ライフサイエンスコーパス: casein kinase 1

1 iotic division is coordinated by a conserved casein kinase 1.

2 y for calcineurin and decreased affinity for casein kinase 1.

3 in of eIF2Bepsilon, can be phosphorylated by casein kinase 1.

4 e Ser45 and Thr41, independent of priming by casein kinase-1.

5 this need, new small molecule inhibitors of casein kinase-1 acting through ATP-competitive and ATP-n

6 Strikingly, loss of casein kinase 1 activity causes constitutive activation

7 Deregulation of CK1 (casein kinase 1) activity can be involved in the develop

8 Casein kinase 1 alpha (CK1 alpha) was shown to directly

9 protein stability of FOXO3A is regulated by Casein Kinase 1 alpha (CK1alpha) in an oncogenic RAS-spe

10 Here, we report that casein kinase 1 alpha (CK1alpha) phosphorylates Cdc25A o

11 We found that casein kinase 1 alpha (Csnk1a1), a serine-threonine kina

12 ung cancer (NSCLC) cell lines, we identified casein kinase 1 alpha (CSNK1A1, CK1alpha).

13 expressing the more distantly related human casein kinase 1 alpha 2 could not.

14 We found that MDMX binds to the casein kinase 1 alpha isoform (CK1alpha) and is phosphor

15 elates with the ability of Foxd1 to regulate casein kinase 1, an NF-AT inhibitory kinase; the latter

16 inus by protein kinase A and subsequently by casein kinase 1 and glycogen synthase kinase 3.

17 rimes subsequent phosphorylation of adjacent casein kinase 1 and glycogen synthase kinase 3.

18 dependent protein kinase and subsequently by casein kinase 1 and glycogen synthase kinase 3.

19 old selectivity against calmodulin kinase 2; casein kinase-1 and -2; CDK1 and -4; mitogen-activated p

20 quential phosphorylation of LRP6 by GSK3 and casein kinase 1, and this dual phosphorylation promotes

21 ae, the redundant YCK1 and YCK2 genes (Yeast Casein Kinase 1) are required for viability.

22 Our results describe a role for casein kinase 1 as a direct regulator of sterol homeosta

23 beta-catenin involves its phosphorylation by casein kinase 1 at the Ser-45 site and by glycogen synth

24 contained a single open reading frame termed casein kinase-1 binding protein (CK1BP).

25 nstrated that Ser(568) was phosphorylated by casein kinase 1 both in vitro and in vivo.

26 signaling pathway that leads from mGluRs to casein kinase 1 (CK1) activation.

27 ubiquitylation were blocked by disruption of casein kinase 1 (CK1) activity, and mass spectrometry an

28 lation was reduced by specific inhibitors of casein kinase 1 (CK1) and casein kinase 2 (CK2) (10 muM

29 untered by distinct NFAT kinases, among them casein kinase 1 (CK1) and glycogen synthase kinase 3 (GS

30 such as phosphorylation of clock proteins by casein kinase 1 (CK1) and glycogen synthase kinase 3 (GS

31 ligase complex upon dual phosphorylation by casein kinase 1 (CK1) and glycogen synthase kinase 3beta

32 In the absence of a Wnt signal, casein kinase 1 (CK1) and glycogen synthase kinase-3beta

33 under physiological conditions and identify Casein Kinase 1 (CK1) as an upstream effector that bidir

34 rylation and that both were inhibited by the casein kinase 1 (CK1) delta/epsilon inhibitor IC261.

35 An increase of casein kinase 1 (CK1) expression has been described in t

36 lated in vitro and in vivo by members of the casein kinase 1 (CK1) family and by glycogen synthase ki

37 Members of the casein kinase 1 (CK1) family are evolutionarily conserve

38 e tau protein kinases include members of the casein kinase 1 (CK1) family of phosphotransferases, whi

39 dies to show that Ser-247 is a target of the casein kinase 1 (CK1) family of protein kinases.

40 Casein kinase 1 (CK1) has been implicated in a variety o

41 Here, the casein kinase 1 (CK1) Hrr25 is shown to be an endocytic

42 We have examined the role of casein kinase 1 (CK1) in connexin-43 (Cx43) gap junction

43 Casein kinase 1 (CK1) is a highly conserved serine/threo

44 Casein kinase 1 (CK1) is one such enzyme; it stimulates

45 The cDNA for casein kinase 1 (CK1) of Plasmodium falciparum was clone

46 ee specific PKA sites or adjacent PKA-primed casein kinase 1 (CK1) sites are replaced by alanine resi

47 Casein kinase 1 (CK1) was identified as the major kinase

48 ength Ci (Ci-155) by protein kinase A (PKA), casein kinase 1 (CK1), and glycogen synthase kinase 3 (G

49 at Ser680 promotes Ser683 phosphorylation by casein kinase 1 (CK1), and these phosphorylation events

50 Phosphorylation of the COPII coat by casein kinase 1 (CK1), Hrr25, contributes to the directi

51 nes; rephosphorylation by kinases, including casein kinase 1 (CK1), restores NFAT to its latent state

52 elsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymph

53 ent manner by the plasma membrane-associated casein kinase 1 (CK1).

54 er-174 and Ser-175 by the nuclear isoform of casein kinase 1 (CK1).

55 egulated by the phosphorylation at Ser(6) by casein kinase 1 (CK1).

56 ain-derived tau filaments are members of the casein kinase-1 (CK1) family of protein kinases.

57 In this study, we determined the role of casein kinase-1 (CK1) in regulating NMDAR activity in th

58 Arsenite also recruited a TDP-43 kinase, casein kinase-1 (CK1), to GADD34.

59 dence that the delta and epsilon isoforms of casein kinase 1 (CK1delta and CK1epsilon) show identical

60 Two such regulators, casein kinase 1 (CKI) and F-box and leucine-rich repeat

61 atalytic domain of Schizosaccharomyces pombe casein kinase-1 complexed with CK17, refined to a crysta

62 Both casein kinase 1 delta (CK1delta) and epsilon (CK1epsilon

63 Casein kinase 1 delta (CK1delta) and its closest homolog

64 Inhibition of casein kinase 1 delta (CK1delta) blocks primary ciliogen

65 can play an important role in dissection of casein kinase-1-dependent processes.

66 Casein kinase 1 epsilon (CK1epsilon) and its closest hom

67 requires both non-canonical Wnt5a ligand and casein kinase 1 epsilon (CK1varepsilon), and that this e

68 species, events that are highly dependent on casein kinase 1 epsilon (termed DOUBLETIME [DBT] in Dros

69 self-renewal, by inducing the expression of casein kinase 1 epsilon.

70 ut not other PI3Kdelta inhibitors, inhibited casein kinase-1 epsilon (CK1epsilon).

71 C compared to the other carcinomas, included casein kinase 1, epsilon and frizzled-7, both members of

72 Csnk1e, the gene encoding casein kinase 1-epsilon, has been implicated in sensitiv

73 be our isolation and characterization of the casein kinase 1 family member Hhp2 as a novel regulator

74 We demonstrate that Casein kinase 1 family members, including isoforms of Ta

75 he Hedgehog pathway are redundant with other Casein kinase 1 family members.

76 s showed that MPAK, which is a member of the casein kinase 1 family of Ser/Thr protein kinases, is re

77 icted protein-serine/threonine kinase in the casein kinase 1 family.

78 ropose that adoption of this conformation by casein kinase-1 family members stabilizes a delocalized

79 Members of the casein kinase-1 family of protein kinases play an essent

80 CK1delta, a member of the ubiquitous casein kinase-1 family, is implicated in the progression

81 Depletion of casein kinase 1 gamma (CSNK-1) in Caenorhabditis elegans

82 a multifaceted approach, we have found that casein kinase 1 gamma 1 (CK1gamma1) carries out this fun

83 ugh a yeast two-hybrid screen, we identified casein kinase 1 gamma 2 (CKIgamma2) as a novel Smad3-int

84 Here, we establish that the casein kinase 1 gamma CSNK-1 and a PIP(2) synthesis enzy

85 involves SOD1-mediated stabilization of two casein kinase 1-gamma (CK1gamma) homologs, Yck1p and Yck

86 ing protein (IQGAP); and three NFAT kinases, casein kinase 1, glycogen synthase kinase 3, and dual sp

87 ts G2 mode by blocking Srs2 DNA helicase and Casein Kinase 1 (Hhp1).

88 We also show casein kinase 1 (Hrr25) is a key kinase that phosphoryla

89 Ser(9) was phosphorylated by casein kinase 1 in vitro in a phosphoserine 6-dependent

90 The structure reveals that IC261 stabilizes casein kinase-1 in a conformation midway between nucleot

91 We show that casein kinase-1 inhibition increases NMDA receptor activ

92 We further evaluated whether D4476, a casein kinase 1 inhibitor, would exhibit selective antil

93 Because casein kinase 1 is associated with sites of polar growth

94 Casein kinase 1 is responsible for most of the hyperphos

95 Casein kinase-1 is a family of ubiquitous eukaryotic pro

96 Yck2 protein is a plasma membrane-associated casein kinase 1 isoform that attaches to membranes via p

97 creen was performed with human Ckidelta (the casein kinase-1 isoform most closely linked to granulova

98 s paralogs in humans may function to recruit casein kinase-1 isoforms to protein complexes involved i

99 e inhibitor with differential activity among casein kinase-1 isoforms, in complex with the catalytic

100 oline-8-sulfonamide (CK17), is selective for casein kinase-1 isolated from a variety of sources.

101 psis (Arabidopsis thaliana) CK1 member named casein kinase 1-like 6 (CKL6) associates with cortical m

102 Inhibition of casein kinase 1 may also contribute to the antitumoral a

103 in 90 and glycogen synthase kinase 3 but not casein kinase 1 nor LATS in YAP-mediated TAZ loss.

104 glycogen synthase kinase 3beta (GSK3beta) or casein kinase 1 or 2 (CK1/2) markedly slowed the decay o

105 ists of two independent domains that contain casein kinase 1 phosphorylation sites.

106 New studies show that casein kinase 1 primes beta-catenin for subsequent phoph

107 Casein kinase 1 protein kinases are ubiquitous and abund

108 depends on the ubiquitin ligase Rsp5 and the casein kinase 1 redundant pair Yck1/Yck2.

109 x with the catalytic domain of fission yeast casein kinase-1 refined to a crystallographic R-factor o

110 he protein kinase A site, Thr-34, and at the casein kinase-1 site, Ser-137, and decreases phosphoryla

111 hosphorylation state of Ser137-DARPP-32, the casein kinase-1 site.

112 n synthase kinase and protein kinase A or of casein kinase 1 slowed the decay of nuclear NFATc1 after

113 sites for cAMP-dependent protein kinase and casein kinase 1 suggest a role for these kinases in Smo

114 e sensitive to pharmacological inhibition of Casein kinase 1, suggesting the possibility of shared cl

115 Our data indicate that casein kinase-1 tonically regulates NMDA receptor activi