ライフサイエンスコーパス: catalytic site

1 s of lentil peptides and residues of the ACE catalytic site.

2 ation of adenosine triphosphate (ATP) to the catalytic site.

3 ects of the inhibitors on the RNA polymerase catalytic site.

4 rate, orienting its targeted arginine to the catalytic site.

5 ergy, but the effect of Y208F extends to the catalytic site.

6 as only associated with proton uptake to the catalytic site.

7 the enzyme, and the oxidized NAD leaves the catalytic site.

8 ng sites to ensure full metal loading of the catalytic site.

9 ream kinase (RSK1) faces the enzyme's (ERK2) catalytic site.

10 ts in a decrease in enzyme reactivity at the catalytic site.

11 ring P-site-992 to the PTK core to reach the catalytic site.

12 well defined region of the molecule near the catalytic site.

13 of the substrate adjacent to the beta-GCase catalytic site.

14 ient substrate transit between membranes and catalytic site.

15 pn11, which controls ubiquitin access to its catalytic site.

16 idues Ser773 and Ser774 in the PI3Kalpha ATP catalytic site.

17 all fungal P450 inhibitors, that dock in the catalytic site.

18 cs to promote the active conformation of the catalytic site.

19 ide, and a hydrophobic patch adjacent to the catalytic site.

20 at, unexpectedly, binds away from the enzyme catalytic site.

21 l as those in the inner six helices form the catalytic site.

22 , and TFB2M, a transient component of mtRNAP catalytic site.

23 ilize the triangular pores for access to the catalytic site.

24 and hydrophilic loops primarily embedding a catalytic site.

25 plementary subunit to regulate access to the catalytic site.

26 he holoenzyme with one and two metals at the catalytic site.

27 tions, with the Sec residue located at their catalytic site.

28 Mn(+2)-Mn(+2) metal bridge formation at the catalytic site.

29 mily member, provided a detailed view of the catalytic site.

30 tion of a radical with a metal cofactor of a catalytic site.

31 the conformation of residues present at the catalytic site.

32 ealed a ligand consistent with Cx-SAM in the catalytic site.

33 que C-terminal domain harboring the putative catalytic site.

34 xin inhibitors that do not interact with the catalytic site.

35 ATX but no interaction with zinc ions of the catalytic site.

36 tions of a collagen triple helix with an MMP catalytic site.

37 result of the steric environment around the catalytic site.

38 (SAM) or S-adenosylhomocysteine (SAH) in the catalytic site.

39 -RhoGAP contains two arginine fingers at its catalytic site.

40 atin-like subdomain of PNPLA1 containing the catalytic site.

41 e binding of the two substrate waters to the catalytic site.

42 a position at the bottom of V1 near an open catalytic site.

43 , CN(-), and CO at three well-differentiated catalytic sites.

44 m (Pt) single atoms are exceptionally active catalytic sites.

45 bound reactants and five are remote from the catalytic sites.

46 affinity for ATP in both the allosteric and catalytic sites.

47 ng was hypothesized to prevent ATP access to catalytic sites.

48 e molecules to identify and titrate specific catalytic sites.

49 rfaces of the complex, which also harbor the catalytic sites.

50 identify structural matches to a library of catalytic sites.

51 positive co-operative interaction among its catalytic sites.

52 a route to custom design ligand-binding and catalytic sites.

53 eight small (RbcS) subunits containing eight catalytic sites.

54 tion sites are more densely populated at the catalytic sites.

55 from inhibitor release and rebinding to PNP catalytic sites.

56 s nSH2 to release its autoinhibition of p110 catalytic sites.

57 a large density of exposed surface reactive/catalytic sites.

58 can have access to both the ATP-binding and catalytic sites.

59 In contrast to catalytic-site ABL1 kinase inhibitors, ABL001 binds to t

60 y of the extended arrays of enantioselective catalytic sites achieve template-directed polymerization

61 highly conserved structural features of the catalytic sites across the class.

62 The architecture of the catalytic site also provided insights into the mechanism

63 find structural matches to a user-specified catalytic site among all Protein Data Bank proteins rapi

64 The presence of a structurally divergent catalytic site and a proline-rich C-terminal subdomain s

65 Multiple arginine residues, located near the catalytic site and at distal sites, can be the ADP-ribos

66 variants formed a distorted and inactivated catalytic site and confirmed that the pentamer interacti

67 S variants which affect the structure of the catalytic site and either decrease or increase the RNase

68 in an increase in the affinity of GTP at the catalytic site and full activation of sGC.

69 f a type II HE with a receptor analog in the catalytic site and identify the mutations underlying the

70 ws them to shuttle protons in and out of the catalytic site and reduce activation barriers.

71 entarity enhance peptide affinity beyond the catalytic site and support a limited selectivity model f

72 substantial differences in the cavity of the catalytic site and surface charge distribution contribut

73 terms that reflect the proficiencies of the catalytic site and the electron transfer pathway in each

74 nities, with the low-affinity site being the catalytic site and the high-affinity site on the protein

75 tudied, yet issues such as the nature of the catalytic site and the role of the reducible support rem

76 tial binding of an ATP molecule to its three catalytic sites and the release of the products of hydro

77 sr-like, cleavage domain containing a single catalytic site, and a C-terminal, SRA-like, 5hmC-binding

78 ent progress on the structure of the natural catalytic site, and on inorganic catalyst function, dete

79 een them was lost upon mutation of the AtMC1 catalytic site, and that the AtMC1 prodomain was not req

80 peptides identified on E3, two were from the catalytic site, and the third was from the interface dom

81 istidine residue in position 265 of the CdtB catalytic site appeared to play a role in the regulation

82 ce motif in the channel leading to the RNase catalytic site are both required for the protective effe

83 ising eight transmembrane alpha-helices, and catalytic site are distinct from those of other IMPs.

84 he ceramide binding pocket and putative zinc catalytic site are exposed to the inner membrane leaflet

85 ral elements in MRDI distal from the MTR-1-P catalytic site are responsible for the invasion phenotyp

86 ignals whereas bifunctional enzymes with two catalytic sites are believed to generate robustness agai

87 We propose the active catalytic sites are cationic interfacial Pt atoms bonded

88 The T1 Cu and the remote catalytic sites are connected via a Cys-His intramolecul

89 erns the relationship between the two ATPase catalytic sites: Are the sites independent of one anothe

90 We show that the Stealth domain harbors the catalytic site, as some mutations in these regions great

91 fic epitaxial growth of Au-Pd alloy horns as catalytic sites at the ends of Au nanorods.

92 The original version of the Catalytic Site Atlas (CSA) published in 2004, which cata

93 roMOL, based on definitions published in the Catalytic Site Atlas (CSA).

94 We also find that incorporating Catalytic Site Atlas attributes does not seem to provide

95 luate whether sequence identity, InterPro or Catalytic Site Atlas sequence signatures provide enough

96 on of CO2 can be achieved on multifunctional catalytic sites available at the metal/oxide interface b

97 The uniform catalytic sites available in MOFs provide a unique oppor

98 of the most kinase-proximal P-site-992, the catalytic site binding of which occurred exclusively in

99 -grained molecular simulations of the P-site/catalytic site binding reactions that precede EGFR self-

100 In the enzyme-DNA cocrystal, the single catalytic site binds two magnesium ions.

101 te inhibitors occupy both the 150 cavity and catalytic site but with alternating occupancy.

102 tutions cluster in regions adjacent to ATL's catalytic site, but the consequences for the GTPase's mo

103 h that can be used to develop more demanding catalytic sites, by derivatizing the surface of solids o

104 trates that NSAH functions by binding at the catalytic site (C-site) where it makes both common and u

105 ueprint for somatic mutations as well as the catalytic site can guide therapeutic targeting of PFK1 a

106 y, I show that bifunctional enzymes with two catalytic sites can exhibit both ultrasensitivity and co

107 spontaneous formation of multiple bimetallic catalytic sites capable to promote the cleavage of a RNA

108 Structural modeling and comparisons, catalytic-site changes and an interspecies chimera indic

109 dicts that this protease adopts a fold and a catalytic site characteristic of minimal PLP catalytic d

110 alent metal ion(s) (Mg(2+) or Mn(2+)) in its catalytic site: chelation of these metal cofactors is an

111 probed for local or global contributions to catalytic site chemistry by generating [15N, 2H]His8-PNP

112 iction is experimentally supported by slowed catalytic site chemistry in isotopically labeled PNP (13

113 [15N, 2H]His8-PNP had reduced catalytic site chemistry larger than proportional to the

114 Catalytic site chemistry was slowed for both [2H]PNP and

115 of the larger protein architecture to alter catalytic site chemistry.

116 y a flexible linker and is far away from the catalytic site, couples F-actin to the enhancement of re

117 on reduction of N2O occurs at a [Cu4(mu4-S)] catalytic site (CuZ*) embedded within the nitrous oxide

118 dentification of a putative C-terminal REase catalytic site D507-H508-N522.

119 ts with the N and C termini of Ago2, not the catalytic site defined by the convergence of the PAZ, MI

120 s revealed remarkable plasticity in the TcTS catalytic site, demonstrating, for the first time, how d

121 for organizing high concentrations of single catalytic sites derived from metallic or oxo-metallic no

122 erexpression of MMP19 with a mutation at the catalytic site did not impair epithelial-mesenchymal tra

123 t for the TSA of the phosphoryl group in the catalytic site differ by only approximately 5 degrees ,

124 tionships Knockdown of GAPDH1 expression and catalytic site disruption validate the essentiality of G

125 d-binding residues, ligand-binding affinity, catalytic sites, Enzyme Commission numbers, Gene Ontolog

126 Of these, isomaltooctaose bound in the catalytic site extended to the second sugar-binding site

127 ssing when only His are heavy supports local catalytic site femtosecond perturbations coupled to tran

128 d based on the crystal structure of the ASPH catalytic site followed by computer-assisted drug design

129 ening, and closes upon disengagement, of the catalytic site following ATP hydrolysis.

130 , enhance microtubule affinity and prime the catalytic site for ATP binding.

131 ains, whereas the DSP integrates them in the catalytic site for position-specific dephosphorylation.

132 xidation in the BFR cavity, to the di-ferric catalytic site for safe reduction of O2.

133 entral cavity facilitate the exposure of the catalytic site for substrate cleavage.

134 (i) the identification of the most relevant catalytic site for the oxygen reduction reaction (ORR) a

135 nanolayers, creating superactive nonmetallic catalytic sites for HER that are more active than those

136 l enzyme (which may employ either one or two catalytic sites for its opposing activities).

137 ngle reaction chamber provides access to all catalytic sites for the intramodule carrier domain.

138 er and yttrium oxides to subsequently act as catalytic sites for the outgrowth of Y(2)BaCuO(5) nanowi

139 ificance of the dimer pentamerization in the catalytic site formation remained elusive.

140 er interactions are essential for productive catalytic site formation.

141 polar aminoacyl-tRNA substrate to access the catalytic site from opposite directions.

142 nerates dimer and dNTP binding to the A2 and catalytic sites generates active tetramer.

143 ynamics of native and F159Y PNPs explore the catalytic-site geometry associated with these catalytic

144 ic uncoupling of femtosecond motions between catalytic site groups and reactants decreased transition

145 The [FeFe]-hydrogenase catalytic site H cluster is a complex iron sulfur cofact

146 erties of the intermediates of the H-cluster catalytic site have not yet been discretely defined.

147 Active catalytic sites have traditionally been analyzed based o

148 The catalytic site identification web server provides the in

149 orms an unusual funnel-like structure with a catalytic site in the cytoplasmic part and a hydrophilic

150 gineer charge clusters that loosely resemble catalytic sites in a scaffold protein with high thermody

151 th curated (968) and automatically annotated catalytic sites in enzyme structures, utilizing a new me

152 providing a physical connection between the catalytic sites in F(1) and the proton translocation cha

153 tic sites, which in turn can be used to find catalytic sites in new structures.

154 al results show that the S-vacancies are new catalytic sites in the basal plane, where gap states aro

155 A, carrying mutations at the predicted MTase catalytic sites in the L protein, were highly attenuated

156 ineating the structures and functions of the catalytic sites in two MMOs: soluble methane monooxygena

157 largely YC-independent fashion near the Wzb catalytic site, inducing allosteric changes therein.

158 target-guided synthesis to design the first catalytic site inhibitor of IDE suitable for in vivo stu

159 n conformation that exposes the transamidase catalytic site involved in protein-protein crosslinking.

160 The SelA catalytic site is close to the dimer-dimer interface, bu

161 The low-pH proton configuration in the catalytic site is deemed critical for the catalytic acti

162 The catalytic site is defined by a fortuitous benzoic acid m

163 detectable hydrolase activity, although its catalytic site is highly conserved with that of family 1

164 However, although the betaE-catalytic site is in the usual "open" conformation, it i

165 site, which selectively binds iron when the catalytic site is occupied.

166 The overall structure of the catalytic site is providing a framework on which to deve

167 se (TIM)'s dimer interface, distant from its catalytic site, is a target site for certain benzothiazo

168 eriplasmic loop of VirD4, in addition to its catalytic site, is essential for early-stage DNA substra

169 the homogeneous controls, likely a result of catalytic site isolation in the MOF which prevents bimol

170 event the placement of aminoacyl-tRNA in the catalytic site, it is commonly assumed that these drugs

171 The rapid effects of catalytic site ligands on conformational changes of F1-b

172 iction enzymes and contains the endonuclease catalytic-site motif of DX20EAK.

173 Extent, timing, and role of non-catalytic-site movements are unknown.

174 xpression of the wild-type gene, but not the catalytic-site mutant, partially rescued a Mendelian mut

175 However, analysis of catalytic site mutants revealed their GGDEF motifs are r

176 Using catalytic site mutants to create Rad50 dimers with only

177 lly blocked at integration by raltegravir or catalytic site mutations (IN(D64N/D116N/E152Q)).

178 Catalytic site mutations of D9 and D10, but not of eithe

179 p codons or activity of D10 was abrogated by catalytic site mutations, without other genomic alterati

180 is virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-typ

181 Duplex stems that support the catalytic site of a minimal type I hammerhead ribozyme w

182 with Ras.GTP binding as a substrate for the catalytic site of activated Sos more weakly than Ras.GDP

183 lar modeling indicated that DPI binds to the catalytic site of ALDH2, and this was confirmed by exper

184 placed between nucleosides 10 and 12, at the catalytic site of Argonaute.

185 Site-directed mutagenesis at the predicted catalytic site of C. crescentus HfsH phenocopied the Del

186 plified that are inhibitors that bind to the catalytic site of DNA gyrase and topoisomerase IV.

187 y of extension of mis-aligned primers in the catalytic site of DnaEBs.

188 ound clinical drug darunavir, located in the catalytic site of enzyme HIV-1 protease.

189 cleoside reversible inhibitor binding at the catalytic site of hRRM1 provides a starting point for th

190 tion suggests that 1a prefers binding at the catalytic site of hTMPK, whereas the hTMPK inhibitors th

191 redicted femtosecond dynamic coupling at the catalytic site of human purine nucleoside phosphorylase

192 d G-proteins support the conclusion that the catalytic site of MeaB is incomplete in the absence of t

193 n-like site is readily delivered to an empty catalytic site of metal-free HAO via an intermolecular t

194 ciated cleavage site does not fit within the catalytic site of MMP-8, a representative fibrillar coll

195 hich coordinates an Fe(II) ion and forms the catalytic site of non-heme iron enzymes.

196 tranded beta-helix fold that constitutes the catalytic site of PHD isoforms appeared responsible for

197 strate that KPT-6566 covalently binds to the catalytic site of PIN1.

198 lecule compound, 1E7-03, that targeted a non-catalytic site of PP1 and increased VP30 dephosphorylati

199 elevated accessibility of ester bonds to the catalytic site of RoL due to increasing polyester chain

200 protein structure predictions, the putative catalytic site of SMase activity is in the alpha2 region

201 emonstrate that inactivating mutation of the catalytic site of SULF1 impairs the above actions of SUL

202 via targeted amino acid substitution in the catalytic site of the C-terminal nucleotide binding doma

203 mpared it to the conformation adopted in the catalytic site of the EAL phosphodiesterases (PDEs).

204 onal changes in the enzyme, including in the catalytic site of the enzyme.

205 ernative splicing of the region encoding the catalytic site of the enzyme.

206 avity where the natural substrates reach the catalytic site of the enzyme.

207 enilins, polytopic proteins that contain the catalytic site of the gamma-secretase protease that rele

208 sensing the effects of ligand-binding to the catalytic site of the H-cluster.

209 e PRNTase (capping) domain projects into the catalytic site of the RdRp, where it appears to have the

210 the characteristics of the inhibitors of the catalytic site of this viral enzyme are reported.

211 iated biological activities, MIF possesses a catalytic site of unknown function between subunits of a

212 dies have shown a plausible structure of the catalytic site of UppP and thus provides insights into t

213 are completely inactive, indicating that the catalytic site of UppP is constituted by these two regio

214 the development of functional models of the catalytic sites of MMOs is described.

215 ggests that several key residues outside the catalytic sites of PEDV nsp5 probably impact NEMO cleava

216 TP or nucleotide-free) at the allosteric and catalytic sites of Sos was comprehensively characterized

217 NTP binding at the eight allosteric and four catalytic sites of the SAMHD1 tetramer.

218 to-tail arrangement causes the RFK and FMNAT catalytic sites of the two neighboring protomers to appr

219 show that one inhibitor, binding within the catalytic site, offers reduced susceptibility to known r

220 two regulatory phosphorylation sites and the catalytic site on human CaMKK2.

221 processes at highly active and well-defined catalytic sites on a light-harvesting electrode surface.

222 l are performed to investigate the nature of catalytic sites on ultrathin graphene sheets.

223 radation (LID) region of hTMPK and block the catalytic site or ATP-binding site, thus attenuating the

224 reported ASD substitutions are located near catalytic sites or within highly conserved regions of th

225 sting of a hydroxylase with a nonheme diiron catalytic site; pMMO is a membrane-bound metalloenzyme w

226 e of stacked tetramers oriented with exposed catalytic sites positioned along the edge of the polymer

227 albeit slightly altered in length and at the catalytic site, provided a clue to the mechanism of P1 D

228 and the "PSGH" fingerprint peptide near the catalytic site, providing structural insight into PgpB s

229 specific substitutions in or near the enzyme catalytic site (R152W, A246T, and D293N, N2 numbering),

230 1 is auto-inhibited through occlusion of the catalytic site rather than by allostery.

231 metal presented preferentially binds to the catalytic site rather than the rubredoxin-like site, whi

232 Thus, the PNP catalytic site recapture of DADMe-ImmH is highly favored

233 ion of loops delineating the entrance to the catalytic site represent the most likely molecular mecha

234 Dimerization brings together the two catalytic sites required for double-strand cleavage, and

235 such beta-strands to stabilize the disrupted catalytic site resided at IDE door subdomain for their d

236 chanical calculations incorporated a crucial catalytic site residue (D313), two magnesium atoms, and

237 ID 3TUU) structures show that Tyr132, a key catalytic site residue, undergoes significant rotational

238 tivity that was abrogated by mutation of the catalytic site residues.

239 of dual specificity phosphatases or to a non-catalytic site, respectively.

240 ral variations, including the absence of the catalytic site responsible for lysozyme inhibition.

241 S6, or disruption of its furin processing or catalytic sites restores focal adhesions, implicating it

242 ) --> DDD(610), which restores the ancestral catalytic site, results in loss of function in Metnase.

243 The catalytic sites, revealed by X-ray structures of optimiz

244 g mutations at a predicted methyltransferase catalytic site (rVSV-K1651A, -D1762A, and -E1833Q) or S-

245 y binding of metal salts is reported for the catalytic site-selective hydro-heteroarylation of dienes

246 , information may be transmitted to a remote catalytic site, selectively directing the formation of e

247 ites in photocatalytic HERs, resulting in a "catalytic site self-optimization".

248 proteasome barrel and restricting access to catalytic sites sequestered in the lumen of the structur

249 Catalytic-site small molecule inhibitors of the class II

250 and dynamics of the apo-state of the hPHPT1 catalytic site, suggesting that if Met95 oxidation alter

251 Matching to a catalytic site template from a GH9 cellulase and other a

252 tions revealed the key interactions with the catalytic site that are stabilized via chloride coordina

253 sidue contacts between the GS domain and the catalytic site that controls the formation and disruptio

254 ibits ATPase activity by stabilizing an open catalytic site that results in tight binding of inhibito

255 forts have targeted a cavity adjacent to the catalytic site (the 150-cavity) in addition to the prima

256 separate regions, including the phosphatase catalytic site, the calcium-binding region 3 (CBR3) loop

257 The phosphatase catalytic site, the CBR3 loop and the Calpha2 loop forme

258 With Na(+) at the catalytic site, the mechanism is observed to be sequenti

259 farther away a subpocket is located from the catalytic site, the more pronounced its role in selectiv

260 With Mg(2+) at the catalytic site, the self-cleavage mechanism is observed

261 (ED) substrate-docking site rather than the catalytic site, the sequence of which had only modest ho

262 At the catalytic site, the tetrahedral intermediate lies covale

263 ed structure and highly charged and reactive catalytic site, they have been regarded as "undruggable.

264 inhibitors into the carbonic anhydrase (CA) catalytic site, thus highlighting the relevant role of n

265 occupancy by a second at the transpeptidase catalytic site, thus lowering the minimal-inhibitory con

266 confirming that ethionine also uses the same catalytic site to form the product SAE.

267 well as its binding mode within the RNase H catalytic site to rationalize its selectivity.

268 are required to orient its acetyltransferase catalytic site to the methylated histone 3-bearing nucle

269 is mechanism, the electrostatic field in the catalytic site turns the electric dipole associated with

270 residue (Phe306), located 12 A away from the catalytic site type-2 Cu (T2Cu), profoundly affects intr

271 Bifunctional coupling of two different catalytic site types has often been invoked to explain e

272 A catalytic site typically consists of one or more atoms o

273 I-LtrI catalytic site variants with low activity could be rescu

274 ductively recruit ASXH to the wild-type BAP1 catalytic site via the ULD, resulting in loss of BAP1 ub

275 mutated heavy and light PNPs to increase the catalytic site vibrational freedom.

276 es predicted to influence the freedom of the catalytic site vibrational modes linked to heavy enzyme

277 In mutants where the C-terminal catalytic site was deleted but the WbdD-interaction site

278 he in cis interaction of P-site-992 with the catalytic site was facilitated by a cleft between the N-

279 ional HECT E3 ligase domain with a conserved catalytic site was identified in the C-terminal region o

280 inconspicuous Ala-to-Ser substitution in the catalytic site was key to the emergence of the type II H

281 olecule inhibitor (SMI#9) targeting the RAD6 catalytic site, we demonstrate that SMI#9 potentiates th

282 s dual specificity, which relies on a single catalytic site, we determined the crystal structure of e

283 pacts of 2'-5' linkage mutants in the pol II catalytic site, we revealed that the presence of 2'-5' l

284 binding domain (RBD) and neuraminidase (NA) catalytic site were identified.

285 te major conformational modifications at the catalytic site when complexed to exosite 1.

286 indicating that ADP can remain bound to the catalytic site where product release occurs for the dura

287 est a rearrangement of loops surrounding the catalytic site, where they extend into the hydrocarbon c

288 ity and understanding performance at defined catalytic sites, whereas the semiconductor bridge ensure

289 id residue positioned at the entrance to the catalytic site: whereas group 1 dandelion PPOs possess a

290 biquitin-binding surface is distant from the catalytic site, which allowed us to mutate this surface

291 at it engages a binding pocket away from the catalytic site, which explains its remarkable selectivit

292 comparison, to generate 3D templates of the catalytic sites, which in turn can be used to find catal

293 residues 110-115 form a mobile cap over the catalytic site, whose flexibility is involved in the swi

294 exosite I with segment Glu-35-Asp-47 and the catalytic site with the region Pro-49-Arg-56, which incl

295 chromesbact as electronic connectors for the catalytic sites with no fine tuning in DeltaEm_b require

296 n them provide opportunities for introducing catalytic sites with precisely defined structures.

297 into the catalytic chamber and disrupts the catalytic site within IDE door subdomain.

298 zygous MYSM1 missense mutation affecting the catalytic site within the deubiquitinase JAB1/MPN/Mov34

299 y by which the substrate is presented to the catalytic site within the enzyme.

300 Identifying the RNA-binding and putative catalytic sites within the DWV virion structure enables