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1 -cadherin and stabilizes the E-cadherin-beta-catenin complex.
2 ting an E3 ligase, Smurf2, to the Smad7/beta-catenin complex.
3 tion of alpha-catenin with the DeltaEXD-beta-catenin complex.
4 fied in immunoprecipitates of the N-cadherin.catenin complex.
5 might involve the disruption of the cadherin/catenin complex.
6 iation of Erbin with the junctional cadherin-catenin complex.
7 ars to be independent of the E-cadherin-beta-catenin complex.
8 ell adhesion and interacts with the cadherin-catenin complex.
9 her and how Wnt signaling regulates the beta-catenin complex.
10 iling to recruit GSK-3beta into the PS1-beta-catenin complex.
11 rs and plays a distinct role in the cadherin-catenin complex.
12 ty inhibits formation of the E-cadherin-beta-catenin complex.
13 dherin or in the composition of the cadherin-catenin complex.
14 amily (LAR-PTP) associates with the cadherin-catenin complex.
15 t polarization depend on the N-cadherin-beta-catenin complex.
16 ermeability due to modulation of VE-cadherin/catenin complex.
17 mouse brain and colocalizes to the cadherin-catenin complex.
18 all levels of alphaE-catenin or the cadherin-catenin complex.
19 here it colocalizes with the E-cadherin/beta-catenin complex.
20 transcriptional activation of the Lef-1-beta-catenin complex.
21 eins, but is not a core part of the cadherin-catenin complex.
22 than when it cannot bind the E-cadherin-beta-catenin complex.
23 by dephosphorylating components of cadherin-catenin complexes.
24 dulate the phosphorylation state of cadherin/catenin complexes.
25 er 1, is also directly regulated by TCF-beta-catenin complexes.
26 blot analysis of immunoprecipitated cadherin/catenin complexes.
27 n is necessary for the formation of PS1/beta-catenin complexes.
28 iation between caspase-8 and E-cadherin:beta-catenin complexes.
29 e designed peptide preserved native APC-beta-catenin complexes.
30 lines greatly increased the stability of APC-catenin complexes.
31 of adherens junctions destabilizes cadherin-catenin complexes.
32 tivates target gene expression via Lef1-beta-catenin complexes.
33 e activation of target genes by Tcf/Lef-beta-catenin complexes.
34 lethal in embryos with compromised cadherin-catenin complexes.
35 Wnt target gene and is activated by TCF-beta-catenin complexes.
36 catenin complexes but not from TRbetaPV-beta-catenin complexes.
37 or that bridges gamma-secretase and cadherin-catenin complexes.
39 o axin/glycogen synthase kinase 3(GSK3)/beta-catenin complexes (AGbetaC) as Wnt decreases Dishevelled
40 present strong evidence that in the cadherin-catenin complex alpha-catenin contributes to the binding
43 uggest that the linkage between the cadherin-catenin complex and actin filaments is more dynamic than
45 PLIN establishes a link between the cadherin.catenin complex and actin that is independent of actomyo
46 o require a stable link between the cadherin-catenin complex and actin that is mediated by alpha-cate
47 ession of the membrane-associated E-cadherin/catenin complex and at a rate higher than those observed
48 hat regulate the levels of the core cadherin-catenin complex and coordinate cadherin-mediated cell-ce
49 lted in dissociation of the VE-cadherin/p120-catenin complex and disassembly of adherens and tight ju
50 em stimulates disassembly of the E-cadherin- catenin complex and increases the cytosolic pool of beta
51 nctions critically depend on the VE-cadherin/catenin complex and its interaction with the actin filam
53 e evidence that JNK binds to E-cadherin/beta-catenin complex and phosphorylates beta-catenin at serin
55 ell adhesion mediated by the E-cadherin/beta-catenin complex and that shibire, the Drosophila homolog
56 causes the breakdown of the N-cadherin/beta-catenin complex and that the organism can sequester beta
57 years, and the link between the VE-cadherin.catenin complex and the actin cytoskeleton remains uncle
60 , interacts with the classical cadherin-beta-catenin complex and with F-actin, but its precise role i
61 gulator of Wnt signaling, is present in beta-catenin complexes and activated in Wnt-signaling cells.
63 iation of vascular endothelial cadherin/beta-catenin complexes and resultant endothelial barrier disr
64 -cadherin/gamma-catenin from N-cadherin/beta-catenin complexes and the identification of multiple mem
65 oresponsive link between the E-cadherin.beta-catenin complexes and the underlying actin cytoskeleton.
66 ated that S100A7 is associated with the beta-catenin complex, and inhibits beta-catenin signaling by
67 of dendritic targeting of the cadherin-beta-catenin complex, and reduction in the amplitude and freq
68 tion with beta-catenin and the cadherin.beta-catenin complex, and the effect of the alpha-catenin act
69 ha-actinin, and vinculin from the E-cadherin-catenin complex, and this coincided with a robust phosph
70 tes cytoskeletal association of the cadherin/catenin complexes, and increases Ca(2+)-dependent cell-c
71 ement membrane and re-established E-cadherin-catenin complexes, and re-organized their cytoskeletons.
72 generate phospho-Smad2 (p-Smad2)-pY654-beta-catenin complexes, and up-regulate mesenchymal target ge
73 llular adhesions formed through the cadherin-catenin complex are important determinants of proper tis
74 sing anti-proN-cadherin showed that cadherin-catenin complexes are assembled prior to localization at
76 binding protein that binds the cadherin.beta-catenin complex as a monomer and whose dimerization pote
77 These data suggest that a core N-cadherin-catenin complex assembles in the endoplasmic reticulum o
80 on of IQGAP1 with components of the cadherin-catenin complex at cell-cell junctions, resulting in imp
81 es the recruitment of PI3K to the E-cadherin-catenin complex at the plasma membrane of human keratino
82 toplasmic tail (CT), loss of E-cadherin/beta-catenin complexes at the adherens junctions (AJs), intra
83 tes interrupts and destabilizes the cadherin-catenin complexes at the cell membrane leading to nuclea
84 a full but inactive complement of E-cadherin-catenin complexes at the cell surface, but they can be t
86 nal model of the cadherin.beta-catenin.alpha-catenin complex based on these new structural data sugge
90 itation analysis determined that the AR/beta-catenin complex binds to the proximal region of the pros
91 little effect on formation of the N-cadherin-catenin complex but instead resulted in increased N-cadh
92 uelch reporter gene activation by LEF-1-beta-catenin complexes but not activation by the transcriptio
93 eta-catenin was dissociated from TRbeta-beta-catenin complexes but not from TRbetaPV-beta-catenin com
94 ecruitment of actin networks to the cadherin-catenin complex, but how such networks are subsequently
97 s part of the E-cadherin-beta-catenin-alphaE-catenin complex (CCC), mammalian alphaE-catenin binds F-
98 f cell type or glycosylation state, although catenin complex composition varied, showing enriched alp
101 enes through the increased formation of beta-catenin complexes containing TCF transcription factors.
102 yers and disrupted membrane VE-cadherin/beta-catenin complexes, decreased beta-catenin phosphorylatio
104 ine phosphatases associate with the cadherin-catenin complex, directly regulating the phosphorylation
105 hosphorylation is normal, p-Smad2-pY654-beta-catenin complexes do not form in the absence of alpha3 o
107 (a survival-promoting component of cadherin-catenin complexes), down-regulation of 51C (an inositol
109 ies at the free end, and the N-cadherin-p120 catenin complex excludes integrin alpha5 at the junction
110 n deacetylation, thereby enhancing LEF1-beta-catenin complex formation and long-range chromatin loopi
112 d with increased cytoplasmic N-cadherin-beta-catenin complex formation as well as enhanced beta-caten
113 on of beta-catenin or inhibition of Tcf/beta-catenin complex formation reduced EpCAM gene expression
114 al cell polarity and affects E-cadherin/beta-catenin complex formation through the control of Wnt5a e
115 n of monomeric catenins and stabilization of catenin complex formation with both APC and cadherins.
116 argely constitutive and integral to cadherin-catenin complex formation, surface stability, and functi
118 d assay, we showed that the minimal cadherin-catenin complex formed stable bonds with an actin filame
119 nd beta-catenin, probably as intact cadherin-catenin complexes from the basolateral membrane of tubul
120 tion of the ZA proteins as intact E-cadherin-catenin complexes from the plasma membrane facilitates t
122 We also demonstrate that the E-cadherin/catenin complex functions as an upstream regulator of th
123 is unknown whether homologs of the cadherin.catenin complex have conserved structures and functions
125 data suggest that APC-catenin and E-cadherin-catenin complexes have opposing effects on intestinal ep
126 N-cadherin and the assembly of the cadherin-catenin complex in cells that express endogenous N-cadhe
127 expression of VE-cadherin/p120-catenin/beta-catenin complex in co-cultured H5V cells was also assess
128 suggest that perturbation of the N-cadherin/catenin complex in heart disease may be an underlying ca
131 n we observed between PTPmu and the cadherin-catenin complex in immunoprecipitates of the phosphatase
132 ial barrier by disrupting a VE-cadherin-beta-catenin complex in lung endothelium from wild-type, but
133 estoration of membrane-associated E-cadherin/catenin complex in TGF-beta1/Delta(beta)RII compound tum
136 osphatase PTPmu associates with the cadherin-catenin complex in various tissues and cells and, theref
138 a) caused the disruption of VE-cadherin/beta-catenin complexes in a Src-dependent manner, decreased b
139 s with the HepII domain caused cadherin/beta-catenin complexes in adherens junctions and actin filame
142 ene is activated by T cell factor (TCF)-beta-catenin complexes in transient transfection assays, sugg
143 ociated PSD-95 and N-cadherin from the delta-catenin complex, increased the association of delta-cate
144 ly, a cross-linking analysis of the cadherin-catenin complex indicated that a large loop located in t
145 high affinity unlike the beta-catenin.alphaE-catenin complex, indicating that alphaT-catenin can dire
146 cate that localized clustering of E-cadherin/catenin complexes into puncta and their association with
147 that the intracellular level of the cadherin/catenin complex is a limiting factor during critical sta
149 e transactivating function of the LEF-1/beta-catenin complex is critical for tumorigenesis and that t
150 ation of the cytoskeleton with the cadherin--catenin complex is essential for strong cell-cell adhesi
152 n is initiated, suggests that the N-cadherin/catenin complex is involved in boundary formation and in
153 lly assembled APC-Axin-GSK3beta-phospho-beta-catenin complex is necessary for the K63-polyubiquitylat
154 ner, and their association with the cadherin-catenin complex is reduced in cells treated with NGF.
155 strates that the disruption of cadherin-beta-catenin complexes is an important molecular event throug
159 That PS1 is a constituent of the cadherin/catenin complex makes that complex a potential target fo
161 The classical cadherin.beta-catenin.alpha-catenin complex mediates homophilic cell-cell adhesion a
162 ta-catenin and other members of the cadherin/catenin complex, namely N-cadherin and alphaN-catenin, e
163 aE9 increased neither the levels of cadherin/catenin complexes nor cell aggregation, suggesting that
164 hypertrophic chondrocytes, TCF x LEF x beta-catenin complexes occupy the consensus TCF x LEF x Sox9
165 ly, upon inactivation of the entire cadherin-catenin complex, only adhesive strengthening between fil
166 migration, whereas augmentation of APC-beta-catenin complexes produces a disordered, nonadhesive mig
167 dhesiveness; augmentation of E-cadherin-beta-catenin complexes produces a highly ordered, "adhesive"
168 tenin (p120ctn), a component of the cadherin-catenin complex, recruits gamma-secretase to cadherins,
172 increasing the relative activity of cadherin-catenin complexes, resulting in enhanced adhesiveness an
173 ipulation of myosin-II activity and cadherin-catenin complexes revealed that this transmission is med
174 he 3.0 A structure of a beta-TrCP1-Skp1-beta-catenin complex reveals the basis of substrate recogniti
176 with actin filaments and the E-cadherin-beta-catenin complex simultaneously, even in the presence of
177 and cytoplasmic pools to regulate E-cadherin/catenin complex stability and cell migration, respective
178 ate steady-state catenin levels and cadherin-catenin complex stability are poorly understood, but act
180 known features of p120-catenin in a cadherin-catenin complex that are critical for our understanding
182 As c-jun is a direct target of the TCF4/beta-catenin complex, the control of tcf4 expression by JNK/c
184 role in the stabilization of the E-cadherin-catenin complex, thereby providing one possible explanat
185 recruits beta-2-spectrin to E-cadherin-beta-catenin complexes, thus providing a direct connection be
188 show that ZOO-1 cooperates with the cadherin-catenin complex to dynamically regulate strong junctiona
189 tein that can physically couple the cadherin.catenin complex to F-actin in the absence of tension.
190 mechanisms by which it anchors the cadherin-catenin complex to the actin cytoskeleton at adherens ju
191 role in the direct anchorage of the cadherin-catenin complex to the actin cytoskeleton, has remained
196 n PIP5K1alpha is recruited by the E-cadherin-catenin complex to the plasma membrane where it provides
198 regulate chemotactic response and ZO-1/alpha-catenin complexes to regulate endothelial barrier integr
199 to which alpha-catenin bridges cadherin.beta-catenin complexes to the actin cytoskeleton has been cha
200 These results may explain how the cadherin-catenin complex transduces mechanical forces at cell-cel
201 g actin filaments and immobilized N-cadherin/catenin complexes, translating into a local reduction of
202 of PI3K to the E-cadherin/beta-catenin/p120-catenin complex via beta-catenin at the plasma membrane
203 that this complex containing Smads/TCF4/beta-catenin complex was able to up-regulate transcription at
204 he polycystin-1/polycystin-2/E-cadherin/beta-catenin complex was disrupted and both polycystin-1 and
205 t the association of Erbin with the cadherin-catenin complex was mediated by the interaction of its P
208 While the protein levels of the cadherin/catenin complex were significantly induced during AF-236
210 might interact with the Axin.APC.GSK-3.beta-catenin complex, where it could modulate the effect of G
211 n depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin
212 translocation in hepatocytes is the Met-beta-catenin complex, which appears to be independent of the
213 ng cell-cell adhesion through the E-cadherin-catenin complex, which controls formation and maintenanc
214 ed PGE(2) induces the formation of EGR1-beta-catenin complex, which interacts with T-cell factor 4/ly
216 120 is a key linker cementing the E-cadherin-catenin complex with the transmembrane protease gamma-se
217 lized and coprecipitated with ARVCF or delta-catenin complexed with beta-catenin and E/N-cadherin.
218 Coimmunoprecipitation confirmed that beta-catenin complexed with both p65 and p50 NF-kappaB protei
220 atically increased interaction of E-cadherin-catenin complexes with vinculin and the actin cytoskelet
221 to the junction in parallel to the cadherin-catenin complex, zoo-1 loss of function reduces the dyna
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