ライフサイエンスコーパス: catenin

1 eventing Axin1-dependent degradation of (2)b-catenin.

2 formation through its interaction with beta-catenin.

3 resulted in the nuclear localization of beta-catenin.

4 , including Prlr/Stat5, TGFbeta and Wnt/beta-catenin.

5 ulation is also capable of inducing Wnt/beta-catenin.

6 of Axin and consequent stabilization of beta-catenin.

7 -catenin through its interactions with alpha-catenin.

8 ce of crosstalk between TGFbeta and Wnt/beta-catenin.

9 , as well as increased total and active beta-catenin.

10 r(86) in the N-terminal domain (NTD) of beta-catenin.

11 endothelial cadherin (VE-cadherin) and beta-catenin.

12 nical Wnt signals by compartmentalizing beta-catenin.

13 y kinase (SFK) FYN as well as Tyr142 in beta-catenin.

14 regulated expression of ATX as well as beta-catenin.

15 wth factor-beta) and immunostaining for beta catenin.

16 14-prostaglandin J2) decrease levels of beta-catenin.

17 duced by Wnt signaling and conferred by beta-catenin.

18 f IRE1alpha repressed the expression of beta-catenin, a key factor that drives colonic tumorigenesis,

19 Jak3-mediated phosphorylation sites in beta-catenin abrogated its AJ localization and compromised ep

20 SUMOylated beta-catenin accumulates at the chromatin and activates multi

21 hat blocking PI3K-AKT pathway-dependent beta-catenin accumulation may represent a potential therapeut

22 marrow microenvironment, which lead to beta-catenin activation and disease progression of MDS.

23 ocal injection of sFRP-2 attenuated the beta catenin activation and fibrosis.

24 Immunostaining revealed beta catenin activation and molecular studies revealed 1.5-2

25 leading to impairment of WNT3a-induced beta-catenin activation and reduced Fgf18 expression in osteo

26 through suppression of p53 and enhances beta-catenin activation and tumor proliferation.

27 s and colonoid cultures and TNF-induced beta-catenin activation in nontransformed human NCM460 cells

28 Increased Wnt/beta-catenin activity in CNS blood vessels during EAE progres

29 These results reveal that APC-regulated beta-catenin activity in cortical progenitors sets the approp

30 mechanisms and the effects of SPDEF on beta-catenin activity in mouse models of colorectal cancer (C

31 was observed to reduce measures of Wnt/beta-catenin activity in osteocytes in the loaded bone.

32 ase load-induced bone formation and Wnt/beta-catenin activity in osteocytes.

33 le for Ror2 in regulating canonical Wnt/beta-catenin activity in vivo, where lentiviral shRNA depleti

34 the developing kidney, tissue-specific beta-catenin activity is regulated by cooperation with cell t

35 Activation of WNT/beta-catenin activity with 6-bromoindirubin-3'-oxime improved

36 Lys05 and could be reverted by inducing beta-catenin activity.

37 tro and in vivo, along with reduced WNT/beta-catenin activity.

38 ay, but rather by reductions in Akt and beta-catenin activity.

39 the endoderm and mesoderm, whereas Wnt/beta-catenin acts as a genome-wide toggle between foregut and

40 processes that the Wnt pathway governs, beta-catenin acts primarily on a single cis element in the DN

41 d Huh-6 xenografts showed expression of beta-catenin, AFP, and Glypican-3 (GPC3).

42 ith cardiac fibroblast-specific loss of beta-catenin after trans-aortic constriction in vivo.

43 Activation of beta-catenin alone results in the formation of highly clonoge

44 ), matrix metallopeptidase 12 (MMP12)/MMP13, catenin alpha3 (CTNNA3), rho GTPase-activating protein 2

45 TGF-beta-induced beta-catenin also regulates NR4A1 expression through formatio

46 EGFR-inhibitor response, including WNT/beta-catenin alterations and cell-cycle-gene (CDK4 and CDK6)

47 nteraction of Kindlin-2 with beta- and gamma-catenin and actin was demonstrated in co-immunoprecipita

48 n-based complexes, including beta- and gamma-catenin and actin, components of adherens junctions (AJ)

49 GC receptor, followed by stimulation of beta-catenin and c-myc pathways.

50 ectly and simultaneously with beta- or gamma-catenin and cortical actin filaments, Kindlin-2 stabiliz

51 as(+/p-) cells showed diminished pCREB, beta-catenin and cyclin D1, and enhanced Nfatc1 levels, condi

52 responsible for Jak3 interactions with beta-catenin and determine the functional implications of pre

53 s between ORF2 and a complex containing beta-catenin and HMGA1 have functional significance.

54 tently infected neurons interacted with beta-catenin and HMGA1 in transfected cells, which resulted i

55 the interaction of the protein CBP with beta-Catenin and inhibiting Wnt-activated genes.

56 h Notch intracellular domain (NICD) and beta-catenin and is required for Ang1-dependent beta-catenin

57 /-) polyps exhibiting reduced levels of beta-catenin and its oncogenic transcriptional target, cyclin

58 eover, NP12 increased the expression of beta-catenin and Nanog in myocardium from AMI mice.

59 This cleavage event occurs between the beta-catenin and p120-binding domains within the cadherin cyt

60 d a regulatory circuit between miR-152, beta-catenin and PKM2 in breast cancer.

61 levels were negatively correlated with beta-catenin and PKM2 levels in breast cancer tissues.

62 rk suggests that GLI2 is a regulator of beta-catenin and provides insights into its role in tumorigen

63 Unexpectedly, beta-catenin and Smad1 binding were associated with both tran

64 vations are consistent with the role of beta-catenin and SNAIL in epidermal stem cell maintenance.

65 beta-catenin and Snail1 expression was generally high in all

66 Specific molecular subgroup of HCA with beta-catenin and sonic hedgehog activation associated with ma

67 found evidence for the NREs binding to beta-catenin and Tcf-suggesting a dual action by beta-catenin

68 wnregulating multiple inhibitors of Wnt/beta-catenin and TGF-beta pathways, leading to their overacti

69 DPN harbor activating mutations in the beta-catenin and the MAP-kinase pathways; this characteristic

70 ciated with high co-expression of SCD1, beta-catenin and the YAP/TAZ downstream target birc5.

71 utations have heterogeneous staining of beta-catenin and variable expression of gonadal receptors and

72 nic mice inducibly expressing oncogenic beta-catenin and/or PIK3CA(H1047R) to follow sequential chang

73 MAD7 degradation, EMT, and induction of beta-catenin, and all of these pathways are inhibited by bis-

74 increased expression of E-cadherin and beta-catenin, and decreased expression of vimentin and snail,

75 e, we have reported that the Hippo, Wnt/beta-catenin, and Notch pathways form an interacting network

76 ption regulator 1 (YAP/TAZ), STAT3, Wnt/beta-catenin, and Notch signaling.

77 more key molecules (including Osterix, beta-catenin, and sonic hedgehog) that play a critical role i

78 ndance and activity, stabilizes nuclear beta-catenin, and stimulates canonical Wnt signaling more eff

79 e verify that MAPK1, CDK1, CDK4, PRMT5, beta-catenin, and UbxD8 are directly ubiquitinated by E6AP in

80 ll types/organ systems in which Myc and beta-catenin are co-expressed.

81 rin, which releases cadherin-associated beta-catenin (Armadillo in Drosophila) and p120-catenin to in

82 In this study, we identified beta-catenin as a new direct target of miR-152.

83 These data established Wnt/beta-catenin as a novel signal produced by infiltrating macro

84 nin and Tcf-suggesting a dual action by beta-catenin as a signal and a feedforward sensor.

85 mutations in CTNNB1, the gene encoding beta-catenin, as a cause of FEVR.

86 Overexpression of KCNQ1 trapped beta-catenin at the plasma membrane, induced a patent lumen i

87 ein interactions, bromodomains, and the beta-catenin/B-cell lymphoma 9 (BCL9) interaction were used t

88 The two beta-catenin/BCL9 inhibitors had low nonspecific binding but

89 olated from AhR-/- livers had increased beta-catenin (beta-Cat) signaling with overexpression of Axin

90 ion-transforming growth factor beta, and Wnt-catenin beta1.

91 SPDEF disrupted beta-catenin binding to TCF1 and TCF3, displacing beta-cateni

92 ensional structure similar to cadherin-bound catenins, binds directly to the E-cadherin cytosolic tai

93 aneously coordinates the attenuation of beta-catenin, both of which are required to execute the osteo

94 iferation because of dysregulation of a beta-catenin/BRN2 transcriptional cascade.

95 Removal of beta-catenin causes MMPs to favor adipogenesis, resulting in

96 Analyzing beta-catenin ChIP sequencing in human cells, we found the 11-

97 VEC/beta-catenin complex also sequesters a core subunit of PRC2 (

98 TGF-beta1 stimulation increases active beta-catenin concentration in cultured corneal fibroblasts th

99 ese results indicate that decreased WNT/beta-catenin contributes to the pathophysiology of LMNA cardi

100 target gene Fam19a5 shows that Myc and beta-catenin cooperate to activate gene expression controlled

101 Here, we show that beta-catenin cooperates with the transcription factor Myc to

102 lates CSF-1-dependent proliferation and beta-catenin/cyclinD1 levels in OC precursors.

103 to facilitate the nuclear transport of beta-catenin, defining a parallel nuclear transport pathway t

104 a and SB216763 in order to activate the beta-catenin-dependent canonical Wnt pathway.

105 self-renewal of stem cells by inducing beta-catenin-dependent signalling through the Wnt receptor fr

106 anced the ability of HMGA1 to stimulate beta-catenin-dependent transcription, suggesting that interac

107 F) reporter assays as a readout for Wnt/beta-catenin-dependent transcription.

108 Induction of GLI2DeltaN enhanced the beta-catenin-dependent transcriptional activation and the sub

109 loping kidney, Wnt9b regulates distinct beta-catenin-dependent transcriptional programs in the renewi

110 an extracellular protein that enhances beta-catenin-dependent Wnt signaling and has previously been

111 ar YAP/TAZ requires inactivation of the beta-catenin destruction complex.

112 ng function, and restored expression of beta-catenin-driven target genes and alveolar epithelial cell

113 s, we reported a novel crosstalk of ARF/beta-catenin dysregulated YAP in Hippo pathway and a new appr

114 as, linked to increased epithelial cell beta-catenin dysregulation.

115 Phosphorylation compartmentalizes Daple/beta-catenin/E-cadherin complexes to cell-cell contact sites,

116 omplex for long-distance trafficking of beta-catenin/E-cadherin complexes to pericentriolar recycling

117 both reduced ROS-induced degradation of beta-catenin/E-cadherin in vitro and ameliorated skin damage

118 n of Src/Abl kinases and degradation of beta-catenin/E-cadherin.

119 Here, we demonstrate that the Wnt/ss-catenin effector Lef1 is required for the differentiatio

120 n1-beta-catenin interaction is lost and beta-catenin escapes ubiquitylation-dependent proteasomal deg

121 fective at reducing average tumor size, beta-catenin expression levels, and the number of aberrant cr

122 MCs) demonstrated constitutive nuclear beta-catenin expression that was dependent on autocrine ATX s

123 In tumor cells with activated beta -catenin, expression of SPDEF induced a quiescent state,

124 ed with beta-catenin, the NTD domain of beta-catenin facilitated its interactions with Jak3.

125 in binding to TCF1 and TCF3, displacing beta-catenin from enhancer regions of genes that regulate the

126 lowed by phosphorylation of and loss of beta-catenin from the nucleus, thereby reducing expression of

127 own of KCNQ1 caused a relocalization of beta-catenin from the plasma membrane and a loss of epithelia

128 beta-catenin that are required for full beta-catenin function.

129 des of this pathway through a series of beta-catenin gain-of-function (GSK3 inhibition and beta-caten

130 berrant beta-catenin nuclear signaling, beta-catenin haploinsufficiency induced aggressive tumor form

131 While beta-catenin has been demonstrated as an essential molecule a

132 as a key common downstream mediator for beta-catenin/Hoxa9 functions in LSK-derived MLL-CSCs.

133 l a novel molecular network mediated by beta-catenin/Hoxa9/Prmt1 in governing leukemic self-renewal.

134 gers the mechanosensitive activation of beta-catenin in adjacent epidermal cells, initiating the foll

135 Constitutive activation of beta-catenin in hematopoietic cells yielded lethal myeloid di

136 that ORF2 was relocalized by HMGA1 and beta-catenin in Neuro-2A cells.

137 umulation and nuclear relocalization of beta-catenin in vitro and in 3D organotypic cultures, accompa

138 E-Cadherin is essential for binding to beta-Catenin in vitro In cultured cells, phosphorylation of s

139 redicts AML patient survival and allows beta-catenin-independent transformation in MLL-CSCs derived f

140 s angiogenesis in HCCs by enhancing Wnt/beta-catenin induced FGF18 expression.

141 wnstream of LRP6, including JNK and WNT/beta-catenin, inhibited the biologic activity of domain 4.

142 4mu8C could suppress the production of beta-catenin, inhibited the proliferation of colon cancer cel

143 oxa9 sensitizes LSK-derived MLL-CSCs to beta-catenin inhibition resulting in abolishment of CSC trans

144 Wnt/beta-catenin inhibition with Dkk-1 prevented the P-induced do

145 isoforms containing a unique N-terminal beta-catenin-interacting domain.

146 NP7S in mammary epithelial cells, Axin1-beta-catenin interaction is lost and beta-catenin escapes ubi

147 These data indicate that Tcf1-beta-catenin interaction is necessary for promoting thymocyte

148 n levels and define PKC as an important beta-catenin interaction partner and signaling opponent of ot

149 orms in mice (p45(-/-)mice) to abrogate beta-catenin interaction.

150 alpha-Catenin is an identified force transducer within cadheri

151 t part of the challenge in antagonizing beta-catenin is caused by its dual functionality as a cell ad

152 t al. show that the junction component alpha-catenin is critical in freely moving cells to promote ad

153 r stem cells and (ii) downregulation of beta-catenin is partially driving effects of Indomethacin in

154 beta-Catenin is the main effector of the canonical Wnt pathwa

155 constitutively bound to LRP5/6 through p120-catenin, is required for the association of the rest of

156 kening of cell-cell interactions in an alpha-catenin knockdown monolayer reduces the defect size and

157 APC deletion deregulates beta-catenin, leads to high Wnt tone, and disrupts Notch1 sig

158 ified a novel pathway for regulation of beta-catenin levels and define PKC as an important beta-caten

159 rylation of GSK3beta, decreasing active beta-catenin levels in both cytoplasmic and nuclear fractions

160 the destruction complex that regulates beta-catenin levels.

161 Here, we conditionally induce beta-catenin loss of function in resident cardiac fibroblasts

162 ardiomyopathy and that drugs activating beta-catenin may be beneficial in affected individuals.

163 NA-binding protein DDB2 is critical for beta-catenin-mediated activation of RNF43, which restricts Wn

164 s GC growth through a novel SOCE/Ca(2+)/beta-catenin-mediated anti-proliferation of GC cells, which i

165 igated the role of TNF signaling in Wnt/beta-catenin-mediated intestinal stem cell and progenitor cel

166 tes that the maintenance of appropriate beta-catenin-mediated Wnt tone is necessary for the orderly d

167 eads to Ras activation, cooperates with beta-catenin mutants (S33Y, S45Y) to yield HCC in mice.

168 ranscription factor networks, including beta-catenin, MYB, TWIST1, SOX7, GATA3 and GATA6.

169 er (ErbB2(KI)), which exhibits aberrant beta-catenin nuclear signaling, beta-catenin haploinsufficien

170 nd LRP5 and LRP6 co-receptors, enabling beta-catenin nuclear translocation and TCF/LEF-dependent gene

171 nteracting with other proteins, such as beta-catenin or SMAD3 to induce oncogenic WNT and TGFbeta sig

172 with common CRC mutations such as APC, beta-catenin, or RNF43.

173 trogen receptor, progesterone receptor, beta-catenin, or vimentin expression between placebo and R-ke

174 in multiple contexts Myc is a target of beta-catenin, our characterization of a cell type-specific en

175 Further, beta-catenin overexpression in PKC-deficient podocytes could

176 n gain-of-function (GSK3 inhibition and beta-catenin overexpression) or loss-of-function experiments

177 Here we show that beta-catenin pathway activity and adult epithelial progenitor

178 ibited strongly decreased autocrine Wnt/beta-catenin pathway activity and reduced Wnt pathway-depende

179 erexpression in ACC cells inhibited Wnt/beta-catenin pathway activity by promoting beta-catenin phosp

180 Mutations of the beta-catenin pathway change the phenotype of a common nevus w

181 sults implicate deregulation of the Wnt/beta-catenin pathway in CNS inflammation and suggest novel th

182 we demonstrate that activity of the Wnt/beta-catenin pathway in fibroblast-like cells in the lesion s

183 e esculetin significantly inhibited Wnt/beta-catenin pathway in vitro and in vivo.

184 enitor-specific inactivation of the APC-beta-catenin pathway indicates that the maintenance of approp

185 se predict differing effects of the WNT/beta-catenin pathway on metastatic progression.

186 The Wnt/beta-catenin pathway plays a role in almost every facet of li

187 1 and Wnt8a, two core components of the beta-catenin pathway, is downregulated by clofibrate.

188 s catalytic subunit Calpha, and the Wnt/beta-catenin pathway.

189 C1 signaling cascades, and also the WNT/beta-catenin pathway.

190 n and function through cAMP/PKA and Wnt/beta-catenin pathways.

191 previously unknown tyrosine residues on beta-catenin phosphorylated by Jak3.

192 a-catenin pathway activity by promoting beta-catenin phosphorylation and degradation, it also inhibit

193 combined therapy, PAKs regulate JNK and beta-catenin phosphorylation and mTOR pathway activation, and

194 t modality is effective in treatment of beta-catenin-positive, GS-positive HCCs.

195 uired for the expression of every Wnt9b/beta-catenin progenitor renewal target assessed as well as fo

196 enin and is required for Ang1-dependent beta-catenin recruitment at the Dll4 locus.

197 Mechanistically, beta-catenin regulates expression of downstream targets of a

198 attempts to develop therapies targeting beta-catenin remain challenging, and none of these targeted t

199 Kindlin-2 binding sites for beta- and gamma-catenin reside within its F1 and F3 subdomains.

200 how allosteric binders may overcome the beta-catenin side effects associated with strong GSK-3beta in

201 eatures by activating the canonical Wnt/beta-catenin signal pathway.

202 Ror2 expression augmented canonical Wnt/beta-catenin signaling activity across multiple basal-like mo

203 8a promoters, ultimately decreasing Wnt/beta-catenin signaling activity, which is associated with rad

204 TBL1XR1 point mutation could alter Wnt/beta-catenin signaling activity.

205 nd Vgll4-4A markedly suppressed YAP and beta-catenin signaling activity.

206 The hyperactivated Wnt/beta-catenin signaling acts as a switch to induce epithelial

207 idates that berberine indeed suppresses beta-catenin signaling and cell growth in colon cancer via bi

208 nfluence of KCNQ1 expression on the Wnt/beta-catenin signaling and epithelial-to-mesenchymal transiti

209 lioma-associated oncogene (GLI) and WNT/beta-catenin signaling are important events in the genesis of

210 and the cell type-specific roles of Wnt/beta-catenin signaling as it relates to liver physiology and

211 Particularly, it activates Wnt/beta-catenin signaling by directly targeting Wnt antagonists,

212 e formation, exogenous elevation of Wnt/beta-catenin signaling can enhance tertiary dentine formation

213 These tumors lack deregulation of APC/beta-catenin signaling components, which are crucial gatekeep

214 Wnt/beta-catenin signaling elicits context-dependent transcriptio

215 Recently elevated Wnt/beta-catenin signaling has been detected in sepsis.

216 esults suggest that reactivation of Wnt/beta-catenin signaling in CNS vessels during EAE/MS partially

217 ht the importance of Th17 cells and Wnt/beta-catenin signaling in HIV control and especially identify

218 r 4 (LGR4) axis in driving aberrant Wnt/beta-catenin signaling in MM.

219 highly context-dependent nature of WNT/beta-catenin signaling in tumors is essential to achieve maxi

220 function of Wise and also modulates Wnt/beta-catenin signaling independently of Wise.

221 Wnt/beta-catenin signaling induces expression of col12a1a/b and d

222 lethal malignancy in which aberrant Wnt/beta-catenin signaling is frequently detected.

223 and homeostasis, precise control of Wnt/beta-catenin signaling is in part achieved by secreted and me

224 Wingless and INT-1 (WNT)/beta-catenin signaling is reduced in COPD; however, the mecha

225 te adhesion, involvement of the Akt/WNT/beta-catenin signaling pathway and relevant phosphatases in V

226 tion results in deregulation of the Wnt/beta-catenin signaling pathway causing overexpression of the

227 Deregulation of the Wnt/beta-catenin signaling pathway drives the development of colo

228 howed an abnormal activation of the Wnt/beta-catenin signaling pathway in a subset of zona fasciculat

229 investigated the molecular role of Wnt/beta-catenin signaling pathway in reparative dentinogenesis u

230 The WNT/beta-catenin signaling pathway is a prominent player in many

231 spite the improved understanding of the beta-catenin signaling pathway over the past three decades, a

232 ting evidence demonstrates that the Wnt/beta-catenin signaling pathway plays a dominant role in bone

233 e significant because the canonical Wnt/beta-catenin signaling pathway promotes neurogenesis and inhi

234 In this review, we discuss the Wnt/beta-catenin signaling pathway, its role in cell-cell adhesio

235 how that lithium, an activator of the Wnt/ss-catenin signaling pathway, slows melanoma progression, b

236 that controls angiogenesis, the Norrin-beta-catenin signaling pathway.

237 ZD4547 downregulated RTK, mTOR, and Wnt/beta-catenin signaling pathways in premalignant mammary tissu

238 ically, T63 activated both BMPs and WNT/beta-catenin signaling pathways.

239 This suggests that Wnt/beta-catenin signaling plays no major role in the formation o

240 o be independent of its activity as Wnt/beta-catenin signaling regulator.

241 LGR5 potentiates WNT/beta-catenin signaling through its unique constitutive intern

242 gest a model whereby Lrp4 modulates Wnt/beta-catenin signaling via interaction with Wnt ligands and a

243 osteoanabolic capacity of activated Wnt/beta-catenin signaling, but serum sclerostin levels in humans

244 al of melanoma cells in response to WNT/beta-catenin signaling, correlating with differing metabolic

245 gh p38 MAPK regulation of canonical Wnt/beta-catenin signaling, increasing alpha-SMA, COL1, and FN sy

246 hat Apcdd1, a negative regulator of Wnt/beta-catenin signaling, is expressed in retinal endothelial c

247 and is implicated in modulation of Wnt/beta-catenin signaling, presumably through its ability to bin

248 Most MMs display aberrant Wnt/beta-catenin signaling, which drives proliferation; however,

249 fied LGR4 as a master controller of Wnt/beta-catenin signaling-mediated breast cancer tumorigenesis,

250 y reduced cerebrovascular canonical Wnt-beta-catenin signaling.

251 n and Sfrp4 consistent with reduced Wnt/beta-catenin signaling.

252 sma levels of molecules involved in Wnt/beta-catenin signaling.

253 ward mechanism to achieve sustained Wnt/beta-catenin signaling.

254 s, but contributed to the activation of beta-catenin signalling for the control of PD-1 and TNF recep

255 ier defects caused by impaired vascular beta-catenin signalling in mice.

256 hy individuals to study the role of Wnt-beta-catenin signalling in myogenic differentiation.

257 cardiomyopathy, suggested decreased WNT/beta-catenin signalling.

258 Only some of the early dorsal beta-catenin signature genes were activated at blastula where

259 In contrast, a slight activation of beta-catenin significantly increased bone formation and sligh

260 mation, cell motility and expression of beta-catenin, Snail, Slug, Zeb1 and N-cadherin, and upregulat

261 The beta-catenin-Snail1-Twist transcription factor cluster is up-

262 How beta-catenin stimulated these two distinct programs was uncle

263 cally, Jak3-mediated phosphorylation of beta-catenin suppressed EGF-mediated epithelial-mesenchymal t

264 beta-catenin suppression by a clinically relevant modality is

265 rall tumor burden, were not affected by beta-catenin suppression.

266 of repression of the KCNQ1 promoter by beta-catenin:T-cell factor (TCF)-4.

267 onstrated by studies of TNF-induced Wnt/beta-catenin target gene expression in murine enteroids and c

268 ll type-specific enhancer for the Wnt9b/beta-catenin target gene Fam19a5 shows that Myc and beta-cate

269 provides insight into the regulation of beta-catenin target genes in the developing kidney, but will

270 vation and the subsequent activation of beta-catenin target genes including cyclin-D1.

271 Upregulation of Wnt/beta-catenin target molecules in the optic cup and stalk may

272 s associated with dramatic decreases in beta-catenin targets and some K-Ras effectors, leading to red

273 -catenin tumors showed up-regulation of beta-catenin targets like glutamine synthetase (GS), leukocyt

274 4A1 expression through formation of the beta-catenin-TCF-3/TCF-4/LEF-1 complex on the NR4A1 promoter.

275 Beta-catenin/Tcf and the TGF-beta bone morphogenetic protein

276 These studies support the role of SATB2/beta-catenin/TCF-LEF pathway in transformation and carcinogen

277 represented by these mRNAs include Wnt/beta-catenin, TGF-beta, and stem cell signaling.

278 n mutations in the CTNNB1 gene encoding beta-catenin that also activate canonical WNT signaling.

279 e PKC-specific phosphorylation sites in beta-catenin that are required for full beta-catenin function

280 moesin) domains of Jak3 interacted with beta-catenin, the NTD domain of beta-catenin facilitated its

281 ns by AJ localization of phosphorylated beta-catenin through its interactions with alpha-catenin.

282 , occludin-ZO-1, CAR-ZO-1, and N-cadherin-ss-catenin), through a down-regulation of p-Akt1-S473 and p

283 a-catenin (Armadillo in Drosophila) and p120-catenin to induce rhomboid.

284 cyte defects caused by up-regulation of beta-catenin transcriptional activities.

285 K-Ras-beta-catenin tumors showed up-regulation of beta-catenin targ

286 wn that coexpression of hMet and mutant-beta-catenin using sleeping beauty transposon/transposase lea

287 a demonstrate that the force-dependent alpha-catenin/vinculin interaction, manipulated here by mutage

288 The pivotal role of beta-catenin was further indicated by the up-regulation of it

289 ep during Jak3 trans-phosphorylation of beta-catenin, where Jak3 directly phosphorylated three tyrosi

290 tion may promote beta-oxidation through beta-catenin, whereas hypertrophy was dependent on mammalian

291 ion of Wnt5A, an intrinsic inhibitor of beta-catenin, which also promotes invasion.

292 Signal in the pathway is transduced by beta-catenin, which in complex with Tcf/Lef regulates transcr

293 PKC and a well-known binding partner of beta-catenin, which promotes its degradation.

294 alpha was associated with activation of beta-catenin, which regulates liver zonation.

295 to induce Wnt3 expression and stabilize beta-catenin, which then synergizes with Activin-induced SMAD

296 s in nuclear export of TGF-beta-induced beta-catenin, which then undergoes proteasome-dependent degra

297 he culture system, IWP2 decreased total beta-catenin while CHIR99021 increased it in nuclear localiza

298 phorylated Jak3 bound to phosphorylated beta-catenin with a dissociation constant of 0.28 mum, and al

299 that high co-expression levels of SCD1, beta-catenin, YAP/TAZ and downstream targets have a strong ne

300 dhesions and cytoskeleton: VE-cadherin, p120-catenin, ZO-1, cortactin, and VASP.