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1 only a single chemical reaction is addressed catalytically.
2 may synergize with photon absorption and act catalytically.
3 of 1 further affords 14a, a chromene product catalytically.
4 sters as a sulfur source can nonetheless act catalytically.
5 uggests that 7-8 atom clusters are effective catalytically.
6 this study, we aimed to distinguish between catalytically active 3D molecules and those that build a
7 the analysis of the correlations between the catalytically active acid-base sites and reactants, it i
8 (kH/kD = 3.0 +/- 0.2), the isolation of the catalytically active alkoxide intermediate, and DFT-mode
9 , the peptide forms a hydrogel which is also catalytically active and maintains its reversible (de-)a
10 show that Thr(507)-phosphorylated deltaKD is catalytically active and not phosphorylated at Ser(359)
12 Ru(II) chloro complex was converted into the catalytically active aqua counterpart by a ligand exchan
18 ontaining full-length PNPase that was either catalytically active but unable to interact with RNase Y
20 rophile and nucleophile by in situ generated catalytically active cationic Pd(II) species facilitates
21 ia thailandensis, we show that delivery of a catalytically active CDI system toxin to immune (self) b
22 ter of single 6-rings that act not only as a catalytically active center, but also as a dealumination
23 ons can selectively channel that energy into catalytically active centres on the nanostructure shell.
25 HDACs may serve as a scaffold to recruit the catalytically active class I HDAC complexes to their sub
26 nal to the phosphorylated Ser/Thr to prime a catalytically active conformation, facilitating phosphor
31 dition, we report the X-ray structure of the catalytically active domain of TbTK in complex with dThd
32 ion from exo-protonated Ni(0) isomers to the catalytically active endo-isomers, but decreases the rat
35 composites, especially the Ag48Pd52/WO2.72, catalytically active for dehydrogenation of formic acid
36 ontrast to the disordered alloy NP, which is catalytically active for hydrogen evolution, ordered AuC
39 ORR activity on the PdCuM NPs stems from the catalytically active hollow sites arising from the ligan
40 growth factor receptor (HER3/ERBB3) and its catalytically active homologs EGFR and HER2 are essentia
41 tion of a new Ru(II) metallocavitand that is catalytically active in alkene epoxidation reactions.
44 , enabling the solvation dynamics around the catalytically active iridium sites to be robustly charac
46 and nitrogen-doped porous carbons containing catalytically active M-N x moieties (M = Mn, Fe, Co, Ni,
48 compartments has inspired the design of new catalytically active materials that self-assemble from b
49 nctional receptors, macrocyles, and cages to catalytically active metal complexes and helix mimics.
50 acts as a four-electron donor ligand to the catalytically active metal fragment [Cp*RuCl] but switch
52 Because of conflicting past reports, the catalytically active metal redox state of the catalyst h
55 etc. have been investigated by synthesizing catalytically active nanostructured TMDs in bulk quantit
57 is not clear whether all these molecules are catalytically active or what other function(s) they prov
58 pathway of increasing the surface density of catalytically active oxygen radical sites on a MoVTeNb o
59 terestingly, a detailed investigation of the catalytically active palladium species pointed toward a
62 d live cell-imaging techniques revealed that catalytically active PKA holoenzymes remained intact wit
65 no acids necessary to produce a foldable and catalytically active polypeptide have shown that a basis
67 sensor used the synergistic activity of the catalytically active Pt nanoparticles on a high surface
70 The atomic structure and identity of the catalytically active sites have been well established fo
71 ificantly increase the density of accessible catalytically active sites in them and facilitate the tr
73 foil enhances the number of low-coordinated catalytically active sites, which dramatically lowers th
77 ld electrodes is due to the formation of the catalytically active species [Mo(bpy)(CO)3](2-) via a se
78 resulting nanoswitch [Cu(2)](+) captures the catalytically active species from solution and the conju
79 icate that under experimental conditions the catalytically active species is [Cu(phen)(SAc)] regardle
82 itochondrial Hsp90, TRAP1, revealed that the catalytically active state is closed in a highly straine
83 chniques, we have obtained a cross-validated catalytically active state of Cas9 HNH domain primed for
84 , polyethylene glycol stabilizes the docked, catalytically active state of the ribozyme, in part thro
89 oteins' compromised ability to assemble into catalytically active supra-tetrameric filaments, as prev
90 adly tunable optical properties coupled with catalytically active surfaces that offer a unique opport
91 tophagy, is dependent on the localization of catalytically active TBK1 to the vicinity of cytosolic b
93 ng the oxidation and reduction mechanisms of catalytically active transition metal nanoparticles is i
94 When expressed in bacteria, yeast or plant, catalytically active variants of CaARP conferred toleran
95 These results demonstrate that XXT5 is a catalytically active xylosyltransferase involved in xylo
96 rate-binding site of MMP-13 and surround the catalytically active Zn(2+) ion without chelating to the
97 Furthermore, features associated with the catalytically active, enzyme-coordinated copper center w
98 can also be included by adding photoactive, catalytically active, or redox-active recognition sites,
99 iative extraction from base-oil molecules on catalytically active, sliding nanometre-scale crystallin
101 for the development of custom proteases that catalytically alter or destroy target proteins for biote
102 e solution was confirmed by monitoring their catalytically amplified collisions with a Hg-coated micr
105 ral cyclopentyl beta-amino esters are formed catalytically by [3+2] cycloaddition reactions of enecar
106 can rapidly and non-intrusively measure the catalytically coked zeolites with sample full body penet
108 e active sites and the di-domain linker form catalytically competent active sites and provide insight
109 straints imposed by the regulatory domain is catalytically competent and that Thr(507) phosphorylatio
110 GaMD also reveals the conformation of a catalytically competent Cas9, which is prone for catalys
111 interdomain interactions that stabilize the catalytically competent closed conformation of the polym
112 l domain of ArfA and RF2 help RF2 to adopt a catalytically competent conformation for peptide release
114 role of the helical domain in establishing a catalytically competent dimeric cyclase conformation.
115 almost isopotential, yet the enzyme retains catalytically competent electron transfer between quinon
116 bstrate while blocking probable formation of catalytically competent interactions with noncognate sub
117 ring reveals the di-iron bridging imido is a catalytically competent intermediate, one of several iro
118 absence of other proteins or cofactors (with catalytically competent kinetics) plus hydroxylated 17al
119 mes bound these less-phosphorylated IPs in a catalytically competent manner, suggesting that IP hydro
122 ransition from the 'initiation' state into a catalytically competent pentameric state, is accompanied
124 merase (RNAP)-promoter closed complex into a catalytically competent RNAP-promoter open complex.
128 ater molecules than occur in the (presumably catalytically competent) pre-transition state (preTS) cr
129 at SpUreG needs a "flexibility window" to be catalytically competent, with both too low and too high
131 its R789 arginine finger, but stabilizes the catalytically-competent conformation and pre-organizes c
132 avidin-horseradish peroxidase conjugate that catalytically converted the 3,3',5,5'-tetramethylbenzidi
133 verted into either a sulfinic/sulfonic acid (catalytically dead and irreversible inactivation) or a s
134 repression of the same lambda promoter by a catalytically dead CRISPR Cas9 protein gave either compr
137 N-null cells with either wild-type PTEN or a catalytically dead mutant stabilizes IP3R3 and induces p
139 Ectopic overexpression of SIRT2, but not its catalytically dead mutant, increased intracellular level
143 e mouse hippocampal CA3-CA1 pathway, but the catalytically-dead mutant did not affect LTD induction.
144 t with H2O2 (k = 2.9 x 10(7) M(-1)s(-1)) and catalytically decomposes H2O2 using Cc as the reducing s
145 mical warfare agents and their simulants are catalytically decontaminated by a new one-dimensional po
146 ng cells using a fusion protein containing a catalytically defective Streptococcus pyogenes Cas9, a c
147 e trans-acting AT to complement modules with catalytically deficient AT domains leads to enzyme acyla
148 Loss of H3K4me1 from enhancers in Mll3/4 catalytically deficient cells causes partial reduction o
150 monstrate that Drosophila embryos expressing catalytically deficient Trr eclose and develop to produc
154 involving dissociation of the ynoate from a catalytically dormant nickelacyclopentadiene intermediat
156 ucturally essential to ensure an optimal and catalytically efficient organization of the PTC, highlig
157 uctural studies indicate that TtuA carries a catalytically essential [4Fe-4S] cluster and requires AT
160 yl-l-methionine (SAM) enzyme that installs a catalytically essential glycyl radical on pyruvate forma
162 ur structural and biochemical studies reveal catalytically essential residues in the dimer-mediated a
165 t a mono-mu-hydroxo diferrous species is the catalytically functional state that reacts with NO and O
166 complexes also promotes nitrene transfer to catalytically generate asymmetric dialkylcarbodiimides f
167 eduction beyond the CO and formate level and catalytically generate products such as methanol is part
168 arbanion equivalents via the intermediacy of catalytically generated benzylcopper derivatives, provid
169 Additionally, the [3+1]-cycloaddition of catalytically generated metallo-enolcarbenes was success
170 results do not support a model in which Mad2 catalytically generates a Mad2-free APC/C inhibitor.
172 strong acid sites that make them very active catalytically, (ii) porosity through the layers and (iii
175 Therefore, determining which residues are catalytically important in this specialized RNase family
176 These data provide biochemical evidence for catalytically important interactions of the P4 helix of
177 coordinated motions and dynamically isolates catalytically important regions of the kinase domain.
180 pH-activity profiles identified at least one catalytically important, ionizable group with an apparen
185 characterized two HemO variants, one that is catalytically inactive (HemO H26A/K34A/K132A or HemOin)
186 We report here the crystal structure of a catalytically inactive (Y324F) mutant of this engineered
188 of non-repetitive coding sites, whereas the catalytically inactive ADAR3 predominantly acts as an in
191 tive but unable to interact with RNase Y, or catalytically inactive but able to interact with RNase Y
192 ckdown and demonstrated RNA editing by using catalytically inactive Cas13 (dCas13) to direct adenosin
193 ic cells using guide RNAs (sgRNAs) to target catalytically inactive Cas9 (dCas9) and offers an altern
194 nstrate that fusion of Tet1 or Dnmt3a with a catalytically inactive Cas9 (dCas9) enables targeted DNA
195 M1 to the cyclin B1 gene promoter via CRISPR-catalytically inactive Cas9 (dCas9) in MVM-infected cell
197 hrough a proteomic approach and the use of a catalytically inactive CLPP, we produced the first compr
198 xes, suggesting that these complexes adopt a catalytically inactive conformation probably important f
201 ctivity and secretion, overexpression of the catalytically inactive D478A FAM20C mutant was detected
204 ion activation of follistatin when used with catalytically inactive dCas9-VP64 or dCas9-p300core fusi
205 Moreover, the utp14 mutants that mimicked a catalytically inactive dhr1 mutant in vivo showed reduce
206 in the C-terminal half of the protein and a catalytically inactive dioxygenase-related N-terminal do
209 CRISPR associated protein 9 (SpCas9) and the catalytically inactive dSpCas9 protein fused to the amin
210 CI when sperm introduce it into eggs, and a catalytically inactive DUB does not induce sterility.
216 at reducing negative feedback (by expressing catalytically inactive ERK2) and increasing negative fee
217 These observations demonstrate that the catalytically inactive FIG4 protein provides significant
218 bilized, both in vitro and in cells, and are catalytically inactive for cognate histone H4 peptide ly
219 eral human polymorphic variants of NEIL1 are catalytically inactive for their DNA glycosylase activit
221 expression of wild-type METTL3, but not of a catalytically inactive form of METTL3, inhibits cell dif
223 tes exhibited a growth defect not rescued by catalytically inactive Glt1, indicating that the glycan
224 ed by the expression of wild type but not by catalytically inactive grk-2 or by the selective express
225 omparison of X-ray crystal structures of two catalytically inactive HigB variants with 70S-HigB bound
226 so effective but significantly less, whereas catalytically inactive JD was completely ineffective.
228 lasmic structures, compared to expression of catalytically inactive MCR-1 (E246A) or MCR-1 soluble co
230 inhibits translation, and both wild-type and catalytically inactive METTL3 promote translation when t
234 l-specific expression of either USP20 or its catalytically inactive mutant revealed anti-inflammatory
235 BIN1[D485N] mice to knock-in mice expressing catalytically inactive mutants of IRAK1 or IRAK4 prevent
237 the X-ray crystallographic structures of two catalytically inactive mutants of protein-tyrosine phosp
239 was actively transferred to a heme-depleted, catalytically inactive nitrate reductase, restoring its
240 nthetic substrate was co-crystallized with a catalytically inactive Phe substitution in the His-Asp c
241 ic pseudophosphatase STYX We reasoned that a catalytically inactive phosphatase might have adopted no
243 dependent on the J-domain of DNAJB6, as the catalytically inactive protein, which carries the H31Q m
245 challenged by new evidence revealing that a catalytically inactive Rab GAP promotes rather than term
249 hain can adopt and prevents the formation of catalytically inactive species upon metal ion binding.
250 substrates and is ordinarily maintained in a catalytically inactive state in the intestine and other
253 stored upon WT-TAK1 expression, but not with catalytically inactive TAK1-K63W, suggesting that TAK1 e
256 evels of uH2AK119, whereas overexpression of catalytically inactive UbE2E1_C131A or UbE2E1 knockdown
257 its these processes allosterically because a catalytically inactive Usp14 mutant also inhibited them.
260 MTase (sMTase) with one fragment fused to a catalytically-inactive Cas9 (dCas9) that directs the fun
267 activation, the fragmented ligands transform catalytically into closed-ring hexahydrotriazine product
269 entation on thousands of loci, generation of catalytically mutant MLL2/COMPASS demonstrated that H3K4
271 ng monomers but also, for the first time, to catalytically polymerize extended Michael systems, like
273 opted inward conformations consistent with a catalytically primed state and delineated a substrate ac
277 y, based on stoichiometric experiments under catalytically relevant conditions, a detailed mechanism
280 ion (PHIP) transfer NMR studies to elucidate catalytically relevant intermediates, as well as to esta
282 n used to image the basal {001} plane of the catalytically relevant M1 phase in MoVTeNb complex oxide
283 series of [Cu4(mu4-S)] model complexes with catalytically relevant oxidation states for the first ti
285 nds the active site, yet the exact nature of catalytically relevant protein motions remains largely u
286 itant generation of cross-coupled product at catalytically relevant rates, indicating the ability of
290 how ubiquinone/ubiquinol exchange occurs on catalytically relevant timescales, and whether binding/d
292 idazolate framework (ZIF-8) as MOF template, catalytically remarkably efficient ligand-free first-row
293 This platform unlocks an opportunity to catalytically repurpose three abundant, orthogonal feeds
294 as H3K27Me3 was thought to be stable and not catalytically reversible, the discovery of the Utx and J
295 h compounds proved to be ca. 10- to 100-fold catalytically superior to the diaryl selenides and their
296 lculations confirm that the Nb2O5 support is catalytically unique compared with other traditional oxi
297 tch can be isomerized to the more stable one catalytically upon reduction, permitting the optimizatio
298 probably a photo-oxidoreductase that employs catalytically useful Chl a molecules, tyrosine YZ, and p
299 8 , 1054 - 1060 ) was reported to produce H2 catalytically via EECC mechanism through a Ni-centered h
300 enerating system, both electron carriers act catalytically with apparent Km = 0.26 mum ferredoxin or
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