ライフサイエンスコーパス: casein kinase 2

1 he pleiotropic protein kinase, CK2 (formerly casein kinase 2).

2 mulation by phosphorylation by CK2 (formerly casein kinase 2).

3 s identified as protein kinase CK2 (formerly casein kinase 2).

4 ing that this phosphorylation is mediated by casein kinase 2.

5 ved sites (Ser712/713) are phosphorylated by casein kinase 2.

6 iated vimentin kinases and identified one as casein kinase 2.

7 t we identified as substrates for Erk1/2 and casein kinase 2.

8 I, whereas Ca(V)1.1-T1579 is a substrate for casein kinase 2.

9 c but not the cardiac CCRK with cyclin H and casein kinase 2.

10 iated by the alpha prime (alpha') subunit of casein kinase 2.

11 n synthase kinase-3beta, whereas stimulating casein kinase 2.

12 es with thapsigargin (10 mum), inhibition of casein kinase 2 (4,5,6,7-tetrabromobenzotriazole; 10 mum

13 overed that murine Arl13b is a substrate for casein kinase 2, a contaminant in our preparation from h

14 Protein kinase CK2 (CK2) (formerly casein kinase 2, a protein Ser/Thr kinase signal that is

15 ine 424 by protein kinase CK2 (also known as casein kinase 2) activated the HDAC3 in vitro.

16 of either Galpha(q) or Galpha(o) stimulates casein kinase 2 activation and Lef/Tcf-sensitive gene ex

17 ha(q) or Galpha(o) blocks Wnt stimulation of casein kinase 2 activation, as does suppression of the p

18 ied extracellular regulated kinase 2 blocked casein kinase 2 activity and increased protein serine/th

19 Herein we show to the contrary that casein kinase 2 activity is rapidly and transiently incr

20 minal kinase; (ii) inhibition of calpain and casein kinase 2 activity; and (iii) induction of fibrobl

21 Casein kinase 2 alpha phosphorylates PDCD5 at Ser-119 to

22 lation sites and two putative GRIP1 kinases, casein kinase 2 and cyclin-dependent kinase 9.

23 transport in beta-cells that is mediated by casein kinase 2 and PP2B.

24 of which contains a large number of putative casein kinase 2 and protein kinase C phosphorylation sit

25 lation through a dynamic interaction between casein kinase 2 and protein serine/threonine phosphatase

26 molecular events of this modulation involved casein kinase 2 and the synaptic vesicle rapid endocytos

27 s NMDA receptor activity by interacting with casein kinase-2 and protein phosphatases in the hypothal

28 As in the case of Nopp140, casein kinase 2 appears to be responsible for the unusua

29 has been shown recently to potently inhibit casein kinase 2 as well as PI3K, we hypothesize that cas

30 The amount of Inh2 kinase attributed to casein kinase 2, based on inhibition by heparin, increas

31 ; allograft inflammatory factor 1 (AIF1) and casein kinase 2, beta polypeptide (CSNK2B), all found in

32 levels of [Ca2+]i KHC was phosphorylated by casein kinase 2, but KHC was rapidly dephosphorylated by

33 rf1 mutation led to the discovery of a novel casein Kinase 2 catalytic subunit (CK2alpha").

34 posttranslationally regulated by TNF-induced casein kinase 2 catalytic subunit (CK2alpha') phosphoryl

35 Casein kinase 2 catalyzed protein serine/threonine phosp

36 anine nucleotide exchange factor (eIF-2B) by casein kinase 2 (CK-2) was previously shown to stimulate

37 ific inhibitors of casein kinase 1 (CK1) and casein kinase 2 (CK2) (10 muM D4476, 100 muM CK2-inhibit

38 rt inhibition as a consequence of endogenous casein kinase 2 (CK2) activation.

39 effects of mutant M1 spastins on FAT involve casein kinase 2 (CK2) activation.

40 ZEBRA, Ser167 and Ser173, are substrates for casein kinase 2 (CK2) and are constitutively phosphoryla

41 We focus on casein kinase 2 (CK2) and demonstrate that the regulator

42 to directly associate with and modulate both casein kinase 2 (CK2) and protein kinase A (PKA), which

43 glycerolipid biosynthesis, is stimulated by casein kinase 2 (CK2) and that a phosphorylated protein

44 This kinase complex contains casein kinase 2 (CK2) and the chromatin transcriptional

45 ified the regulatory (beta) subunit of human casein kinase 2 (CK2) as a CDC34-interacting protein and

46 In this study, we identified casein kinase 2 (CK2) as a critical modulator of NADPH o

47 We identify casein kinase 2 (CK2) as a key regulator of temperature

48 We also identify casein kinase 2 (CK2) as a kinase activity in embryonic

49 Previous work has implicated casein kinase 2 (CK2) as the kinase responsible for this

50 ave identified polo-like kinase 1 (Plk1) and casein kinase 2 (CK2) as two kinases of CLIP-170 and map

51 Casein kinase 2 (CK2) binds to the NHE3 C-terminus and c

52 This protein kinase was identified as casein kinase 2 (CK2) by immunoblot and mass spectrometr

53 e that phosphorylated CD45 was identified as casein kinase 2 (CK2) by use of an in-gel kinase assay i

54 ormally long circadian periods, we show that casein kinase 2 (CK2) has a role in determining period l

55 d for robust in vitro phosphorylation by the casein kinase 2 (CK2) holoenzyme, a cytoplasmic kinase s

56 Our previous results highlighted a role for casein kinase 2 (CK2) in the modulation of dopamine D1 r

57 We demonstrate a role for protein kinase casein kinase 2 (CK2) in the phosphorylation and regulat

58 iated stimulation, PTEN is phosphorylated by casein kinase 2 (CK2) in the Ser380-Thr382-Thr383 cluste

59 tified serine 358 as a specific site used by casein kinase 2 (CK2) in vitro and in vivo.

60 A, S167 and S173, that are phosphorylated by casein kinase 2 (CK2) in vitro are also phosphorylated i

61 7 -: tetrabromobenzotriazole (TBB), a potent casein kinase 2 (CK2) inhibitor, as a strong suppressor

62 enhanced by LXR ligands and reduced both by casein kinase 2 (CK2) inhibitors and by activation of it

63 rylation by either protein kinase C (PKC) or casein kinase 2 (CK2) inhibits the assembly of myosin-II

64 beta subunit of the serine/threonine kinase casein kinase 2 (CK2) interacts specifically with the cy

65 Casein kinase 2 (CK2) is a multifunctional second messen

66 The protein kinase casein kinase 2 (CK2) is a pleiotropic and constitutivel

67 Casein kinase 2 (CK2) is a typical serine/threonine kina

68 Casein kinase 2 (CK2) is oncogenic and frequently upregu

69 Although protein kinase casein kinase 2 (CK2) is readily detected in MKs and pla

70 Previous research suggests that casein kinase 2 (CK2) may be a promising therapeutic tar

71 Previous in vitro studies indicated that casein kinase 2 (CK2) mediated the phosphorylation of NS

72 We have previously shown that casein kinase 2 (CK2) negatively regulates dopamine D1 a

73 We demonstrated that increased activity of casein kinase 2 (CK2) observed in HPC and in MDSC could

74 w that murine caspase-9 is phosphorylated by casein kinase 2 (CK2) on a serine near the site of caspa

75 at shock and antioxidants induced Hsp90, and casein kinase 2 (CK2) phosphorylated INrf2Thr55.

76 Casein kinase 2 (CK2) phosphorylates the NR2B subunit wi

77 The MRE11-PIH1D1 interaction is dependent on casein kinase 2 (CK2) phosphorylation of two acidic sequ

78 The Foxc2 amino terminus has a consensus casein kinase 2 (CK2) phosphorylation site at serine 124

79 ariant of the formin FHOD3 that introduces a casein kinase 2 (CK2) phosphorylation site.

80 the C terminus, which was predicted to be a casein kinase 2 (CK2) phosphorylation site.

81 ) of MDC1, which contains multiple consensus casein kinase 2 (CK2) phosphorylation sites.

82 and overexpression experiments, we show that casein kinase 2 (CK2) promotes stress granule dynamics.

83 that phosphorylation of recombinant TFIIF by casein kinase 2 (CK2) reduces or eliminates some of the

84 As the casein kinase 2 (CK2) site at serine 392 is the C-termin

85 serine residues 16 and 18, which are within casein kinase 2 (CK2) sites, and serine residue 114, whi

86 ctivated through pharmacologic inhibition of casein kinase 2 (CK2) to eradicate disease in high-risk

87 sh1 is phosphorylated by the Cka2 subunit of casein kinase 2 (CK2) to promote its E3 activity for Cse

88 Casein kinase 2 (CK2) was one of the first protein kinas

89 Casein kinase 2 (CK2) was previously reported to be over

90 he major site of in vitro phosphorylation by casein kinase 2 (CK2) was the conserved Ser(232) in the

91 ntly shown that the serine/threonine kinase, casein kinase 2 (CK2), a major regulator of cell growth

92 Casein Kinase 2 (CK2), a positive regulator of Wnt signa

93 CD5 activates casein kinase 2 (CK2), a serine/threonine kinase that co

94 ere, we report that Brg1 is also a target of casein kinase 2 (CK2), a serine/threonine kinase, in pro

95 wn previously to require the Cka2 subunit of casein kinase 2 (CK2), a ubiquitous enzyme with multiple

96 Casein kinase 2 (CK2), a ubiquitous kinase, regulates se

97 Inhibition of casein kinase 2 (CK2), an enzyme implicated in DNA damag

98 eral kinases among these proteins, including casein kinase 2 (CK2), and a new bud neck-associated pro

99 nsists of Daz interacting protein 1 (Dzip1), casein kinase 2 (CK2), and B56 containing protein phosph

100 dentify the heterotetrameric protein kinase, casein kinase 2 (CK2), as a new KSR1-binding partner.

101 recovered cDNA revealed a unique isoform of casein kinase 2 (CK2), CK2alpha".

102 on was dependent on XRCC1 phosphorylation by casein kinase 2 (CK2), enhancing XRCC1's interaction wit

103 on events catalyzed first by MEK and then by casein kinase 2 (CK2), followed by interaction with impo

104 e, and this phosphorylation was catalyzed by casein kinase 2 (CK2), the levels of which were dramatic

105 1 and Fhl1, Ifh1 forms a complex (CURI) with casein kinase 2 (CK2), Utp22, and Rrp7.

106 -LDH associates with NDPK-A, AMPK alpha1 and casein kinase 2 (CK2), whereas H-LDH associates with loc

107 a striking resemblance to that of eukaryotic casein kinase 2 (CK2), which also exhibits dual nucleoti

108 d51 phosphorylation at threonine 13 (T13) by casein kinase 2 (CK2), which in turn triggers direct bin

109 Wnt stimulation induces the casein kinase 2 (CK2)-dependent phosphorylation of LRP6

110 We have also noted that casein kinase 2 (CK2)-directed phosphorylation of Pax7 a

111 In this report, we show that a casein kinase 2 (CK2)-like protein kinase co-purifies wi

112 cal/functional relationship between CD45 and casein kinase 2 (CK2).

113 osphorylated at its N terminus with purified casein kinase 2 (CK2).

114 vity showed it to be identical to Drosophila Casein Kinase 2 (CK2).

115 extremely low concentration of tightly bound casein kinase 2 (CK2).

116 various kinases, including GPCR kinases and casein kinase 2 (CK2).

117 the unsuspected tyrosine kinase activity of casein kinase 2 (CK2).

118 ISA analyses and Western blotting to measure casein kinase 2 (CK2).

119 by the disease-relevant signalling protein, casein kinase 2 (CK2).

120 orylated on conserved serines 487 and 491 by casein kinase 2 (CK2).

121 t human cytomegalovirus pUL84 interacts with casein kinase 2 (CK2).

122 nts indicate that phosphorylation of TLE1 by casein kinase-2 (CK2) at Ser-239 and Ser-253 is necessar

123 Casein kinase-2 (CK2) promotes cell survival and is upre

124 Conversely, casein kinase-2 (CK2)-inhibitor increases Ikaros functio

125 how that the catalytic subunit of Drosophila casein kinase 2 (CK2alpha) is expressed predominantly in

126 ynthase promoter activity were controlled by casein kinase 2 complexed with protein serine/threonine

127 to mutation to alanine or disruption of the casein kinase 2 consensus sequence directing phosphoryla

128 uired Rab11-dependent trafficking and FAM20C/casein kinase 2-dependent C-terminal phosphorylation of

129 required for insulin induction of Sort1 in a casein kinase 2-dependent manner and that inhibition of

130 B by markedly enhancing GTPCH-1 activity via casein kinase 2-dependent phosphorylation on serine 81.

131 M1-type muscarinic receptors and occur in a casein kinase-2-dependent manner.

132 How casein kinase 2 exerts an influence in Wnt signaling is

133 an influence in Wnt signaling is not clear; casein kinase 2 has been reported to be constitutively a

134 Casein kinase 2 has been shown to affect Wnt/beta-cateni

135 other kinases; only c-src (IC50, 15 microM), casein kinase 2 (IC50, 20 microM), erk 1 (IC50, 20 micro

136 The serine is phosphorylated by casein kinase 2 in in vitro assays.

137 These data support a role for casein kinase 2 in regulation of protein synthesis by do

138 These findings illustrate a new function of casein kinase 2 in the endothelium and provide insight i

139 inase 2 as well as PI3K, we hypothesize that casein kinase 2 inhibition is responsible for the enhanc

140 in-1, and parkin, whereas treatment with the casein kinase 2 inhibitor 5,6-dichloro-1-beta-d-ribofura

141 on spontaneous release was reproduced by the casein kinase 2 inhibitor 5,6-dichlorobenzimidazole ribo

142 tric-oxide synthase transcription, we used a casein kinase 2 inhibitor coupled with immunoprecipitati

143 r localization of Atx3 was not affected by a casein kinase-2 inhibitor or by mutating a predicted nuc

144 he protein phosphatase 1/2A, calcineurin, or casein kinase-2 inhibitor.

145 osphoprotein Dishevelled, demonstrating that casein kinase 2 is downstream of heterotrimeric G protei

146 dues including two serines phosphorylated by casein kinase 2 is required for the localization of VMAT

147 Thus, casein kinase 2 is shown to be regulated by Wnt3a and es

148 CK2 (formerly called casein kinase 2) is a ubiquitous messenger-independent s

149 Casein kinase 2-mediated phosphorylation at VHL N-termin

150 ERK promotes casein kinase 2-mediated phosphorylation of alpha-cateni

151 Furthermore, inhibitors of casein kinase 2 mimicked the effect of phosphatase treat

152 Protein kinase CK2 (formerly casein kinase 2 or II) is a ubiquitous and highly conser

153 Chemical inhibition of casein kinase 2 or suppression of its expression blocks

154 We report here that casein kinase 2 phosphorylates a conserved threonine res

155 Upon hypertrophic stimuli, casein kinase 2 phosphorylates DPF3a at serine 348.

156 We also show that casein kinase 2 phosphorylates G3BP1 at serine 149 in vi

157 900 (Ser900) as a unique site of reversible casein kinase 2 phosphorylation in the cytoplasmic domai

158 This mutation introduces a putative casein kinase 2 phosphorylation site in C57BL/6J-A20 not

159 id repeat motifs which exhibit homology with casein kinase 2 phosphorylation sites.

160 ylation of calmodulin by protein kinase CK2 (casein kinase 2) rapidly and reversibly modulated KCNQ2

161 a physical interaction between S6KII and the casein kinase 2 regulatory subunit (CK2beta), suggesting

162 We now show that TFIIF phosphorylated by casein kinase 2 remains competent to support PIC assembl

163 ation of ErbB2 or loss of the betasubunit of casein kinase 2, shifted the whole population toward a f

164 sin-IIA heavy chain is phosphorylated on the casein kinase 2 site (S1943).

165 Secretion of DEK is modulated by casein kinase 2, stimulated by interleukin-8, and inhibi

166 Casein kinase 2 stimulates the biogenesis of Tom22 and T

167 an interacting protein, protein kinase C and casein kinase 2 substrate in neurons 1 (PACSIN1).

168 The PACSIN (protein kinase C and casein kinase 2 substrate in neurons) adapter proteins c

169 Further, AP-1 contained bound casein kinase-2 that phosphorylated GGA1 and GGA3, there

170 The MSY2 associated kinase is not casein kinase 2, the kinase believed to phosphorylate mR

171 This activity, and the ability of casein kinase 2 to use GTP as a phosphate donor, may be

172 ermore, GSH antagonism of the Ser/Thr kinase casein kinase 2 was by comparison weak (<25%).

173 Some interesting cross reactivity with casein kinase-2 was also identified, and structural feat

174 n FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negati