual aminomalonyl-acyl carrier protein extender unit and the signature carbamoy
163 nce of specific members of the mitochondrial carrier protein family that have previously been associa
164 t the interface that optimally position acyl carrier protein for acyl delivery and that directly invo
165 o damaged endothelium and also serves as the carrier protein for coagulation factor VIII (FVIII), pro
166 Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsula
167 ate studies identify UbcH7 as the cognate E2 carrier protein for E6AP, although related Ubc5 isoforms
170 roposal that A-type proteins can function as carrier proteins for clusters assembled on U-type protei
171 bolism using inhibitors to prevent acyl-acyl carrier protein formation or glycerol-phosphate acyltran
172 f structural information on substrate-loaded carrier proteins has hindered our understanding of NRPS
173 the inherent conformational mobility of acyl carrier protein have stymied previous attempts to visual
174 hen loaded onto phosphopantetheinylated acyl carrier protein (holo-MbtL) to form covalently acylated
175 ctivation of apo-ACPP to generate holo-(acyl carrier protein) (holo-ACPP) in an early step of fatty a
176 ies of an adenylation domain and its partner carrier protein in apo-, holo-, and substrate-loaded for
180 hondrial NAD is imported from the cytosol by carrier proteins, in mammals, the mechanism of how this
181 we chemically synthesized and linked GH to a carrier protein, including keyhole limpet hemocyanion, d
182 Increased expression of additional solute carrier proteins, including Slc5a12 (>10-fold) were also
184 of insulin-like growth factor type 1 and its carrier protein insulin-like growth factor binding prote
185 We infer that similar principles underlie carrier protein interactions with other enzymes of the S
186 , are required to convert beta-ketoacyl acyl-carrier protein intermediates of the fatty acid biosynth
188 rmylating oxygenase (ADO) converts acyl-Acyl Carrier Proteins into corresponding n-1 alkanes via alde
189 2 complex mediates the import of hydrophobic carrier proteins into the mitochondrial inner membrane.
191 a proline-derived pyrrolyl group bound to a carrier protein is first halogenated and then elaborated
192 cate that biotin transfer to biotin carboxyl carrier protein is impacted by seven substitutions, the
194 attachment of polysaccharide antigens to the carrier protein is thought to be imperative to the immun
195 y of BexX to selectively distinguish sulphur-carrier proteins is given a structural basis using X-ray
196 ort of presequence-containing precursors and carrier proteins is impaired in PC-deficient mitochondri
198 provide evidence that covalent attachment to carrier proteins is not required for conversion of T-ind
199 nocytogenes encode two functional enoyl-acyl carrier protein isoforms based on their ability to compl
200 Cryptosporidium ACS (and related acyl-[acyl-carrier-protein]-ligases) as pharmacological targets but
202 present the first structure of an NRPS aryl carrier protein loaded with its substrate via a native t
203 nzyme contains four subunits, having an acyl-carrier protein (MdcC subunit) with a distinct prostheti
204 ays and rewiring acyl-CoA and acyl-ACP (acyl carrier protein) metabolism in Yarrowia lipolytica hold
205 s indicated that covalent modifications to a carrier protein modulate domain communication, suggestin
206 on and thus activation of mitochondrial acyl carrier protein (mtACP) of mitochondrial fatty acid synt
207 tochondrial proteins including the phosphate carrier protein, NADH dehydrogenase 1alpha subcomplexes
208 as monothiol glutaredoxin, GrxD, and the FeS carrier protein NfuA are located outside of these define
209 Escherichia coli iron-sulfur (Fe-S) cluster carrier protein NfuA efficiently reconstitutes the auxil
213 which a molecular antigen is conjugated to a carrier protein, offer the opportunity to circumvent the
215 ithout the need for any additional adjuvant, carrier protein, or special pharmaceutical preparation (
216 cs is not compromised by the presence of the carrier protein partner, and use this approach to determ
217 have been used as mimics of the natural acyl carrier protein pathway intermediates to assay FASII enz
218 delivered between enzyme centers by peptidyl carrier protein (PCP) domains, which makes PCP interacti
219 le tethered to a conserved, type II peptidyl carrier protein (PCP), as exemplified by PltL in the bio
220 re sorted according to their affinity to the carrier protein PDE6delta and the ability of Arl3 but no
223 rmational differences among the stalled acyl carrier proteins provide the molecular basis for the ass
225 tool to specifically inhibit the enoyl-acyl carrier protein reductase (FabI) of C. trachomatis to de
226 acterial target of 6-OH-BDE-47 as enoyl-acyl carrier protein reductase (FabI), an essential and widel
227 ridone compound that inhibits the enoyl-acyl carrier protein reductase (FabI), has recently been show
231 anobacterial pathway consisting of acyl-Acyl Carrier Protein reductase and an aldehyde-deformylating
233 lts show that FabI is the primary enoyl-acyl carrier protein reductase of type II bacterial fatty aci
237 Acquired haem is distributed by haemolymph carrier protein(s) and sequestered by vitellins in the d
239 me polysaccharide conjugated to heterologous carrier proteins selects for and expands carbohydrate-sp
241 ring lipid A synthesis (Raetz pathway), acyl carrier protein shuttles acyl intermediates linked to it
243 We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/38A2) by the
244 d molecular motors, identified as the solute carrier protein SLC26a5, that drive somatic motility at
245 ember of a very interesting family of solute carrier proteins (SLCs), some of which have been suggest
246 are covalently attached to the heterodimeric carrier protein SoxYZ through conjugation to a cysteine
249 ALT proteins used endogenous fatty acyl-acyl carrier protein substrates to generate fatty acids that
250 tty acyl-coenzyme A (CoA) or fatty acyl-acyl carrier protein substrates to primary fatty alcohols.
251 d concomitant loss of the mitochondrial acyl carrier protein subunit ACPM1 from the enzyme complex an
252 jugate vaccines recruit CD4(+) T cells via a carrier protein, such as tetanus toxoid (TT), resulting
254 ehydrogenase complex and beta-keto acyl-acyl carrier protein synthase III from Bacillus subtilis to s
256 ndrial fatty acid synthesis by ketoacyl-acyl carrier protein synthase is not vital for protein lipoyl
257 ains provided by mitochondrial ketoacyl-acyl carrier protein synthase to meet the high lipoate requir
259 iosynthetic pathway, the beta-ketoacyl-(acyl carrier protein) synthase III (FabH)-like enzyme PqsBC c
260 ar fatty acids are activated by an acyl-acyl carrier protein synthetase (AasN) and validate type II f
261 the only cytoplasmic Synechocystis acyl-acyl carrier protein synthetase (SynAas) were highly resistan
263 for reacylation by acyltransferase/acyl-acyl carrier protein synthetase on the inner leaflet of the m
264 ted cardiolipin by acyltransferase/acyl-acyl carrier protein synthetase, demonstrating the first evid
265 ative substrate, l-threonine appended to the carrier protein, SyrB1, but hydroxylates C5 of l-norvali
266 the biosynthetic operon for NOS, as an acyl carrier protein that delivers 3-methylindolic acid (MIA)
267 rate that SLC25A46, like Ugo1, is a modified carrier protein that has been recruited to the outer mit
268 In sum, our results established NIS as a carrier protein that interacts with a major cell signali
269 helix-coiled-coil-helix domain 4 (CHCHD4), a carrier protein that mediates p53 import into the mitoch
270 s by coupling bacterial polysaccharides to a carrier protein that recruits heterologous CD4 T cells t
271 al absorption is thought to be mediated by a carrier protein that still remains to be identified.
273 ncing uncovered a few genes encoding sulphur-carrier proteins that are probably involved in the biosy
274 tic up-regulation of a specialized acyl-acyl carrier protein thioesterase paralog and the concerted r
275 heterologous over-expression of an acyl-acyl carrier protein thioesterase, or by suppression of fatty
276 with cDNAs for various Cuphea FatB acyl-acyl carrier protein thioesterases (FatB) that produce a vari
278 tween the substrate and product forms of the carrier protein through differences in their interaction
279 e a comprehensive molecular description of a carrier protein throughout its life cycle and demonstrat
280 ious attempts to visualize structurally acyl carrier protein tied to an overall catalytic cycle.
281 the utility of PfMSP8 as a parasite-specific carrier protein to enhance the production of complex mal
282 studied calmodulin (CaM) as a more universal carrier protein to express many types of AMPs in E. coli
283 accharide and used its tetanus toxoid as the carrier protein to produce the now-licensed, highly effe
284 site at the core of the enzyme, allowing two carrier proteins to dock with Cy and deliver their subst
285 om initial assembly on scaffold proteins via carrier proteins to final incorporation into FeS apoprot
286 ved by the covalent conjugation of CPSs with carrier proteins to produce glycoconjugate vaccines.
287 expression of mitochondrial malonyl CoA-acyl carrier protein transacylase, a key enzyme in the pathwa
288 s well as decarboxylase (MdcD-MdcE) and acyl-carrier protein transferase (MdcA) catalytic activities.
290 The affinity between myristoylated cargo and carrier protein, Unc119, varies between subnanomolar and
292 ethodology in vitro to reversibly label acyl carrier protein variants and apply these tools to NMR st
293 oligosaccharides can be covalently bound to carrier proteins via the reducing end pentyl amine linke
294 nyl-CoA as the methyl acceptor, malonyl-acyl carrier protein was a far better acceptor of methyl grou
296 ody response against the human albumin-based carrier protein, which was prevented by using a mouse al
298 of the structure and dynamics of an apo-aryl carrier protein with those of its modified forms reveale
299 bound to transcobalamin and haptocorrin: two carrier proteins with very different biological properti
300 Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt acti
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