ライフサイエンスコーパス: catalytic cycle

1 the stereodetermining transmetalation in the catalytic cycle.

2 ns that mimic different steps in the overall catalytic cycle.

3 es support each of the proposed steps in the catalytic cycle.

4 ane followed by alkene binding completes the catalytic cycle.

5 tant to the decay of Co(I), thus closing the catalytic cycle.

6 d HBpin, which acts to drive turnover of the catalytic cycle.

7 ion states and intermediates involved in the catalytic cycle.

8 involved in the rate-determining step of the catalytic cycle.

9 yl-phosphate intermediate of the phosphatase catalytic cycle.

10 roduct in solution and thereby establishes a catalytic cycle.

11 ts a contribution of the metal center in the catalytic cycle.

12 iron(III), substrate, and temperature to the catalytic cycle.

13 the metal oxidation state changes during the catalytic cycle.

14 f mononuclear ruthenium intermediates in the catalytic cycle.

15 propose to represent two snapshots along the catalytic cycle.

16 trated to be a potential intermediate in the catalytic cycle.

17 the rates of both association and the inner catalytic cycle.

18 to the enzyme and subjected to a second CCA catalytic cycle.

19 nsiderable conformational changes during the catalytic cycle.

20 d amine in the generation of a more complete catalytic cycle.

21 onstrating they are directly involved in the catalytic cycle.

22 imine formation was shown to be part of the catalytic cycle.

23 ectron to cytochrome P450 (P450) in the P450 catalytic cycle.

24 and rate-limiting step in the proposed Rh(I)-catalytic cycle.

25 A substrate, representing three steps of the catalytic cycle.

26 esents a structural intermediate in the MCAK catalytic cycle.

27 ereodetermining hydride transfer step of the catalytic cycle.

28 n active alpha2beta2 complex to complete the catalytic cycle.

29 tion and completes a novel P(III)/P(V) redox catalytic cycle.

30 sters to acylate the enzyme and initiate the catalytic cycle.

31 t CmlI-peroxo is the reactive species of the catalytic cycle.

32 ormational change is an integral part of the catalytic cycle.

33 bound NO2 with proximal NH4(+) completes the catalytic cycle.

34 ral part of the H-cluster taking part in the catalytic cycle.

35 active intermediate that was proposed in the catalytic cycle.

36 ally acyl carrier protein tied to an overall catalytic cycle.

37 ole of protein conformational entropy in its catalytic cycle.

38 ions provide a detailed understanding of the catalytic cycle.

39 irectly with the transmetalation step of the catalytic cycle.

40 odule in three key biochemical states of its catalytic cycle.

41 ne the 'dynamic' reaction coordinate for the catalytic cycle.

42 leavage is the turnover-limiting step of the catalytic cycle.

43 re combined to study the initial step of the catalytic cycle.

44 -NO2 under reaction conditions to complete a catalytic cycle.

45 lladium acetate, are retained throughout the catalytic cycle.

46 drug-binding cavities is coupled to the ATP catalytic cycle.

47 l data are presented to support the proposed catalytic cycle.

48 ble to detect a reactive intermediate of the catalytic cycle.

49 ibility of the open-closed transition in the catalytic cycle.

50 ibility of each of the proposed steps of the catalytic cycle.

51 ted state that occurs transiently during the catalytic cycle.

52 version of catalyst configuration after each catalytic cycle.

53 s helped to further elucidate the IDH1 R132H catalytic cycle.

54 to explore the basic elementary steps of the catalytic cycle.

55 ghly selective C-Se bond-forming step in the catalytic cycle.

56 as utilized to eliminate dimerization in the catalytic cycle.

57 ner is not the turnover-limiting step of the catalytic cycle.

58 by conformational changes occurring over the catalytic cycle.

59 eads to different propagating species in the catalytic cycle.

60 structure and dynamics during the telomerase catalytic cycle.

61 of the elementary steps that constitute the catalytic cycle.

62 a3, Cu(B), Y288, and E286 used to define the catalytic cycle.

63 t, biochemical approaches to interrogate the catalytic cycle.

64 is possible and likely to participate in the catalytic cycle.

65 catalyzed aerobic conditions to complete the catalytic cycle.

66 onal equilibrium for individual steps in the catalytic cycle.

67 reductive elimination is key for a potential catalytic cycle.

68 GK, two sequential enzymes in the glycolysis catalytic cycle.

69 ta-ketone intermediates assembled during the catalytic cycle.

70 ge kinetics in the first three states of the catalytic cycle.

71 vidence is provided for the key steps of the catalytic cycle.

72 compared states the enzyme visits during its catalytic cycle.

73 ing interactions during the native multistep catalytic cycle.

74 mperatures above 0 degrees C during a normal catalytic cycle.

75 Preliminary studies suggest a Ni(I)/Ni(III) catalytic cycle.

76 ire a reductive step for the turnover of the catalytic cycle.

77 hat Cl(-) is bound to SERT during the entire catalytic cycle.

78 site that changes shape and size during its catalytic cycle.

79 s, a plausible mechanism is proposed for the catalytic cycle.

80 ion of the Re catalyst and completion of the catalytic cycle.

81 alkyl chloroformates through a Pd(II)/Pd(IV) catalytic cycle.

82 erization of functional intermediates in the catalytic cycle.

83 dules, each revealing a distinct step in the catalytic cycle.

84 undergo the proposed elementary steps of the catalytic cycle.

85 roduct-released" states of the enzyme in the catalytic cycle.

86 the catalytic recycling experiments in five catalytic cycles.

87 ve been discovered and explained in terms of catalytic cycles.

88 in the study of the individual steps in the catalytic cycles.

89 he competing rates of transmetalation in the catalytic cycles.

90 o different (Pd(II)/Pd(IV) and Pd(II)/Pd(0)) catalytic cycles.

91 tion mechanisms as proposed intermediates in catalytic cycles.

92 indicate that the reaction proceeds via two catalytic cycles.

93 redox processes during two-electron steps of catalytic cycles.

94 the dominant halogen, hydrogen, and nitrogen catalytic cycles.

95 s sample multiple conformations during their catalytic cycles.

96 d that Mo-bpy maintains its structure during catalytic cycling.

97 on the O-O bond splitting transition of the catalytic cycle (A --> P(R)), it has been proposed that

98 usters give rise to an exponentially growing catalytic cycle, a specific realization of Dyson's notio

99 A mechanism comprising a nickel catalytic cycle, a zirconium catalytic cycle, and Zr-->N

100 the successful merger of two separate chiral catalytic cycles: a chiral anion phase-transfer catalysi

101 late group allows water to bind early in the catalytic cycle, allowing intramolecular proton-coupled

102 alone and in complex with key ligands of its catalytic cycle and antiviral iminosugars, including two

103 talytic reaction as well as each step in the catalytic cycle and by low-temperature detection of inte

104 ine the crucial ADP release step in myosin's catalytic cycle and detected reversible rotations of two

105 olve the redox and protonation events in the catalytic cycle and determine their intrinsic thermodyna

106 H2O2 is thus consumed in a catalytic cycle and leads to less efficient HOBr scaveng

107 This conformation provides insight on IRAP's catalytic cycle and reveals significant active-site plas

108 nsufficient to account for the complete NRPS catalytic cycle and that the loaded state of the PCP mus

109 ling both a proposed intermediate in the CDO catalytic cycle and the essential NHase Fe-S(O)(Cys114)

110 olecular heterodimer, kinetic studies on the catalytic cycle, and a thorough analysis of transition s

111 nformational states of human P-gp during the catalytic cycle, and demonstrate that, following ATP hyd

112 ll intermediates with an empty bridge in the catalytic cycle, and the electron pair that constitutes

113 pate in the elementary steps of the proposed catalytic cycle, and their ability to serve as competent

114 rising a nickel catalytic cycle, a zirconium catalytic cycle, and Zr-->Ni transmetalation is proposed

115 ycle belongs to a degenerate optimum of auto-catalytic cycles, and b) the set of targets for investig

116 es that are sampled at various points in the catalytic cycles, and for the capsid protein of the huma

117 ra of the molecular species formed along the catalytic cycle are modeled using a combination of molec

118 Dual catalytic cycles are proposed, with a relatively fast en

119 ctively support a novel molybdenum(IV)-based catalytic cycle as being operative.

120 in a polymerase in order to complete a full catalytic cycle as well as prepare for DNA translocation

121 least one substrate is bound throughout the catalytic cycle, as the rate of (18)O-labeled water inco

122 steps involved in reactions directly on the catalytic cycle, as well as off-cycle processes.

123 identified several key intermediates in the catalytic cycle, as well as those related to catalyst de

124 enases, is used to identify the point in the catalytic cycle at which a highly reactive metal-hydrido

125 ions to alkynes and alkenes with up to 10(4) catalytic cycles (at least 2 orders of magnitude superio

126 equence is shown to play a major role in the catalytic cycle based on RNA binding, processive elongat

127 fate, the majority of which trigger the P450 catalytic cycle, but in an uncoupled mode rather than on

128 H3 or C6H5) are not intermediates within the catalytic cycle, but rather are off-loop species.

129 ial role in the rate determining step of the catalytic cycle, but the exact nature of this complex is

130 onjugation and deconjugation needed for each catalytic cycle, but this model remains unsubstantiated.

131 rated 5'-deoxyadenosyl radical initiates the catalytic cycle by abstracting a hydrogen atom from subs

132 in the resting state but revealed within the catalytic cycle by cleavage of the MS-Fe(NO)2 bond from

133 on or sp(3)-CH insertion then terminates the catalytic cycle by formation of highly substituted funct

134 monodentate phosphine ligand, interrupts the catalytic cycle by preventing enone reduction.

135 enerate diaryl sulfoxides involving multiple catalytic cycles by a single catalyst.

136 In step 1 of the catalytic cycle, collision induced dissociation (CID) of

137 inetic isotope effects are consistent with a catalytic cycle comprising hydrogenation of the hydrogen

138 mplexes, leaving some doubt that a canonical catalytic cycle consisting of an initial oxidative addit

139 We find that the key step in the proposed catalytic cycle-decomposition of the alkoxyamine derived

140 a could be observed as resting states of the catalytic cycle, depending on the initial [PhMeSiH2]:[be

141 The catalytic cycle described herein is also one of the firs

142 In the catalytic cycle electrons are transferred intramolecular

143 A combination of cobalt and nickel catalytic cycles enables a highly branch-selective (Mark

144 ation of the phenoxazine catalyst during the catalytic cycle encourages the synthesis of well-defined

145 lene being the turnover-limiting step of the catalytic cycle, followed by a concerted [3+2] cycloaddi

146 s evaluated computationally by examining the catalytic cycle for catalyst 1 with a conformation where

147 The sequences of steps 1 and 2a close a catalytic cycle for decarboxylative carbon-carbon bond c

148 Based on (77)Se NMR spectroscopy, a catalytic cycle for diselenide 8b, involving aminoebsele

149 The turnover-limiting step in the catalytic cycle for hydroboration of the internal alkene

150 results in new mechanistic insight into the catalytic cycle for hydrogenation of acetophenone by Noy

151 to rhodium via O-coordination throughout the catalytic cycle for hydrogenation.

152 d,p)/LANL2DZ) were used to determine a model catalytic cycle for the hydrosilation of acetone with Ph

153 responding alkoxide followed by entering the catalytic cycle for the iron-catalyzed hydrosilylation.

154 We proposed the modified catalytic cycle for the Ni(cod)(dcype)-catalyzed C-H/C-O

155 The turnover-limiting step in the catalytic cycle for the reaction of vinylarenes is the b

156 A novel catalytic cycle for the reaction with formic acid is pro

157 The mechanistic details of the catalytic cycles for all the individual processes are es

158 of 2, indicating that 5 and 2 share the same catalytic cycles for both metathesis and isomerization,

159 Along the catalytic cycle, four electrons are subsequently removed

160 A detailed catalytic cycle has been derived for typical 2-Cys Prxs,

161 vated alkenes proceeding via a Pd(II)/Pd(IV) catalytic cycle has been developed.

162 a complete free energy inventory of the KSI catalytic cycle has been identified.

163 C-H arylation via a Pd(II)/Pd(IV) catalytic cycle has been one of the most extensively stu

164 no such species that is part of a competent catalytic cycle has yet been isolated.

165 u generated Ru(0) to Ru(II), to continue the catalytic cycle, has been extended.

166 the intermediate palladium complexes in the catalytic cycle have been prepared and characterized, an

167 etic profiles of the successive steps of the catalytic cycle have been studied by performing stoichio

168 Catalytic cycles have been proposed but the mechanisms o

169 e extent of its binding decreases during the catalytic cycle, implying that lipid A release is linked

170 omplexes representing different steps of the catalytic cycle, implying that these stretches of the pr

171 propriate reductants and acids to access the catalytic cycle in a stepwise fashion, permitting direct

172 e is the result of a fundamentally different catalytic cycle in which ethane CH activation (and not p

173 nd dynamic changes of alphaTS throughout its catalytic cycle, in the absence of the beta-subunit.

174 ceeds through a formally Ti(II)/Ti(IV) redox catalytic cycle, in which an azatitanacyclobutene interm

175 alysis provides a seamless continuum for the catalytic cycle, incorporating large motions by four loo

176 inetics characterization of the complete SQR catalytic cycle indicates that GSH serves as the physiol

177 The X-ray structures with key catalytic cycle intermediates highlight that an insertio

178 first crystal structure of AMSDH and several catalytic cycle intermediates.

179 tial Diels-Alderases; however, whether their catalytic cycles involve a concerted or stepwise cycliza

180 st to the originally proposed mechanism, the catalytic cycle involves an intramolecular protonation a

181 A proposed catalytic cycle involves C-C bond formation by oxidative

182 The first phase of the catalytic cycle involves generation of the key catalytic

183 Our data also demonstrate that the catalytic cycle involves two redox states, the three- an

184 Mechanistic studies support the catalytic cycle involving a Ni(0)/Ni(II) couple for this

185 with the kinetic study, these data suggest a catalytic cycle involving a reactive L(n)Ru horizontal l

186 Mechanistic data that supports a catalytic cycle involving oxidative addition into the al

187 studies provide evidence for a Pt(II)/Pt(IV) catalytic cycle involving rate-limiting C-C bond-forming

188 The most likely mechanism is a cationic catalytic cycle involving the palladium oxidation states

189 The accepted mechanism of HALS comprises a catalytic cycle involving the rapid combination of a nit

190 e the transient intermediates as well as the catalytic cycle involving wild-type (wt) and mutant TcDy

191 takes place by tandem catalysis through two catalytic cycles involving dehydrogenation of the alcoho

192 f H2O in each of the elementary steps of the catalytic cycle, involving the formation of the peroxo c

193 At least three catalytic cycles, involving the decarboxylation of formi

194 [(bpp)NiCl] complex relevant to the proposed catalytic cycle is also described.

195 uantum chemistry calculations, show that the catalytic cycle is driven via the redox activity of both

196 , CO2 dissociates on the oxide surface and a catalytic cycle is established without coke deposition.

197 er 50 years ago that the initial step in the catalytic cycle is facilitated by a protonated Schiff ba

198 The rate-limiting step (RLS) in the catalytic cycle is not the oxidative addition of an aren

199 Au with the redox properties of Pd within a catalytic cycle is particularly appealing for the synthe

200 Furthermore, all reaction flux in the closed catalytic cycle is predicted to flow through an O-O bond

201 A catalytic cycle is proposed in which NH2-CAM reacts with

202 A catalytic cycle is proposed together with some further a

203 how these radicals are quenched to close the catalytic cycle is under debate.

204 DFT calculations, a mechanism involving two catalytic cycles is proposed wherein the alternating cop

205 als control" of small motions throughout the catalytic cycle, is common within the radical SAM enzyme

206 The two redox events in the catalytic cycle occur on the [4Fe-4S]H subcluster at sim

207 Cys Prxs, however, little is known about the catalytic cycle of 1-Cys Prxs.

208 complete description of the water oxidation catalytic cycle of 4H(+), manifesting the key functional

209 strate engineering approaches to control the catalytic cycle of a full PKS module harboring multiple

210 over a role for the linker in regulating the catalytic cycle of AAA1.

211 insight into the individual steps during the catalytic cycle of an ECF transporter in a lipid environ

212 pecies are key reaction intermediates in the catalytic cycle of both enzymes (e.g., oxygenases) and s

213 ate that it is possible to mimic the natural catalytic cycle of CYP101Fe(3+) by using pulse radiolysi

214 as the observation that intermediates of the catalytic cycle of cytochrome oxidase are dynamically mo

215 The rate-determining step in the catalytic cycle of E. coli dihydrofolate reductase is te

216 to conformational motion occurring over the catalytic cycle of ecDHFR.

217 examined for all enzyme complexes along the catalytic cycle of Escherichia coli dihydrofolate reduct

218 A key question concerning the catalytic cycle of Escherichia coli dihydrofolate reduct

219 ing substrate binding steps pertinent to the catalytic cycle of flavin-dependent monooxygenases.

220 nder H2 suggests that the final steps in the catalytic cycle of H2 oxidation by Hyd-1 involve sequent

221 d (iii) the inhibition of the redox-mediated catalytic cycle of horseradish peroxidase (HRP) by its s

222 the first time the transient response of the catalytic cycle of human sulfite oxidase immobilized on

223 Theoretical studies on the overall catalytic cycle of isomerizing alkoxycarbonylation revea

224 erved bound heme-iron-PN intermediate in the catalytic cycle of nitric oxide dioxygenase (NOD) enzyme

225 s of nucleic acid handling that underlie the catalytic cycle of repeat synthesis derive from both act

226 provide insight into the thermodynamics and catalytic cycle of the amide-to-ester transformation.

227 the O-O and first C-H activating step of the catalytic cycle of the binuclear nonheme iron enzyme Del

228 in enzyme design: Compounds I and II in the catalytic cycle of the Cytochrome P450 enzymes have been

229 s and QC/MM calculations, we investigate the catalytic cycle of the glycyl radical enzyme 4-hydroxyph

230 en reduction and rapid IET by the TNC in the catalytic cycle of the MCOs.

231 des, allowing us to identify the most likely catalytic cycle of the reaction.

232 two transmembrane domains (TMDs) to the ATP catalytic cycle of the two nucleotide-binding domains (N

233 Possible hydroxylating intermediates in the catalytic cycle of this well-characterized enzyme have b

234 Our study focuses on understanding the catalytic cycle of two different human PLA2s: the cytoso

235 undergo further hydrolysis to form a closed catalytic cycle of water splitting.

236 es for functionalization of C-H bonds in the catalytic cycles of a range of O2-activating iron enzyme

237 been implicated as key intermediates in the catalytic cycles of dioxygen activation by non-haem iron

238 -peroxo intermediates are key species in the catalytic cycles of nonheme metalloenzymes, but their ch

239 O, are central reactive intermediates in the catalytic cycles of numerous heme proteins and a variety

240 The reactive intermediate in the catalytic cycles of these enzymes is a high-spin S = 2 F

241 With these two chiral catalytic cycles operating together in a matched sense,

242 possible to correlate these states with the catalytic cycle or the activity of the enzyme.

243 The catalytic cycle proceeds without the need for external o

244 al small-molecule activation, and in several catalytic cycles proposed for nickel-containing enzymes,

245 e at three distinct steps in its complicated catalytic cycle, provide insights into the elusive mecha

246 n-transfer (ET) reactions of the nitrogenase catalytic cycle remain obscure.

247 nature of helicase configurations during the catalytic cycle remain.

248 ese structures suggest successive steps in a catalytic cycle revealing that AC undergoes large confor

249 ves, a computational examination of the full catalytic cycle reveals that a benzoic acid byproduct ch

250 mber for the overall reaction, implying that catalytic cycling speeds up throughput.

251 bon C-H bonds, but the challenges of closing catalytic cycles still remain; many f-block complexes sh

252 tein that undergo large movements during the catalytic cycle, such as in enzymes or transporter prote

253 c studies along with kinetic modeling of the catalytic cycle support a positive-order dependence in b

254 e mechanism, eventually leading to a refined catalytic cycle that also bears relevance to asymmetric

255 that the selectivity arises from an unusual catalytic cycle that combines both polar and radical ste

256 Hydrogen peroxide (H2O2) drives a catalytic cycle that includes the following three distin

257 metric and NMR mechanistic studies support a catalytic cycle that involves a well-defined eta(6)-aren

258 A catalytic cycle that relies on a cobalt(I)-(III) redox c

259 viour is reversible and can be formed into a catalytic cycle that requires molecular communication be

260 e PR --> F transition is the first step in a catalytic cycle that requires proton transfer from the b

261 calculations allow us to propose a complete catalytic cycle that uncovers an unprecedented pathway i

262 ate mechanism consists of two interdependent catalytic cycles that operate in sequence: a fast Cu(II)

263 During the catalytic cycle, the flavin cofactor is intermittently r

264 bsorption reveals that, for each step in the catalytic cycle, the sacrificial reductant, 3-mercaptopr

265 During the catalytic cycle, the transported cations become transito

266 During the catalytic cycle, the two subclusters change oxidation st

267 ity, relies on the interplay of two distinct catalytic cycles: the aminocatalytic electron-relay syst

268 ancillary ligands at the gold catalyst; the catalytic cycle then proceeds via monoaurated intermedia

269 ferent series of final steps in one Rh-based catalytic cycle, thereby enabling access to the otherwis

270 of the hydrogen-binding intermediate of the catalytic cycle, thereby providing key information about

271 n states of nickel alkoxides in an operative catalytic cycle, thereby providing transient access to N

272 We confirmed that the pathway forms a catalytic cycle through (13)C-carbon labeling.

273 h fast stochastic domain contacts during the catalytic cycle thus provides, to our knowledge, a new p

274 to rapidly supply the second electron of the catalytic cycle to camphor-bound CYP101[FeO2](2+) Judgin

275 ne is unexpected but, in fact, vital for the catalytic cycle to close.

276 This methodology simultaneously uses three catalytic cycles to achieve hydridic C-H bond abstractio

277 brates among different reduced states of the catalytic cycle under steady-state conditions.

278 tarting point for a theoretical study of the catalytic cycle using DFT calculations.

279 utational investigations of key steps of the catalytic cycle using the density functional theory have

280 A plausible catalytic cycle was characterized by DFT/B3LYP-D3 and in

281 nic pathways were compared, and a reasonable catalytic cycle was identified.

282 The ON/OFF catalytic cycle was run three times in situ.

283 can act at a number of steps in the topo II catalytic cycle, we used multiple independent, biochemic

284 hat the Co-Co interaction evolves during the catalytic cycle: weakening upon N2 binding, breaking wit

285 intermediates, and transition states of the catalytic cycle were calculated for the two model reacti

286 lysis methodology suggested two steps in the catalytic cycle were involved as turnover determining.

287 Plausible activation pathways and catalytic cycles were computed in the gas phase (M06-L/d

288 f the active IPr-Pd(0) catalyst to enter the catalytic cycle when these substituted precatalysts are

289 hydrides and dihydrogen complexes, including catalytic cycles where these reactions are proposed or o

290 me c oxidase is the first redox state in its catalytic cycle, where proton transfer through the K-cha

291 al PCs operates via a single photoexcitation/catalytic cycle, where the TM complex plays a "double du

292 es within the H-cluster occurring during the catalytic cycle, whereas the CN(-) signals seem to be re

293 yme cytochrome P450cam undergoes a multistep catalytic cycle wherein two electrons are transferred to

294 ational DFT studies were used to explore the catalytic cycle which appears to involve amine-borane li

295 We propose a plausible catalytic cycle, which involves a pentacoordinate silico

296 In particular, in the second phase of the catalytic cycle, which involves three separate reduction

297 which generally preserves the oxo palladium catalytic cycle widely accepted in the literature, is pr

298 Integration of this phosphine catalytic cycle with Taniguchi's azocarboxylate catalyti

299 enyl disulfide ((PhS)2) operates on a common catalytic cycle with thiophenol (PhSH) by way of photoly

300 goes large conformational changes during its catalytic cycle, with its two domains rotating apart by