ライフサイエンスコーパス: cartilage loss

1 d specific (91%) but not sensitive (23%) for cartilage loss.

2 fundamentally different from those producing cartilage loss.

3 observed when posterior femur regions showed cartilage loss.

4 PRD can compromise this function and produce cartilage loss.

5 s in increased disability and progression of cartilage loss.

6 and ACL tears was associated with more rapid cartilage loss.

7 reased subchondral bone activity can predict cartilage loss.

8 raphic risk factors was predictive of future cartilage loss.

9 ic regression models were applied to predict cartilage loss.

10 were evaluated as possible risk factors for cartilage loss.

11 at might otherwise contribute to progressive cartilage loss.

12 disease, including protection from bone and cartilage loss.

13 ly associated with an increased risk of fast cartilage loss.

14 point to reflect osteoarthritis progression/cartilage loss.

15 rtilage loss, and only 20 (5.8%) showed fast cartilage loss.

16 ls were subregions in that same knee without cartilage loss.

17 bone marrow lesions (BMLs) have been tied to cartilage loss.

18 medial extension were related to ipsilateral cartilage loss.

19 nd reduced height also increased the risk of cartilage loss.

20 calcinosis was not associated with increased cartilage loss.

21 rong association between meniscal damage and cartilage loss.

22 this function has important consequences for cartilage loss.

23 ion was associated with an increased risk of cartilage loss.

24 with a higher baseline BML score had greater cartilage loss.

25 rging BMLs are strongly associated with more cartilage loss.

26 incident and progressive medial tibiofemoral cartilage loss.

27 miss a substantial proportion of knees with cartilage loss.

28 owed a higher average rate of progression of cartilage loss (22%) than that seen in those who had int

29 s related predominantly to a reduced risk of cartilage loss (adjusted OR = 0.3, 95% CI 0.1-0.8).

30 ment, and laxity each predicted tibiofemoral cartilage loss after controlling for the other factors.

31 artment) and determine their relationship to cartilage loss and ACL tears.

32 ion between clinical outcome and severity of cartilage loss and bone marrow edema in the medial femor

33 APM was associated with greater severity of cartilage loss and bone marrow edema in the same compart

34 iographically, patients experience continued cartilage loss and destructive bone changes as they age,

35 especially vitamin C, may reduce the risk of cartilage loss and disease progression in people with OA

36 e acetonide every 3 months on progression of cartilage loss and knee pain.

37 echanical stress can accelerate the onset of cartilage loss and progression to OA in transgenic mice.

38 nt swelling, histopathological signs of AIA, cartilage loss and suppressed TNFalpha induction.

39 or, pegsunercept, the number of osteoclasts, cartilage loss, and number of TNF-alpha and receptor act

40 Of 347 knees, 90 (25.9%) exhibited cartilage loss, and only 20 (5.8%) showed fast cartilage

41 tory of these lesions, their relationship to cartilage loss, and the association between change in th

42 ociation between change in these lesions and cartilage loss are unknown.

43 gions of the tibiofemoral joint, and defined cartilage loss as an increase in score (scale 0-4) at an

44 on of joint space narrowing is predictive of cartilage loss assessed on MRI, radiography is not a sen

45 Using quantitative cartilage loss assessment, local factors that independen

46 p between baseline alignment and subregional cartilage loss at 2 years, adjusting for age, sex, body

47 ationship between severity of full-thickness cartilage loss at baseline and incident SCs.

48 reater quadriceps strength protected against cartilage loss at the lateral compartment of the patello

49 r quadriceps strength was protective against cartilage loss at the lateral compartment of the patello

50 e and at 15 and 30 months was used to assess cartilage loss at the tibiofemoral and patellofemoral jo

51 ater quadriceps strength had no influence on cartilage loss at the tibiofemoral joint, including in m

52 association between quadriceps strength and cartilage loss at the tibiofemoral joint.

53 ties in both early and chronic OA, including cartilage loss, bone edema, synovial enhancement, osteop

54 s with chondrocalcinosis had a lower risk of cartilage loss compared with knees without chondrocalcin

55 It is unclear how articular cartilage loss contributes to pain in patients with knee

56 the medial compartment, 104 knees (46%) had cartilage loss detected by MRI.

57 To simulate cartilage loss from disease or injury, the top layers of

58 nd that changes in oxygen tensions following cartilage loss from injury or disease alter cartilage me

59 d in each plate, with progression defined as cartilage loss >2 times the coefficient of variation for

60 Cartilage loss in a subregion was defined as an increase

61 us alignment with a reduction in the risk of cartilage loss in certain lateral subregions.

62 d with a reduction in the risk of subsequent cartilage loss in certain medial subregions and neutral

63 as dichotomous predictors in each model) on cartilage loss in each of the 5 plates within a compartm

64 and their death by apoptosis contributes to cartilage loss in inflammatory joint diseases, such as r

65 hanism of the long-term alignment effects on cartilage loss in knee OA.

66 s is unrelated to the risk of joint space or cartilage loss in knee OA.

67 inal BMD loss is associated with progressive cartilage loss in knees with OA.

68 MRI can detect interval cartilage loss in patients over a short period (<2 years

69 scured the rate and variability of articular cartilage loss in subjects with knee OA.

70 ion between clinical outcome and severity of cartilage loss in the lateral femoral condyle and latera

71 A reduced risk of cartilage loss in the lateral subregions was associated

72 rsus valgus) knees each have reduced odds of cartilage loss in the lateral subregions.

73 ersus varus) knees each have reduced odds of cartilage loss in the medial subregions and that neutral

74 A reduced risk of cartilage loss in the medial subregions was associated w

75 confidence interval 5.6-9.9, P < 0.0001) for cartilage loss in the same subregion compared with subre

76 The incidence of arthritis and cartilage loss in vaccinated DBA/1 mice was remarkably l

77 Cartilage loss is a leading cause of disability among ad

78 rgoing great compressive stress and in which cartilage loss is inevitable.

79 Cartilage loss may be partial or complete, and it may af

80 Cartilage loss occurred frequently in the central region

81 exhibited two or more subregions with severe cartilage loss (odds ratio [OR], 16.5; 95% confidence in

82 t space narrowing on radiographic images and cartilage loss on MRI, using a generalized estimating eq

83 radiographic progression being predictive of cartilage loss on MRI.

84 amin D supplementation for preventing tibial cartilage loss or improving WOMAC knee pain in patients

85 Knees were also classified as having cartilage loss or osteophyte growth if their maximal joi

86 SBA may directly influence overlying cartilage loss or serve as a marker of an area undergoin

87 nce interval [95% CI] 2.2-16.2) but not with cartilage loss (OR 1.6, 95% CI 0.8-3.1), while medial ty

88 le medial type 2 BMLs were related to medial cartilage loss (OR 6.1, 95% CI 1.0-35.2).

89 tly or compared quantitative and qualitative cartilage loss outcomes.

90 We evaluated the association of cartilage loss over 30 months with the presence of basel

91 Cartilage loss over 6 months is rare, but may be detecte

92 t baseline had a predilection for more rapid cartilage loss (P <or= 0.93).

93 After adjustment for full-thickness cartilage loss, prevalent BMLs showed a strong and signi

94 ontribution of MCs to joint inflammation and cartilage loss remains poorly understood.

95 the BOKS, vitamin D levels were unrelated to cartilage loss seen on MRI.

96 In the BOKS, we evaluated cartilage loss semiquantitatively, using the Whole-Organ

97 djustment for BMLs, prevalent full-thickness cartilage loss showed a significant but much less import

98 compartment showed more rapid progression of cartilage loss than cartilage lesions in the anterior an

99 l proportion of knees (80 of 189 [42%]) with cartilage loss visible on MRI when no radiographic progr

100 Adjusted relative risk of cartilage loss was 2.03 (95% confidence interval [CI]: 1

101 for change in the number of subregions with cartilage loss was assessed using Poisson regression, wi

102 Fast cartilage loss was defined as a WORMS of at least 5 (lar

103 Cartilage loss was determined from knee radiographs take

104 Cartilage loss was graded in the anterior, central, and

105 ation of BML change with medial tibiofemoral cartilage loss was not significant after adjusting for a

106 Cartilage loss was present if the score in any region of

107 d synovitis or effusion) to the risk of fast cartilage loss were assessed by using a multivariable lo

108 Risk factors for tibiofemoral cartilage loss were baseline meniscal extrusion (adjuste

109 Predictors of patellofemoral cartilage loss were effusion and prevalent cartilage dam

110 Predictors of patellofemoral cartilage loss were effusion, with an adjusted odds rati

111 Disease severity and cartilage loss were evaluated by histopathological analy

112 Strong predictors of fast cartilage loss were high BMI (adjusted odds ratio [OR],

113 Predictors of tibiofemoral cartilage loss were prevalent cartilage damage, bone mar

114 on, even after adjustment for full-thickness cartilage loss, which supports the bone contusion theory

115 ithin a knee were defined as subregions with cartilage loss, while controls were subregions in that s

116 also recorded in only one case of acetabular cartilage loss with both methods.

117 observers was found in four cases of femoral cartilage loss with both MRa and CTa.

118 ciation of prevalent BMLs and full-thickness cartilage loss with incident SCs in the same subregion w

119 SBA is strongly associated with cartilage loss within the same subregion of a knee.

120 re evaluated whether SBA was associated with cartilage loss within the same subregion of the knee.