ライフサイエンスコーパス: catalytic mechanism

1 utamate residue is not relevant for the PatZ catalytic mechanism.

2 tep in this strictly ordered ternary complex catalytic mechanism.

3 sferases in folds, and share a two-metal-ion catalytic mechanism.

4 to TsdA and can be inferred to use a related catalytic mechanism.

5 in coding segments uncover the two-metal-ion catalytic mechanism.

6 atures of the Fl(N5[O]) species and the EncM catalytic mechanism.

7 hii, strongly supports an active role in the catalytic mechanism.

8 mol for the slowest step in the iron(IV)-oxo catalytic mechanism.

9 binding affinity, catalytic efficiency, and catalytic mechanism.

10 ction to provide structural insight into its catalytic mechanism.

11 and implicate the cofactor oxo group in the catalytic mechanism.

12 help to understand the initial steps of the catalytic mechanism.

13 tural and spectroscopic investigation of its catalytic mechanism.

14 enzymes, showing convergent evolution of the catalytic mechanism.

15 at 14-3-3 inhibits the complex through a non-catalytic mechanism.

16 ructures illuminate important aspects of the catalytic mechanism.

17 hey operate from a basic structural fold and catalytic mechanism.

18 log Rap through an ill-defined non-canonical catalytic mechanism.

19 esidues are most consistent with a retaining catalytic mechanism.

20 cal participation of this Glu residue in the catalytic mechanism.

21 ates that has led to an understanding of the catalytic mechanism.

22 test the roles of His 141 and Asp 142 in the catalytic mechanism.

23 active site loop that were critical for the catalytic mechanism.

24 about the mode of substrate binding and the catalytic mechanism.

25 etails of the thiol-disulfide oxidoreductase catalytic mechanism.

26 nctioning as the reactive nucleophile in the catalytic mechanism.

27 amino group of the donor participates in the catalytic mechanism.

28 f TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism.

29 nate diester, consistent with a nucleophilic catalytic mechanism.

30 tes providing more complete snapshots of the catalytic mechanism.

31 o used be for electrochemical studies of the catalytic mechanism.

32 , TC, with direct implications for the eIF2B catalytic mechanism.

33 ural basis for its substrate selectivity and catalytic mechanism.

34 oli, and identify key features of the likely catalytic mechanism.

35 ating that they are likely to share a common catalytic mechanism.

36 aches have revealed critical features of its catalytic mechanism.

37 ment of transient species important to their catalytic mechanism.

38 es an isomerization process within its known catalytic mechanism.

39 uggested roles for Glu-48 and His-164 in the catalytic mechanism.

40 ide chains to improve activity and probe the catalytic mechanism.

41 s as an essential prerequisite for proposing catalytic mechanisms.

42 or the RNA-based RNase P, suggesting similar catalytic mechanisms.

43 scopic and computational characterization of catalytic mechanisms.

44 nt control and a deeper understanding of the catalytic mechanisms.

45 bon bonding is critical to understanding the catalytic mechanisms.

46 t task owing to uncertainties over the exact catalytic mechanisms.

47 secutive reactions by using hitherto unknown catalytic mechanisms.

48 onserved amino acid sequences, and plausible catalytic mechanisms.

49 n, and have been shown to exhibit a range of catalytic mechanisms.

50 esis analyses, provide explanations of their catalytic mechanisms.

51 binding sites, substrate binding sites, and catalytic mechanisms.

52 as a key role in the deacylation step of the catalytic mechanism, allowing the acyl-enzyme adduct to

53 ning the reaction thermodynamics and thereby catalytic mechanism and activity.

54 esign of ligands was based on a possible SN1 catalytic mechanism and as mimics of the carbocation in

55 fundamental understanding of the formation, catalytic mechanism and degradation of active sites.

56 rk both for investigations of the class I FH catalytic mechanism and for drug design aimed at fightin

57 a Pseudomonas MDC and give insights into its catalytic mechanism and function.

58 , several mechanistic details, including the catalytic mechanism and GTP hydrolysis-driven conformati

59 roviding insight into the serine recombinase catalytic mechanism and how resolvase interacts with the

60 unctional studies in cells, we elucidate the catalytic mechanism and mode of tubulin-specific acetyla

61 up to 1.5A provide elegant insights into the catalytic mechanism and molecular basis for their three

62 However, despite extensive study, the catalytic mechanism and molecular basis of substrate rec

63 PR/MM for a semiquantitative analysis of the catalytic mechanism and nature of transition state in AP

64 tes for an atomic-level understanding of the catalytic mechanism and rational design of high-performa

65 understand the role of enzyme motions in the catalytic mechanism and recognition.

66 Little is known about the catalytic mechanism and regulation of alarmone synthesis

67 ty analysis, these results shed light on the catalytic mechanism and substrate recognition of zgammaG

68 . fluorescens substrate, indicating a common catalytic mechanism and substrate recognition.

69 The catalytic mechanism and substrate specificity of a major

70 The catalytic mechanism and substrate specificity of cinnamo

71 The catalytic mechanism and the active-site fold, however, a

72 investigated to obtain further clues to the catalytic mechanism and the substrate specificity.

73 w insight into substrate recognition and the catalytic mechanism and thus will aid inhibitor design.

74 To better understand AOC's catalytic mechanism and to elucidate the structural prop

75 II introns and the spliceosome share common catalytic mechanisms and probably common evolutionary or

76 The results provide insights into the enzyme catalytic mechanisms and reveal structural snapshots of

77 le in the MACiE, EzCatDb (Database of Enzyme Catalytic Mechanisms) and SFLD (Structure Function Linka

78 ve been determined, although the structures, catalytic mechanisms, and substrate specificities of GH6

79 luble methyltransferases, and aspects of its catalytic mechanism are unknown.

80 a protein superfamily, and its structure and catalytic mechanism are unknown.

81 itude suggests the involvement of additional catalytic mechanisms as well.

82 We conclude that the most likely catalytic mechanism begins with abstraction of a hydroge

83 nts at a potential role for adenine-6 in the catalytic mechanism besides the previously identified in

84 we advanced in our understanding of the ACD catalytic mechanism by discovering that the enzyme trans

85 e synthase structure, enabled probing of the catalytic mechanism by mutagenesis, demonstrating the es

86 In this work, we investigated the catalytic mechanism by rational site-directed mutagenesi

87 The catalytic mechanism by which the hairpin ribozyme accele

88 The CAO catalytic mechanism can be divided into two half-reactio

89 Here, we delineate a catalytic mechanism common to lecithin:retinol acyltrans

90 The data support a two-stage catalytic mechanism consisting of (1) "catalyst oxidatio

91 nge has mostly proved ineffective because of catalytic mechanism constraints and required chaperone c

92 This catalytic mechanism couples together the growth of insol

93 However, the understanding of its catalytic mechanism, despite the recently determined cry

94 contains a dimetal active site involved in a catalytic mechanism distinct from that of the housekeepi

95 e-directed mutagenesis reveal aspects of its catalytic mechanism, especially retinyl moiety isomeriza

96 hen cleaving xylan, suggesting that distinct catalytic mechanisms exist for xylan and glucan cleavage

97 driving ingredient for the activation of the catalytic mechanism, followed by their geminal coupling

98 vides an insight into substrate recognition, catalytic mechanism for acetyl transfer, and features un

99 We propose a catalytic mechanism for alpha-N-terminal methylation.

100 e substrate Me-S-CoM and thus imply the same catalytic mechanism for both substrates.

101 for convergent evolution toward a conserved catalytic mechanism for citrate production.

102 On the basis of (77)Se-NMR experiments, a catalytic mechanism for diselenide 6 was proposed involv

103 CglI and NgoAVII enzymes may employ a unique catalytic mechanism for DNA cleavage.

104 we have characterized a reverse protonation catalytic mechanism for hSCAN-1 and determined its free

105 hese structures of APN illustrate a detailed catalytic mechanism for its aminopeptidase activity.

106 n the catalytic pathway and suggest a common catalytic mechanism for Nudix hydrolases.

107 The catalytic mechanism for oxidizing alcohols to carboxylat

108 ient to hydrolyze PGP, indicating a specific catalytic mechanism for PgpB in PG biosynthesis.

109 scribed, and it clearly suggests an SN2 type catalytic mechanism for the beta4GalT7 enzyme.

110 llow us to propose a pitcher-catcher type of catalytic mechanism for the isomerization.

111 ions of an unprecedented dynamic single-atom catalytic mechanism for the oxidation of carbon monoxide

112 The catalytic mechanism for the production of H2 and CO2 fro

113 lations were used to identify a preferential catalytic mechanism for the transformation of acetylene,

114 the active site has allowed us to propose a catalytic mechanism for these enzymes.

115 A catalytic mechanism for this unique enzyme is proposed.

116 [(13)C]acetate, and NMR, we investigated the catalytic mechanism for VoTPS1 and provide evidence for

117 results presented support bioorganometallic catalytic mechanisms for IspG and IspH, and open up new

118 AP/UBE3A suggest convergent evolution of the catalytic mechanisms for prokaryotic and eukaryotic liga

119 for environmental remediation, but detailed catalytic mechanisms for these enzymes are not yet known

120 covalent interaction, suggesting a different catalytic mechanism from those of other DNA glycosylases

121 ile our knowledge of the ADAR2 structure and catalytic mechanism has grown over the years, our knowle

122 serve as a general acid, but its role in the catalytic mechanism has not been established conclusivel

123 Still, its exact catalytic mechanism has remained unclear.

124 sed on knowledge of the 3D-structure and the catalytic mechanism, (ii) combinatorial design, requirin

125 residues suggests that IcaB uses an altered catalytic mechanism in comparison to other characterized

126 n phosphorylase support the idea of a common catalytic mechanism in GT-B enzymes independent of the s

127 ing a well-defined platform for studying the catalytic mechanism in the solution phase.

128 These studies support an unusual catalytic mechanism in which an initial masked C-H bond

129 We propose a catalytic mechanism in which lysine-180 acts as a cataly

130 e structure of the active site, we propose a catalytic mechanism in which serine 127 plays a key role

131 C proteins transfer palmitate via a two-step catalytic mechanism in which the enzyme first modifies i

132 This unusual arrangement suggests a catalytic mechanism in which the two copies of dIII alte

133 oA synthetases supports a domain alternation catalytic mechanism in which these enzymes' C-terminal d

134 kinetic properties of the mutants suggest a catalytic mechanism in which Tyr(487) and Gly(491) work

135 Although catalytic mechanisms in natural enzymes are well underst

136 f DMSP cleavage, enabling elucidation of the catalytic mechanism, in which the residue Tyr271 of DddY

137 The structures reveal the underlying catalytic mechanism, in which two zinc ions activate a w

138 However, little is known about the catalytic mechanisms, including the parameters that dete

139 The proposed catalytic mechanism involves consecutive alkyne-carbonyl

140 The proposed catalytic mechanism involves two catalytic triads that p

141 l group was produced, consistent with a RedG catalytic mechanism involving hydrogen abstraction from

142 mutational, kinetic and modeling analyses, a catalytic mechanism involving leaving group stabilizatio

143 rium labeling studies, are consistent with a catalytic mechanism involving olefin-dione oxidative cou

144 afel slope of 150 mV/decade, indicative of a catalytic mechanism involving rate-limiting one-electron

145 itions, along with other data, corroborate a catalytic mechanism involving ruthenium(0)-mediated alle

146 On the basis of these results, we propose a catalytic mechanism involving substrate tautomerization,

147 the active site and analysis of kinetics, a catalytic mechanism involving two water molecules and re

148 amplitude and oxidation/reduction peaks, the catalytic mechanism is an electron-proton coupled proces

149 Sequence analysis suggests that the proposed catalytic mechanism is common for bacterial Tmms.

150 Sequence comparisons suggested that the catalytic mechanism is conserved among the bacterial hom

151 ding and catalysis and demonstrated that the catalytic mechanism is conserved between human and plant

152 This finding suggests that the catalytic mechanism is more similar to the mechanism of

153 roceeds through a four-step reaction but the catalytic mechanism is not fully understood at the atomi

154 A catalytic mechanism is proposed.

155 y mutagenesis studies, and a structure-based catalytic mechanism is proposed.

156 In addition, a two-metal catalytic mechanism is proposed.

157 The catalytic mechanism is still unknown.

158 Their catalytic mechanism is unknown.

159 lativorans (ex. Mesorhizobium) sp. BNC1, its catalytic mechanism is unknown.

160 Although their catalytic mechanism is well characterized and the cataly

161 Furthermore, using a non-catalytic mechanism, MMP-9 promotes rounded-amoeboid 3D

162 ght on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.

163 op new strategies to probe the structure and catalytic mechanism of a ribozyme.

164 Here we have studied the catalytic mechanism of alkaline phosphatase (AP), which

165 The hypothesized catalytic mechanism of alpha-terpineol-to-1,8-cineole co

166 The results reveals a conserved catalytic mechanism of AlucJHEH toward JH.

167 , providing further support for the proposed catalytic mechanism of AmiA.

168 er, the role of fast dynamics in the overall catalytic mechanism of an enzyme has not been addressed.

169 results provide important insights into the catalytic mechanism of archaeal DHNAs.

170 We report the crystal structure and the catalytic mechanism of Asp f3, a two-cysteine type perox

171 To elucidate the catalytic mechanism of ATP hydrolysis by YchF, we have t

172 our findings provide fresh insight into the catalytic mechanism of AURKA, and identify a key structu

173 The catalytic mechanism of BACE-1 requires water-mediated pr

174 While the iterative catalytic mechanism of bacterial NRPSs is known, it rema

175 These findings unveil a one-base catalytic mechanism of C2 deprotonation/reprotonation vi

176 ly, these data give a new perspective on the catalytic mechanism of CCoAOMTs and provide a basis for

177 However, the detailed catalytic mechanism of CE is unclear due to the lack of

178 NA and 2',5' cGAMP provided insight into the catalytic mechanism of cGAS.

179 The catalytic mechanism of class A beta-lactamases is often

180 ction of the conserved residue Lys 73 in the catalytic mechanism of class A type beta-lactamase enzym

181 e structural framework and insights into the catalytic mechanism of CpsUbiX.

182 These results document the catalytic mechanism of CYP121 and improve our understand

183 report here a detailed investigation of the catalytic mechanism of DCS using a variety of mechanisti

184 EPR-based strategies for investigating the catalytic mechanism of decarboxylation are complicated b

185 irical valence bond simulations to probe the catalytic mechanism of DFPase as well as temperature, pH

186 active strategy to understand the underlying catalytic mechanism of different edge sites and improve

187 s and provide insights for understanding the catalytic mechanism of dithiol oxidases involved in natu

188 ovide insights into the atomic structure and catalytic mechanism of DNase II.

189 The proposed catalytic mechanism of DNMT1 involves nucleophilic attac

190 irected mutagenesis allowed us to derive the catalytic mechanism of DrrA from the FTIR difference spe

191 Protein mass-modulated effects in the catalytic mechanism of Escherichia coli dihydrofolate re

192 the transformation products to elucidate the catalytic mechanism of estrogens' transformation by lacc

193 nds of introns and provides insight into the catalytic mechanism of exon ligation.

194 To further our understanding of the catalytic mechanism of GHMP kinases with the purpose of

195 active site, consistent with studies of the catalytic mechanism of GlpG that suggest that TM5 serves

196 The structure and catalytic mechanism of group II introns have recently be

197 is finding radically changes the view on the catalytic mechanism of H2O2 production by Cu-Abeta, and

198 le for histidine-162 and threonine-36 in the catalytic mechanism of HCT.

199 The proposed catalytic mechanism of human UGDH involves Lys(220) as g

200 ing have been shown to play key roles in the catalytic mechanism of hydrolytic NAD(P)-dependent aldeh

201 ogether, our results suggested the potential catalytic mechanism of hydroxylation by YfcM.

202 In this paper, we have studied the catalytic mechanism of L-asparaginase II computationally

203 lts have provided a new understanding of the catalytic mechanism of L-asparaginases that is in agreem

204 To date we lack structural insights into the catalytic mechanism of lariat-forming ribozymes.

205 rovide insights regarding differences in the catalytic mechanism of MIBS and the mechanisms of (+)-bo

206 The results provide insights into the catalytic mechanism of MOBC relaxases, which differs rad

207 While there is broad agreement on the catalytic mechanism of multicopper oxidases (MCOs), the

208 data highlight potential differences for the catalytic mechanism of NOHA oxidation between mammalian

209 nt new insights into the previously proposed catalytic mechanism of NOS.

210 Many questions remain about the catalytic mechanism of OxDC although it has been propose

211 stability of plausible intermediates in the catalytic mechanism of OxDC, and suggests that removal o

212 Understanding the details of the catalytic mechanism of Pgp is therefore critical to the

213 s are discussed in context of a model of the catalytic mechanism of Pgp.

214 To study the catalytic mechanism of phosphorylation catalyzed by cAMP

215 nsights into the product specificity and the catalytic mechanism of protein arginine methyltransferas

216 nt H(2) accumulation in the dark because the catalytic mechanism of pyruvate:ferredoxin oxidoreductas

217 The catalytic mechanism of RlmH enzyme is unknown.

218 tions in the SA binding site, we propose the catalytic mechanism of SGE and SAG formation and that SA

219 The catalytic mechanism of standard NTR involves a large con

220 , suggesting the importance of Arg-94 in the catalytic mechanism of the bc(1) complex in R. sphaeroid

221 t examines the substrate, metal binding, and catalytic mechanism of the enzyme.

222 n atoms, and computation to characterize the catalytic mechanism of the enzyme.

223 This work reveals the catalytic mechanism of the first known plant flavin mono

224 her understand the substrate specificity and catalytic mechanism of the HCT/HQT, we performed structu

225 rting point for research on the dynamics and catalytic mechanism of the HDV ribozyme and demonstrate

226 H-bond and dispersion contact as part of the catalytic mechanism of the Na(+),K(+)-ATPase.

227 The catalytic mechanism of the organo-mediated Beckmann rear

228 nhibitors has provided new insights into the catalytic mechanism of the protease and its conformation

229 hanics (QM/MM) calculations to elucidate the catalytic mechanism of the rate-determining amine oxidat

230 lts shown here provide new insights into the catalytic mechanism of the secretion ATPase superfamily.

231 ystal structure of TPST2, which revealed the catalytic mechanism of the tyrosine sulfation reaction.

232 ntal principles of catalysis by PSII and the catalytic mechanism of the WOC.

233 the stroma and consistent with the canonical catalytic mechanism of these enzymes.

234 anges in structural dynamics with the unique catalytic mechanism of this enzyme.

235 The catalytic mechanism of this metal-independent glycosyltr

236 to gain insights into the structure and the catalytic mechanism of this unusual Dtrx.

237 However, the catalytic mechanism of this very unusual sulfur-sacrific

238 ine bacterial Tmm (RnTmm) and elucidated the catalytic mechanism of TMA oxidation by RnTmm.

239 derstanding of the substrate recognition and catalytic mechanism of Tps2 and provide a structural bas

240 n calorimetry experiments to investigate the catalytic mechanism of Trm10 in vitro.

241 The catalytic mechanism of Uba6 is further supported by inhi

242 ates in VAO, providing new insights into the catalytic mechanism of VAO and related enzymes that oxid

243 d the development of a detailed model of the catalytic mechanism of WaaA.

244 Our results provide insights into the catalytic mechanism of Xer recombination and a model for

245 tic performance were built for understanding catalytic mechanisms of bimetallic catalysts toward desi

246 ociated with DNA recognition by cGAS and the catalytic mechanisms of cGAMP generation.

247 es common to natural heme-containing enzymes.Catalytic mechanisms of enzymes are well understood, but

248 icantly advanced in our understanding of the catalytic mechanisms of GHs and GTs, not only the molecu

249 ural studies have focused on elucidating the catalytic mechanisms of individual multidomain proteins

250 informatic results, provide insight into the catalytic mechanisms of the Cy domain and implicate a pr

251 elis complexes, which illuminate distinctive catalytic mechanisms of the lysine adenylylation reactio

252 actor and substrate binding sites and on the catalytic mechanisms of these enzymes, comparing them wi

253 ese and mutational data, allow us to infer a catalytic mechanism operative in GlmU(Mtb).

254 n paid to improving our understanding of its catalytic mechanisms or substrate preferences.

255 RNA synthetase classes possess sophisticated catalytic mechanisms: pre-steady state bursts, significa

256 The catalytic mechanism proposed for the carboxylation of ox

257 nding direct support to the 'ping-pong'-like catalytic mechanism proposed for YopJ effectors.

258 The DddY structure and proposed catalytic mechanism provide a better understanding of ho

259 uitous Prx scaffold, and their structure and catalytic mechanism reconcile a plethora of partly confl

260 A controversy has arisen regarding its catalytic mechanism related to the function of the activ

261 This Review critically examines the catalytic mechanisms relevant to each specific applicati

262 conserved autoproteolysis sequence, but its catalytic mechanism remains unknown.

263 conformation, with catalytic residues and a catalytic mechanism remarkably similar to canonical prot

264 lusively by hydrogen bonds, and the proposed catalytic mechanism requires multiple proton-transfer ev

265 The reported dynamic single-atom catalytic mechanism results from the ability of the gold

266 Although these proteases use an unrelated catalytic mechanism, rotation of equivalent helices cont

267 While the updated catalytic mechanism shares features with the serine prot

268 is a zinc-dependent metallopeptidase with a catalytic mechanism similar to that of glutamate carboxy

269 found that this enzyme follows an acid-base catalytic mechanism similar to the bacterial DHNAs, exce

270 complex, yielding seminal insights into its catalytic mechanism, substrate specificity, allosteric r

271 ong to multiple distinct classes and share a catalytic mechanism that arose through convergent evolut

272 re-guided mutagenesis, leads us to propose a catalytic mechanism that establishes LarE as a paradigm

273 ncy, providing an unusual substrate-assisted catalytic mechanism that limits efficient ubiquitin tran

274 cribed in this work suggests a novel type of catalytic mechanism that relies on the forced atomic pro

275 ubstrate binding and the two-cation-assisted catalytic mechanisms that are shared by eukaryotic C3POs

276 Emphasis is placed on reaction types and catalytic mechanisms that showcase both the chemical div

277 ay structure of NadA will help us unveil its catalytic mechanism, the last step in the understanding

278 More significantly, simplification of catalytic mechanisms through the incorporation of chemic

279 ing us with the most thorough picture of the catalytic mechanism to date.

280 t-driven model, this approach offers a novel catalytic mechanism to irreversibly inhibit protein func

281 We propose two catalytic mechanisms to account for our experimental res

282 FPase and PON1 also likely utilize identical catalytic mechanisms to hydrolyze their respective subst

283 The catalytic mechanisms underlying Escherichia coli alkalin

284 s that were designed to test features of the catalytic mechanism used by the adenine glycosylase MutY

285 quantitative and detailed description of the catalytic mechanism utilized by DsbA that offers insight

286 A two-step catalytic mechanism was extrapolated: the catalyst trans

287 The catalytic mechanism was monitored by means of three two-

288 Its catalytic mechanism was previously proposed to involve a

289 To understand the catalytic mechanism, we have crystallized the ternary co

290 ecifically hydrolyzed Efb via a nucleophilic catalytic mechanism were found in the blood of healthy h

291 Insights into the catalytic mechanism were gained by using variable concen

292 ATP synthases operate by a rotary catalytic mechanism where proton translocation through t

293 omputational studies indicate a bifunctional catalytic mechanism whereby the thioimidate activates th

294 ed us to deduce a detailed and complete IspG catalytic mechanism, which describes all stages from ini

295 vance makes necessary the knowledge of their catalytic mechanism, which in the case of retaining GTs

296 However, details about the complex mIPS catalytic mechanism, which requires oxidation, enolizati

297 ficity by retaining core closure as a common catalytic mechanism while optimizing substrate-binding i

298 enzymes which share a general superfold and catalytic mechanism, while they differ in the nature of

299 Inteins display a diversity of catalytic mechanisms within a highly conserved fold that

300 core metabolic enzymes that share a fold and catalytic mechanism yet possess strict specificity for t