ライフサイエンスコーパス: catalytic core

1 rticle, crosslinks extensively with this RNA catalytic core.

2 tical PDE6alpha' subunits form the cone PDE6 catalytic core.

3 , TER and p65 in the ribonucleoprotein (RNP) catalytic core.

4 n the TREX1 CTR and lysines within the TREX1 catalytic core.

5 unique extended loop that protrudes from the catalytic core.

6 docking of the P1 duplex into the ribozyme's catalytic core.

7 t, deubiquitination, and movement toward the catalytic core.

8 quires all four SEN complex subunits and the catalytic core.

9 3 of the Class II aminoacyl-tRNA synthetase catalytic core.

10 ck sensing by the ZnF to nick joining by the catalytic core.

11 2 endonuclease/exonuclease/phosphatase (EEP) catalytic core.

12 ation increases the rate of switching in the catalytic core.

13 g the reactive site and buckling the DNAzyme catalytic core.

14 enzymatic activity to point mutations of the catalytic core.

15 modified by EGL-9, and mutation of the EGL-9 catalytic core.

16 ion, followed by a two-step unfolding of the catalytic core.

17 the same binding site as the DNA ligase III catalytic core.

18 ion of nucleotide identity in their putative catalytic core.

19 ing significant conformational change on the catalytic core.

20 e are peripheral to an essentially identical catalytic core.

21 f the cleavage site projecting away from the catalytic core.

22 )-Lys(259)-Glu(285) constitute the conserved catalytic core.

23 ich reside as dangling overhangs outside the catalytic core.

24 ackbone fold and a Cys-, His-, and Asp-based catalytic core.

25 rg-185, an arginine in a crucial loop of its catalytic core.

26 ine, introduced at specific sites within the catalytic core.

27 rotein substrates through a highly conserved catalytic core.

28 rates is uncoupled from their binding to the catalytic core.

29 d 60 residues downstream (CRD) of the kinase catalytic core.

30 presenilin (PS1 or PS2), the gamma-secretase catalytic core.

31 y share a approximately 400 kDa five-subunit catalytic core.

32 one of three domains constituting the LigIII catalytic core.

33 s that associate with different parts of the catalytic core.

34 nduced structural rearrangements of the CRL1 catalytic core.

35 ng the co-folded hTERT-hTR ribonucleoprotein catalytic core.

36 e signal for branching is transmitted to the catalytic core.

37 dentified in our screen map to dynein's AAA+ catalytic core.

38 DgkB and the mammalian diacylglycerol kinase catalytic cores.

39 .2 +/- 0.2) x 10(2) M(-1) s(-1)) or the MerA catalytic core (1.2 x 10(2) M(-1) s(-1)), establishing t

40 ication inhibits the recruitment of the PP2A catalytic core (A and C subunits).

41 gh-resolution crystal structures of the RET1 catalytic core alone and in complex with UTP analogs.

42 ng a multidomain fold, with a (betaalpha)(8) catalytic core and a separate glucan binding domain with

43 A transcription and consists of a 10-subunit catalytic core and a subcomplex of subunits Rpb4 and Rpb

44 oloenzyme contains a ribonucleoprotein (RNP) catalytic core and additional proteins that modulate the

45 The 2,492-nt Ll.LtrB intron comprises a catalytic core and an ORF, which encodes a protein, LtrA

46 ar interactions occurring between the kinase catalytic core and autoinhibitory/regulatory region.

47 g in a different family, were located in the catalytic core and completely disrupted QARS aminoacylat

48 H domain (RH) of Prp8 near the spliceosome's catalytic core and demonstrate that prp8 alleles that ma

49 The catalytic core and dimer interface regions of H352Y clos

50 e of both variants ablating a portion of the catalytic core and dimer-interface contacts of native Ty

51 lular protease complex consisting of the 20S catalytic core and its associated regulators, including

52 te-independent compound binding to the Sirt6 catalytic core and potent activation of Sirt6-dependent

53 t of metabolosomes, BMCs that share a common catalytic core and process distinct substrates via speci

54 non-catalytic core; contacts between the non-catalytic core and Rrp44, which inhibit exoribonuclease

55 key regulatory role by interacting with the catalytic core and scaffolding inactive heterotrimeric G

56 reveals the paths of TER in the TERT-TER-p65 catalytic core and single-stranded DNA exit; extensive s

57 typically long MKLP1 neck domain between the catalytic core and the coiled coil and thereby reconfigu

58 hat occurs at a higher frequency than in the catalytic core and which correlates with the rate of pro

59 loited in vitro reconstitution of the enzyme catalytic core and/or a PCR-amplified activity assay rea

60 Although their catalytic cores and fundamental mechanisms of transcript

61 nsion, are affected by many mutations in the catalytic core, and also require a signal peptide.

62 d side chains, limiting accessibility of the catalytic core, and interfering with homodimerization.

63 specific C-terminal extension, the conserved catalytic core, and the presence of a signal peptide.

64 ious works, both the allosteric receptor and catalytic core are designed, rather than evolved.

65 on the undocking rates of the P1 helix with catalytic core are discussed.

66 is observed when the hairpin stems of enzyme catalytic cores are open under UV irradiation.

67 motif-containing betabetaalpha-metal finger catalytic core augmented by an interesting 'finger-loop'

68 ufficient to revert the structure of the CRL catalytic core back to its unmodified form.

69 ing two conserved internal domains forming a catalytic core but a highly divergent N terminus.

70 The two share a catalytic core but diverge in their tail regions.

71 ide bonds that reside outside the beta-sheet catalytic core but likely assist the folding of the TIKI

72 The NTR is attached to the catalytic core by hydrogen bonds and stacking forces alo

73 om MerB by the N-terminal domain (NmerA) and catalytic core C-terminal cysteine pairs of its coevolve

74 nly K9 DON was able to block modification of catalytic core C409 near the dimer interface.

75 Unique structural elements outside of the catalytic core called "cap domains" are thought to provi

76 The PduL structure, in the context of the catalytic core, completes our understanding of the struc

77 one of the complexes was found to be the 20S catalytic core complex of the proteasome.

78 Here we present structures of the JMJD2A catalytic core complexed with methylated H3K36 peptide s

79 iquitin chain assembly complex, of which the catalytic core component is heme-oxidized iron regulator

80 Human Argonaute 2 (hAgo2), the catalytic core component of the RNA-induced silencing co

81 have a modular structure in which a central catalytic core composed of nucleotidyltransferase and ol

82 Members of class I deoxyribozymes carry a catalytic core composed of only 15 conserved nucleotides

83 e coordination of a magnesium ion within the catalytic core comprised of the highly conserved acidic

84 crystal structure of the intact cytoplasmic catalytic core [comprising the dimerization and histidin

85 Moreover, several AGC catalytic core conserved residues that interact with the

86 NA path to Rrp6 that penetrates into the non-catalytic core; contacts between the non-catalytic core

87 SCF enzymes share a common catalytic core containing Cul1Rbx1, which is directed to

88 On the opposite side of the APC, the dynamic catalytic core contains the cullin-like subunit APC2 and

89 helix removes the branch adenosine from the catalytic core, creates a space for 3' exon docking, and

90 A weak interaction with the catalytic core domain (CCD) and a strong interaction wit

91 and HIV integrase predominantly involves the catalytic core domain (CCD) and the C-terminal domain (C

92 ibrary of 971 fragments against the HIV-1 IN catalytic core domain (CCD) followed by a fragment expan

93 e most potent IN inhibitor 11j within the IN catalytic core domain (CCD) is described as well as its

94 The x-ray crystal structure of the catalytic core domain (CCD) of IN in complex with the IN

95 By dissecting the catalytic core domain (CCD) of IN into short structural

96 three domains: the N-terminal domain (NTD), catalytic core domain (CCD), and C-terminal domain (CTD)

97 mined the three-dimensional structure of its catalytic core domain (CCD).

98 (CTD) and a structural homology model of the catalytic core domain (CCD).

99 ains (NmerA) that can transfer Hg(2+) to the catalytic core domain (Core) for reduction to Hg(0).

100 RT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct exp

101 DH reveals a distorted (betaalpha)(8) barrel catalytic core domain and a hydrophobic alpha-helical do

102 ally, in our model, the junction between the catalytic core domain and C-terminal domain adopts a hel

103 erization of IN via interactions between the catalytic core domain and the CTD and that understanding

104 n vitro The full-length Rev1 protein and its catalytic core domain are similar in their ability to su

105 structure of the Cronobacter sakazakii RecQ catalytic core domain bound to duplex DNA with a 3' sing

106 ibitor binding at the dimer interface of the catalytic core domain but at the same time markedly impa

107 erse biological functions but share a common catalytic core domain composed of six membrane-spanning

108 cence-based studies on the recombinant MMP-2 catalytic core domain demonstrated that anacardic acid d

109 tures have shown that ALLINIs bind at the IN catalytic core domain dimer interface and bridge two int

110 e three-domain organization, consisting of a catalytic core domain flanked by amino- and carboxy-term

111 about enzyme mechanisms, but to date the IN catalytic core domain has proven resistant to such an an

112 We report three structures of the catalytic core domain of hPus1 from two crystal forms, a

113 Here we show that the conserved catalytic core domain of SIRT1 has very low catalytic ac

114 activity, induces structural changes in the catalytic core domain of the enzyme.

115 f one monomer with the C-terminal domain and catalytic core domain of the second monomer as well as d

116 e most C-terminal beta-barrel domain and the catalytic core domain of tTG.

117 In this format, the IN catalytic core domain produced a K(i) of 15.2 nm while c

118 ed the X-ray structure of the drug-resistant catalytic core domain protein, which provides means for

119 C-terminal region stably associates with the catalytic core domain to form a SIRT1 holoenzyme.

120 nd we use this system to select mutations in catalytic core domain V (DV) that partially rescue retro

121 in cis because of evolutionarily restrictive catalytic core domain-carboxy-terminal domain linker reg

122 itors that are known to function through the catalytic core domain.

123 the N- and C-terminal domains that flank the catalytic core domain.

124 irst NMR studies of a soluble variant of the catalytic core domain.

125 tween the IN C-terminal domain (CTD) and the catalytic core domain.

126 ive site to the C-terminal segment of Rev1's catalytic core domain.

127 Here, structures of the catalytic-core domain of JMJD2A with and without alpha-k

128 fragments, in which interactions between the catalytic core domains play a prominent role.

129 udies based on both the HIV-1 IN and RNase H catalytic core domains provided new structural insights

130 eir effect on the orientations of the PH and catalytic core domains relative to the lipid membranes.

131 r, characterized by interactions between two catalytic core domains.

132 we present the crystal structure of the CBP catalytic core encompassing the bromodomain (BRD), CH2 (

133 A polymerase (RNAP) holoenzyme consists of a catalytic core enzyme (alpha(2)betabeta'omega) in comple

134 rial RNA polymerase holoenzyme consists of a catalytic core enzyme in complex with a sigma factor tha

135 erial RNA polymeras holoenzyme consists of a catalytic core enzyme in complex with a sigma factor tha

136 ed protein arginine methyltransferase (PRMT) catalytic core flanked by unique pre- and post-core regi

137 nents of Epac and allows the exposure of the catalytic core for effector binding without imposing sig

138 ing efficient transfer of Hg(2+) to the MerA catalytic core for reductive detoxification.

139 we determined crystal structures of the XPD catalytic core from Sulfolobus acidocaldarius and measur

140 propose a model of the [Co(NH3)6]3+-mediated catalytic core generated by MC-SYM that is consistent wi

141 We have shown that the p50-bound RNP catalytic core has a relatively low rate of tandem repea

142 udding yeast telomerase, which consists of a catalytic core in association with two regulatory protei

143 eostasis has been linked to presenilins, the catalytic core in gamma-secretase complexes cleaving the

144 mic structural rearrangements throughout the catalytic core in response to site-specific chemical mod

145 We present here the structure of Pol kappa catalytic core in ternary complex with DNA and an incomi

146 The crystal structures of the CARM1 catalytic core in the apo and holo states reveal cofacto

147 association with the recombinant telomerase catalytic core increases enzyme activity.

148 ough variable regions that determine how the catalytic core is activated and recruited to phosphoryla

149 Thus, the ISWI ATPase catalytic core is an intrinsically active DNA translocas

150 Rod PDE6 catalytic core is composed of two distinct subunits, PDE

151 anchors the flexible activation loop to the catalytic core is frequently mutated in disease patients

152 te that the trefoil turn of the HDV ribozyme catalytic core is in a state of dynamic equilibrium not

153 A model for the assembly pathway of the catalytic core is proposed.

154 Although the catalytic core is similar to that of the PutA PRODH doma

155 ingle residue in the last alpha helix of the catalytic core, kinesin-7 (CENP-E) exhibited this same b

156 mon SNPs are randomly distributed within the catalytic core, known disease SNPs consistently map to r

157 regulatory components of Epac2 away from the catalytic core, making the later available for effector

158 n nearly all other EPKs, suggesting that the catalytic core may have coevolved with the C-tail in AGC

159 nt mutations into the highly conserved DD35E catalytic core motif of the foamy virus integrase sequen

160 5NT also interacts with the catalytic core of AC, mainly via the C1 domain, to enhan

161 mparison of GRK6 with GRK2 confirms that the catalytic core of all GRKs consists of intimately associ

162 evidence that the GAUT1:GAUT7 complex is the catalytic core of an HG:GalAT complex and that cell wall

163 mTOR forms the catalytic core of at least two distinct signaling comple

164 15th nucleotide of a duplex, while the DDDE catalytic core of AtAGO2 is important for recognition of

165 iously undefined functional nodes within the catalytic core of CESA.

166 rystal structure of the AUM cap fused to the catalytic core of chronophin to 2.65 A resolution and pr

167 ic catalytic subunits (alphabeta), while the catalytic core of cone PDE6 (alpha') is a homodimer.

168 his is the first example of mutations in the catalytic core of cystathionine beta-synthase that resul

169 Subunit III of the three-subunit catalytic core of cytochrome c oxidase (CcO) contains no

170 al function is to add two copper ions to the catalytic core of cytochrome c oxidase (COX).

171 d that the C-terminal extension flanking the catalytic core of Dbp4 plays an important role in the re

172 smin) regulates TLS via interaction with the catalytic core of DNA polymerase-eta (poleta), and that

173 the dehydratase domain of CylM resembles the catalytic core of eukaryotic lipid kinases, despite the

174 deletion of presenilin1 and presenilin2, the catalytic core of gamma-secretase, in Ngn3- or Pax6-expr

175 er disease mutations in presenilin (PS), the catalytic core of gamma-secretase, invariably increase t

176 es, referred to as PS1 and PS2, comprise the catalytic core of gamma-secretase.

177 is cavity is large enough to accommodate the catalytic core of group II intron RNA.

178 Here we report the crystal structure of the catalytic core of HOIP in its apo form and in complex wi

179 t biochemical and structural analysis of the catalytic core of hpol eta.

180 Here we report the crystal structure of the catalytic core of human DNA polymerase alpha (Pol alpha)

181 have determined the crystal structure of the catalytic core of human MEC-17 in complex with its cofac

182 the purification and characterization of the catalytic core of human RecQ4.

183 We also show that the catalytic core of human Rev1 is uniquely augmented by tw

184 The catalytic core of ligase III is the second DNA nick-bind

185 We conclude that the catalytic core of MERS PLpro, i.e. without the Ubl2 doma

186 are TM glycines and that TM4, located at the catalytic core of MFS proteins, forms a helix that surfa

187 The catalytic core of MRN/X comprised of the Mre11 nuclease

188 talytic activity; however, the ZIP-sensitive catalytic core of PKC is known to participate in the enz

189 the autoinhibitory X/Y-linker region of the catalytic core of PLC-epsilon markedly activates the enz

190 Pol2, called Pol2core, that consists of the catalytic core of Pol and retains both polymerase and ex

191 hit and multiple-hit competition assays, the catalytic core of pol eta was found to insert dGMP oppos

192 s report, we describe the interaction of the catalytic core of pol eta with primer-templates containi

193 eaf (clf) allele, carrying a mutation in the catalytic core of PRC2, strongly enhanced the clf phenot

194 Here, we identify basic amino acids in the catalytic core of Rag1 specifically important for transe

195 at) values are normal with Delta117PheH, the catalytic core of rat phenylalanine hydroxylase, ranging

196 The catalytic core of rod PDE6 is a unique heterodimer of PD

197 yQ-expanded ataxin-7 directly bound the Gcn5 catalytic core of SAGA while in association with its reg

198 The crystal structure of the catalytic core of SAMHD1 reveals that the protein is dim

199 describe the 1.85-A crystal structure of the catalytic core of SARS-CoV PLpro and show that the overa

200 As the catalytic core of SHP-2 shares extremely high homology t

201 The catalytic core of Tetrahymena telomerase comprises a ter

202 The catalytic core of the [FeFe]-hydrogenase (HydA), termed

203 Presenilin-1 (PS1) is the catalytic core of the aspartyl protease gamma-secretase.

204 ernary complex and appear to function as the catalytic core of the Cas system to process CRISPR RNA i

205 gion, and propose how they interact with the catalytic core of the complementary subunit to regulate

206 The catalytic core of the complex can be either of two close

207 The catalytic core of the complex is believed to be composed

208 ecruited by the MTA1 corepressor to form the catalytic core of the complex.

209 bone bond in the substrate, we find that the catalytic core of the DNAzyme unwinds and the overall co

210 cate that at the pH of optimal activity, the catalytic core of the enzyme adopts a structure in which

211 ing subunit that is not directly part of the catalytic core of the enzyme located in the mitochondria

212 ndicates that the DHHC motif constitutes the catalytic core of the enzyme required for autopalmitoyla

213 dies showed that the alpha subunit forms the catalytic core of the enzyme, while the beta subunit con

214 ignal peptide and the start of the conserved catalytic core of the enzyme.

215 op of Cdk9 to allow substrates to access the catalytic core of the enzyme.

216 This domain represents a catalytic core of the enzyme.

217 ues to probe the electronic structure of the catalytic core of the enzyme.

218 each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase.

219 the putative substrate-docking site and the catalytic core of the gamma-secretase.

220 Since residue 17 is buried within the catalytic core of the hammerhead in the X-ray structure,

221 oss-linking strategy was explored within the catalytic core of the Hammerhead ribozyme (HHRz).

222 the nuclease-null dCas9 protein fused to the catalytic core of the human acetyltransferase p300.

223 Here we report the crystal structure of the catalytic core of the human m(6)A writer complex compris

224 present the first structural detail into the catalytic core of the human system and reveal that the c

225 the phosphodiester backbone of the conserved catalytic core of the intron RNA, allowing the protein t

226 Drosha, the catalytic core of the microprocessor complex, has a crit

227 The catalytic core of the monomer is accommodated only near

228 egration of the Mn(4)Ca(1)Cl(x) cluster, the catalytic core of the oxygen-evolving machinery within t

229 The catalytic core of the peptidyl-alpha-hydroxyglycine alph

230 ane protein flavocytochrome b (Cyt b) is the catalytic core of the phagocyte NADPH oxidase and genera

231 The catalytic core of the phagocyte NADPH oxidase is a heter

232 Flavocytochrome b(558), the catalytic core of the phagocytic NADPH oxidase, mediates

233 utations, P78R/K102N, that are housed in the catalytic core of the protein and compared it to the eff

234 to the tyrosine recombinase family, but the catalytic core of the protein seems to have somewhat dif

235 rucial insights into the organization of the catalytic core of the replisome and form an important st

236 This robustness suggests that the catalytic core of the ribosome is an ancient construct t

237 f homologous mRNA by Argonaute proteins, the catalytic core of the RNA-induced silencing complex (RIS

238 3' position of the deoxycytidine C13 in the catalytic core of the same DNAzyme caused significant de

239 HDAC1/2) regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-represso

240 SF3B1, which functions at the catalytic core of the spliceosome, was the second most f

241 a phylogenetically conserved complex at the catalytic core of the spliceosome.

242 a distance by pulling substrate RNA from the catalytic core of the spliceosome.

243 Formation of catalytic core of the U12-dependent spliceosome involves

244 for the mechano-chemical cycle of the common catalytic core of these helicases.

245 , cleavage kinetics, and conformation of the catalytic core of this hammerhead, leading to a ribozyme

246 The catalytic core of this oxidase consists of a complex bet

247 The catalytic core of this protein-RNA complex is a 250-kDa

248 The catalytic core of VKOR is a four transmembrane helix bun

249 Here we report crystal structures of the catalytic core of yeast Pol alpha in unliganded form, bo

250 In the active state, the catalytic core oscillates between open, intermediate, an

251 The catalytic core (p65-TER-TERT) is assembled with a three-

252 The Tetrahymena telomerase holoenzyme catalytic core (p65-TER-TERT) was recently modeled in ou

253 unanticipated role as a hub between the RNP catalytic core, p75-p19-p45 subcomplex, and the DNA-bind

254 ry gamma-subunits (Pgamma) which bind to the catalytic core (Palphabeta) to inhibit catalysis and sti

255 This large, multisubunit complex comprises a catalytic core particle (20S proteasome) and a regulator

256 subunit that binds with high affinity to the catalytic core, pol gamma-alpha, to stimulate its activi

257 s, but that regions N- and C-terminal to the catalytic core potentiate catalytic efficiency by betwee

258 talytic core that is very different from the catalytic core present in the structure of the "minimal"

259 to specific mRNAs where regions outside the catalytic core promote the formation of different comple

260 ase and selected peptidase activities of the catalytic core proteasome at low micromolar concentratio

261 th the PA200 proteasome activator to the 20S catalytic core proteasome.

262 nclear whether the CTD communicates with the catalytic core region of Rpb1 and thus must be physicall

263 While the U6 snRNA catalytic core remains firmly held in the active site ca

264 teractions are coupled to yield an activated catalytic core remains unknown.

265 The most tightly folded catalytic core, resembling that of the reaction product,

266 t homology to nSMase2 and possesses the same catalytic core residues as members of the extended N-SMa

267 The enhancement is greater for hTDG catalytic core (residues 111-308 of 410), indicating the

268 we present the crystal structures of SAMHD1 catalytic core (residues 113-626) tetramers, complexed w

269 , sigma factors (sigmas), associate with the catalytic core RNA polymerase to guide it through the es

270 or LipB reside both in the lipoyl domain and catalytic core sequences.

271 The structure reveals a conserved stable catalytic core shared with other GCN5 superfamily acetyl

272 hin the system, without interfering with the catalytic core, similar to structural rearrangements tha

273 Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions betw

274 vity of cMLCK appears to be intrinsic to its catalytic core structure rather than an autoinhibitory s

275 the biogenesis of the mitochondrion-encoded catalytic core subunit 2 (COX2) result in myopathies.

276 atalytic domains, DNA-binding regions, and a catalytic core targeting the histone tails, LSD1-CoREST

277 e tandem repeat synthesis and bridge the RNP catalytic core, Teb1, and the p75 subunit of the holoenz

278 tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, reveal

279 y Pol31-Pol32N subunits relative to the Pol3 catalytic core that best agrees with the experimental sc

280 nuclear RNA exosome includes a 9-subunit non-catalytic core that binds Rrp44 (Dis3) and Rrp6 subunits

281 an autoregulatory segment C terminus of the catalytic core that blocks myosin regulatory light chain

282 generated a predicted structure of the XTUT7 catalytic core that indicated histidine 1269 was likely

283 g the rate-enhancing peripheral domain has a catalytic core that is very different from the catalytic

284 between the cellulose binding domain and the catalytic core that only changes subtly.

285 bridize to 16S rRNA to form 32 deoxyribozyme catalytic cores that produce a fluorescent signal.

286 rminal domain to clamp parts of the intron's catalytic core, that at least one C-terminal domain inse

287 needed for RNA replication contain at their catalytic core the class I RNA ligase, an artificial rib

288 centers around a cullin-RING-like E3 ligase catalytic core; the "Arc Lamp" is a hub that mediates tr

289 Although the proteins share a common catalytic core, they have different specificities and co

290 l Skp1-binding region and thereby to the SCF catalytic core; this result adds to the model proposed p

291 mS ribozyme adopts an intricate multi-strand catalytic core through the formation of a pseudoknot str

292 ding WD40, or DWD proteins) to the CUL4-ROC1 catalytic core to constitute a potentially large number

293 roteins that modulate the ability of the RNP catalytic core to elongate telomeres.

294 with the Arg-128 residues positioned in the catalytic cores to facilitate melting of dsDNA and gener

295 th a homology-based chain trace of the CesA8 catalytic core, were modeled into a previously determine

296 ilon rotation within the F(1)alpha(3)beta(3) catalytic core where substrates are bound and products a

297 ognition of a phylogenetically-conserved RPR catalytic core, whose minimal attributes we further defi

298 Proteasomes are composed of a 20S catalytic core with or without one or two activator comp

299 erase holoenzyme requires association of the catalytic core with the telomere adaptor subcomplex (TAS

300 nector loop into a hydrophobic pocket of the catalytic core, with the coiled-coil aligned near the en