ライフサイエンスコーパス: catalytic RNA

1 etal binding site observed in the hammerhead catalytic RNA.

2 f pre-tRNA processing in vitro, i.e. it is a catalytic RNA.

3 understanding the structure and function of catalytic RNA.

4 up II introns are mobile elements as well as catalytic RNAs.

5 neral mechanism for the evolution of complex catalytic RNAs.

6 utionary roots in the chemical repertoire of catalytic RNAs.

7 de insights on the structure and function of catalytic RNAs.

8 terogeneous cleavage kinetics common to many catalytic RNAs.

9 directly as structural, regulatory, or even catalytic RNAs [1, 2].

10 l RNase P holoenzyme is composed of a large, catalytic RNA and a small protein.

11 Nase P is a ribonucleoprotein made up of one catalytic RNA and five protein cofactors including L7Ae,

12 the RNase P holoenzyme consists of one large catalytic RNA and one small protein subunit, in archaea

13 n bacterial and organellar genomes, are both catalytic RNAs and retrotransposable elements.

14 ncorporating ligand-responsive self-cleaving catalytic RNAs (aptazymes) into guide RNAs, we developed

15 New ligand-binding and catalytic RNAs are being created at a rapid pace.

16 Small catalytic RNAs are commonly produced either by transcrip

17 of protein, but several distinct classes of catalytic RNAs are known to promote chemical transformat

18 nomics" annotated proteins and catalytic/non-catalytic RNAs are studied in this context.

19 The catalytic, RNA-binding and oligomerization domains of th

20 tructed an empirical fitness landscape for a catalytic RNA by combining next-generation sequencing, c

21 n the tertiary folding of a variety of large catalytic RNAs by providing a specific binding site for

22 sequence) complementary to a target RNA, the catalytic RNA can be converted into a sequence-specific

23 ailed understanding of the biochemistry of a catalytic RNA can facilitate the design of customized ri

24 caged RNA molecules: the light-regulation of catalytic RNA cleavage by RISC and the light-regulation

25 Typical RNase P consists of a catalytic RNA component and a protein moiety.

26 prokaryotic RNaseP holoenzyme consists of a catalytic RNA component and a protein subunit (RNaseP pr

27 A deletion mutant of the catalytic RNA component of Escherichia coli RNase P miss

28 Although the structure of the catalytic RNA component of ribonuclease P has been well

29 ssential for the folding and function of the catalytic RNA component of the tRNA processing enzyme ri

30 es were a ribonucleoprotein with a conserved catalytic RNA component.

31 he mutations create local distortions of the catalytic RNA component.When combined with a variety of

32 The hairpin ribozyme is a small catalytic RNA composed of two helical domains containing

33 The hairpin ribozyme is a small catalytic RNA comprised of two internal loops carried on

34 Group II introns are structurally complex catalytic RNAs considered evolutionarily related to the

35 The hairpin ribozyme is a small catalytic RNA consisting of two domains, A and B, which

36 The hairpin ribozyme, a small catalytic RNA consisting of two helix-loop-helix motifs,

37 Like protein enzymes, catalytic RNAs contain conserved structure motifs import

38 f-splicing group I introns, like other large catalytic RNAs, contain structural domains.

39 ) complex, consistent with the idea that the catalytic RNA core forms stepwise during the B to B(act)

40 the processing of mir-376a2 independently of catalytic RNA editing activity.

41 Integrator is endowed with a core catalytic RNA endonuclease activity, which is required f

42 e ancestors of nuclear pre-mRNA introns, are catalytic RNAs found in bacteria, archaea, and eukaryote

43 a point mutation at nucleotide 86 of RNase P catalytic RNA from Escherichia coli (A(86)-->C(86)) incr

44 tation at nucleotides 224 and 225 of RNase P catalytic RNA from Escherichia coli (G(224)G(225) --> AA

45 a point mutation at nucleotide 95 of RNase P catalytic RNA from Escherichia coli (G(95) --> U(95)) in

46 utation at nucleotide position 80 of RNase P catalytic RNA from Escherichia coli (U80--> C80) increas

47 us to expand by 60% the total number of this catalytic RNA from prokaryotes.

48 iments revealed that we have selected a dual-catalytic RNA from random sequences: the RNA promotes bo

49 This catalytic RNA functions as a riboswitch, with activator-

50 icated in the activities of three classes of catalytic RNA: group I introns, group II introns, and 23

51 nd hybridoma technology and the discovery of catalytic RNA have led to new and very promising alterna

52 The smallest catalytic RNA identified to date is a manganese-dependen

53 It was one of the first catalytic RNAs identified and the first that acts as a m

54 rve as efficient templates for generation of catalytic RNAs in vitro.

55 ted in functionally critical motifs in large catalytic RNAs, in riboswitches, and in regulatory eleme

56 ent structures have been determined for this catalytic RNA, including two NMR structures of the isola

57 synthetic target-binding aptamers as well as catalytic RNAs, including the hammerhead ribozyme.

58 The emergence of catalytic RNA is believed to have been a key event durin

59 y to understanding the structural biology of catalytic RNA is determining the underlying networks of

60 A Ca2+-requiring catalytic RNA is shown to create 5' phosphate-phosphate

61 the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of

62 The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activato

63 Nase MRP is a ribonucleoprotein with a large catalytic RNA moiety that is closely related to the RNA

64 The hammerhead ribozyme is a small catalytic RNA molecule.

65 particularly as required cofactors for many catalytic RNA molecules (ribozymes).

66 Catalytic RNA molecules can achieve rate acceleration by

67 A population of catalytic RNA molecules has been engineered to operate a

68 It was one of the first catalytic RNA molecules identified and consists of a sin

69 Catalytic RNA molecules possess simultaneously a genotyp

70 A population of catalytic RNA molecules shows significantly different be

71 Ribozymes are catalytic RNA molecules that can be designed to cleave s

72 Hammerhead ribozymes are small catalytic RNA molecules that can be designed to specific

73 Ribozymes are small, catalytic RNA molecules that can be engineered to down-r

74 Ribozymes are small catalytic RNA molecules that can be engineered to enzyma

75 Ribozymes, catalytic RNA molecules that cleave a complementary mRNA

76 Group II introns are large catalytic RNA molecules that fold into compact structure

77 Ribozymes are catalytic RNA molecules that recognize their target RNA

78 also provided the platform to develop those catalytic RNA molecules, called ribozymes, as trans -act

79 Catalytic RNA molecules, or ribozymes, have generated si

80 To determine if this catalytic RNA motif has a wider distribution, we decided

81 ary antigenome contain the same cis-cleaving catalytic RNA motif that plays a crucial role in virus r

82 It utilizes a self-cleaving catalytic RNA motif to process multimeric intermediates

83 is delta virus (HDV) harbors a self-cleaving catalytic RNA motif, the genomic HDV ribozyme, whose cry

84 a virus (HDV) employs a unique self-cleaving catalytic RNA motif, the HDV ribozyme, during double-rol

85 ary antigenome contain a common cis-cleaving catalytic RNA motif, the HDV ribozyme, which plays a cru

86 among the smallest and simplest of the known catalytic RNA motifs and has a unique metal ion specific

87 Together, these results imply that similar catalytic RNA motifs can arise under fairly simple condi

88 nd glmS ribozymes comprise a family of small catalytic RNA motifs that catalyze the same reversible p

89 This novel approach to the synthesis of catalytic RNAs offers a number of differences and potent

90 cted mutations within Ll.ltrB, either in the catalytic RNA or in the intron-encoded protein gene ltrA

91 cription can be extended to the synthesis of catalytic RNAs outside the hammerhead ribozyme motif; (i

92 The 154 kDa complex consists of a large catalytic RNA (P RNA), a small protein cofactor and a ma

93 T7 DNA primase is composed of a catalytic RNA polymerase domain (RPD) and a zinc-binding

94 nition of a specific template sequence and a catalytic RNA polymerase domain.

95 mplexity and activity in a comparison of two catalytic RNAs (ribozyme ligases), raising the possibili

96 Inhibition of gene expression by catalytic RNA (ribozymes) requires that ribozymes effici

97 reactions involving oligonucleotides such as catalytic RNA (ribozymes).

98 Diverse small molecules interact with catalytic RNAs (ribozymes) as substrates and cofactors,

99 The effectiveness of catalytic RNAs (ribozymes) should be increased when they

100 interactions drive the stepwise assembly of catalytic RNA structures.

101 This enzyme from Escherichia coli contains a catalytic RNA subunit (M1 ribozyme) and a protein subuni

102 s a tRNA-processing enzyme and consists of a catalytic RNA subunit (M1 RNA) and a protein component (

103 Bacterial RNase P is comprised of a catalytic RNA subunit and a lone protein cofactor which

104 e involved in tRNA maturation, consists of a catalytic RNA subunit and a protein cofactor.

105 RNase P in eubacteria has a large, catalytic RNA subunit and a small protein subunit that a

106 e 5'-end of mature tRNA and is composed of a catalytic RNA subunit and a small protein subunit.

107 In bacteria, RNase P is composed of a catalytic RNA subunit and an associated protein subunit

108 dent reconstitutions of Pfu RNase P with its catalytic RNA subunit and two interacting protein cofact

109 cleaving the cognate RNA ligand, M1 RNA, the catalytic RNA subunit of E. coli RNase P, in the presenc

110 By linking a guide sequence to the catalytic RNA subunit of RNase P (M1 RNA), we constructe

111 pecific ribozyme (M1GS RNA) derived from the catalytic RNA subunit of RNase P from Escherichia coli w

112 pecific ribozyme (M1GS RNA) derived from the catalytic RNA subunit of RNase P from Escherichia coli w

113 pecific ribozyme (M1GS RNA) derived from the catalytic RNA subunit of RNase P from Escherichia coli w

114 M1 RNA, the catalytic RNA subunit of RNase P from Escherichia coli,

115 ate from or covalently linked to M1 RNA, the catalytic RNA subunit of RNase P.

116 Bacterial ribonuclease P contains a catalytic RNA subunit that cleaves precursor sequences f

117 chia coli, this RNP complex is composed of a catalytic RNA subunit, M1 RNA, and a protein cofactor, C

118 tions in tRNA biosynthesis, is composed of a catalytic RNA subunit, M1 RNA, and a protein cofactor, C

119 The enzyme possesses a putatively catalytic RNA subunit, structurally related to that of R

120 ssential protein subunits in addition to the catalytic RNA subunit.

121 of varied coenzyme ribozymes using a single catalytic RNA subunit.

122 The hairpin ribozyme is a small catalytic RNA that accelerates reversible cleavage of a

123 The hairpin ribozyme is a small catalytic RNA that achieves an active configuration by d

124 he hairpin ribozyme is an example of a small catalytic RNA that catalyses the endonucleolytic transes

125 Ribonuclease P (RNase P) contains a catalytic RNA that cleaves precursor tRNA (pre-tRNA) to

126 bozyme riboswitch is the first known natural catalytic RNA that employs a small-molecule cofactor.

127 examples of chemical modifications within a catalytic RNA that enhance the rate of the chemical step

128 se ribonuclease P (RNase P) is composed of a catalytic RNA that is assisted by protein subunits.

129 ein U1A was engineered into a segment of the catalytic RNA that is dispensable for catalysis.

130 mS ribozyme is the first naturally occurring catalytic RNA that relies on an exogenous, nonnucleotide

131 The hammerhead ribozyme is a catalytic RNA that requires divalent metal cations for a

132 The glmS ribozyme is a catalytic RNA that self-cleaves at its 5'-end in the pre

133 Group II introns are large catalytic RNAs that are ancestrally related to nuclear s

134 rpin ribozyme belongs to the family of small catalytic RNAs that cleave RNA substrates in a reversibl

135 Group II introns are catalytic RNAs that have been proposed to be the evoluti

136 located in different folding domains of the catalytic RNA, the first in the substrate binding domain

137 crystal structure has been reported of a new catalytic RNA, the TS ribozyme, that has been identified

138 are predicted for several nucleotides in two catalytic RNAs, the hairpin ribozyme and the hepatitis d

139 trans-cleavage substrate interacts with the catalytic RNA via tertiary interactions.

140 The turnover number of the catalytic RNA was found to depend on the binding of at l

141 on rate constant for every point mutant of a catalytic RNA, we demonstrated that abundance in seriall

142 ion conditions, crystals of a 247 nucleotide catalytic RNA were obtained.

143 s modified for nuclease stability can target catalytic RNAs when the elements of tertiary interaction

144 he hairpin ribozyme is an example of a small catalytic RNA which catalyses the endonucleolytic transe

145 This results in monomer-length catalytic RNAs which have self-complementary sequences t

146 ng-lived misfolded conformation of a group I catalytic RNA with efficiencies that depend on the stabi

147 The hairpin ribozyme is a small catalytic RNA with reversible phosphodiester cleavage ac

148 ribozyme is among the smallest of the known catalytic RNAs, with an active site consisting of a six-