ライフサイエンスコーパス: cathepsin C

1 e acylation vs deacylation half-reactions of cathepsin C.

2 odial ortholog of the lysosomal exopeptidase cathepsin C.

3 et lysosomal thiol protease, consistent with cathepsin C.

4 OLFM4 was found to interact with cathepsin C, a cysteine protease that plays an important

5 trophil bactericidal activity by restricting cathepsin C activity and its downstream granule-associat

6 athepsin G, and proteinase 3), which require cathepsin C activity for processing and maturity, were a

7 The cathepsin C activity in neutrophils from OLFM4(-)/(-) mi

8 assay to demonstrate an almost total loss of cathepsin C activity in PLS patients and reduced activit

9 We demonstrated that OLFM4 inhibited cathepsin C activity in vitro and in vivo.

10 expression of cystatin F suppressed cellular cathepsin C activity.

11 ld-type and Lman1(-/-) mice in the levels of cathepsin C and cathepsin Z in liver lysates or alpha1-a

12 The activities of cathepsin C and its downstream proteases (neutrophil ela

13 ld be necessary before cystatin F can engage cathepsin C and we show that the intracellular form of c

14 Cathepsin C, another cysteine proteinase with a rather d

15 Thus, cathepsin Cs are critical to T. gondii growth and differ

16 endopeptidases cathepsin B and L, T. gondii cathepsin Cs are exopeptidases and remove dipeptides fro

17 T. gondii cathepsin Cs are required for peptide degradation in the

18 We identified cathepsin C as critical for Leu-Leu-OMe-induced cell dea

19 We examined the cathepsin C-catalyzed hydrolysis of dipeptide substrates

20 The cysteine protease cathepsin C (CatC) activates granule-associated proinfla

21 Despite previous reports identifying cathepsin C, cathepsin Z, and alpha1-antitrypsin as addi

22 mutations that inactivate cysteine protease cathepsin C (CTSC), which processes a variety of serine

23 Strikingly, cathepsin C deficiency not only blocked Leu-Leu-OMe-medi

24 ntified as the activator of NSP4 in vivo, as cathepsin C deficiency resulted in a complete absence of

25 activity of the lysosomal cysteine protease cathepsin C/dipeptidyl peptidase I (DPPI).

26 l loss of cathepsin C in mice with OLFM4 and cathepsin C double deficiency.

27 ESCP is homologous to cathepsin C enzymes of higher eukaryotes, but is disting

28 re syndrome, and evaluated the gene encoding cathepsin C for mutations.

29 Mutations of the lysosomal protease cathepsin C gene (CTSC) have been shown to be the geneti

30 Addition of these cathepsin C gene mutations into the expanding Papillon-L

31 In contrast, removal of cathepsin C had no effect on either tumor formation or p

32 Recently, mutations in the gene encoding cathepsin C have been disclosed in a limited number of f

33 cantly compromised by the additional loss of cathepsin C in mice with OLFM4 and cathepsin C double de

34 recombinant cystatin F was unable to inhibit cathepsin C in vitro even though overexpression of cysta

35 60, which is currently in clinical trials as cathepsin C inhibitor for the treatment of cystic fibros

36 The specific cathepsin C inhibitor, Gly-Phe-dimethylketone, selective

37 precise N-terminal truncation that creates a cathepsin C inhibitor.

38 tachyzoites was completely inhibited by the cathepsin C inhibitor.

39 Cathepsin C inhibitors also limited the in vivo infectio

40 By targeting cathepsin C, it may regulate diverse immune cell effecto

41 /endosomal enzyme-related genes (cystatin C, cathepsin C, lysozyme, and prosaposin) did not require d

42 inetic parameters and sKIEs for the proposed cathepsin C mechanism, integration of both steady-state

43 sins from Toxoplasma gondii, including three cathepsin Cs, one cathepsin B, and one cathepsin L.

44 gene (CTSC) encoding the lysosomal protease cathepsin C (or dipeptidyl aminopeptidase I) lies within

45 Cathepsin C, or dipeptidyl peptidase I, is a lysosomal c

46 hly conserved amino acid residues within the cathepsin C polypeptide.

47 substrate of cathepsins B, L, and S, but not cathepsin C, potentially explaining their differential e

48 g retrovirus and analyzed the cystatin C and cathepsin C promoters.

49 he structural effects caused by mutations in cathepsin C protein (CTSC).

50 atumoral collagenase (to digest collagen) or cathepsin C (to digest decorin) each increased diffusion

51 Using the dipeptide substrate Ser-Tyr-AMC, cathepsin C was characterized in both steady-state and p

52 Moreover, cathepsin C was identified as the activator of NSP4 in v

53 rent immune cell types is the aminopeptidase cathepsin C, which regulates the activation of effector