ライフサイエンスコーパス: catalytic domain

1 ansmitting the hormone binding signal to the catalytic domain.

2 bstrate and by an acidic patch in the kinase catalytic domain.

3 complexes that form over a large part of the catalytic domain.

4 cAMP, stimulates the activity of the PDE10A catalytic domain.

5 dopt a rigid structure, which stabilizes the catalytic domain.

6 nd a segment in the N-terminal region of the catalytic domain.

7 the available crystal structure of the GtfC catalytic domain.

8 by mitigating the global unfolding of LPL's catalytic domain.

9 targets as Ser33 and Ser34 in the N-terminal catalytic domain.

10 city to bind DNA and the processivity of the catalytic domain.

11 and a reporter of complementation within the catalytic domain.

12 lateral movements during the activity of the catalytic domain.

13 ), UCR1 and -2, which precede the C-terminal catalytic domain.

14 kely the pseudosymmetric site located in the catalytic domain.

15 ation and ROS production requiring the Sirt1 catalytic domain.

16 ET1ALT lacks the CXXC domain but retains the catalytic domain.

17 ertase Furin (RXXR) between the pro- and the catalytic domain.

18 -stranded RNA binding domains (dsRBDs) and a catalytic domain.

19 ukaryotic kingdoms and a conserved cytosolic catalytic domain.

20 al domain did not result in unmasking of the catalytic domain.

21 ite near Arg-106, which is distinct from the catalytic domain.

22 sts that this residue interacts with the MKK catalytic domain.

23 s at the junction of the propeptide with the catalytic domain.

24 giotensin converting enzyme 2, but without a catalytic domain.

25 ivity by directly binding to its ATP-binding catalytic domain.

26 l region and a carboxy-terminal caspase-like catalytic domain.

27 ce a detailed topological model of the CesA8 catalytic domain.

28 air in vivo by inactivating each of the four catalytic domains.

29 approximately 80% sequence identity in their catalytic domains.

30 regions that connect the protease-resistant catalytic domains.

31 in the N-terminal regulatory and C-terminal catalytic domains.

32 phospho-tail interacts with both the C2 and catalytic domains.

33 ry or the net homo-FRET between Venus-tagged catalytic domains.

34 switch to augment reductase activity in the catalytic domains.

35 induce an active dimeric conformation of the catalytic domains.

36 ted proteins, four of which were modified in catalytic domains.

37 catalytic site characteristic of minimal PLP catalytic domains.

38 tional units of CaMKII holoenzyme are paired catalytic-domains.

39 re, we present high-resolution structures of catalytic domain 2 from Danio rerio HDAC6 (henceforth si

40 as been proposed to bind, in addition to the catalytic domain, a site at the PAH N-terminal regulator

41 a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-dom

42 delivery of its N-terminal adenylate cyclase catalytic domain (AC domain) into the cytosol, generates

43 We also observed that the DddY catalytic domain adopts a typical beta-barrel fold and c

44 In the complex structure, the catalytic domain adopts an open conformation, with the K

45 On the anionic membrane, the catalytic domain adopts multiple orientations, including

46 ease and virulence, and glycosylation at the catalytic domain affects its thermostability; however, g

47 lated TrCel7A domains, we determine that the catalytic domain alone is sufficient for processive moti

48 AMTS structure comprises a metalloproteinase catalytic domain and a carboxy-terminal ancillary domain

49 es, we found that native HjLPMO9A contains a catalytic domain and a family-1 carbohydrate-binding mod

50 RgNanH comprises a GH33 catalytic domain and a sialic acid-binding carbohydrate-

51 The C terminus of UBR5 harbors the HECT catalytic domain and an adjacent MLLE domain.

52 They consist of a separable C-terminal catalytic domain and an N-terminal transmembrane flippas

53 The VPS34 catalytic domain and BECN1:ATG14 subcomplex do not touch

54 extending from near the top of the enzyme's catalytic domain and crossing the membrane domain of the

55 ns, is composed of 747 amino acids forming a catalytic domain and extended N- and C-terminal regions.

56 rate-binding domain immediately precedes the catalytic domain and has tight associations with it.

57 We show that PolDIP2 binds to PrimPol's catalytic domain and identify potential binding sites.

58 By enhancing the linkage between ADAR's catalytic domain and the guide RNA, and by introducing a

59 sensitivity conferral protein (OSCP) to the catalytic domain and the membrane domain of subunit b to

60 ap, we explored the roles of residues of the catalytic domain and the regulatory subunit of human PI3

61 In particular, the catalytic domain and the RNA-binding domain can move aro

62 s tight mechanochemical coupling between the catalytic domain and the rotating central shaft, as well

63 globular Sgf73 subunit lies between the Ubp8 catalytic domain and the ZnF-UBP domain and has been pro

64 ved by synergistic combination of E2-derived catalytic domain and tridomain.

65 They contain highly homologous catalytic domains and flexible C-terminal hypervariable

66 ng the regulatory domains docked against the catalytic domains and preventing substrate binding.

67 expressed, although some do not have active catalytic domains and their expression can be altered du

68 through association between the Rad50 ATPase catalytic domains and undergoes extensive conformational

69 The enzyme has a membrane extrinsic catalytic domain, and a membrane intrinsic domain where

70 fragment encompassing the propeptide and the catalytic domain, and found that the former runs across

71 near the junction between the prodomain and catalytic domain, and inhibits MMP9 by two mechanisms.

72 ts the dislodging and tethering of the VPS34 catalytic domain, and its regulation by VPS15, as a mast

73 of a C-terminal part of HUWE1, including the catalytic domain, and reveal an asymmetric auto-inhibite

74 on analyses and identified S1777, in TRPM7's catalytic domain, and S1565, in TRPM7's exchange domain

75 of Ubp10, USP36, also has IDRs flanking its catalytic domain, and these IDRs similarly contain bindi

76 t this fibrolytic bacterium uses diverse GH5 catalytic domains appended with different CBMs, includin

77 's disease (PD) have been identified in both catalytic domains, as well as in several of its multiple

78 organization or eventually consisted of one catalytic domain associated with a non-catalytic accesso

79 sphorylates UBE3A in a region outside of the catalytic domain at residue T485 and inhibits UBE3A acti

80 sertion, and orientation/localization of the catalytic domain at the membrane conjointly determine th

81 obe the functions of individual PKS and NRPS catalytic domains at the cellular metabolic level.

82 determined the crystal structure of the LuxO catalytic domain bound to a broad-spectrum inhibitor.

83 e report the crystal structures of the SETD2 catalytic domain bound to H3K36M or H3K36I peptides with

84 le, non-amphiphilic monomer with a canonical catalytic domain but a distinct C terminus compared with

85 THEMIS lacks defined catalytic domains but contains two tandem repeats of a d

86 'large' SRs contain a compact amino-terminal catalytic domain, but differ conspicuously in their carb

87 istone deacetylase 1 (HDA-1), with an intact catalytic domain, but HDA-1 was not essential for de nov

88 We show that mutant ADAMTS-5 lacking the catalytic domain, but with a full suite of ancillary dom

89 udokinase domain regulates activation of the catalytic domain by forming receptor-regulated inhibitor

90 w that an N-terminal fragment comprising the catalytic domain can interact both with itself and with

91 t human RHOGAPs, from which 57 have a common catalytic domain capable of terminating RHO protein sign

92 odular architecture composed of a C-terminal catalytic domain (CAT), a central Trp-Gly-Arg (WGR) doma

93 TrCel7A consists of a catalytic domain (CD) and a smaller carbohydrate-binding

94 eveloped an optogenetic toolbox fused to the catalytic domain (CD) of DNA-methyltransferase3A (DNMT3A

95 linker connected to an N- and O-glycosylated catalytic domain (CD)-a domain architecture common to ma

96 hermore, we investigated the binding of TET1-catalytic domain (CD)-GFP to DNA by Fluorescent Correlat

97 Its C-terminal catalytic domain (CD2) alone is capable of binding singl

98 we present kinetic evidence showing that the catalytic domains (CDs) of TET2 and TET1 from mouse and

99 an alternative strategy that utilizes multi-catalytic domain cellulases.

100 e report a strong linear correlation between catalytic domain complementation and cyclase activity up

101 Its catalytic domain comprises the carboxy-terminal half (co

102 The crystal structure of LKA1gp49 catalytic domain consists of a beta-helix, an insertion

103 The catalytic domain consists of a central mixed beta-sandwi

104 lex that suggests that both the PNKP FHA and catalytic domains contact the XRCC4 coiled-coil and LigI

105 1-3 and helix 2 on the opposite face of the catalytic domain contribute to membrane binding.

106 presented of the 220 phosphodiesterase (PDE) catalytic domain crystal structures present in the Prote

107 inant MMP12 peptide fragments, including its catalytic domain, CTD, and a 20 amino acid peptide withi

108 increasing the expression of ATP synthase's catalytic domain, cytochrome c oxidase and its tyrosine

109 er, acquired resistance mutations within the catalytic domain decrease the efficacy of this strategy

110 mission, whereas overexpressing Tet3 or Tet1 catalytic domain decreased it.

111 g the crystal structure of the human nSMase2 catalytic domain determined at 1.85-A resolution.

112 We fused the catalytic domain (DHPH domain) of the RhoA activator ARH

113 affected by two LytM factors with degenerate catalytic domains, DipM and LdpF, which may serve as reg

114 or approximately 54% of the conformers whose catalytic domain directly interacts with the bilayer.

115 of K-Ras4B, thought to minimally impact the catalytic domain, directly interacts with the active sit

116 whereas mutation R360P in the N lobe of the catalytic domain disrupted an autoinhibitory mechanism,

117 i, which typically comprise multiple, single catalytic domain enzymes for biomass degradation, some b

118 An analog that docked poorly in the GtfC catalytic domain failed to inhibit the activity of Gtfs

119 composed of a pyridoxal 5'-phosphate-binding catalytic domain, flanked by the following two domains:

120 -anchored farnesyl and unrestrained HVR, the catalytic domain fluctuates reinlessly, exposing its eff

121 Residues Thr-123 and Phe-382 in the catalytic domain form a latch-like interaction with hydr

122 dy to the cysteine-rich domain liberates the catalytic domain from autoinhibition, enhancing enzymati

123 However, both the N- and C-terminal non-catalytic domains from all mammalian tolloids bind chord

124 The catalytic domain has a metallophosphatase fold, and two

125 nt and implications of the variations in the catalytic domain have not been described, and it is uncl

126 ependent conformational dynamics of the Cas9 catalytic domains (HNH and RuvC), responsible for concer

127 of Ca(2+)/CaM, elicited a large decrease in catalytic-domain homo-FRET, which was blocked by mutatin

128 3 to Val (E183V) mutation in the CaMKIIalpha catalytic domain, identified in a proband diagnosed with

129 nsient nature of ACP interactions with these catalytic domains imposes a major obstacle for investiga

130 Here we report structures of the A3B catalytic domain in a new crystal form that show alterna

131 rane binding involves helices 3 and 4 of the catalytic domain in addition to the farnesyl and polybas

132 deubiquitinating activity by maintaining the catalytic domain in an active conformation.

133 ggesting a role for Set1A independent of its catalytic domain in ESC self-renewal.

134 e governs the ability of K2 to bind the (pro)catalytic domain in favor of zymogen, thereby enforcing

135 Its crystal structure shows the catalytic domain in its active conformation with a short

136 e functional coupling between a reader and a catalytic domain in KDM5A--suggests a model for the spre

137 report the first structures of the APOBEC3B catalytic domain in multiple crystal forms.

138 he translocation domain interaction with the catalytic domain in serotype D.

139 y exposed protein surface extending from the catalytic domain in the C terminus of A3G to its N termi

140 rier domains and transported to neighbouring catalytic domains in an assembly line fashion.

141 this approach by constructing models for all catalytic domains in the human tyrosine kinase family, u

142 le of p58C in the coordinated actions of two catalytic domains in the primosome and ultimately could

143 of GlnRS, whereas missense mutations in the catalytic domain induce misfolding of the enzyme.

144 2) appears to strengthen the pseudosubstrate-catalytic domain interaction in a nucleotide-dependent m

145 spectrometric analyses showed that the UCR2-catalytic domain interaction occurs in trans, and establ

146 We find the soluble catalytic domain interacts directly with the membrane-as

147 large conformational changes in the GRK5 RH/catalytic domain interface upon receptor binding.

148 into the Jumonji domain, which separates the catalytic domain into two fragments (JmjN and JmjC).

149 nomer form a tight hairpin, bringing the two catalytic domains into an active dimerized state.

150 he complex, including one in which the VPS34 catalytic domain is dislodged from the complex but remai

151 The structure of the alpha3beta3-catalytic domain is likewise closely similar to those of

152 owever, how the NTD activates the C-terminal catalytic domain is unclear.

153 membrane region, which links the NTD and the catalytic domain, is necessary and sufficient for activa

154 t on the structural organization of APOBEC3B catalytic domain, its substrate specificity and its poss

155 ficity are determined within the phosphatase catalytic domain itself.

156 The kinase-like non-catalytic domain (KIND) of Spire directly interacts with

157 are dichain toxins, comprising an N-terminal catalytic domain (LC) disulfide bond linked to a C-termi

158 o 5 pc-9 molecules to the apoptosome and one catalytic domain may be parked on the hub, when an odd n

159 The Ubp8 catalytic domain mediates additional contacts with H2B,

160 sical interaction between the C-terminal and catalytic domains mediates ARTEMIS autoinhibition.

161 the PDE4B subtype, we generated mice with a catalytic domain mutant form of PDE4B (Y358C) that has d

162 is a zinc metalloprotease consisting of two catalytic domains (N- and C-).

163 the X-ray crystallographic structure of the catalytic domain of A-PGS from the opportunistic human p

164 veral drug-resistant mutations affecting the catalytic domain of Abl and other tyrosine kinases are n

165 ntration-dependent manner and the N-terminal catalytic domain of ACT (AC domain) is necessary and suf

166 To mediate repair, we exploit the catalytic domain of Adenosine Deaminase Acting on RNA (A

167 ion crystal structure of the Vif-binding and catalytic domain of APOBEC3F (A3F).

168 To study this phenomenon, the catalytic domain of APOBEC3G (A3G-CTD), an ssDNA-specifi

169 we identify a direct interaction between the catalytic domain of Aurora-A and a site flanking Myc Box

170 y occupies four distinct subsites within the catalytic domain of bacterial and human ThrRSs.

171 volving (i) the ubiquitin carboxyl hydrolase catalytic domain of BAP1, which interacts with the hydro

172 n efficient system for the production of the catalytic domain of CA IX in methylotrophic yeast Pichia

173 d to a p.Ser381Phe substitution in the CDC25 catalytic domain of CalDAG-GEFI.

174 through direct binding to the conserved HNH catalytic domain of Cas9.

175 rk reports a low resolution structure of the catalytic domain of CESA1 from Arabidopsis (Arabidopsis

176 Cre-mediated conditional elimination of the catalytic domain of CYLD induced dHSCs to exit quiescenc

177 ngineered zinc finger protein fused with the catalytic domain of dnmt3a.

178 Here we targeted the catalytic domain of E3 ligase, CHIP, to YFP-tagged KCNQ1

179 er two histidines (H227 and H230) lie in the catalytic domain of eEF2K.

180 fused a catalytically inactive dCas9 to the catalytic domain of Gin recombinase using an optimized f

181 tructural studies showed that the C-terminal catalytic domain of human A3B has a tightly closed activ

182 The crystal structure of the catalytic domain of KAT2A in complex with succinyl-CoA a

183 present the 1.05 A crystal structure of the catalytic domain of LytA in complex with a synthetic cel

184 oxide spin labels) in the active site of the catalytic domain of matrix metalloproteinase-12 (MMP-12

185 As a proof of principle, we used the catalytic domain of matrix metalloproteinase-14 (MMP-14)

186 Mutations in the catalytic domain of Mps1 that give rise to inhibitor res

187 NLRP3 associated with the catalytic domain of NEK7, but the catalytic activity of

188 Here, we identify the complete catalytic domain of nSMase2, which was misannotated beca

189 mpounds from this series in complex with the catalytic domain of PDE1B and PDE10A were determined, al

190 ramide was revealed to interact with the PIK-catalytic domain of PI3KC2beta and affect its compartmen

191 T590 and T597 in the variable insert of the catalytic domain of PIP5K6, and this modification inhibi

192 ion (P-CR), one of two unique domains in the catalytic domain of plant CesAs, was solved to 2.4 A res

193 a Cdc37 phosphomimetic peptide bound to the catalytic domain of PP5.

194 ally examining weak interactions between the catalytic domain of protein kinase Calpha and 14 substra

195 The catalytic domain of protein tyrosine kinases can interco

196 ecame spontaneously active when v-Src or the catalytic domain of Pyk2 was coexpressed with CFTR and w

197 Here we report that the N-terminal non-catalytic domain of separase binds to the C-terminal tai

198 ing of deactivated Cas9 (dCas9) nuclease and catalytic domain of the DNA methyltransferase DNMT3A tar

199 ing), a technique that couples an RBP to the catalytic domain of the Drosophila RNA-editing enzyme AD

200 ATP synthase, upon its dissociation from the catalytic domain of the enzyme.

201 stal structure has been determined of the F1-catalytic domain of the F-ATPase from Caldalkalibacillus

202 inal region of LifA shares homology with the catalytic domain of the large clostridial toxins, which

203 rporates two amino acid substitutions in the catalytic domain of the light chain (LC) metalloprotease

204 diate filaments identified a mutation in the catalytic domain of the MAP kinase 7 orthologue sma-5(kc

205 ction between CNNM2 and PRL-1 occurs via the catalytic domain of the phosphatase.

206 . monocytogenes strains and to determine the catalytic domain of the phosphodiesterase PdeA.

207 d zinc-associated Cys-X-X-Cys motif near the catalytic domain of the protein, decreases SIRT6 deacety

208 op interaction between the substrate and the catalytic domain of the ribozyme, resulting in a rearran

209 nformation of the substrate, docked into the catalytic domain of the ribozyme.

210 By linking the catalytic domain of the RNA editing enzyme ADAR to an an

211 9 insert into hydrophobic pockets within the catalytic domain of the same subunit to stabilize the in

212 enzymatic function, a second mutation in the catalytic domain of this enzyme (R1625C) resulted in a c

213 eover, we show that active RasC binds to the catalytic domain of TOR, suggesting a mechanism of TORC2

214 igands that bind in the "palm" region of the catalytic domain of USP7 and inhibit its catalytic activ

215 cular dynamics simulations revealed that the catalytic domain of wild-type Cel7A and the FCA398 varia

216 Here we report the crystal structure of the catalytic domain of zebrafish PIP5K1A at 3.3 A resolutio

217 Gbetagamma also binds the C1/C2 catalytic domains of AC5 and AC6.

218 CAs (full-length CA I, II, VII, and XIII and catalytic domains of CA IX and XII) were characterized u

219 ocalized at the interface between the C2 and catalytic domains of cPKCs in an inactive kinase.

220 activity contributing to GEF activation, the catalytic domains of CYK-4 and ECT-2 directly interact.

221 ylation to specific gene loci by conjugating catalytic domains of DNA methyltransferases (DNMTs) to e

222 ed linker between the calmodulin-binding and catalytic domains of eEF2K.

223 The catalytic domains of most eukaryotic protein kinases are

224 In addition, using IAV without the stalk and catalytic domains of NA as a live attenuated vaccine was

225 ) found in the linker region between the two catalytic domains of the enzyme.

226 This structure is similar to those of core catalytic domains of the foot-and-mouth disease virus le

227 Point mutations in the predicted catalytic domains of the STELLO proteins indicate that t

228 Superimposition of the catalytic domains of ThiC and glutamate mutase shows tha

229 Lyn was nullified by point mutations of Lyn catalytic domain or Src homology 2 (SH2) or SH3 domains

230 to their bacterial counterparts, yet several catalytic domains originated via horizontal gene transfe

231 mic volume without any appreciable change in catalytic-domain pair proximity or subunit stoichiometry

232 If correct, kinase-activity would require catalytic-domain pair separation.

233 The functional significance of catalytic-domain pairing is not known.

234 the autoinhibited holoenzyme is organized as catalytic-domain pairs distributed around a central olig

235 In addition to its catalytic domain, PHD2 contains an evolutionarily conser

236 Dehydratase (DH) catalytic domains play an important role during polyketi

237 Furthermore, TET1 catalytic domain possessed demethylase activity in cance

238 Revealed is a catalytic domain related in fold to Ulp family deubiquit

239 repeats, rather than the C-terminal oxidase catalytic domain, represent the major deacetylase/deacet

240 In contrast, key catalytic domain residues and even a UDP-GlcNAc oxygen i

241 Here we present the first structure of the catalytic domain (residues 201-589) of the class I PhaC

242 and 3, which encode negative regulatory and catalytic domains, respectively.

243 TDP2 consists of a C-terminal catalytic domain responsible for its phosphodiesterase a

244 he conserved His residue in the hypothesized catalytic domain results in a complete loss of HHAT palm

245 1, which contains an Alu exon peptide in its catalytic domain, RNA sequencing analyses of A-to-I edit

246 s also expressed in cardiac muscle with high catalytic domain sequence similarity with other MLCKs bu

247 structural and sequence analysis of class II catalytic domains shows that bacterial GlyRS is closely

248 hat the linker forms an integral part of the catalytic domain structure, covering a hydrophobic patch

249 y of these mutants, we elucidated a new MLK4 catalytic domain structure.

250 ne kinase family, using all available kinase catalytic domain structures from any organism as structu

251 ERManI and GMIA have similar catalytic domain structures, but each enzyme cleaves dis

252 roups that target the ATP-lid portion of the catalytic domain, such as a six-membered ring, confer se

253 ion of procaspase-8 filaments containing the catalytic domain, suggesting that procaspase-8 interacti

254 Ectopic expression of TET1 catalytic domain suppressed colony formation and induced

255 l-1,6-deoxynojirimycin revealed a TIM barrel catalytic domain that contains a deep substrate-binding

256 member of the novel lyase family revealed a catalytic domain that displays an (alpha/alpha)6 barrel-

257 ses a major conformational transition in the catalytic domain that increases PAR production.

258 teins contain a bromodomain flanking the HAT catalytic domain that is important for the targeting of

259 ation of an alpha-helical region in the core catalytic domain that is juxtaposed to ssDNA, suggesting

260 ons that encode a transposase with a DD(E/D) catalytic domain that is topologically similar to RNase

261 l segments, within a construct of the myosin catalytic domain that lacks other reactive cysteines.

262 1 subunit N-terminal domain or in the CaMKII catalytic domain that largely prevent the in vitro inter

263 de RNA, and by introducing a mutation in the catalytic domain, the efficiency of converting a U A: G

264 the wild-type K-Ras4B (K-Ras4B(WT)-GTP/GDP) catalytic domain, the K-Ras4B(WT)-GTP-GAP complex, and t

265 erminal partner (VirA (C)DD) or a downstream catalytic domain, the N-terminal DD (VirFG (N)DD) exhibi

266 ichia pastoris, we also demonstrate that the catalytic domain, the N-terminus and the C- terminus of

267 including the papain-like protease 2 (PLP2) catalytic domain, the ubiquitin-like domain 2 (Ubl2), an

268 omains of individual subunits, including the catalytic domains, the interaction interfaces between su

269 thiolate subdomain away from the rest of the catalytic domain, thereby disrupting the NAD(+) and acet

270 Despite similarities in their catalytic domains, these ACs differ in regulation.

271 of NRPS catalysis is based around sequential catalytic domains: these are organized into modules, whe

272 etalloproteases (MMPs) with highly conserved catalytic domains, this strategy failed to identify inhi

273 bility of F12 to reversibly bind to the (pro)catalytic domain through K2 with high affinity and highl

274 structures revealing the MCR-1 periplasmic, catalytic domain to be a zinc metalloprotein with an alk

275 ctly binds Tip60 at a region adjacent to the catalytic domain to promote the protein acetyltransferas

276 inetic domain that transduces force from the catalytic domain to the lever arm to accomplish the powe

277 s of CesA, accessory proteins, or other CesA catalytic domains to control substrate delivery.

278 ane anchor that drives hexamerization of the catalytic domains to form the ATPase active sites.

279 furthermore, provides geometric access of L4 catalytic domains to the DNA ends during ligation and of

280 here and a globular-structured SUMO-binding catalytic domain, to stabilize p53.

281 el (MSM) to simulate the activation of c-Src catalytic domain, used as a prototypical tyrosine kinase

282 minal anticodon binding domains and that the catalytic domain uses a newly evolved group I intron bin

283 s and interacts with the minor groove of the catalytic domain V.

284 findings support the view that the karilysin catalytic domain was co-opted by competent bacteria thro

285 The X-ray crystal structure of the catalytic domain was determined at 2.1 A resolution and

286 The PLP2 catalytic domain was found to have both deubiquitinating

287 teraction of T3lec or T4lec with ppGalNAc-T2 catalytic domain was not mediated by carbohydrate.

288 The catalytic domain was overexpressed in Escherichia coli,

289 truncates comprising the disintegrin and/or catalytic domains were able to competitively block full-

290 res of the PRRSV nsp11 and coronavirus nsp15 catalytic domains were perfectly superimposed, especiall

291 to detect relative orientations of the Cas9 catalytic domains when associated with on- and off-targe

292 of resistant secondary mutations at the FLT3 catalytic domain, which is mainly on D835.

293 LOX or are located at a highly conserved LOX catalytic domain, which is relatively invariant in the p

294 nsists of tetratricopeptide repeat (TPR) and catalytic domains, which, together with UDP-GlcNAc, are

295 ion of individual structural elements in the catalytic domain while myosin is in complex with actin.

296 vealed that DddY contains a cap domain and a catalytic domain with a Zn(2+) bound at its active site.

297 It comprises a flat cylindrical catalytic domain with five-fold alpha/beta-propeller arc

298 Thus, despite sharing the catalytic domain with ROCK2, ROCK1 appears to be the dom

299 resulted in an in-frame linkage of the PRKCA catalytic domain with the N-terminal of ATP2B4 and high

300 We find that a non-catalytic domain within Cas9, REC3, recognizes target co