ライフサイエンスコーパス: catalytic antibody

1 r Arg90Cit and Glu52Ala mutants, and the 1F7 catalytic antibody.

2 Cope rearrangement compared to the germ line catalytic antibody.

3 tes in conjunction with a unique broad-scope catalytic antibody.

4 state stabilization in the evolution of this catalytic antibody.

5 r effect on reactions promoted by engineered catalytic antibodies.

6 erate the germline and affinity-matured AZ28 catalytic antibodies.

7 splay to generate a panel of closely related catalytic antibodies.

8 low the procurement of a wide range of novel catalytic antibodies.

9 The catalytic antibody 13G5 catalyzes a disfavored exo Diels

10 Catalytic antibody 15A10 hydrolyzes the benzoyl ester of

11 antigen binding loops from a murine-derived catalytic antibody, 17E8, onto a human antibody framewor

12 steroids to antibody DB3 and of a hapten to catalytic antibody 1E9 are computed and compared to expe

13 ight into the evolution of the redox active, catalytic antibody 28B4, the germline genes used by the

14 graphic structure of the Fab fragment of the catalytic antibody, 29G11, complexed with an (S)-norleuc

15 ivities (% ee) derived from an enamine-based catalytic antibody 33F12 and a chiral organocatalyst.

16 Furthermore, this is the first example of catalytic antibody 38C2 displaying regioselectivity on a

17 The catalytic antibody 38C2 only reacted with surface-expose

18 In addition, catalytic antibody 38C2 was able to selectively differen

19 tivation using the prohormone insulin(D) and catalytic antibody 38C2 with potential therapeutic appli

20 The crystal structure of the esterase catalytic antibody 48G7 has been determined in the prese

21 posure to the bacterium and reduction of the catalytic antibody activity following infection.

22 to the substrate (the compound on which the catalytic antibody acts) lead to dramatic differences in

23 Here we demonstrate a novel CocH form, a catalytic antibody analog, which is a fragment crystalli

24 eve this goal: namely, computational design, catalytic antibodies and mRNA display.

25 fficiency of natural enzymes evolve, but the catalytic antibodies are much more accepting of a wide r

26 Catalytic and non-catalytic antibodies are studied in this context of acti

27 Sequence analysis of the four catalytic antibodies, as well as four inactive antibodie

28 tic receptor fulfils a role reminiscent of a catalytic antibody by stabilizing the planar transition

29 Catalytic antibodies (CAbs) occur naturally in healthy i

30 Catalytic antibodies capable of oxidatively degrading th

31 Peptide bond-hydrolyzing catalytic antibodies (catabodies) could degrade toxic pr

32 assical immunization methods do not generate catalytic antibodies (catabodies), but recent findings s

33 In this approach, a catalytic antibody catalyzes the covalent conjugation of

34 turnover of a photochemical reaction using a catalytic antibody could be observed.

35 inogen activator inhibitor, addition of anti-catalytic antibodies directed against urokinase plasmino

36 of four related Fab fragments of a family of catalytic antibodies displaying differential levels of e

37 An array of substances, including catalytic antibodies, DNA, RNA, antigens, live bacterial

38 by antibodies 13G5 and 4D5 as well as other catalytic antibodies elicited in the same immunizations

39 Activity of catalytic antibodies for hydrolysis of enol ethers is de

40 g the first example of a naturally occurring catalytic antibody for polysaccharides.

41 s indicate the power of initial selection of catalytic antibodies from a biased antibody library in b

42 The existence of catalytic antibodies has been known for decades.

43 The forte of catalytic antibodies has resided in the control of the g

44 Catalytic antibodies have been shown to have chemoselect

45 However, few catalytic antibodies have efficiencies that approach tho

46 Catalytic antibodies have emerged as being without peer

47 Catalytic antibodies have shown great promise for cataly

48 Many naturally occurring catalytic antibodies have since been isolated from human

49 This study demonstrates the utility of catalytic antibodies in examining the relationship betwe

50 Catalytic antibodies induced by GNT-KLH were also shown

51 Although the discovery of catalytic antibodies initially aroused great interest be

52 One of the fascinations of catalytic antibodies is the possibility of harnessing th

53 t catalysts for related reactions, including catalytic antibodies (kcat/kuncat=10(6) to 10(8)) and an

54 pplicable in repetitive format for screening catalytic antibody libraries.

55 To provide a new approach, the high-activity catalytic antibody mAb 15A10 was elicited using a transi

56 aine hydrolysis catalyzed by an anti-cocaine catalytic antibody, mAb15A10, were studied by using a no

57 report a chemotherapeutic strategy based on catalytic antibody-mediated prodrug activation.

58 g the chemistry of the well studied aldolase catalytic antibodies of which mAb 38C2 is a member.

59 Whilst catalytic antibodies, on average, have marginally higher

60 Re-engineered natural enzymes and catalytic antibodies, possessing tailored binding pocket

61 cellular fibrinogen-binding protein (Efb) by catalytic antibodies produced with no exposure to the ba

62 erent from that induced by the antibody; the catalytic antibody produces a distortion which is simila

63 and structural data are consistent with the catalytic antibody providing oxyanion stabilization as i

64 cloning and kinetic analysis of a family of catalytic antibodies raised against a common transition

65 In this regard, the presence of catalytic antibodies recognizing host antigens has been

66 is one of the most promising achievements of catalytic antibody research.

67 n as one of the few systems where the mature catalytic antibody shows a negative correlation between

68 une system and reveals that the evolution of catalytic antibodies significantly predates their ration

69 putative site was found in 14 of 63 (22.2%) catalytic antibody structures and 119 of 1602 (7.4%) ant

70 these structures are the highest resolution catalytic antibody structures to date and provide insigh

71 within the hydrophobic environments of this catalytic antibody than speculated for natural aldolase

72 This process yielded aldolase catalytic antibodies that approximated the rate accelera

73 n criteria of the immune system are changed, catalytic antibodies that have the efficiency of natural

74 IgG catalytic antibodies that specifically hydrolyzed Efb vi

75 A powerful application resulted in catalytic antibodies that use an enamine mechanism akin

76 body 38C2 is the prototype of a new class of catalytic antibodies that were generated by reactive imm

77 the key lessons learned from the science of catalytic antibodies--that binding energy can be convert

78 Among catalytic antibodies, the well-characterized antibody 43

79 arginally higher active site burial than non-catalytic antibodies, these values are generally smaller

80 defense function for constitutively produced catalytic antibodies to a putative superantigenic site o

81 Furthermore, naturally occurring catalytic antibodies to microbial determinants have been

82 s can be readily used to optimize binding of catalytic antibodies to transition-state analogs, and wh

83 This is an inaugural report of a catalytic antibody utilizing dendrimers as substrates an

84 The catalytic antibodies were prepared by reactive immunizat

85 ese prodrugs are selectively unmasked by the catalytic antibody when it is applied at therapeutically

86 nues for the improvement of first generation catalytic antibodies with chorismate mutase activity.

87 yield a functional single-chain version of a catalytic antibody with chorismate mutase activity.

88 rationally designed cocaine antagonist and a catalytic antibody with potential for medicinal use.