ライフサイエンスコーパス: catechol-O-methyltransferase

1 e modified by variation in the gene encoding catechol O-methyltransferase.

2 thionine ([3H]SAM) in presence of endogenous catechol-O-methyltransferase.

3 od substrates for recombinant and endogenous catechol-O-methyltransferase.

4 hylation of select tyrphostins by endogenous catechol-O-methyltransferase.

5 In genetically modified mice with reduced catechol-O-methyltransferase activity there was selectiv

6 Inhibition of catechol-O-methyltransferase activity with tyrphostin AG

7 ethylated to less polar monomethyl ethers by catechol-O-methyltransferase, an enzyme present in many

8 ently reported isotope-effect variations for catechol-O-methyltransferase and its mutant structures.

9 e involves three enzymes: monoamine oxidase, catechol O-methyltransferase, and sulfotransferase.

10 receptor, ATP-binding cassette subfamily B, catechol-O-methyltransferase, and cytochrome 2D6 current

11 mechanism of inhibition by quercetin of the catechol O-methyltransferase-catalyzed O-methylation of

12 Catechol-O-methyltransferase catalyzes the methylation o

13 allele encoding the low activity variant of catechol O-methyltransferase (COMT) and aggressive behav

14 The human gene for catechol O-methyltransferase (COMT) contains a common po

15 Human catechol O-methyltransferase (COMT) contains three commo

16 The catechol O-methyltransferase (COMT) gene affects how lon

17 ional polymorphism (Val(108/158) Met) in the catechol O-methyltransferase (COMT) gene and eye trackin

18 etween the Val158/108Met polymorphism of the catechol O-methyltransferase (COMT) gene and schizophren

19 tional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene underlies some

20 could result from haploinsufficiency of the catechol O-methyltransferase (COMT) gene, located within

21 tional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene.

22 uenced by a valine/methionine variant in the catechol O-methyltransferase (COMT) gene.

23 Catechol O-methyltransferase (COMT) inhibitors are an es

24 In the prefrontal cortex, the enzyme catechol O-methyltransferase (COMT) is critical in the m

25 Catechol O-methyltransferase (COMT) is the enzyme respon

26 Catechol O-methyltransferase (COMT) plays important role

27 The catechol O-methyltransferase (COMT) Val158Met polymorphi

28 Catechol O-methyltransferase (COMT), the major enzyme de

29 Catechol O-methyltransferase (COMT)-catalyzed methylatio

30 Using catechol O-methyltransferase (COMT, EC 2.1.1.6) and thio

31 in Parkinson's disease, namely the genes for catechol-O-methyltransferase (COMT Val(158)Met) and micr

32 The catechol-O-methyltransferase (COMT) 158Val --> Met polym

33 ltransferase activity, the methyltransferase catechol-O-methyltransferase (COMT) and a known selectiv

34 ies of genetic variation in these systems in catechol-O-methyltransferase (COMT) and in metabotropic

35 he genotype of the Val158Met polymorphism in catechol-O-methyltransferase (COMT) as an index of relat

36 Participants were genotyped for catechol-O-methyltransferase (COMT) at the Val158Met loc

37 Human catechol-O-methyltransferase (COMT) catalyzes a methyl t

38 Catechol-O-methyltransferase (COMT) catalyzes the methyl

39 Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-meth

40 i) to determine whether polymorphisms in the catechol-O-methyltransferase (COMT) gene affect the rela

41 The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activit

42 methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associ

43 ect of the Val108/158Met polymorphism in the catechol-O-methyltransferase (COMT) gene in children bef

44 The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene is an important

45 functional polymorphism (Val(158)Met) in the catechol-O-methyltransferase (COMT) gene is associated w

46 The catechol-O-methyltransferase (COMT) gene is located in t

47 Functional genetic variants in the catechol-O-methyltransferase (COMT) gene result in a dif

48 In particular, the catechol-O-methyltransferase (COMT) gene, located on chr

49 ional polymorphism (Val(108/158) Met) in the catechol-O-methyltransferase (COMT) gene, which accounts

50 a functional polymorphism (Val158Met) in the catechol-O-methyltransferase (COMT) gene, whose protein

51 r (OPRM1), multidrug resistance (ABCB1), and catechol-o-methyltransferase (COMT) genes are associated

52 hisms in the dopamine transporter (DAT1) and catechol-O-methyltransferase (COMT) genes.

53 or placebo (n = 537) and were stratified by catechol-O-methyltransferase (COMT) genotype activity (h

54 A functional polymorphism in the gene for catechol-O-methyltransferase (COMT) has been shown to af

55 Catechols are O-methylated by catechol-O-methyltransferase (COMT) in a SAM consuming r

56 Administering L-dopa with a catechol-O-methyltransferase (COMT) inhibitor to block i

57 Catechol-O-methyltransferase (COMT) inhibitors delay the

58 Catechol-O-methyltransferase (COMT) is a key enzyme for

59 Catechol-O-methyltransferase (COMT) is a key enzyme in t

60 Catechol-O-methyltransferase (COMT) is a key regulator o

61 Catechol-O-methyltransferase (COMT) is a major enzyme co

62 O-Methylation catalyzed by catechol-O-methyltransferase (COMT) is a Phase II metabo

63 The gene encoding catechol-O-methyltransferase (COMT) is a strong candidat

64 Catechol-O-methyltransferase (COMT) is one of the major

65 The Val158Met polymorphism of human catechol-o-methyltransferase (COMT) is one of the most w

66 Catechol-O-methyltransferase (COMT) metabolizes dopamine

67 Catechol-O-methyltransferase (COMT) modulates dopamine l

68 human TR3 gene overlapped with the gene for catechol-O-methyltransferase (COMT) on a complementary D

69 Catechol-O-methyltransferase (COMT) plays an important r

70 Catechol-O-methyltransferase (COMT) plays both a regulat

71 uals homozygous for the met158 allele of the catechol-O-methyltransferase (COMT) polymorphism (val158

72 Additionally, catechol-O-methyltransferase (COMT) polymorphism has bee

73 our-hour urinary hydroxytyrosol and HVAL and catechol-O-methyltransferase (COMT) rs4680 genotypes wer

74 Here we show that pregnant mice deficient in catechol-O-methyltransferase (COMT) show a pre-eclampsia

75 as a function of baseline PFC DA [indexed by catechol-O-methyltransferase (COMT) Val(158)Met genotype

76 cortex plasticity, while additionally taking catechol-O-methyltransferase (COMT) Val158Met and kidney

77 The catechol-O-methyltransferase (COMT) val158met polymorphi

78 authors assessed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphi

79 t study, we address the role of the gene for catechol-O-methyltransferase (COMT), a key modulator of

80 els are associated with genetic variation in catechol-O-methyltransferase (COMT), a regulatory enzyme

81 oratory has identified an early reduction in catechol-O-methyltransferase (COMT), an enzyme responsib

82 Catechol-O-methyltransferase (COMT), an important therap

83 he DAT1 VNTR and functional polymorphisms in catechol-O-methyltransferase (COMT), DRD2, and DRD4 were

84 O-Methylation, catalyzed by catechol-O-methyltransferase (COMT), inactivates catecho

85 metabolite of estradiol and is generated by catechol-o-methyltransferase (COMT), induces invasion of

86 Enzymatic methyl transfer, catalyzed by catechol-O-methyltransferase (COMT), is investigated usi

87 in inactivating and packaging NE, including catechol-O-methyltransferase (COMT), monoamine oxidase-A

88 is amplified by allelic variants in a gene, catechol-O-methyltransferase (COMT), regulating catechol

89 (OPRD1), cannabinoid receptor 1 (CNR1), and catechol-o-methyltransferase (COMT), was strongly associ

90 enols are very rapidly O-methylated by human catechol-O-methyltransferase (COMT), we are interested i

91 ion of a fungal tyrosinase and the mammalian catechol-O-methyltransferase (COMT), which can effect th

92 he enzymes proline dehydrogenase (PRODH) and catechol-O-methyltransferase (COMT), which modulate the

93 s and quercetin strongly inhibit human liver catechol-O-methyltransferase (COMT)-mediated O-methylati

94 n the expression of tyrosine hydroxylase and catechol-O-methyltransferase (COMT).

95 ent in humans is the Val/Met polymorphism in catechol-O-methyltransferase (COMT).

96 he rs4680 single-nucleotide polymorphism for catechol-O-methyltransferase (COMT).

97 ulated by the dopamine transporter (DAT) and catechol-O-methyltransferase (COMT).

98 he frontal cortex is critically dependent on catechol-O-methyltransferase (COMT).

99 ith a functional polymorphism (Val158Met) in catechol-O-methyltransferase [COMT], a gene that indexes

100 estradiols to methoxyestradiols (mediated by catechol-O-methyltransferase, COMT).

101 gle gene regions (e.g. opioid receptor mu-1, catechol-O-methyltransferase, cytochrome P450 2D6) and o

102 y of properties is observed between GNMT and catechol O-methyltransferase, despite significant differ

103 unctional polymorphism (val(158)-met) in the catechol O-methyltransferase gene, which has been shown

104 enotype at the Val158Met polymorphism of the catechol-O-methyltransferase gene predicts both impulsiv

105 The COMT (catechol-O-methyltransferase) gene has been linked to a

106 r common mutations in the human factor V and catechol-O-methyltransferase genes.

107 Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at in

108 le nucleotide tandem repeat, and the Val/Val catechol-O-methyltransferase genotype had greater decrea

109 ormance (p < 0.002) and with the val(158)met catechol-O-methyltransferase genotype.

110 a proof-of-concept, we study three enzymes (catechol-O-methyltransferase, glucose-6-phosphate dehydr

111 hydroxyestradiol by hamster kidney cytosolic catechol O-methyltransferase (IC50 approximately 10-14 m

112 in which we administered the brain penetrant catechol-O-methyltransferase inhibitor tolcapone or plac

113 a novel, once-daily, potent third-generation catechol-O-methyltransferase inhibitor.

114 g several other medications, such as MAOBIs, catechol-O-methyltransferase inhibitors, or dopamine ago

115 ibution of ER proteins, such as calnexin and catechol-O-methyltransferase, into a large centrosomal a

116 te to changes in cortical dopamine levels as catechol-O-methyltransferase is the main mode of inactiv

117 22q11.2 deletion syndrome, we identified the catechol-O-methyltransferase low-activity allele (COMT(L

118 the differential activity of membrane-bound catechol-O-methyltransferase (MB-COMT) due to altered pr

119 enosyl-L-homocysteine, a potent inhibitor of catechol-O-methyltransferase-mediated methylation of 3,4

120 oncompetitive inhibitor of DNMTs) during the catechol-O-methyltransferase-mediated O-methylation of t

121 enes also implicated in schizophrenia (e.g., catechol-O-methyltransferase, neuregulin-1).

122 10 homozygous for Val/Val and 10 for Met/Met catechol-O-methyltransferase polymorphisms) underwent (1

123 e-derivatives like 3-iodothyronamine (T1AM), catechol-O-methyltransferase products like 3-methoxytyra

124 A common polymorphism in the human gene for catechol-O-methyltransferase results in replacement of V

125 r O-methylation by human recombinant soluble catechol-O-methyltransferase (S-COMT) is a feasible deto

126 aken together, we concluded that CTOMT1 is a catechol-O-methyltransferase that produces guaiacol in t

127 We used the well-characterized enzyme catechol O-methyltransferase to demonstrate that the ass

128 hic Parkinson's disease as a function of the catechol-O-methyltransferase Val(158)Met polymorphism us