ライフサイエンスコーパス: catenane

1 for the synthesis of a covalently closed DNA catenane.

2 the pi-donor ring by the pi-acceptor ring [2]catenane.

3 the product of recombination is a four-node catenane.

4 pology (the Lk value) of the constructed DNA catenane.

5 tted DNA molecule is a right-hand four-noded catenane.

6 are specifically linked to form a four-noded catenane.

7 e structure and a linked DNA circle within a catenane.

8 links, Borromean rings, and a Star of David catenane.

9 gly interlocked rings), the simplest type of catenane.

10 ally isomeric with the doubly interlocked [2]catenane.

11 nce state within the rigid and robust homo[2]catenane.

12 different types of donor-acceptor [2] and [3]catenanes.

13 isomerism in the minor asymmetric [1(5)2(3)] catenanes.

14 conformational properties of supercoiled DNA catenanes.

15 so one of the simplest families of knots and catenanes.

16 the unlinking of negatively (-) supercoiled catenanes.

17 A molecules can yield a variety of knots and catenanes.

18 rying the secondary binding motifs in the [3]catenanes.

19 subsequent one-electron oxidations of the [3]catenanes.

20 ant increase in the yields of the individual catenanes.

21 rates: unknots, unlinks, and torus knots and catenanes.

22 es, while that of Flp yields multiply linked catenanes.

23 cles can be unlinked or form multiply linked catenanes.

24 zations of [2]pseudorotaxanes to give the [2]catenanes.

25 cromolecular complexes such as rotaxanes and catenanes.

26 DNA molecules that are consistent with full catenanes.

27 psi can be bypassed in multiply interlinked catenanes.

28 tion introduced one additional node into the catenanes.

29 presentations of the corresponding knots and catenanes.

30 configurations of the corresponding knots or catenanes.

31 ents are placed on opposite rings of dimeric catenanes.

32 hese compounds are macrocyclic rings and not catenanes.

33 ially form multiply interlinked right-handed catenanes.

34 ites for resolvase, the latter to create DNA catenanes.

35 op region could serve as building blocks for catenanes.

36 he discovery of crown ethers, carcerands and catenanes.

37 d poly[13-130]catenanes, and cyclic poly[4-7]catenanes.

38 lymerization of macrocycles and metalated [2]catenanes.

39 e conformational interconversions of four [2]catenanes (1-4) containing a dibenzo-34-crown-10 ether (

40 as a large 5-(4-tert-butylphenyl)-1,3-xylyl (catenanes 2-4), a narrower 1,3-xylyl (catenanes 5-7), or

41 The translational isomerizations of nine [2]catenanes (2-10) containing an electron-rich dibenzo-34-

42 xylyl (catenanes 2-4), a narrower 1,3-xylyl (catenanes 5-7), or a narrow 1,4-xylyl (catenanes 8-10) g

43 ylyl (catenanes 5-7), or a narrow 1,4-xylyl (catenanes 8-10) group.

44 preparation of structures that include a [2]catenane, a [2]rotaxane, and a doubly threaded [3]rotaxa

45 odgett molecular monolayers of a bistable [2]catenane, a bistable [2]pseudorotaxane, and a single-sta

46 ied out the first directed synthesis of a [2]catenane, a plethora of strategies now exist for the con

47 mma delta resolvase, which recombined nicked catenanes about half as well as it did supercoiled subst

48 c [2]catenane (SC.7PF6) and an asymmetric [2]catenane (AC.7PF6) on reaction of the 1:1 complex with d

49 These new [2]catenanes act effectively as molecular switches which ar

50 analysis have revealed that the ZnP-C(60)-[2]catenane adopts an extended conformation with the chromo

51 l elements of a family of self-assembled [2]-catenanes affect their equilibrium stability versus comp

52 ed-valence (BIPY2)(*3+) state inside both [2]catenanes, an observation which is in good agreement wit

53 t of anion recognition as compared to the HB catenane analogue.

54 fabricated from a single monolayer of the [2]catenane, anchored with phospholipid counterions, and sa

55 barrier of 14.4 kcal mol(-1) for the larger catenane and 17.0 kcal mol(-1) for the smaller one.

56 xane structure that self-assembled into a [3]catenane and [4]catenanes at room temperature in aqueous

57 trinuclear helicates interlock to form a [2]catenane and bis[2]catenane, bearing 14 chirality elemen

58 ial synthesis in water of an all-acceptor [2]catenane and of different types of donor-acceptor [2] an

59 distinctions between this single-station [2]catenane and other more traditional bi- and multistation

60 ion, as the cyclic components in interlocked catenane and rotaxane structures, for constructing assem

61 The yield of four-node catenane and the efficiency of recombination in the pres

62 d inversion reactions yielded the four noded catenane and the three noded knot, respectively, as the

63 ally interlocked compounds, such as bistable catenanes and bistable rotaxanes, have been used to brin

64 In this study, by forming DNA catenanes and determining their topology (the linking nu

65 with various compounds, including degenerate catenanes and free dumbbells, which cannot and do not sw

66 true regardless of the relative sizes of the catenanes and knots.

67 ficient and selective access to a variety of catenanes and offers an unprecedented opportunity to exp

68 hat result in the efficient syntheses of two catenanes and one rotaxane, assisted by radical-pairing

69 s exhibited a reduced ability to resolve DNA catenanes and pathological chromatin bridges formed duri

70 Although many syntheses of molecular catenanes and rotaxanes have been reported, molecular kn

71 (i) the self-assembly of bipyridinium-based catenanes and rotaxanes in solution, (ii) the self-organ

72 The synthesis of catenanes and rotaxanes using the hard trivalent transit

73 g the properties of Coulombically challenged catenanes and rotaxanes, but it also opens up the possib

74 es has been realized in a variety of systems-catenanes and rotaxanes, chiroptical molecular switches,

75 ynthetic topological nanostructures, such as catenanes and rotaxanes, have been engineered using supr

76 For both catenanes and rotaxanes, removal of the metal ion via re

77 in contrast with more conventional bistable catenanes and rotaxanes, the mechanical movement of the

78 unique properties residing in the resulting catenanes and rotaxanes.

79 xes for molecular switching devices, such as catenanes and rotaxanes; ion-channels by ligand gating;

80 -based macrocyclic libraries contain both [2]catenanes and sequence isomers, which can be distinguish

81 The formation of catenanes and their constitutions are found to be depend

82 The synthesis of two-ring catenanes and their switchable reconfiguration by pH, me

83 and complex molecular topologies (including catenanes and trefoil and pentafoil knots).

84 ar poly[7-26]catenanes, branched poly[13-130]catenanes, and cyclic poly[4-7]catenanes.

85 interlocked subunits, such as rotaxanes and catenanes, and structures in which many inorganic cluste

86 re used as precursors for the preparation of catenane- and pseudorotaxane-decorated NPs of various co

87 riazole-pyridinium-containing acyclic and [2]catenane anion host systems are described.

88 gle-station mechanically switchable hetero[2]catenane are reported.

89 gs and the crossings of multiply interlinked catenanes are also preferentially removed by Topo IV.

90 namically controlled reactions to synthesize catenanes are detailed.

91 Catenanes are produced during DNA replication and are fo

92 In the vicinity of centromeres, catenanes are resolved by spindle forces, but linkages m

93 The mechanical bonds of the catenanes are therefore as strong, or stronger, mechanic

94 Supercoiled catenanes are unlinked at an even more increased rate by

95 rties of (+) and (-) supercoiled replication catenanes are very different, these properties per se do

96 Sister chromatid intertwines (SCIs), or catenanes, are topological links between replicated chro

97 tein chainmail: topologically linked protein catenanes arranged with icosahedral symmetry.

98 In this series, catenane assembly is controlled by a fine balance betwee

99 The efficiency of the catenane assembly process can be enhanced by manipulatin

100 result, two translational isomers of the [2]catenane associated with these electronically different

101 In solution, irradiation of the [2]catenane at 275 nm results in electron transfer from one

102 sites faster than that with one site and the catenanes at an intermediate rate, while Cfr10I gave sim

103 hat self-assembled into a [3]catenane and [4]catenanes at room temperature in aqueous solution.

104 able electrochromic properties render the [2]catenane attractive for use in electro-optical devices.

105 thermodynamic characterization of a protein catenane based on a dimeric mutant of the p53tet domain

106 recent design of a backbone cyclized protein catenane based on the p53tet domain suggested that topol

107 afoil knot and doubly and triply entwined [2]catenanes based on circular Fe(II) double helicate scaff

108 Donor-acceptor [2]catenanes based on cyclobis(paraquat-p-phenylene) as the

109 describe a minimal two-state mechanism for a catenane-based molecular motor.

110 ate, electronically addressable, bistable [2]catenane-based molecular switching device was fabricated

111 es interlock to form a [2]catenane and bis[2]catenane, bearing 14 chirality elements, respectively.

112 ly-interlocked molecules, such as rotaxanes, catenanes, Borromean rings, and Solomon knots.

113 s per mole) to a mixture of linear poly[7-26]catenanes, branched poly[13-130]catenanes, and cyclic po

114 hat PepA instructs Cre to produce four-noded catenane, but is not required for recombination at these

115 n directs subsequent covalent capture of the catenane by ring-closing olefin metathesis.

116 e of metal ions to template the synthesis of catenanes by Sauvage and co-workers was a pivotal moment

117 y (+) supercoiled, and the unlinking of such catenanes by type IIA topoisomerases proceeds much more

118 On average, close to two bistable [2]catenanes can be incorporated per repeating unit of the

119 troelectrochemical experiments show that the catenanes can be reversibly switched among as many as se

120 These were converted by resolvase to catenanes carrying one SfiI site on each ring.

121 Perturbations to the catenane cause compensating changes in the NCNs structur

122 stallographic analysis of a series of halide catenane complexes reveal strong XB interactions in the

123 bile hydrazone linkages of the individual [2]catenane components may be 'locked' by increasing the pH

124 wo bistable [2]rotaxanes and one bistable [2]catenane composed of CBPQT(4+) rings encircling dumbbell

125 on of a surface-attached double-stranded DNA catenane composed of two intact interlinked DNA nano-cir

126 le organic radicals, trapped within a homo[2]catenane composed of two rigid and fixed cyclobis(paraqu

127 enane represents the smallest ring size of a catenane composed solely of polypeptide segments.

128 Two redox-active bistable [2]catenanes composed of macrocyclic polyethers of differen

129 A tristable [2]catenane, composed of a macrocyclic polyether incorporat

130 Two donor-acceptor [3]catenanes-composed of a tetracationic molecular square,

131 An octacationic homo[2]catenane comprised of two mechanically interlocked cyclo

132 e Carlo simulations of braid, supercoil, and catenane configurations demonstrate how a preference for

133 id-state structures of the donor-acceptor [2]catenanes confirm their mechanically interlocked nature,

134 A novel dynamic [3]catenane consisting of a large four-station central macr

135 nant receptor structure was an elaborate [2]-catenane consisting of two interlocked macrocyclic trime

136 These new catenanes contain both the donor and acceptor components

137 A series of catenanes containing different permutations of the insul

138 ated on separate rings of right-handed torus catenanes containing six or more nodes.

139 the sterically less encumbered series of [2]catenanes containing the 1,3-butadiyne moiety.

140 conformational interconversions in these [2]catenanes containing the rigid bis(p-benzyl)methyl tethe

141 tion arises: what role does topology play in catenanes containing TTF units?

142 with two sites in a single DNA molecule; on catenanes containing two interlinked rings of DNA with o

143 wo copies of their recognition sites, and on catenanes containing two interlinked rings of DNA with o

144 A new class of [2]catenanes containing zinc(II)-porphyrin (ZnP) and/or [60

145 The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functi

146 , in isomeric [3]- and doubly interlocked [2]catenanes controls the formation of TTF radical dimers w

147 A bis-phenanthroline [2]catenane copper complex, consisting of one olefinic macr

148 mechanically interlocked framework of the [3]catenanes creates the ideal arrangement and ultrahigh lo

149 ugment decatenation rather than compete with catenane crossings for their removal.

150 nuclease EcoP1I was analysed on circular and catenane DNA in a variety of buffers with different salt

151 Catenane dynamic processes were additionally probed thro

152 g hydrogen bonds, and beta-turn types on [2]-catenane energetics.

153 elineate how these factors contribute to [2]-catenane equilibrium speciation/stability.

154 These bistable [2]catenanes exemplify a design strategy for achieving redo

155 aining also one DNP unit) of the isomeric [3]catenane exhibit slightly different redox properties com

156 he mechanically interlocked nature of the [3]catenanes facilitates the formation of the TTF radical d

157 This new electron donor-acceptor catenane family has been subjected to extensive spectros

158 The minimalist nature of the [2]catenane flashing ratchet design permits certain mechani

159 to (+) supercoiled over (-) supercoiled DNA catenanes for unlinking.

160 analysis, we demonstrate that the studies of catenanes formed from two ssDNA molecules can yield valu

161 trophoretic migration of different knots and catenanes formed on the same size DNA molecules is simpl

162 It was found recently that DNA catenanes, formed during replication of circular plasmid

163 The catenane from the plasmid with one EcoR124I site, carryi

164 o IV rapidly removes positive supercoils and catenanes from DNA but is significantly slower when conf

165 e assembly of new types of donor-acceptor [2]catenanes from dynamic combinatorial libraries (DCL) in

166 nots is accompanied by a small amount of RNA catenane generation.

167 hesis of an electrochemically addressable [2]catenane has been achieved following formation by templa

168 synthesis of functionalized macrocycles and catenanes has been developed using "click" chemistry in

169 Each of these catenanes has specific structural requirements, allowing

170 th the free macrocyclic polyether and the [2]catenane have led to a deeper fundamental understanding

171 Both these highly charged [2]catenanes have been isolated as air-stable monoradicals

172 Two donor-acceptor [2]catenanes have been synthesized and characterized from a

173 DNA with two sites, which indicates that the catenanes have more freedom for site juxtaposition than

174 Catenanes have not been previously observed in proteins

175 nically interlocked molecules (rotaxanes and catenanes) have already revolutionized molecular electro

176 at by replacing the BIPY(2+) units in homo[2]catenane HC(*7+)-composed of two mechanically interlocke

177 CC) of a new generation of donor-acceptor [2]catenanes highlights the power of DCC to access unpreced

178 ly different binding pockets in a dynamic [2]catenane host is demonstrated in the solid state by mani

179 onstrates unambiguously the fact that the [2]catenane host provides a uniquely different binding pock

180 iation constant values determined for the [2]catenane in competitive organic-aqueous solvent mixtures

181 icient route to the tetrathiafulvalene-based catenane in high yield.

182 s well as by X-ray crystallography of the [2]catenane in its bisradical tetracationic redox state.

183 e affords the corresponding difunctionalized catenane in one step in 85-92% yield.

184 The [2]catenane in which the macrocyclic polyether is mechanica

185 Furthermore, the spontaneous assembly of catenanes in aqueous dynamic systems gives a fundamental

186 The crystal structure of one of the [2]catenanes in its trisradical tricationic redox state pro

187 cessary to facilitate resolution of retained catenanes in mitosis.

188 verse strategies that exist for synthesizing catenanes in the 21st century and examines their emergin

189 sed the activity of EcoPI and EcoP15I on DNA catenanes in which the recognition sites were either on

190 halide selectivity is observed in the XB [2]catenane, in comparison to the acyclic XB receptor, due

191 A donor-acceptor [3]catenane incorporating two cyclobis(paraquat-p-phenylene

192 Two [2]catenanes incorporating bispyrrolotetrathiafulvalene (BP

193 The model [2]-catenane is self-assembled from dipeptide building block

194 One of these catenanes is different from earlier related interlocked

195 e synthesis of three-, five-, and seven-ring catenanes is presented, and their switchable reconfigura

196 eversible redox-switching of the bistable [2]catenanes is retained inside the MOF, as evidenced by so

197 structures, including fibers, rings, tubes, catenanes, knots, and cages, have shown that the quatern

198 udy different topological forms of DNA rings-catenanes, knots, and supercoils.

199 supercoils ahead of the replication fork or catenane-like right-handed windings (precatenanes) of th

200 Two [3]catenane 'molecular flasks' have been designed to create

201 Catenanes - molecules consisting of interlocked macrocyc

202 The small rings in these [2]- and [3]catenanes move in discrete steps between different bindi

203 In this catenane, movement of the CBPQT(4+) ring in its differen

204 We find that the small ring in the [2]catenane moves with high positional integrity but withou

205 ion of motion, while the two rings in the [3]catenane mutually block each other's movement to ensure

206 ods to make these proteins and more: protein catenanes, neoglycoproteins, and artificial protein mole

207 The initial catenanes obtained after workup are Cu-free.

208 Gin recombination of catenanes occurred even if the recombinational enhancer

209 radical cationic (TTF(*+))2 dimer in the [2]catenane occurs only fleetingly compared with its promin

210 heir potential for the preparation of linear catenanes of higher order.

211 axane, as well as in a couple of bistable [2]catenanes of the donor-acceptor vintage--can be elucidat

212 ted, (ii) in the case of the two bistable [2]catenanes--one containing a crown ether with tetrathiafu

213 ghted and to conclude, attempts to fabricate catenanes onto surfaces and into metal organic framework

214 triggered reversible reconfiguration of the catenane or rotaxane structures provides a means to yiel

215 terlocked circular DNA nanostructures, e.g., catenanes or rotaxanes, provide functional materials wit

216 We construct catenanes out of two short (60/70 nt) ssDNA molecules by

217 merase II (topo II), the enzyme that removes catenanes persisting between sister chromatids following

218 These unique [2]catenanes present a promising prototype for the fabricat

219 The formation of the catenane proceeded efficiently, and the overall structur

220 be linked together to generate the cyclic [3]catenane product.

221 can switch between two-noded and four-noded catenane products.

222 Formation of a catenane proved that the linkage crossed a turn rather t

223 exes derived from both the substrate and the catenane recombination product.

224 By showing that the DNA catenane remains intact after RCA reactions, we prove th

225 ng transcriptional regulation, supercoil and catenane removal, and site-specific recombination.

226 e identical to those of related (phen)2Cu(I) catenanes reported by Sauvage and co-workers.

227 ese results, and on the observation that the catenanes represent kinetic bottlenecks in the reaction

228 aph, the topologically non-trivial knots and catenanes represent some of chemistry's most challenging

229 The [3]catenane represents the smallest ring size of a catenane

230 ) FRT sites are a 3-noded knot and a 4-noded catenane, respectively.

231 e tristable and bistable [2]rotaxanes and [2]catenane reveal a mechanism which involves a bisradical

232 The solid-state structure of the [2]catenane reveals a nearly perfect fit of the interlocked

233 wo different structures, a macrocyclic and a catenane ring.

234 me molecule of DNA or by the interlinking of catenane rings, than when released from the tether.

235 The directional rotation of [2]- and [3]catenane rotary molecular motors and the transport of su

236 otation of up to 87% of crown ethers in a [2]catenane rotary motor.

237 Examples include the catenane, rotaxane, and knot interlocked structures.

238 ation (DAPQT(2(*+))), affords a symmetric [2]catenane (SC.7PF6) and an asymmetric [2]catenane (AC.7PF

239 These [2]catenanes show a predominant amount (>95:5) of the co-co

240 ectroscopic analysis of this hexacationic [2]catenane shows a dramatic upfield shift of the resonance

241 nstitutionally different TTF units in the [2]catenane still experience long-range electronic intramol

242 ionalized further or used to incorporate the catenane structure into other DNA assemblies.

243 s may be a driving force for assembly of the catenane structure.

244 plementation of the dynamically reconfigured catenane structures for the programmed organization of A

245 logical objects such as supercoiled ring and catenane structures.

246 Polyhedral catenanes, such as a cube or a truncated octahedron, hav

247 -induced circumrotatory motion in a hetero[3]catenane system is demonstrated where the exotic dual ro

248 We describe the synthesis of a [2]catenane that consists of two triply entwined 114-member

249 the synthesis and functional application of catenanes that have occurred since the Millennium.

250 The class of catenanes that may be described as "molecular machines"

251 py methods to identify the types of knots or catenanes that migrate in different bands on the agarose

252 in the CBPQT(4+) ring for both of the two [2]catenanes, that is governed by a free energy barrier of

253 In all desymmetrized [2]catenanes the co-conformation is dominated by the strong

254 In the case of the [2]catenane, the formation of the TTF hetero radical dimer

255 nts flank either the enhancer or promoter in catenanes, the enhancer cannot activate the promoter on

256 interlocked compounds, such as rotaxanes and catenanes, the molecules are held together by mechanical

257 ntiparallel sites on four-noded right-handed catenanes, the normal product of Xer recombination at ps

258 nce (TTF2)(*+) dimers are similar in the two catenanes, the radical cationic (TTF(*+))2 dimer in the

259 We showed that in (-) supercoiled DNA catenanes this protein-bound bent segment becomes nearly

260 esent the preparation of a three-dimensional catenane through a self-assembly process that relies on

261 We studied the equilibrium formation of DNA catenanes to assess the conformational properties of sup

262 from the reliable synthesis of rotaxanes and catenanes to molecular rotary motors, shuttles, muscles,

263 king has limited the scope of donor-acceptor catenanes to strictly alternating stacks of donor (D) an

264 ked dsDNA nanostructures, like rotaxanes and catenanes, to achieve diverse mechanical operations.

265 This model tightly prescribes the knot or catenane type of previously uncharacterized data.

266 Unfolding and refolding of the catenane was consistent with a two-state process.

267 The NMR structure of the [3]catenane was determined, suggesting that burial of hydro

268 The non-variant core of the [2]-catenane was shown only to adopt type II' and type VIII

269 ercoiled, multiply interlinked, right-handed catenanes, we detect specific regions where DNA segments

270 cally interlocked structure of the resulting catenane were established by NMR spectroscopy, mass spec

271 The catenanes were cleaved by SfiI almost as readily as a si

272 Catenanes were formed by cyclizing linear DNA with long

273 re, parallel psi sites on right-handed torus catenanes were not substrates for Xer recombination.

274 the resolvase synaptic complexes with nicked catenanes were recombination intermediates.

275 If gyrase alone were inhibited, most of the catenanes were unlinked.

276 cases, including two fully desymmetrized [2]catenanes where both donors and acceptors are different,

277 a series of desymmetrized donor-acceptor [2]catenanes where different donor and acceptor units are a

278 Poly[n]catenanes, where the molecular chains consist solely of

279 ed synthesis of a bistable donor-acceptor [2]catenane wherein both translational isomers--one in whic

280 Here we report the synthesis of a cyclic [3]catenane, which consists of three mutually interpenetrat

281 The highly energetic octacationic homo[2]catenane, which is capable of accepting up to eight elec

282 A bistable donor-acceptor [2]catenane, which is composed of a crown ether containing

283 (MIMs)--specifically, bistable rotaxanes and catenanes--which exhibit reset lifetimes between their O

284 enzymes produce different types of knots or catenanes while acting on circular DNA in vitro and in v

285 pared with its prominent existence in the [3]catenane, while both dimers are absent altogether in the

286 se in the {2+2} macrocycle present in the [2]catenane, while comparison with its topological isomer r

287 Four donor-acceptor [2]catenanes with cyclobis(paraquat-p-phenylene) (CBPQT4+)

288 -B monomers self-assemble into octameric [2]-catenanes with high selectivity for [1(3)2](2), where 1

289 spanning two sites have longer lifetimes on catenanes with one site in each ring than on circular DN

290 d on the same ring were cleaved efficiently, catenanes with sites on separate rings were not cleaved.

291 ght-handed knots and decatenate right-handed catenanes without acting on right-handed plectonemes in

292 d DNA, as well as decatenate postreplicative catenanes, without causing their torsional relaxation.

293 no two rings are interlinked in a chain-like catenane, yet the three rings cannot be separated.