ライフサイエンスコーパス: catarrhalis

1 thogens Haemophilus influenzae and Moraxella catarrhalis .

2 termed pilin, which is encoded by pilA in M. catarrhalis.

3 with the ubiquitous surface protein A2 of M. catarrhalis.

4 valuated further as a vaccine antigen for M. catarrhalis.

5 ghly conserved among clinical isolates of M. catarrhalis.

6 y disease (COPD) who acquired and cleared M. catarrhalis.

7 cing of the genes in clinical isolates of M. catarrhalis.

8 ypes A, B, and C) in clinical isolates of M. catarrhalis.

9 the spent culture supernatant fluid from M. catarrhalis.

10 zae, Streptococcus pneumoniae, and Moraxella catarrhalis.

11 n the serum-resistant phenotype of Moraxella catarrhalis.

12 dies made specifically during carriage of M. catarrhalis.

13 esistance and a vaccine candidate against M. catarrhalis.

14 episodes of acquisition and clearance of M. catarrhalis.

15 and immunoassays to measure antibodies to M. catarrhalis.

16 be a potential vaccine candidate against M. catarrhalis.

17 idate antigen on the bacterial surface of M. catarrhalis.

18 arginine, a strict growth requirement of M. catarrhalis.

19 the production of lysozyme inhibitors by M. catarrhalis.

20 important nutritional virulence factor in M. catarrhalis.

21 of basic amino acids to support growth of M. catarrhalis.

22 ve candidate as a vaccine antigen against M. catarrhalis.

23 zed a substrate binding protein, SBP2, of M. catarrhalis.

24 ificantly contributes to the virulence of M. catarrhalis.

25 is and function of these phospholipids in M. catarrhalis.

26 Streptococcus spp., 0.06/0.12; for Moraxella catarrhalis, 0.06/0.12; for Staphylococcus spp., 0.12/0.

27 sites are methylated in the genome of the M. catarrhalis 25239 ModM2 on strain.

28 ates), H. influenzae (1545 isolates), and M. catarrhalis (456 isolates).

29 ransferase genes (lgt) were identified in M. catarrhalis 7169, a strain that produces a serotype B LO

30 f the complete LOS glycoform expressed by M. catarrhalis 7169.

31 lococcus epidermis; 15%, 10%, 16%, Moraxella catarrhalis; 9%, 25%, 19%, and Streptococcus Pneumonia;

32 cterium-host cell cocultures using Moraxella catarrhalis, a respiratory tract disease-causing bacteri

33 icensed vaccines available against Moraxella catarrhalis, a significant human respiratory pathogen.

34 The N-terminal portion of the M. catarrhalis acid phosphatase A (MapA) was most similar (

35 emonstrate that the involvement of Hag in M. catarrhalis adherence to A549 and HMEE cells is conserve

36 the MhaB proteins play distinct roles in M. catarrhalis adherence.

37 S) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the patho

38 dies comparing the abilities of wild-type M. catarrhalis and an isogenic TFP mutant to colonize the n

39 We focused our study on M. catarrhalis and found that PRELP binds the majority of c

40 M. catarrhalis and H. influenzae colonization of the airway

41 Colonization with M. catarrhalis and H. influenzae induced a mixed T helper c

42 n understanding human immune responses to M. catarrhalis and in elucidating the elements of a protect

43 Furthermore, these findings suggest that M catarrhalis and S pneumoniae contribute to the severity

44 e components of a novel TPS identified in M. catarrhalis and suggest that these proteins may be invol

45 nces membrane attack complex formation on M. catarrhalis and thus leads to increased serum sensitivit

46 to be localized to the outer membrane of M. catarrhalis and was not detected either in the soluble c

47 cutoffs were not found for S. aureus and M. catarrhalis, and a lack of confirmed case data limited t

48 larity to HumA, a heme receptor of Moraxella catarrhalis, and contains conserved motifs found in many

49 mutants in Neisseria meningitidis, Moraxella catarrhalis, and most recently in Acinetobacter baumanni

50 are expressed during human infection with M. catarrhalis, and represent potential vaccine antigens.

51 The immune response to H influenzae, M catarrhalis, and S pneumoniae was analyzed in 292 infant

52 thologs in Pseudomonas aeruginosa, Moraxella catarrhalis, and Staphylococcus aureus, bacteria that oc

53 neumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus.

54 luenzae, Streptococcus pneumoniae, Moraxella catarrhalis, and Staphylococcus aureus.

55 neumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus.

56 al strains Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae is associated

57 viously shown that expression of both the M. catarrhalis aniA (encoding a nitrite reductase) and norB

58 children with otitis media infected with M. catarrhalis, antibody levels against peptide A were sign

59 antigenic variation, the pilin subunit of M. catarrhalis appears to be more highly conserved as there

60 Many strains of Moraxella catarrhalis are resistant to the bactericidal activity o

61 oniae, Haemophilus influenzae, and Moraxella catarrhalis are the etiologic agents of acute bacterial

62 with S. pneumoniae, H. influenzae, and/or M. catarrhalis at 4 weeks of age.

63 Analysis of total RNA extracted from M. catarrhalis ATCC 43617 cells grown under iron-replete an

64 pen reading frame in the genome of Moraxella catarrhalis ATCC 43617 that was highly conserved among M

65 eotide sequence from the genome of Moraxella catarrhalis ATCC 43617 was annotated and used both to as

66 e passenger domain from another predicted M. catarrhalis autotransporter confirmed the translocation

67 unfinished genome sequence of a strain of M. catarrhalis available in the GenBank database was analyz

68 TFP-deficient M. catarrhalis bacteria exhibit diminished adherence to euk

69 In this study, we show that M. catarrhalis binds factor H via the outer membrane protei

70 ces phagocytic killing of serum-opsonized M. catarrhalis by human neutrophils in vitro.

71 over, COMP inhibits phagocytic killing of M. catarrhalis by human neutrophils.

72 In this report we have demonstrated that M. catarrhalis can also utilize hemin as a sole source of i

73 Moraxella catarrhalis causes otitis media in children and exacerba

74 normally extends from the surface of the M. catarrhalis cell.

75 dditionally, our studies demonstrate that M. catarrhalis cells form a mature biofilm in continuous-fl

76 were then used to analyze total RNA from M. catarrhalis cells grown in a continuous-flow biofilm sys

77 ion of global transcriptome expression by M. catarrhalis cells in vivo.

78 luble cytoplasmic fraction from disrupted M. catarrhalis cells or in the spent culture supernatant fl

79 We recently demonstrated that M. catarrhalis cells that express the nitrite reductase (An

80 thelial cells relevant to pathogenesis by M. catarrhalis (Chang, HEp2, A549, and/or 16HBE14o(-)).

81 l surface structures are expressed by all M. catarrhalis clinical isolates evaluated.

82 ontribution of TFP to the early stages of M. catarrhalis colonization.

83 thogens Streptococcus pyogenes and Moraxella catarrhalis colonize overlapping regions of the human na

84 Although Moraxella catarrhalis continues to be a significant cause of disea

85 Furthermore, M catarrhalis detected alongside rhinovirus increased the

86 M. catarrhalis DNA microarrays containing 70-mer oligonucle

87 unoinformatics tools were used to predict M. catarrhalis epitopes that could offer immunoprotection a

88 Two of the other three M. catarrhalis ETSU-9 transposon insertion mutants that had

89 periments showed that introduction of the M. catarrhalis ETSU-9 uspA2H gene into Escherichia coli con

90 Moraxella catarrhalis ETSU-9 was subjected to random transposon in

91 In this study, we discovered that M. catarrhalis expresses a cardiolipin synthase (CLS), term

92 ee isogenic pil mutants demonstrated that M. catarrhalis expresses type IV pili that are essential fo

93 ults with COPD make antibody responses to M. catarrhalis following infection, but little is known abo

94 or the previously unidentified tropism of M. catarrhalis for ciliated NHBE cells.

95 of generating large quantities of CD from M. catarrhalis for vaccine use, the CD gene from O35E was c

96 an lung epithelial cells, thus protecting M. catarrhalis from intracellular killing by epithelial cel

97 ctivity in immunogenicity and in clearing M. catarrhalis from mouse lungs.

98 howed significantly enhanced clearance of M. catarrhalis from the lung compared to that in the contro

99 ned from adults with COPD who had cleared M. catarrhalis from the respiratory tract following infecti

100 in-specific protection after clearance of M. catarrhalis from the respiratory tract.

101 who had acquired and subsequently cleared M. catarrhalis from their respiratory tracts were studied i

102 tant analysis was used to identify Moraxella catarrhalis gene products necessary for biofilm developm

103 We identified and cloned the M. catarrhalis genes encoding PilA, the major pilin subunit

104 Additionally, 200 M. catarrhalis genes were found to be downregulated when th

105 More than 100 M. catarrhalis genes were upregulated in vivo, including op

106 cription-PCR (RT-PCR) analyses identified M. catarrhalis genes whose expression was affected by oxida

107 The M. catarrhalis genome encodes a predicted truncated denitri

108 entified three open reading frames in the M. catarrhalis genome that encode homologues of the two-par

109 nsity of Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae, and Staphylococcus

110 binds respiratory tract pathogens Moraxella catarrhalis, Haemophilus influenzae, and Streptococcus p

111 M. catarrhalis has a growth requirement for arginine; thus,

112 M. catarrhalis has a putative oligopeptide permease ABC tra

113 D of nontypeable Haemophilus influenzae, M. catarrhalis has become a high-priority pathogen in otiti

114 Lipooligosaccharide (LOS) from Moraxella catarrhalis has the potential to elicit bactericidal ant

115 The sequenced M. catarrhalis hemagglutinin-like locus of strain 7169 has

116 A mutation in the M. catarrhalis hfq gene affected both the growth rate of th

117 Provision of the wild-type M. catarrhalis hfq gene in trans eliminated these phenotypi

118 The presence of the wild-type M. catarrhalis hfq gene in trans in an E. coli hfq mutant f

119 This M. catarrhalis hfq mutant exhibited altered expression of s

120 gene whose expression was altered in the M. catarrhalis hfq mutant.

121 tic mobility shift assay showed that this M. catarrhalis Hfq protein could bind RNA derived from a ge

122 The C-terminal half of the M. catarrhalis Hfq protein was very hydrophilic and contain

123 M. catarrhalis HumA expressed on the surface of an Escheric

124 t promising peptide-based vaccine against M. catarrhalis Immunoinformatics predicts that it should ha

125 episodes of acquisition and clearance of M. catarrhalis in 50 patients; 57 (47.5%) of the acquisitio

126 Growth of Moraxella catarrhalis in a biofilm resulted in marked upregulation

127 These results indicate that growth of M. catarrhalis in a biofilm results in increased expression

128 ppA and resulted in enhanced clearance of M. catarrhalis in a mouse pulmonary clearance model.

129 wn about the mucosal antibody response to M. catarrhalis in adults with COPD.

130 nding of COMP correlates with survival of M. catarrhalis in human serum by inhibiting bactericidal ac

131 Neisseria meningitidis, as well as Moraxella catarrhalis in humans.

132 best 3 peptides and then challenged with M. catarrhalis in the pulmonary clearance model.

133 ons and is critical for full virulence of M. catarrhalis in the respiratory tract in facilitating int

134 erstanding the mucosal immune response to M. catarrhalis in the setting of COPD and in elucidating th

135 Little is known about the role of M. catarrhalis in this common disease.

136 al cell lines relevant to pathogenesis by M. catarrhalis, including NCIH292 lung cells, middle ear ce

137 asopharyngeal tissues isolated from these M. catarrhalis-infected animals revealed the presence of si

138 known about the human immune response to M. catarrhalis infection in vivo.

139 COPD patients who had recently cleared an M. catarrhalis infection to serum samples collected prior t

140 in the pathogenesis and host response to M. catarrhalis infections are warranted.

141 in the pathogenesis and host response to M. catarrhalis infections are warranted.

142 will likely decrease acute and recurrent M. catarrhalis infections in prone populations.

143 ldren, it is likely that the incidence of M. catarrhalis infections will continue to rise.

144 A vaccine to prevent M. catarrhalis infections would have an enormous global imp

145 so showed reduced lung inflammation after M. catarrhalis infections.

146 s would benefit from a vaccine to prevent M. catarrhalis infections.

147 ines or therapeutic interventions against M. catarrhalis infections.

148 l cells and antibodies against it inhibit M. catarrhalis interactions with the receptor.

149 Moraxella catarrhalis is a causative agent of otitis media in chil

150 Moraxella catarrhalis is a common cause of otitis media in childre

151 Moraxella catarrhalis is a common respiratory tract pathogen that

152 Moraxella catarrhalis is a Gram-negative aerobic diplococcus that

153 Moraxella catarrhalis is a gram-negative mucosal pathogen of the h

154 Moraxella catarrhalis is a Gram-negative obligate aerobe that is a

155 Moraxella catarrhalis is a human pathogen causing otitis media in

156 Moraxella catarrhalis is a human pathogen that causes otitis media

157 Moraxella catarrhalis is a human respiratory tract pathogen that c

158 Moraxella catarrhalis is a major cause of acute otitis media in yo

159 Moraxella catarrhalis is a respiratory tract pathogen commonly cau

160 Moraxella catarrhalis is a significant cause of otitis media and e

161 Moraxella catarrhalis is a strict human pathogen that causes otiti

162 Moraxella catarrhalis is a ubiquitous human-specific bacterium com

163 uggesting that nitric oxide catabolism in M. catarrhalis is accomplished primarily by the norB gene p

164 Moraxella catarrhalis is an established pathogen that is causing s

165 Moraxella catarrhalis is an exclusively human pathogen that is an

166 Moraxella catarrhalis is an important bacterial cause of otitis me

167 Moraxella catarrhalis is an important cause of otitis media in chi

168 Moraxella catarrhalis is an important cause of respiratory infecti

169 Moraxella catarrhalis is an important cause of respiratory infecti

170 Moraxella catarrhalis is an important human mucosal pathogen causi

171 Moraxella catarrhalis is an important respiratory tract pathogen,

172 ter membrane protein CD (OMPCD) of Moraxella catarrhalis is an outer membrane protein with several at

173 ion with S. pneumoniae, H. influenzae, or M. catarrhalis is associated with increased risk of pneumon

174 The outer membrane protein CD of Moraxella catarrhalis is considered to be a potential vaccine anti

175 nstrated that the zinc ABC transporter of M. catarrhalis is critical for invasion of respiratory epit

176 Moraxella catarrhalis is frequently present in the sputum of adult

177 er methylated arginine supports growth of M. catarrhalis is important in understanding fitness in the

178 ant because an intracellular reservoir of M. catarrhalis is present in the human respiratory tract an

179 zation of the human nasopharynx by Moraxella catarrhalis is presumed to involve attachment of this ba

180 Moraxella catarrhalis is subjected to oxidative stress from both i

181 major outer membrane component of Moraxella catarrhalis, is a possible virulence factor in the patho

182 The hag gene product of M. catarrhalis isolate O35E was expressed in the heterologo

183 clearance of both O35E and a heterologous M. catarrhalis isolate, TTA24.

184 total of 7,860 community-acquired Moraxella catarrhalis isolates (SENTRY Antimicrobial Surveillance

185 equence of mclS is highly conserved among M. catarrhalis isolates and is predicted to encode a protei

186 were cross-reactive towards six different M. catarrhalis isolates and promoted bacterial clearance of

187 Moraxella catarrhalis isolates express lipooligosaccharide (LOS) m

188 nic mclS mutant strains were generated in M. catarrhalis isolates O35E, O12E, and McGHS1 and containe

189 to human cells, the hag genes from three M. catarrhalis isolates were cloned and expressed in a nona

190 were cross-reactive towards 24 different M. catarrhalis isolates.

191 Therefore, M. catarrhalis lgt3 was introduced into a defined beta(1-4)

192 M. catarrhalis likely causes approximately 10% of exacerbat

193 tanding of the humoral immune response to M. catarrhalis LOS epitopes developed during natural infect

194 genes was identified in the three Moraxella catarrhalis LOS serotype strains.

195 ction and characterization of an isogenic M. catarrhalis lpxA mutant in strain O35E.

196 Cloning and expression of the M. catarrhalis mapA gene in Escherichia coli confirmed the

197 verse respiratory pathogens: NTHI, Moraxella catarrhalis (MC), Streptococcus pneumoniae (SP), and non

198 major phospholipid constituents of Moraxella catarrhalis membranes are phosphatidylglycerol, phosphat

199 microg/mL; MIC(90), 0.015 microg/mL) and M. catarrhalis (MIC(50), 0.06 microg/mL; MIC(90), 0.12 micr

200 ation by Staphylococcus species or Moraxella catarrhalis might involve symptom appearance in pre-seas

201 he human host and establish an infection, M. catarrhalis must be able to effectively attach to the re

202 Moraxella catarrhalis (Mx) is a common cause of otitis media and e

203 inds the majority of clinical isolates of M. catarrhalis (n = 49) through interaction with the ubiqui

204 that the majority of clinical isolates of M. catarrhalis (n = 49), but not other tested bacterial pat

205 In this study, we constructed an M. catarrhalis norB mutant and showed that planktonic growt

206 mation were used to construct a series of M. catarrhalis O12E strains that differed only in the numbe

207 Testing of M. catarrhalis O35E katA and ahpC mutants for their abiliti

208 AniA protein is bactericidal for a Moraxella catarrhalis O35E norB mutant but not for wild-type O35E

209 or NsrR under aerobic conditions and that M. catarrhalis O35E nsrR mutants are unable to grow in the

210 pA and lipB did not affect the ability of M. catarrhalis O35E to attach to a human bronchial epitheli

211 Moraxella catarrhalis O35E was shown to synthesize a 105-kDa prote

212 This is the first report of M. catarrhalis ompCD mutants, and our findings demonstrate

213 vaccines derived from individual serotype M. catarrhalis only showed partial protection coverage.

214 ction with Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae (odds ratio [OR

215 enty-four hours after inoculation, viable M. catarrhalis organisms were recovered from the nasal cavi

216 nfluenzae, P = 7.1 x 10(-10)), TNF-alpha (M. catarrhalis, P = 1.5 x 10(-9); H. influenzae, P = 5.9 x

217 nd macrophage inflammatory protein-1beta (M. catarrhalis, P = 1.6 x 10(-11); H. influenzae, P = 2.7 x

218 17 response with high levels of IL-1beta (M. catarrhalis, P = 2.2 x 10(-12); H. influenzae, P = 7.1 x

219 Although little is known about M. catarrhalis pathogenesis, our laboratory has previously

220 available regarding the initial steps of M. catarrhalis pathogenesis, this organism must be able to

221 al system for studying the early steps of M. catarrhalis pathogenesis.

222 This newly described M. catarrhalis protein, termed HumA, is capable of directly

223 treptococcus pneumoniae (range, 39%-57%), M. catarrhalis (range, 63%--69%), and S. aureus (range, 9%-

224 nd 11% for H influenzae, S pneumoniae, and M catarrhalis, respectively, with detection of rhinovirus

225 Colonization densities of M. catarrhalis, S. aureus, and P. jirovecii are unlikely to

226 Colonization of the hypopharynx with M. catarrhalis, S. pneumoniae, H. influenzae, and Staphyloc

227 Moraxella catarrhalis, S. pyogenes, and culture-negative episodes

228 assay (ELISA), containing the three major M. catarrhalis serotypes together with a complete series of

229 M. catarrhalis serum resistance was dramatically decreased

230 rrhoea, Haemophilus influenzae and Moraxella catarrhalis share the property of targeting the carcinoe

231 immunoglobulin A (IgA) is the predominant M. catarrhalis-specific immunoglobulin isotype and that the

232 iation for Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jir

233 ilT, and pilQ mutants were constructed in M. catarrhalis strain 7169.

234 e introduction of the same mutations into M. catarrhalis strain ETSU-4 showed that the growth of a ET

235 h the uspA2 gene from the serum-sensitive M. catarrhalis strain MC317.

236 Inactivation of the mapA gene in M. catarrhalis strain O35E reduced the acid phosphatase act

237 ntire uspA2 gene from the serum-resistant M. catarrhalis strain O35E resulted in a serum-sensitive ph

238 identified three gene products of Moraxella catarrhalis strain O35E that resemble TPS proteins and d

239 ulator, was identified and inactivated in M. catarrhalis strain O35E, resulting in an increase in sen

240 to be an adhesin expressed by the Moraxella catarrhalis strain O35E, which also displays esterase an

241 A spontaneous UspA2H-negative variant of M. catarrhalis strain O46E, designated O46E.U2V, was found

242 fractory to transposon mutagenesis, so an M. catarrhalis strain was constructed that was both able to

243 osition on four different serum-resistant M. catarrhalis strains and their serum-sensitive uspA2 muta

244 TCC 43617 that was highly conserved among M. catarrhalis strains and which encoded a predicted protei

245 Many Moraxella catarrhalis strains are resistant to the bactericidal ac

246 njugates provides protection against most M. catarrhalis strains by eliciting humoral and cellular im

247 Moraxella catarrhalis strains can express either a UspA2 protein o

248 The use of mutant and recombinant M. catarrhalis strains confirmed that the ORF113 protein wa

249 tive effect on biofilm formation by these M. catarrhalis strains in the crystal violet-based assay.

250 erial clearance of all three serotypes of M. catarrhalis strains in vaccinated mice, but also elevate

251 om the uspA2 genes in the serum-resistant M. catarrhalis strains O35E and O12E resulted in a drastic

252 nd C followed by challenge with different M. catarrhalis strains of three serotypes.

253 quence analysis of mcaP from eight Moraxella catarrhalis strains revealed that the gene product is hi

254 quence analysis of the mapA gene from six M. catarrhalis strains showed that this protein was highly

255 The wild-type M. catarrhalis strains that formed the most extensive biofi

256 ment regulator C4b-binding protein by the M. catarrhalis strains used in this study was found to be h

257 protein Hag in the adherence of multiple M. catarrhalis strains was examined.

258 ) of the uspA2 genes in several different M. catarrhalis strains were shown to contain various number

259 ssion of aniA and norB in three different M. catarrhalis strains, as measured by both DNA microarray

260 istribution of modM alleles in a panel of M. catarrhalis strains, isolated from the nasopharynx of he

261 o be present in the uspA2H genes of other M. catarrhalis strains.

262 expression of serum resistance by certain M. catarrhalis strains.

263 the pathogenic bacterial species, Moraxella catarrhalis, Streptococcus pneumoniae, and Haemophilus i

264 ble Haemophilus influenzae (NTHi), Moraxella catarrhalis, Streptococcus pyogenes, and culture-negativ

265 ORFs encoding several well-characterized M. catarrhalis surface proteins including Hag, McaP, and Mc

266 sporter that is present in all strains of M. catarrhalis tested.

267 proteins involved in the biosynthesis of M. catarrhalis TFP and determined that the TFP expressed by

268 done on Neisseria meningitidis and Moraxella catarrhalis; the two other organisms with this capabilit

269 A2 is involved in the serum resistance of M. catarrhalis; this represents the first example of vitron

270 ELP enhances host innate immunity against M. catarrhalis through increasing complement-mediated attac

271 odies were found to decrease adherence of M. catarrhalis to A549 human lung cells by up to 47% and to

272 ly shown to be involved in the ability of M. catarrhalis to both attach to human cell lines in vitro

273 could contribute to the ability of Moraxella catarrhalis to colonize the human nasopharynx.

274 s used to determine whether attachment of M. catarrhalis to human bronchial epithelial (HBE) cells in

275 a lipoprotein essential to the ability of M. catarrhalis to persist in an animal model.

276 ly shown to be involved in the ability of M. catarrhalis to persist in the chinchilla nasopharynx wer

277 resulted in a decrease in the ability of M. catarrhalis to survive in the chinchilla nasopharynx ove

278 evenfold, thereby demonstrating that this M. catarrhalis TPS system directly mediates binding to huma

279 -reactivity toward all three serotypes of M. catarrhalis under transmission electron microscopy.

280 r findings uncover a novel mechanism that M. catarrhalis uses to evade host innate immunity.

281 antibiotic resistance cartridge into the M. catarrhalis uspA2 gene resulted in the conversion of a s

282 M. catarrhalis usually resists complement-mediated serum ki

283 ere atraumatically inoculated with Moraxella catarrhalis via the nasal route.

284 in sham-inoculated animals confirmed that M. catarrhalis was exposed to significant host-derived fact

285 such as Haemophilus influenzae and Moraxella catarrhalis was found to be associated with the highest

286 potential role of TFP in colonization by M. catarrhalis was further investigated using in vivo studi

287 The genes were transcribed when M. catarrhalis was grown in vitro.

288 No growth of wild-type M. catarrhalis was observed in minimal medium in which argi

289 The duration of carriage of M. catarrhalis was shorter with exacerbations compared with

290 tudy indicated that a wild-type strain of M. catarrhalis was very resistant to killing by exogenous h

291 treptococci, Haemophilus spp., and Moraxella catarrhalis were minimal due to the high potency of ceft

292 oniae, Haemophilus influenzae, and Moraxella catarrhalis were performed on all nasal samples.

293 oniae, Haemophilus influenzae, and Moraxella catarrhalis were significantly associated with AOM (P <

294 oniae, Haemophilus influenzae, and Moraxella catarrhalis) were identified in airway secretions sample

295 Moraxella catarrhalis, which depends on adherence to epithelial ce

296 The respiratory pathogen Moraxella catarrhalis, which resides in the mucosa, is highly resi

297 Testing of 11 additional serum-resistant M. catarrhalis wild-type isolates and their uspA1 and uspA2

298 roscopy experiments demonstrated that the M. catarrhalis wild-type isolates O35E, O12E, TTA37, V1171,

299 pecifying the putative transporter of the M. catarrhalis wild-type strains O35E, O12E, and McGHS1 res

300 o-component signal transduction system in M. catarrhalis yielded a mutant unable to grow in liquid me