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1 th accessory subunit surrounding the central cation channel.
2 LGC-55 anion channel to an excitatory LGC-55 cation channel.
3 rm 4 (TRPV4), a polymodal swelling-sensitive cation channel.
4 tor that forms a nonselective homotetrameric cation channel.
5 ient receptor potential melastatin 1 (TRPM1) cation channel.
6 t Receptor Potential Melanostatine 2 (TRPM2) cation channel.
7 on binding and transport of this promiscuous cation channel.
8 s TRPM2, a Ca(2+), Na(+), and K(+) permeable cation channel.
9 conformational changes to the gating of the cation channel.
10 construct forms an essentially non-selective cation channel.
11 ed them with dTrpA1, a temperature-sensitive cation channel.
12 eurons using a nonnative genetically encoded cation channel.
13 glutamate to the opening of a transmembrane cation channel.
14 des the two-pore channel 2 (TPC2) protein, a cation channel.
15 ember 6 (TRPC6) gene encoding a nonselective cation channel.
16 1) proteins are heat-activated nonselective cation channels.
17 or blockade of transient receptor potential cation channels.
18 Channelrhodopsins (ChRs) are light-gated cation channels.
19 tivity within this superfamily of tetrameric cation channels.
20 function and expression of Ca(2+)-permeable cation channels.
21 sensitive transient receptor potential (TRP) cation channels.
22 uding voltage, stretch, and ligand-activated cation channels.
23 ay have broad applications for voltage-gated cation channels.
24 long to the TRP superfamily of non-selective cation channels.
25 rent was mediated mainly by sodium-permeable cation channels.
26 are relatives of classical voltage-activated cation channels.
27 ntity and form Ca(2+)-permeable nonselective cation channels.
28 represent Ca(2+) influx through single TRPV4 cation channels.
29 nges in pH, and three are putative ACh-gated cation channels.
30 ed to transient receptor potential canonical cation channels.
31 -dependent excitation involving non-specific cation channels.
32 Two-pore channels (TPCs) are endolysosomal cation channels.
33 2X7R) belongs to the P2X family of ATP-gated cation channels.
34 ls (CNGCs) are nonspecific, Ca(2+)-permeable cation channels.
35 -dependent excitation involving non-specific cation channels.
36 sed in both animals and plants as organellar cation channels.
37 ctivated cyclic-nucleotide-gated nonspecific-cation channels.
38 cyclic-nucleotide-gated (CNG), nonselective cation channels.
39 osophila TRPA1 (transient receptor potential cation channel A1) was necessary for normal activity pat
42 atin 8 (TRPM8) channel is a Ca(2+)-permeable cation channel activated by cold, voltage, phosphatidyli
44 ential vanilloid 1 (TRPV1) is a nonselective cation channel activated by multiple stimuli and is impl
45 P2X receptors are trimeric, non-selective cation channels activated by ATP that have important rol
48 um ion binding (P = 3.55 x 10(-)(1)(5)), and cation channel activity (P = 2.77 x 10(-)(1)(4)) were si
49 his issue of Neuron highlights voltage-gated cation channel activity as a likely link and culprit.
52 demonstrating that nonselective sarcolemmal cation channel activity plays a critical role in causing
53 locus-encoded beta-subunit of rod cGMP-gated cation channel and associated glutamic acid rich protein
54 l recordings show that it is a non-selective cation channel and that its activity depends on Ca(2+) c
55 tivated, but Ca2+ -impermeable, nonselective cation channels and are expressed both in atrial and in
56 (h)KCNE beta subunits each regulate various cation channels and are linked to inherited cardiac arrh
60 among the most highly efficient light-gated cation channels and the most blue-shifted channelrhodops
61 ent and transient receptor channel potential cation channel ankyrin subtype 1 (TRPA1)-deficient mice
62 n mutations in mechanically activated Piezo1 cation channels are associated with the dehydrating RBC
64 ient receptor potential (TRPC3) nonselective cation channels are effectors of G-protein-coupled recep
65 ansient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved
66 hat sensory cilia and polycystin-2 (Pkd2), a cation channel, are required for sensing ciliary motilit
68 ) melastatin 4 (TRPM4) is a widely expressed cation channel associated with a variety of cardiovascul
69 n channels (ASICs) are neuronal proton-gated cation channels associated with nociception, fear, depre
72 ich encodes the transient receptor potential cation channel, can cause familial episodic pain syndrom
75 the plasma membrane and formed pH-sensitive cation channels, causing collapse of cellular Na(+) and
76 esumptive transient receptor potential (TRP) cation channel, CED-11, that acts in the dying cell to p
78 MCH neurons the gene for the light-sensitive cation channel, channelrhodopsin-2, was inserted into th
80 Canonical (TRPC) proteins form nonselective cation channels commonly known to be activated downstrea
81 ENaC, which is not a component of the glioma cation channel complex, had no effect on cyclin-dependen
83 rant receptors are heteromeric odorant-gated cation channels comprising a conventional odorant-sensit
84 eceptor potential 1 (TRPC1) Ca(2+)-permeable cation channels contribute to vascular tone and blood ve
85 PC6 and function as diacylglycerol-activated cation channels coordinately, the role of TRPC6 in heart
87 aC) and nonselective cyclic-nucleotide-gated cation channels creates the major driving force for reab
88 d 1 (TRPV1) is a polymodal, Ca(2+)-permeable cation channel crucial to regulation of nociceptor respo
90 a suggested that hyperpolarization-activated cation channel currents and T-type calcium channel curre
91 rpolarization-activated and nucleotide-gated cation channels decreasing the firing rate of MNCs and t
94 We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and
95 Kenyon cells by expressing a thermosensitive cation channel (dTrpA1) leads to a decrease in sNPF immu
96 cially activated via a temperature-sensitive cation channel (dTRPA1), males followed and extended the
97 as largely eliminated during the blockade of cation channels due to the internal dialysis of Cs(+) ,
98 axonal transport (HSPB1, DYNC1H1, DCTN1) and cation-channel dysfunction (ATP7A and TRPV4) in motor-ne
100 nt stimulator of Ca(2+) influx through TRPA1 cation channels (EC50 ca. 200 nM), thereby explaining it
101 3 (TRPC3), a calcium-permeable, nonselective cation channel endowed with high constitutive function,
102 l Melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel essential for immunocyte activation, insu
103 de-gated (CNG) ion channels are nonselective cation channels, essential for visual and olfactory sens
104 sual disease caused by mutations in TRPM1, a cation channel expressed by both melanocytes and retinal
105 ntial melastatin 8 (TRPM8) is a nonselective cation channel expressed in a subpopulation of sensory n
106 l melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel expressed in immune cells of phagocytic l
107 vanilloid type 1 (TRPV1) is a non-selective cation channel expressed in sensory neurons of the dorsa
110 s caused by mutations in MCOLN1, a lysosomal cation channel from the transient receptor potential (TR
112 omeostasis, AQP1 also acts as a nonselective cation channel gated by cGMP, a property shown previousl
116 tor potential ankyrin 1 (TRPA1) nonselective cation channel has a conserved function as a noxious che
117 stand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin cells
119 (trpv1, trpv4) encode temperature-sensitive cation channels hypothesized to mediate thermoresponses
121 , TRPP2) is a Ca(2+)-permeable, nonselective cation channel implicated in Ca(2+) transport and epithe
123 f a plant ion channel and identify the first cation channel in plant mitochondria from a molecular po
125 function as Ca(2+) conducting, non-selective cation channels in endothelial, smooth muscle, and neuro
127 ated with altered expression and function of cation channels in pulmonary arterial smooth muscle cell
128 DP- and PI(3,5)P2-sensitive Ca(2+)-permeable cation channels in the endolysosomal system of cells, as
129 alanced translocation disruption of TRPC6, a cation channel, in a non-syndromic autistic individual.
130 encoding polycystin-L (PCL), a non-selective cation channel, increases neuronal excitability and the
131 It is postulated that mechanically activated cation channels initiate touch sensation, but the identi
132 eptors are commonly known as plasma membrane cation channels involved in a wide variety of cell funct
133 imeric adenosine-5'-triphosphate (ATP)-gated cation channels involved in fast signal transduction in
135 ient Receptor Potential Melastatin 4 (TRPM4) cation channel is abundantly expressed in cardiac cells,
136 (TRPC5), a calcium-permeable, non-selective cation channel is expressed in the periphery, but there
138 e-shift displayed by hyperpolarization-gated cation channels is likely caused by structural changes a
139 vation of transient receptor potential (TRP) cation channels is one of the most striking examples of
141 7 (TRPM7) and member 6 (TRPM6) are divalent cation channel kinases essential for magnesium (Mg(2+))
143 receptor potential mucolipin 1 (TRPML1) is a cation channel located within endosomal and lysosomal me
144 urea receptor-1-transient receptor potential cation channel M4 is upregulated only after brain injury
146 eraction, claudin-14 blocks the paracellular cation channel made of claudin-16 and -19, critical for
147 (TRPC6), a nonselective and Ca(2+)-permeable cation channel, mediates pathophysiological responses wi
148 2) expressed in endothelial cells (ECs) is a cation channel mediating Ca(2+) entry in response to int
154 est that P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by lumi
155 nation of the Asp-96 homolog is required for cation channel opening and occurs >10-fold faster than r
156 channels in the ER/SR and the non-selective cation channels or putative 'Ca(2+) leak channels', incl
157 channels in the ER/SR and the non-selective cation channels or putative 'Ca2+ leak channels', includ
158 hR-2), a direct light-activated nonselective cation channel originally discovered in Chlamydomonas re
159 d forms a pore complex with the ligand-gated cation channel P2X7, allowing the release of excitatory
161 kd2L1 (also called TRPP3) is a non-selective cation channel permeable to Ca(2+), Na(+), and K(+) and
162 et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical
163 shown that the endothelial mechanosensitive cation channel PIEZO1 is required for flow-induced ATP r
164 at platelets and Meg-01 cells express the MS cation channel Piezo1, which may contribute to Ca(2+) en
165 that the mechanically activated nonselective cation channel Piezo2 was expressed in sensory endings o
169 vestigated if TRPV4, a temperature-sensitive cation channel, plays an important role in acute itch in
171 d at whether the P2X1 receptor, an ATP-gated cation channel present on platelets, neutrophils, and ma
172 ensing ion channel 1 (ASIC1), a proton-gated cation channel primarily expressed in the nervous system
175 euromediators and expression of chemosensory cation channels, protein gene product 9.5 (PGP 9.5), and
177 proteins form a superfamily Ca(2+)-permeable cation channels regulated by a range of chemical and phy
178 potential channel (TrpC) family, a family of cation channels regulated by activation of phospholipase
179 sential for proper localization of the TRPM1 cation channel required for ON BC light-evoked depolariz
180 oid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat, protons, and
181 PA-type glutamate receptors are ligand-gated cation channels responsible for a majority of the fast e
183 n the vacuole, cooperating with the vacuolar cation channel SlTPC1 and the two vacuolar H(+)-pumps, S
184 ocal Ca(2+) signal generated by nonselective cation channels stimulates TMEM16A channels to induce my
185 PGP9.5; TRPV1; transient receptor potential cation channel subfamily A, receptor 1 (TRPA1); TRPV4; t
189 EGFPf) from the transient receptor potential cation channel subfamily M member 8 (TRPM8(EGFPf/+)) loc
190 n of Piezo2 and transient receptor potential cation channel subfamily M member 8 (TRPM8) transcripts
191 minals, whereas transient receptor potential cation channel subfamily M member 8 immunolabeled (cold
193 (TRPA1); TRPV4; transient receptor potential cation channel subfamily M, member 8 (TRPM8); and nerve
194 ssion of TRPV1; transient receptor potential cation channel subfamily M, receptor 8 (TRPM8); and PGP
195 channel 2a, and transient receptor potential cation channel subfamily member M8 (TRPM8) in sensory ga
196 l activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) and CB1Rs.
197 ated afferents [transient receptor potential cation channel subfamily V member 1 (TRPV1) expressing C
200 smitted via the transient receptor potential cation channel subfamily V member 1 (TRPV1) population b
201 ively as either transient receptor potential cation channel subfamily V member 1 (TRPV1)-sensitive or
203 channel TRPV1 (transient receptor potential cation channel subfamily V member 1), but the mechanisms
204 higher baseline transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) expressio
205 ablation of the transient receptor potential cation channel subfamily V, receptor 1 (TRPV1)-substance
206 oid type-1, -3; transient receptor potential cation channel, subfamily A, member 1) have been implica
207 utations in the transient receptor potential cation channel, subfamily C, member 6 (TRPC6) gene encod
208 pression of the transient receptor potential cation channel, subfamily C, member 6 (TRPC6), consisten
210 )-dependent and transient receptor potential cation channel, subfamily M, member 7 (TRPM7)-dependent
211 ration, and the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), in intest
214 channels are members of the large tetrameric cation channels superfamily but are considered to be uni
215 te (PtdIns(4,5)P2) -modulated, non-selective cation channel that belongs to the family of melastatin-
216 (TRPC5) is a nonselective, Ca(2+)-permeable cation channel that belongs to the large family of trans
217 (CaChR1) is a low-efficiency light-activated cation channel that exhibits properties useful for optog
218 eceptor (P2X7R) is an ATP-gated nonselective cation channel that induces inflammatory responses in ce
219 (TRPM3) is a calcium-permeable nonselective cation channel that is expressed in a subset of dorsal r
222 n-2 (ChR2) is a light-activated nonselective cation channel that is found in the eyespot of the unice
223 nonical type 5 (TRPC5) is a Ca(2+)-permeable cation channel that is highly expressed in the brain and
224 1) or vanilloid receptor 1 is a nonselective cation channel that is involved in the detection and tra
225 or potential channel TRPP2 is a nonselective cation channel that is mutated in autosomal dominant pol
226 otential channel 1 (TRPC1) is a nonselective cation channel that is required for Ca(2+) homeostasis n
227 l mucolipin 1 (TRPML1) is a Ca(2+)-releasing cation channel that mediates the calcium signalling and
228 s a TRP-type, Ca(2+)-permeable non-selective cation channel that plays an important role in Ca(2+) si
229 ) channels are Ca(2+)-permeable nonselective cation channels that are activated by a wide variety of
230 Piezo1 and Piezo2 as mechanically activated cation channels that are expressed in many mechanosensit
231 onstitute an important class of ligand-gated cation channels that are involved in the majority of exc
233 rinatal development, 90-pS stretch-activated cation channels that could be blocked by Ca(2+) and by F
234 zo1 and Piezo2 encode mechanically activated cation channels that function as mechanotransducers invo
236 alcium channels (SOCs) are calcium-selective cation channels that mediate calcium entry in many diffe
237 spartate receptors (NMDARs) are ligand-gated cation channels that mediate excitatory synaptic transmi
238 AMPA receptors (AMPARs) are glutamate-gated cation channels that mediate fast excitatory neurotransm
239 acid receptors (AMPARs) are glutamate-gated cation channels that mediate fast excitatory synaptic tr
240 glutamate receptors (iGluRs) are tetrameric cation channels that mediate synaptic transmission and p
241 Mammalian TRICs function as K(+)-permeable cation channels that provide counter ions for Ca(2+) han
242 MDA) receptors are heteromeric non-selective cation channels that require the binding of glycine and
244 P2X receptor channels are ATP-activated cation channels that serve important roles in sensory si
246 f residues characteristic of the chlorophyte cation channels, these proteins are cation-conducting ch
247 excitatory synaptic transmission by forming cation channels through the membrane that open upon glut
248 tivated anion channels (TMEM16A, TMEM16B), a cation channel (TMEM16F) and proteins with unclear funct
250 e activation of transient receptor potential cation channels to attenuate cytosolic Ca2+ influx, impl
255 ly mediated by the activation of nociceptive cation channels transient receptor potential ankyrin 1 a
256 upled to hyperactivation of the nonselective cation channel, transient receptor potential canonical c
257 ceptors are mediated by two Ca(2+) permeable cation channels, transient receptor potential (TRP) and
258 ABSTRACT: The type A trimeric intracellular cation channel (TRIC-A) is a major component of the nucl
259 tivation of the transient receptor potential cation channels (TRP) TRPV1, TRPV4, and TRPA1 causes vis
260 t low temperatures activate a cold-sensitive cation channel, TRPA-1, which triggers a complex signali
262 Transient receptor potential "canonical" cation channels (TRPC) are involved in many cellular act
264 (2+) influx mediated by the mechanosensitive cation channel TRPC6, which activates host calpain that
266 ubpopulation expresses the calcium activated cation channel TRPM5 (transient receptor potential chann
268 and function of the polymodal non-selective cation channel TRPV1 (transient receptor potential vanil
270 ensitive actuator, "Magneto," comprising the cation channel TRPV4 fused to the paramagnetic protein f
271 yses localized the putative mechanosensitive cation channel TRPV4 to the plasma membrane of primary a
273 mily member 1 (WNT1), trimeric intracellular cation channel type b (TRIC-B), and old astrocyte specif
275 channelrhodopsin-2 (PsChR2), are light-gated cation channels used as optogenetic tools for photocontr
276 Blocking signaling through mechanosensing cation channels using GsMTx4 negated the ability of neur
278 , including the transient receptor potential cation channel V1 expressed in the nociceptive neurons o
280 In contrast, transient receptor potential cation channel vanilloid subtype 1 channels were dispens
281 Furthermore, transient receptor potential cation channel vanilloid type 1 appears to counter the a
283 urrents is well documented for voltage-gated cation channels (VGCC), and it is considered a voltage-s
284 n activates a Na(+)-permeable, non-selective cation channel via depolarization-induced rise in [Ca(2+
285 The transient receptor potential-like (TRPL) cation channel was a direct target for camphor in gustat
286 nts of the non-selective Bacillus cereus NaK cation channel we examine are all selective for K(+) ove
288 tion-activated cyclic nucleotide-gated (HCN) cation channels, which are concentrated on dendritic spi
291 yrin 1 (TRPA1) channel is a Ca(2+)-permeable cation channel whose activation results from a complex s
292 resents a novel architecture of a tetrameric cation channel whose ion selectivity mechanism appears t
293 RPM7) is a ubiquitous, constitutively active cation channel with a cytosolic alpha-kinase domain that
296 l vanilloid 4 (TRPV4) channels--nonselective cation channels with considerable Ca(2+) conductance--ha
297 mucolipins) constitute a family of endosomal cation channels with homology to the transient receptor
298 1-3) of eukaryotic voltage- and ligand-gated cation channels with two non-equivalent tandem pore-form
299 Most viroporins are monovalent selective cation channels, with few showing the ability to conduct
300 rm of a tunable, high-conductance vertebrate cation channel, zTrpa1b, coupled with photo-activated ch
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