ライフサイエンスコーパス: cathelicidin

1 icrobial function with antimicrobial peptide cathelicidin.

2 nnate antimicrobial peptide LL-37, the human cathelicidin.

3 e magnitude of inflammation and increases in cathelicidin.

4 but it did not attenuate vitamin D3-induced cathelicidin.

5 VDR and the downstream antimicrobial peptide cathelicidin.

6 , leading to VDR activation and induction of cathelicidin.

7 duction of antimicrobial peptides, including cathelicidin.

8 nst skin infection through the expression of cathelicidin.

9 zes with vitamin D to increase expression of cathelicidin.

10 ptides such as alpha- and beta-defensins and cathelicidin.

11 targeted deletion of Camp, the gene encoding cathelicidin.

12 ted with AD and with decreased expression of cathelicidin.

13 D on related antibacterial proteins such as cathelicidin.

14 function relationship of homologous primate cathelicidins.

15 g small interfering RNA (siRNA) specific for cathelicidin, 1,25D(3)-induced cathelicidin mRNA and pro

16 OCS1-3, TGF-beta1b), antimicrobial peptides (cathelicidin-1 and hepcidin), and the macrophage growth

17 Our results show that chicken cathelicidin-2 kills E. coli by permeabilizing the bacte

18 In this article, we show that chicken cathelicidin-2 kills Escherichia coli in an immunogenica

19 ease activity and differential processing of cathelicidin accompanied increased KLK expression.

20 Endothelial-bound cathelicidin activates formyl-peptide receptor 2 on clas

21 lts demonstrate that doxycycline can prevent cathelicidin activation, and suggest a previously unknow

22 However, little is known about how these cathelicidins affect TLR activation in the context of co

23 hanisms in the lung and the possible role of cathelicidin against different pulmonary pathogens in vi

24 In assay of cell binding to HA, cathelicidins also significantly inhibited this process,

25 the hCLD, LL-37, and the precursor form, pro-cathelicidin (also known as hCAP18), and we found that t

26 gs by demonstrating that expression of human cathelicidin alters multiple signaling pathways in a ker

27 nals elicited by serum amyloid protein A and cathelicidins, among others.

28 t AM were found to secrete beta-defensin and cathelicidin AMP homologues, and the GBS ponA mutant was

29 tamin D3 (1,25D3)-induced gene expression of cathelicidin AMP in keratinocytes, suggesting a negative

30 act as a DAMP in the skin and how the human cathelicidin AMP LL-37 might influence growth factor pro

31 he interaction between tritrpticin (TRP3), a cathelicidin AMP, and micelles of different chemical com

32 glucocorticoids triggered the expression of cathelicidin, an antimicrobial critical for antimycobact

33 Antimicrobial peptides, such as cathelicidin and beta defensins, directly kill microbes

34 D receptor or SRC3 blocked the induction of cathelicidin and CD14 by 1,25D3.

35 rate or trichostatin A) and 1,25D3 increased cathelicidin and CD14 expression and enhanced the antimi

36 ced expression of the antimicrobial peptides cathelicidin and DEFB4, being up-regulated by IFN-gamma,

37 Cathelicidin and human beta-defensin 2 mRNA expression w

38 The increased abundance and activity of cathelicidin and kallikrein 5 (KLK5), a predominant tryp

39 ng to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium

40 37 is generated upon proteolytic cleavage of cathelicidin and limits invading pathogens by directly t

41 found to be mediated in part by secretion of cathelicidin and was significantly increased by antibiot

42 ads to the vitamin D-dependent production of cathelicidin and, at the same time, an antimicrobial act

43 pregulation of macrophage NO, NADPH oxidase, cathelicidin, and autophagy mechanisms, but whether vita

44 M1 also binds murine cathelicidin, and its virulence contribution in a murine

45 NETs consisted of eDNA, histones, cathelicidin, and neutrophil elastase.

46 The cathelicidin antimicrobial peptide (Camp) gene was upreg

47 Cathelicidin antimicrobial peptide (CAMP) is a naturally

48 r Typhi and S. Typhimurium will induce human cathelicidin antimicrobial peptide (CAMP) production, an

49 (S1P), regulates production of a major AMP, cathelicidin antimicrobial peptide (CAMP), in response t

50 lls to produce an innate immune element, the cathelicidin antimicrobial peptide (CAMP).

51 of the multifunctional antimicrobial peptide cathelicidin antimicrobial peptide (CAMP).

52 or (VDR)-dependent mechanisms regulate human cathelicidin antimicrobial peptide (CAMP)/LL-37 in vario

53 )D) enhances innate immunity by inducing the cathelicidin antimicrobial peptide (hCAP).

54 CD14 and TLR2, complementing an increase in cathelicidin antimicrobial peptide expression.

55 ction was mediated through the production of cathelicidin antimicrobial peptide from adipocytes becau

56 These include the cathelicidin antimicrobial peptide gene and the TLR core

57 ly localizes with elevated expression of the cathelicidin antimicrobial peptide LL-37.

58 let-derived antimicrobials in serum, and the cathelicidin antimicrobial peptide LL-37.

59 deI and ompD are important for resistance to cathelicidin antimicrobial peptide, a mouse AMP produced

60 esponding to residues 7-27 of the only human cathelicidin antimicrobial peptide, LL37, is shown to ex

61 Using MCs derived from mice deficient in cathelicidin antimicrobial peptide, we showed that antim

62 Cathelicidin antimicrobial peptides are present at sites

63 These observations provide evidence that cathelicidin antimicrobial peptides mediate an anti-infl

64 mycin, the susceptibility of the bacteria to cathelicidin antimicrobial peptides or serum complement

65 Mast cells (MC) express cathelicidin antimicrobial peptides that act as broad-sp

66 tibility to reactive oxygen species and host cathelicidin antimicrobial peptides, which correlated wi

67 ability of PilB to mediate GBS resistance to cathelicidin antimicrobial peptides.

68 ate immune responses, such as the release of cathelicidin antimicrobial peptides.

69 heterodimer [S100A8/A9]) in the cytosol and cathelicidin antimicrobial protein (CAMP) in endosomes.

70 C/EBP-epsilon protein and lactoferrin (Ltf), cathelicidin antimicrobial protein (Camp), and lipocalin

71 ricidal effects, whereas the human and mouse cathelicidins appeared to mediate protection through inc

72 As many functions of cathelicidin are mediated through formyl peptide recepto

73 Cathelicidins are a family of bacteriocidal polypeptides

74 Cathelicidins are a family of cationic peptides expresse

75 Cathelicidins are a family of endogenous antimicrobial p

76 Cathelicidins are a gene family best known for their ant

77 These data lead us to propose that cathelicidins are a key, nonredundant component of host

78 Cathelicidins are antimicrobial peptides of the innate i

79 ides such as human beta-defensins (hBDs) and cathelicidins are critical for protection against infect

80 Cathelicidins are essential in the protection against in

81 Cathelicidins are host defense peptides, expressed in th

82 Although cathelicidins are known to modulate activation by severa

83 peptides (AMPs), such as beta-defensins and cathelicidins, are essential components of innate and ad

84 nd/or IFN-gamma, which promotes induction of cathelicidin, as well as antimycobacterial activity, wer

85 cantly associated with greater increments in cathelicidin at days 1 and 3 (p=0.04 and 0.004, respecti

86 olecalciferol induces the secretion of human cathelicidin, at the concentrations produced in vitro, c

87 ct response, whereas local administration of cathelicidin before sensitization inhibited the allergic

88 Host-defense molecules, cathelicidin, beta-defensin, and S100A8/A9, were also up

89 In vitro, cathelicidin bound directly to staphylokinase and augmen

90 r, we provide evidence that the induction of cathelicidin by glucocorticoids is not sufficient for ma

91 n part on the balance between degradation of cathelicidins by amebic released cysteine proteinases an

92 al and nucleic acid-complexing properties of cathelicidins can mediate pDC activation-promoting adapt

93 Antimicrobial peptides such as cathelicidins can modulate inflammation by interfering w

94 Our results show that chicken cathelicidin (CATH)-2 strongly enhances DNA-induced acti

95 , we examined the contribution of the murine cathelicidin, cathelicidin-related antimicrobial peptide

96 murine beta-defensin 3 (mBD3), mBD4, and the cathelicidin cathelin-related antimicrobial peptide (CRA

97 pimecrolimus enhances distinct expression of cathelicidin, CD14, and human beta-defensin-2 and beta-d

98 ailability prevented TGF-beta1 from inducing cathelicidin, CD14, or TLR2 in human keratinocytes, whil

99 quences from native helical families such as cathelicidins, cecropins, and magainins we demonstrate t

100 We show that cathelicidin concentrates in Lamp1 positive compartments

101 Cathelicidins constitute potent antimicrobial peptides c

102 Cathelicidin contributes to mucosal defense against epit

103 f the role of the neutrophil granule protein cathelicidin (CRAMP in mouse, LL37 in human) in atherosc

104 ted with MC derived from either wild-type or cathelicidin-deficient (Camp(-/-)) mice and challenged w

105 ing Pseudomonas aeruginosa (PA) keratitis in cathelicidin-deficient (KO) mice.

106 Cathelicidin-deficient mice exhibited an increased susce

107 Skin from cathelicidin-deficient mice exhibited reduced ability to

108 Correspondingly, colonic mucosa of cathelicidin-deficient mice exhibited reduced expression

109 Cathelicidin-deficient mice showed considerable suscepti

110 Camp(-/-) mice lacking cathelicidin demonstrated a large increase in ear swelli

111 effect on the antibacterial activity of the cathelicidin-derived antibacterial peptide LL37.

112 addition to its antibacterial activity, the cathelicidin-derived LL-37 peptide induces multiple immu

113 LL-37 is the only cathelicidin-derived polypeptide found in humans.

114 pared with controls, and immunoabsorption of cathelicidin diminished antimicrobial activity.

115 able E. coli In total, this study shows that cathelicidins do not affect immune activation by viable

116 However, mouse cathelicidin does influence recognition of CpG as bone m

117 in, at the concentrations produced in vitro, cathelicidin does not trigger autophagy.

118 ia were more susceptible to human and murine cathelicidins due to increased binding by these peptides

119 and viral infections through the release of cathelicidin during degranulation.

120 othesized that staphylokinase interacts with cathelicidin during the early pathogenesis of S. aureus

121 Cathelicidin (encoded by Camp) is an antimicrobial pepti

122 MP [cathelin-related antimicrobial peptide]) cathelicidins, essential components of the mammalian inn

123 Mice lacking the antimicrobial peptide cathelicidin experienced less severe infection than wild

124 Taken together, these data indicate that cathelicidin expressed from myeloid cells promotes CS-in

125 f this study was to characterize the role of cathelicidin expressed in non-tumorous cells in a precli

126 HAT activity was important to keratinocyte cathelicidin expression as the combination of histone de

127 The regulation of cathelicidin expression involves myeloid p65/RelA and so

128 In this study, we hypothesize that cathelicidin expression is induced in MCs by the activat

129 Cathelicidin expression localized to mucosal macrophages

130 ntimicrobial peptide from adipocytes because cathelicidin expression was decreased by inhibition of a

131 gnificantly lower numbers of CD1a+ cells and cathelicidin expression were noted as compared to CS-nai

132 l and granular layer of the skin, similar to cathelicidin expression.

133 nses such as reactive oxygen species and the cathelicidin family of antimicrobial peptides.

134 -3 (OV-3), an alpha-helical peptide from the cathelicidin family, demonstrating an increased antimicr

135 e LL-37/hCAP18, the only human member of the cathelicidin family, plays important roles in killing va

136 -spectrum human antimicrobial peptide in the cathelicidin family.

137 Cathelicidin, for example, is a vitamin D-dependent gene

138 Cathelicidins form a family of small host defense peptid

139 in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and

140 The cathelicidin fragments however, did maintain their antim

141 n silico dissection of crotalicidin (Ctn), a cathelicidin from a South American pit viper, yielded fr

142 Expression of cathelicidin from bone marrow-derived immune cells regul

143 Deletion of the murine cathelicidin gene Cnlp enhanced an allergic contact resp

144 Despite upregulating cathelicidin, glucocorticoids failed to promote macropha

145 These results suggest that cathelicidin has anti-inflammatory activity in skin that

146 Cathelicidin has dual functions in the skin, acting as a

147 ver, to date vitamin D-induced production of cathelicidin has not been shown to have an effect on the

148 LL-37, the only human cathelicidin, has been implicated in tumorigenesis, but

149 hort cationic antimicrobial peptides, called cathelicidins, have previously been shown to modulate TL

150 to ROS and were unable to process endogenous cathelicidin hCAP-18 into the antibacterial peptide LL-3

151 the carboxypeptide cleavage product of human cathelicidin (hCAP18), LL-37, which are co-packaged alon

152 Here, we show that neutrophil-derived cathelicidins (human: LL37, mouse: CRAMP) induce adhesio

153 e protected from spore-induced death by each cathelicidin in a time- and dose-dependent manner.

154 We studied the role of cathelicidin in allergic contact dermatitis, a model req

155 DNA to wild-type mice induced expression of cathelicidin in colons of control mice and mice with DSS

156 We examined whether macrophages express cathelicidin in colons of mice with experimental colitis

157 these results indicate that the functions of cathelicidin in control of TLR9 activation may include b

158 derstood, we investigated the requirement of cathelicidin in controlling transplantable tumors in mic

159 The role of cathelicidin in enabling SCTE-mediated inflammation is v

160 2 increases the production and expression of cathelicidin in mast cells, thereby enhancing their capa

161 Increased expression of cathelicidin in monocytes and experimental models of col

162 emonstrate a previously unrecognized role of cathelicidin in NK cell antitumor function.

163 These findings confirm the role of cathelicidin in skin inflammatory responses and suggest

164 i could not reverse this effect or influence cathelicidin in the absence of 1,25D3, suggesting that b

165 th rosacea express abnormally high levels of cathelicidin in their facial skin and that the proteolyt

166 nt data have suggested contrasting roles for cathelicidin in tumor development.

167 eine proteinase 1 (EhCP1), induce intestinal cathelicidins in human intestinal epithelial cell lines

168 ese observations underline the importance of cathelicidins in sensing bacterial products and regulati

169 In addition, other cathelicidins, including human, mouse, pig, and dog cath

170 Expression of cathelicidin increased in the inflamed colonic mucosa of

171 ncrements were associated with early greater cathelicidin increases, suggesting a possible mechanism

172 Furthermore, endogenous murine cathelicidin, induced by infection, has a fundamental ro

173 Cathelicidin inhibited HA induced MIP-2 release from mou

174 coupled or EGF-R signaling, both targets of cathelicidin inhibited HA-induced MIP-2 release.

175 o analyses showed that human, mouse, and pig cathelicidins inhibited Bacillus anthracis bacterial gro

176 Cathelicidins inhibited TLR4 but not TLR2 mediated induc

177 we demonstrate that MCs are key mediators of cathelicidin-initiated skin inflammation.

178 y inhibited in the presence of siRNA against cathelicidin, instead leading to enhanced intracellular

179 ry and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-acti

180 Cathelicidin is a proposed defender against infection of

181 The activity of cathelicidin is controlled by enzymatic processing of th

182 Cathelicidin is possibly involved in the regulation of t

183 These data demonstrate that cathelicidin is required for the 1,25D(3)-triggered anti

184 Degradation of intestinal cathelicidins is a novel function of E. histolytica cyst

185 but was found to be increased in the skin of cathelicidin knockout and ovalbumin-sensitized filaggrin

186 is finding was demonstrated by the fact that cathelicidin knockout mice (Camp(-/-)) permitted faster

187 nd functional characteristics with mammalian cathelicidin-like host defense peptides (HDPs), we propo

188 defense molecule belonging to the family of cathelicidin-like proteins (gb|ADZ24001.1), is in fact a

189 MCs are also one of the primary sources of cathelicidin LL-37 (Cath LL-37), an antimicrobial peptid

190 owth factor (cutoff value, 42.92 pg/mL), and cathelicidin LL-37 (cutoff value, 3221.01 pg/mL) is pres

191 only to protamine but also to alpha-helical cathelicidin LL-37 and beta-sheet defensin human neutrop

192 The neutrophil peptides cathelicidin LL-37 and lipocalin 2 restricted growth of

193 We propose that the human cathelicidin LL-37 has the paradoxical effect of stimula

194 The human cathelicidin LL-37 is a multifunctional host defense pep

195 MP, and beta-defensin RBD-1; (iii) the human cathelicidin LL-37 killed KIM6 cells as well as rBALF di

196 significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep comp

197 this article, we demonstrate that the human cathelicidin LL-37 mediates an antiviral effect on RSV b

198 Cathelicidin LL-37 plays an essential role in innate imm

199 mponent of the innate immunity system, human cathelicidin LL-37 plays an essential role in protecting

200 nt, SapA, was somewhat more sensitive to the cathelicidin LL-37 than the parent strain and was partia

201 In fact, the only human cathelicidin LL-37 triggers rapid sensing of nucleic aci

202 arkable increases in hBD-1, hBD-3, and human cathelicidin LL-37 were not observed.

203 tralize the antichlamydial activity of human cathelicidin LL-37, a host antimicrobial peptide secrete

204 ncountered during human infection, including cathelicidin LL-37, alpha-defensins, and beta-defensins.

205 f antimicrobials such as beta-defensins, the cathelicidin LL-37, cytokeratin-derived antimicrobial pe

206 wed that human beta-defensins 2 and 3, human cathelicidin LL-37, human neutrophil protein 1, and meli

207 uman beta-defensin-2, human beta-defensin-3, cathelicidin LL-37, psoriasin) and cytokines (TSLP, IL-2

208 uce peptides, such as beta-defensins and the cathelicidin LL-37, that are both antimicrobial and that

209 ing alpha-defensins, beta-defensins, and the cathelicidin LL-37.

210 ensins, ELR-negative CXC chemokines, and the cathelicidin LL-37.

211 Antimicrobial peptides, such as the cathelicidin LL-37/hCAP-18 and its mouse homolog catheli

212 min D metabolites regulate the expression of cathelicidin (LL-37), which is an endogenous antimicrobi

213 des (human beta-defensin [hBD]-2 and -3, and cathelicidin [LL-37]) are studied in an organotypic dent

214 eptide (CRAMP; an ortholog of the sole human cathelicidin, LL-37), were infected transurethrally with

215 sis where the defensins and the single human cathelicidin, LL-37, may contribute to disease.

216 The cleavage product of cathelicidin, LL-37, was assayed by ELISA.

217 re of the human CLD (hCLD) of the sole human cathelicidin, LL-37.

218 cterized antimicrobial activity is the human cathelicidin, LL-37.

219 as well as through direct pDC activation by cathelicidin (LL37).

220 ies to NETs as well as the ortholog of human cathelicidin/LL37 (CRAMP), a molecule externalized in th

221 ese differences were due to MC expression of cathelicidin, MC-deficient mice were reconstituted with

222 In addition, through their production of cathelicidin, MCs have the capacity to oppose invading p

223 Induction of cathelicidin-mediated antimicrobial pathway against intr

224 These findings suggest that cathelicidins might be utilized to augment the initial i

225 specific for cathelicidin, 1,25D(3)-induced cathelicidin mRNA and protein expressions were efficient

226 racellular M. tuberculosis and expression of cathelicidin mRNA and protein.

227 Secondary outcomes included leukocyte cathelicidin mRNA expression, plasma cytokine levels (IL

228 The relative expression level for cathelicidin mRNA was elevated in both the involved and

229 ng potent antimicrobial functions of porcine cathelicidins, nothing is known about their ability to p

230 In this study, we explored the effects of cathelicidins on DNA-induced activation of chicken macro

231 Calcitriol-treated patients had higher cathelicidin (P = 0.04) and IL-10 (P = 0.03) mRNA expres

232 study, we demonstrate that the murine mature cathelicidin peptide (CRAMP), encoded by the mouse gene

233 The human cathelicidin peptide LL-37 enhances recognition of nucle

234 e conditions inhibited the generation of the cathelicidin peptide LL-37 from its precursor protein hC

235 ry concentrations of the human antimicrobial cathelicidin peptide LL-37 stimulate expression of the G

236 mass spectrometry (SELDI-TOF-MS) analysis of cathelicidin peptide purified from mast cells defined th

237 Human LL-37 is a multifunctional cathelicidin peptide that has shown a wide spectrum of a

238 diated in part by the expression of a unique cathelicidin peptide.

239 These cathelicidin peptides are a result of a post-translation

240 that the proteolytically processed forms of cathelicidin peptides found in rosacea are different fro

241 In mice, injection of the cathelicidin peptides found in rosacea, addition of SCTE

242 Cathelicidin peptides, which facilitate immune recogniti

243 line through inhibiting generation of active cathelicidin peptides.

244 Among the porcine cathelicidins, phylogenetic analysis of the C-terminal m

245 The highest positively charged cathelicidin, PMAP-36, was found to be the most potent p

246 M1 protein also binds the cathelicidin precursor hCAP-18, preventing its proteolyt

247 ein 7 (KLK7) control enzymatic processing of cathelicidin precursor in the skin and regulate the even

248 to better understand how these may influence cathelicidin processing and function.

249 l that HIF-1alpha regulation of keratinocyte cathelicidin production is critical to their antibacteri

250 l extracellular traps, and kill bacteria via cathelicidin production.

251 obial components through TLR2 and respond by cathelicidin production.

252 In this location cathelicidins promote adhesion of classical monocytes an

253 Cathelicidins promote atherosclerosis by enhancement of

254 vels of thymic stromal lymphopoietin (TSLP), cathelicidin, proteases, that is, the kallikreins (KLK)-

255 Cathelicidin protects against induction of colitis in mi

256 y to release antimicrobial peptides, such as cathelicidin, protects against bacterial infections when

257 milar to the structure of the CLD of the pig cathelicidin, protegrin-3.

258 The primary outcome was plasma cathelicidin protein levels assessed 24 hours after stud

259 ) versus placebo (n = 31) had similar plasma cathelicidin protein levels at 24 hours (P = 0.16).

260 triol administration did not increase plasma cathelicidin protein levels in critically ill patients w

261 Therefore, cathelicidins provide a novel mechanism by which the imm

262 vivo evidence that endogenous expression of cathelicidin provides defense against corneal PA infecti

263 onic antimicrobial peptides (CAMPs), the rat cathelicidin rCRAMP, and beta-defensin RBD-1; (iii) the

264 vitro, LzMPC up-regulated the expression of cathelicidin-related antimicrobial peptide (CRAMP) in ma

265 elicidin LL-37/hCAP-18 and its mouse homolog cathelicidin-related antimicrobial peptide (CRAMP), are

266 the contribution of the murine cathelicidin, cathelicidin-related antimicrobial peptide (CRAMP), to i

267 o the antimicrobial peptides polymyxin B and cathelicidin-related antimicrobial peptide (CRAMP).

268 e probably through induced expression of the cathelicidin-related antimicrobial peptide and inducible

269 oeae concurrently with the downregulation of cathelicidin-related antimicrobial peptide and secretory

270 ociated with reduced local expression of the cathelicidin-related antimicrobial peptide as well as ev

271 was dramatically inhibited, by LL37 or mouse cathelicidin-related antimicrobial peptide in macrophage

272 The expression of cytokines/chemokines and cathelicidin-related antimicrobial peptide was assessed

273 d corneas of adult B6, TLR5(-/-), Camp(-/-) (cathelicidin-related antimicrobial peptide), or PMN-depl

274 l microglia cells, induced the expression of cathelicidin-related antimicrobial peptide, and remarkab

275 nduced protection was partially abrogated in cathelicidin-related antimicrobial peptide-deficient mic

276 enes, most notably the antimicrobial peptide cathelicidin-related antimicrobial peptide.

277 Crotalicidin (Ctn), a cathelicidin-related peptide from the venom of a South A

278 nsin, human beta-defensin-3 (hBD-3), and the cathelicidin-related peptide, LL-37.

279 Consequently, cathelicidins represent an inducible target for preventa

280 Thus, cathelicidin resistance is essential for the pathogenesi

281 Absence of cathelicidin resulted in significantly delayed clearance

282 ulence mechanism by which S. aureus exploits cathelicidin to promote fibrinolysis, leading to enhance

283 s the most closely related of the 11 porcine cathelicidins to human LL-37.

284 suggesting a negative regulatory function on cathelicidin transcription.

285 alpha- and -defensin-, magainin-, and cathelicidin-type antimicrobial peptides (AMPs) can kill

286 cytometric analysis showed that only the pig cathelicidin was capable of directly arresting vegetativ

287 use inhibition of sensitization by exogenous cathelicidin was dependent on the presence of functional

288 Protection afforded by the porcine cathelicidin was due to its bactericidal effects, wherea

289 Cathelicidin was initially identified as an antimicrobia

290 Cathelicidin was observed to be abundant in tumor-infilt

291 To determine whether induction of cathelicidin was required for the vitamin D-triggered an

292 Colon expression of cathelicidin was significantly reduced in TLR9(-/-) mice

293 In a mouse intranasal infection model, cathelicidin was strongly up-regulated in the airways du

294 of the waaY mutant to other cationic helical cathelicidins was unaffected, indicating that particular

295 MCs deficient in cathelicidin were less efficient in killing vaccinia vir

296 sing dextran sulfate sodium (DSS); levels of cathelicidin were measured in human primary monocytes.

297 t in expression of the antimicrobial peptide cathelicidin, which is required for 1,25D3 antimicrobial

298 [1,25(OH)2D] is important for production of cathelicidins, which in turn, are critical for antibacte

299 cidins, including human, mouse, pig, and dog cathelicidins, which lack antimicrobial activity under c

300 this study, we examined the interactions of cathelicidin with HA.