ライフサイエンスコーパス: cartilaginous

1 littermates and their skeletons were largely cartilaginous.

2 isiform insertion of ligament or muscle with cartilaginous abnormalities of the PTJ was assessed.

3 Infection of human cartilaginous airway epithelium (HAE) and a hamster mode

4 rast, differentiated epithelial cells in non-cartilaginous airways maintain quiescence by activating

5 re, we show that during homeostasis, BSCs in cartilaginous airways maintain their stem cell state by

6 Non-cartilaginous airways neutrophilia was inversely correla

7 s (BSCs) in the protected environment of the cartilaginous airways.

8 tive or chemical material, to impede further cartilaginous and bony deterioration.

9 dine deaminase (AID), an enzyme expressed in cartilaginous and bony fish that is also required for so

10 It is absent in cartilaginous and bony fish, and it is common to all tet

11 hagfish) and gnathostomes (jawed vertebrates-cartilaginous and bony fishes), based on their distinct

12 molecule (BALM) has also been identified in cartilaginous and bony fishes, and we report in this stu

13 d fins are exemplified by extinct and extant cartilaginous and bony fishes.

14 of the two living gnathostome lineages: the cartilaginous and bony vertebrates.

15 in the formation of periodically alternating cartilaginous and non-cartilaginous domains in the ventr

16 of the alpha1(XI) collagen (COL11A1) gene in cartilaginous and non-cartilaginous tissues and in coord

17 of electroreceptors and ampullary organs in cartilaginous and non-teleost bony fishes, and indicate

18 electric fields are used for hunting by both cartilaginous and non-teleost bony fishes.

19 ted two stratified layers of histogenesis of cartilaginous and osseous phenotypes.

20 Developing cartilaginous and ossified skeletal anlagen is encapsula

21 ite 2HG were measured in a series of central cartilaginous and vascular tumors, including samples fro

22 formation and more strikingly, boosted digit cartilaginous anlaga elongation, synovial joint formatio

23 re required for the vascular invasion of the cartilaginous anlage and the ossification of long bones.

24 We describe new evidence for a notochord, cartilaginous arcualia, gill pouches, articulations with

25 st accuracy for the detection of osseous and cartilaginous bodies combined (92%) and was significantl

26 Cuboid (3- or 6-mm-long sides) osseous and cartilaginous bodies were implanted in 16 cadaveric knee

27 allus formation, and could be used to induce cartilaginous callus formation.

28 (VNO) is a chemoreceptor organ enclosed in a cartilaginous capsule and separated from the main olfact

29 Development of the cartilaginous capsule of the inner ear is dependent on i

30 information gleaned mostly from both modern cartilaginous (chondrichthyan) and bony (osteichthyan) f

31 oliferation of limb bud mesenchyme and small cartilaginous condensations, and syndactyly is associate

32 attern and formation of additional postaxial cartilaginous condensations.

33 on of dense nodules reminiscent of embryonic cartilaginous condensations.

34 Cartilaginous constructs were engineered by using bovine

35 Both environments yielded cartilaginous constructs, each weighing between 0.3 and

36 ow a range of joint abnormalities, including cartilaginous continuities between juxtaposed skeletal e

37 Because it is expressed primarily in the cartilaginous cores of developing long bones during embr

38 al flexor tendons passed through cartilages, cartilaginous cristae and ridges on the plantar side of

39 centuries these have been overlooked as mere cartilaginous curiosities.

40 in a hydrogel and injected into the embedded cartilaginous cylinders following removal of the silicon

41 CFTR(-/-) mice exhibited similar congenital cartilaginous defects that may reflect a common Cl(-) se

42 B-8 interface, linking EIIIB to skeletal and cartilaginous development, wound healing, and tumorigene

43 Bone elongation originates from cartilaginous discs (growth plates) at both ends of a gr

44 riodically alternating cartilaginous and non-cartilaginous domains in the ventral mesenchyme.

45 silon-caprolactone) scaffold, induced robust cartilaginous ECM formation by hMSCs.

46 for the stylopod initiates normally but the cartilaginous element subsequently fails in growth, chon

47 node grafts often contain elongated, jointed cartilaginous elements arranged in three distinct proxim

48 How do cartilaginous elements attain their characteristic size

49 Bioassays revealed that cartilaginous elements in Day 5.5, 8.5, and 10 chick emb

50 lood vessel reduction in the vicinity of the cartilaginous elements in the Vegfa CKO mice raise the p

51 tion of Ihh, normal expression of Ihh in the cartilaginous elements is retained.

52 dynamic and distinct expression patterns in cartilaginous elements of developing chicken limbs.

53 The cartilaginous elements of each arch are formed from sepa

54 ural crest derivatives (pigment cells and/or cartilaginous elements of the jaw).

55 EGF are not detected in the differentiating cartilaginous elements or muscle primordia of the limb,

56 se to the condensations and subsequently the cartilaginous elements that serve as the templates of th

57 nal inactivation of murine VHL (Vhlh) in all cartilaginous elements to investigate its role in endoch

58 Interestingly, the transgenic cartilaginous elements were ill defined, intermingled wi

59 Bmpr1b in cartilage are able to form intact cartilaginous elements, double mutants develop a severe

60 mice display ectopic mineralization in many cartilaginous elements.

61 the failure of fusion or the elimination of cartilaginous elements.

62 and found reduced cranial size and abnormal cartilaginous elements.

63 Sequence comparison between human and the cartilaginous elephant shark (Callorhinchus milii) revea

64 vasive estimation of the degeneration of the cartilaginous end plate; however, the accuracy of T2*-ba

65 ied at ages 51, 57, and 66 years) containing cartilaginous end plates and subchondral bone were prepa

66 ciently marked that the mice are born with a cartilaginous endochondral skeleton.

67 f LCM to the gene expression analysis of the cartilaginous epiphyseal growth plate of normal newborn

68 During fetal development, the cartilaginous epiphysis of the distal femur transformed

69 on in MR imaging signal intensity within the cartilaginous epiphysis of the distal femur.

70 The underlying cartilaginous epiphysis was deranged as well and display

71 stem cell differentiation and formation of a cartilaginous extracellular matrix (ECM) using a lentivi

72 The cartilaginous extracellular matrix produced by the cultu

73 Cartilaginous fish (e.g., sharks) are derived from the o

74 Cartilaginous fish (sharks, skates, and rays) are in the

75 d to have recombined with the TRD locus in a cartilaginous fish ancestor >200 million years ago and e

76 the SCPP genes arose after the divergence of cartilaginous fish and bony fish, implying that early ve

77 in this sense, the TCR-beta genes in this cartilaginous fish and humans are more similar than are

78 fide bonds found in new antigen receptors of cartilaginous fish and in camelid heavy-chain variable d

79 hologous to IgW, an Ig isotype found only in cartilaginous fish and lungfish, demonstrating that IgD/

80 Ig genes in cartilaginous fish are encoded by multiple individual lo

81 Cartilaginous fish are the oldest animals that generate

82 The cartilaginous fish are the oldest phylogenetic group in

83 Cartilaginous fish are the phylogenetically oldest livin

84 Sharks and other cartilaginous fish are the phylogenetically oldest livin

85 lements can be identified through the use of cartilaginous fish as a baseline.

86 We have established a cartilaginous fish cell line [Squalus acanthias embryo c

87 prerequisite for their identification, this cartilaginous fish culture system also provides a physio

88 a neural crest origin has been proposed for cartilaginous fish electroreceptors.

89 hat Spi-D arose before the divergence of the cartilaginous fish from the lineage leading to the mamma

90 The recent cartilaginous fish genome project suggests that most eff

91 These molecular data suggest that cartilaginous fish have augmented their humoral immune r

92 he Tm and secretory (Sec) mRNAs of the novel cartilaginous fish Ig isotypes, IgW and IgNAR, are prese

93 to account for poor immune responsiveness in cartilaginous fish should be abandoned.

94 roup that includes tetrapods, and more basal cartilaginous fish showed pectoral innervation that was

95 Eos in Raja eglanteria (clearnose skate), a cartilaginous fish that is representative of an early di

96 ervation of the Ikaros multigene family from cartilaginous fish through mammals, these studies define

97 leotides) are significantly smaller than the cartilaginous fish TRs (478-559 nucleotides) and tetrapo

98 ric TCRs containing amphibian, bony fish, or cartilaginous fish Vbetas can recognize antigens present

99 rectifying Kv channel predicted from skate (cartilaginous fish) ampullary organ electrophysiology.

100 Chondrichthyans (cartilaginous fish) are the most distant group to amniot

101 albumin in a comprehensive range of bony and cartilaginous fish, from the Asia-Pacific region, and co

102 In most jawed vertebrates including cartilaginous fish, membrane-bound IgM is expressed as a

103 he PU.1 family of transcription factors in a cartilaginous fish, Raja eglanteria, are described here.

104 fin development in embryos of the primitive cartilaginous fish, Scyliorhinus canicula (dogfish) usin

105 ere we report the whole-genome analysis of a cartilaginous fish, the elephant shark (Callorhinchus mi

106 s of the Dlx gene family of a representative cartilaginous fish, the leopard shark, Triakis semifasci

107 by cell lineage tracing that the gills of a cartilaginous fish, the little skate (Leucoraja erinacea

108 of trunk neural crest cells in embryos of a cartilaginous fish, the little skate (Leucoraja erinacea

109 the four TCR chains for the first time in a cartilaginous fish, the nurse shark (Ginglymostoma cirra

110 ification of TCR-expressing lymphocytes in a cartilaginous fish.

111 n the common ancestor of the mammals and the cartilaginous fish.

112 ajor histocompatibility complex genes from a cartilaginous fish.

113 an and epigonal tissues, which are unique to cartilaginous fish.

114 existed not long before the emergence of the cartilaginous fish.

115 eak" adaptive immune responses documented in cartilaginous fish.

116 iversification and clonal selection exist in cartilaginous fish.

117 and the adult skeleton of modern jawless and cartilaginous fish.

118 all fish analysed, except for gummy shark a cartilaginous fish.

119 complete loss of reactivity was observed for cartilaginous fish.

120 be identified in lineages as far as that of cartilaginous fish.

121 long-term in vivo fate-mapping study in any cartilaginous fish.

122 kedly diversified in the lineages leading to cartilaginous fishes (Chondrichthyes) and bony vertebrat

123 Cartilaginous fishes (e.g., sharks and skates) possess a

124 We studied two cartilaginous fishes and described their brainstem supra

125 s subsequently diverged into two groups, the cartilaginous fishes and the bony vertebrates.

126 teral line placodes form electroreceptors in cartilaginous fishes by undertaking the first long-term

127 The IgM H chain gene organization of cartilaginous fishes consists of 15-200 miniloci, each w

128 secreted calcium-binding phosphoproteins in cartilaginous fishes explains the absence of bone in the

129 Furthermore, the adaptive immune system of cartilaginous fishes is unusual: it lacks the canonical

130 ignificantly related to body mass for birds, cartilaginous fishes, and mammals.

131 are present in jawed vertebrates, including cartilaginous fishes, but not in jawless vertebrates or

132 ation occurred in an ancestor in common with cartilaginous fishes, giving rise to a separate p53 gene

133 asmobranchs, or is the ancestral pattern for cartilaginous fishes, requires examination of a represen

134 In cartilaginous fishes, the immunoglobulin (Ig) light chai

135 Moreover, unlike other cartilaginous fishes, there are no germline-joined VDJ a

136 lineages of jawed vertebrates, including the cartilaginous fishes, which represent the most phylogene

137 l motoneurons is the primitive condition for cartilaginous fishes.

138 udes the Wnt9 sequences found in jawless and cartilaginous fishes.

139 rescence has evolved at least three times in cartilaginous fishes.

140 up is represented by the chondrichthyans, or cartilaginous fishes.

141 first to show that the pattern is present in cartilaginous fishes.

142 tion diversity that evolved independently in cartilaginous fishes.

143 e of facial prominences and extension of the cartilaginous framework.

144 Cartilaginous growth plate abnormalities persisted in ad

145 owever, it causes structural collapse of the cartilaginous growth plate as a result of impaired proli

146 pressed in proliferating chondrocytes of the cartilaginous growth plate but also in chondrocytes that

147 n, affects many tissues, most strikingly the cartilaginous growth plate in the growing skeleton, lead

148 elete HIF-1alpha in an avascular tissue: the cartilaginous growth plate of developing bone.

149 s coordinately with growth of the underlying cartilaginous growth plate.

150 ing and hypertrophic chondrocytes within the cartilaginous growth plate.

151 mammalian target of rapamycin (mTOR) in the cartilaginous growth plate.

152 and remodeling and in the development of the cartilaginous growth plates of endochondral bone.

153 tants were analyzed for abnormalities in the cartilaginous head skeleton.

154 Our results link low-grade IL-8-mediated cartilaginous inflammation in OA to altered chondrocyte

155 ed abnormal epiphyseal cartilage thickening, cartilaginous islands within ossified tissue, and less f

156 follistatin a (fsta) and emx2, in regulating cartilaginous joints in the hyoid arch.

157 se in sulfate incorporation into GAGs in the cartilaginous layer as though the tissue measured was fr

158 Because avian sclera has a cartilaginous layer as well as the fibrous layer found i

159 on as does the mammalian sclera, whereas the cartilaginous layer changes in the opposite direction.

160 The responses of the cartilaginous layer may be controlled by the fibrous lay

161 bited by atropine in whole sclera and in its cartilaginous layer.

162 In the cartilaginous layers, the incorporation of label into pr

163 null vascular disease presents as calcifying cartilaginous lesions and mineral deposition along elast

164 The association between cartilaginous lesions and osteoarthritic changes was cal

165 Cartilaginous lesions and osteophytes were easily identi

166 High-grade cartilaginous lesions can be evaluated reliably with low

167 p(-/-) mice dramatically reduced the size of cartilaginous lesions in the aortic media, attenuated ca

168 Subsequently, primary cartilaginous lesions within the epiphyseal cartilage de

169 lity in Mgp(-/-);Tgm2(-/-) mice with reduced cartilaginous lesions.

170 Chondroblastomas are benign cartilaginous lesions; however, intervention is necessar

171 During limb skeletogenesis the cartilaginous long bone anlagen and their growth plates

172 nulomatous lesions and residual degenerating cartilaginous masses are also present in the bones of th

173 d fused with each other into large amorphous cartilaginous masses.

174 surgical excision of the ossicle and/or free cartilaginous material may give good results in skeletal

175 te differentiation affects mineralization of cartilaginous matrix in a non-cell autonomous fashion; m

176 emonstrated a more dense, negatively charged cartilaginous matrix in control cultures.

177 tilage, fibrocartilage, and a nonmineralized cartilaginous matrix with lacunae containing chondrocyte

178 However, the main constituents of the cartilaginous matrix, aggrecan and type II collagen, are

179 with collagen IX that could destabilize the cartilaginous matrix.

180 and skeletogenesis, is also expressed in pre-cartilaginous mesenchymal condensations in the developin

181 organ anlage that was dependent upon midline cartilaginous/mesenchymal tissues.

182 In 75% of Cthrc1 transgenic mice, cartilaginous metaplasia of medial smooth muscle cells w

183 e cell phenotype and provide an etiology for cartilaginous metaplasia of the arterial wall.

184 d a cellular and matrix-rich neointima, with cartilaginous metaplasia of the vascular media.

185 Between 4 and 8 weeks, the cartilaginous metaplasia resolved and the intimal lesion

186 The synovium was hyperplastic, and cartilaginous metaplasia was observed in the joint space

187 liest manifestation, the lesion was entirely cartilaginous (n = 1).

188 interface between the nasal bone process and cartilaginous nasal septum.

189 then Sox9 expression was induced, leading to cartilaginous nodules and particles in the presence of B

190 hondrium becomes deranged and interrupted by cartilaginous outgrowths in Hereditary Multiple Exostose

191 e associated with defective formation of the cartilaginous pharyngeal skeleton.

192 Otor and Col2A1 are coexpressed in the cartilaginous plates of the neural and abneural limbs of

193 y a patchy mode of ossification of a massive cartilaginous precursor and that the predigits act funct

194 , sphenoid and ethmoid bones that arise from cartilaginous precursors in the early embryo.

195 ondensation, but alters the formation of the cartilaginous primordia.

196 and KAT, but not collagen type II (ColII), a cartilaginous protein.

197 um likely caused the short bones and ectopic cartilaginous protrusions.

198 region encoded by exon IIIA disappears from cartilaginous regions just after condensation in vivo an

199 Pln mRNA and protein are highly expressed in cartilaginous regions of developing mouse embryos, but n

200 lialized sites as well as in chondrocytes in cartilaginous regions of the embryo.

201 taphysis), signal intensity and thickness of cartilaginous regions seen on MR images were correlated

202 ginous regions and from 200 to 210 mmol/L in cartilaginous regions.

203 he growth plate, and a prolonged presence of cartilaginous remnants in the spongiosa, confirming a de

204 diameter conducting airways are supported by cartilaginous rings and smooth muscle tissue and are lin

205 e in the perichondrium surrounding avascular cartilaginous rudiments; the source of trabecular osteob

206 Coculturing cartilaginous sclera from normal eyes with fibrous scler

207 or was expressed by cells in the fibrous and cartilaginous sclera in equatorial regions of the eye.

208 ecially from recovering eyes, also inhibited cartilaginous sclera.

209 th uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thick

210 -deficient mice fail to remodel the primary, cartilaginous skeletal anlagen.

211 ments that enforces a distortion of the soft cartilaginous skeletal elements and bone shapes.

212 inuous Wnt/beta-catenin signaling in nascent cartilaginous skeletal elements blocks chondrocyte hyper

213 Through programmed tissue substitution, the cartilaginous skeletal model is replaced by trabecular b

214 accompanied by a severe dysmorphology of the cartilaginous skeleton and failure of maturation of seve

215 -1 counterpart (hERG3Delta81) throughout the cartilaginous skeleton of transgenic mice, using Col2a1

216 that are expressed during development of the cartilaginous skeleton.

217 argely from neural crest cells that form the cartilaginous skeleton.

218 imarily through the growth plate, which is a cartilaginous structure at the end of long bones made up

219 essed in and function in the growth plate, a cartilaginous structure that causes bone elongation and

220 The epiphysis of developing bones is a cartilaginous structure that is eventually replaced by b

221 Cartilaginous structures are at the core of embryo growt

222 Certain embryonic bones and cartilaginous structures develop abnormally, with verteb

223 and Col2a1-Cre/R26R lines indicated that non-cartilaginous structures in the knee such as cruciate li

224 which contribute to a subset of the bony and cartilaginous structures of the skull.

225 In particular, fibrocartilaginous and cartilaginous structures on the plantar surface of the a

226 tracheal equivalent composed of cylindrical cartilaginous structures with lumens lined with nasal ep

227 icer results in embryos lacking craniofacial cartilaginous structures, cardiac outflow tract septatio

228 structural and functional changes in the two cartilaginous structures.

229 r grafts, tracheal splints, heart tissue and cartilaginous structures.

230 The tendon sheath, the fibrous capsule, and cartilaginous surfaces were better visualized at MR arth

231 It develops as a cartilaginous template that is replaced by bone through

232 ainly by the human cells and formed over the cartilaginous template.

233 y B. burgdorferi components can persist near cartilaginous tissue after treatment for Lyme disease.

234 nd signaling molecules during development of cartilaginous tissue and is essential for proper chondro

235 m cell therapy could enhance regeneration of cartilaginous tissue and serve as a potential therapeuti

236 native ECM, the nanofiber scaffolds enhanced cartilaginous tissue formation, suggesting their potenti

237 Correlations between cartilaginous tissue function and MR imaging parameters

238 ded with cells and so provide a template for cartilaginous tissue growth.

239 s (OA), characterized by degeneration of the cartilaginous tissue in articular joints, severely impai

240 applications in monitoring the integrity of cartilaginous tissue in vivo.

241 dues of nonviable spirochetes can persist in cartilaginous tissue long after treatment and may contri

242 ression was also seen in the skin and in the cartilaginous tissue of developing skeleton.

243 of musculoskeletal degeneration in bony and cartilaginous tissue regions.

244 biomechanical characteristics of this fibro-cartilaginous tissue.

245 tients show diffuse ectopic calcification of cartilaginous tissues and impaired midface development.

246 agen (COL11A1) gene in cartilaginous and non-cartilaginous tissues and in coordination with different

247 nique, rare autoimmune disorder in which the cartilaginous tissues are the primary targets of destruc

248 In addition, overgrowth of the cartilaginous tissues is observed in the rib cartilage,

249 aracterized by recurrent inflammation of the cartilaginous tissues of the ears, nose, peripheral join

250 proliferated and differentiated, but ectopic cartilaginous tissues protruded into the perichondrium.

251 lation of aggrecan, a major ECM component of cartilaginous tissues that confers resistance to compres

252 zed by recurrent episodes of inflammation of cartilaginous tissues, can be life-threatening, debilita

253 te that the novel SLRP CHADL is expressed in cartilaginous tissues, influences collagen fibrillogenes

254 In non-cartilaginous tissues, type I collagen accounts for the

255 gulatory molecules that have a major role in cartilaginous tissues.

256 mineralized structures but also in soft and cartilaginous tissues.

257 stenosis because of incomplete formation of cartilaginous tracheal support.

258 he characteristic chemotherapy resistance of cartilaginous tumors (overexpression of P-glycoprotein)

259 Although some cartilaginous tumors are characterized by specific or re

260 ic skeletal disorder characterized by benign cartilaginous tumors called exostoses that form next to

261 ndrome are characterized by multiple central cartilaginous tumors that are accompanied by soft tissue

262 A separate subset of 116 cartilaginous tumors with outcome data was used for vali

263 In the validation arm of 116 cartilaginous tumors, MYC was frequently amplified in G2

264 ers, 31 other CNS-tumors, and 120 IDH-mutant cartilaginous tumors, we identified that the association

265 cation and therapy of this diverse family of cartilaginous tumors.

266 Hypoxia-preconditioned implants remained cartilaginous, whereas normoxia-preconditioned implants

267 ormly distributed throughout the fibrous and cartilaginous zones of the TMJ condyle.