ライフサイエンスコーパス: causal

1 ted to determine whether this association is causal.

2 ence, this association does not appear to be causal.

3 nduction and that these relationships may be causal.

4 t any reported association might actually be causal.

5 recently the association was suggested to be causal.

6 highly dynamic Abeta oligomers are the main causal agent associated with the onset of AD.

7 ning moth Cameraria ohridella, the bacterial causal agent of bleeding canker disease Pseudomonas syri

8 cific to the fungus Ceratocystis fagacearum, causal agent of oak wilt.

9 Fusarium oxysporum f. lycopersici (Fol), the causal agent of tomato wilt disease, produces effector p

10 While causal agents of WPND are known, current research is lac

11 amework considering effects of polygenicity, causal allele frequency divergence, and heritability.

12 llution studies have purported to have used "causal analysis," generating the impression that studies

13 This study uses genotypic information as a causal anchor to help decipher the likely role of DNA me

14 oil factor family (TFF) members, including a causal and correlative association of TFF1 with prostate

15 rompt a re-consideration of evolutionary and causal aspects of parental decision making, by suggestin

16 ese results provide evidence supportive of a causal association between abdominal adiposity and these

17 irection of biases would reduce the positive causal association between diabetes and LTBI.

18 mendelian randomisation analyses probing the causal association between obesity and its many putative

19 Our findings provide little evidence of a causal association between smoking initiation and schizo

20 New research has demonstrated a causal association between the timing of experimentally

21 Evidence supports a causal association of sleep apnea with the incidence and

22 working nonpoor and the working poor but no causal association of within-person differences in worki

23 gnificant mitral valve disease, suggesting a causal association.

24 ogies have limited progress in elucidating a causal association.

25 riants as instrumental variables to test for causal associations.

26 Under standard causal assumptions, estimates can be interpreted as caus

27 We estimated that SVs are causal at 3.5-6.8% of eQTLs-a substantially higher fract

28 he visual system, current knowledge of their causal basis, and methods for assessing attentional dysf

29 These results based on causal brain lesions complement prior neuroimaging studi

30 of brain activity can be used to investigate causal brain-behavior relationships.

31 Seasonal cold is causal, but, we contend, principally as an ecologically

32 the Nunavik Inuit, we found no other likely causal candidate variant than rs80356779.

33 sality, thus, expected to decipher nonlinear causal cardio-postural-musculoskeletal interactions.

34 rage an exploration of the ways to break the causal chain between these complex phenotypes, which cou

35 disintegrates almost completely through the causal chain underlying aggression and violence.

36 We also argue that causal cognition may be more general than social learnin

37 nal investigation is required to establish a causal connection.

38 These findings provide evidence for a causal contribution of M1 to motor memory formation when

39 bilities) are often interpreted to reflect a causal contribution of neurons to task performance.

40 ses of rhythmic stimulation to elucidate the causal contributions of synchrony to specific aspects of

41 In the present work, we investigate causal contributions of the basolateral amygdala (BLA) a

42 Causal copy-number variants were found in 12 patients (1

43 Our results suggest an independent causal deleterious effect of overweight and obesity on c

44 rther studies are necessary to elucidate the causal direction of this association and the potential r

45 However, the causal direction of this relation remains ambiguous.We u

46 In this work, we apply state-of-the art causal discovery methods on a large collection of public

47 he caveats we need to overcome for automated causal discovery to become a part of the routine data an

48 imental conditions can be used to facilitate causal discovery, and apply two fundamental methods that

49 ociated with these disorders could represent causal disease risk alleles whose effect may be modifiab

50 logically based diagnoses work best for mono-causal disorders and those where the causes all operate

51 G --> COPr) through the significantly higher causal drive in the direction towards SBP and COPr.

52 While many applications of causal effect estimation use propensity score methods or

53 is prevented tumor development, indicating a causal effect in tumorigenesis.

54 This total causal effect may potentially encompass multiple mediati

55 instrumental variable for BMI to assess the causal effect of BMI at age 7 y on disordered eating pat

56 We examined the causal effect of BMI on asthma, hay fever, allergic sens

57 F) study (n = 2,564) and tested the possible causal effect of each metabolite with glucose and type 2

58 randomization analyses are consistent with a causal effect of higher genetically predicted grip stren

59 ty on current asthma, whereas no independent causal effect of physical activity was found.

60 There was little evidence in support of a causal effect of schizophrenia on smoking initiation (OR

61 ily-based study failed to find support for a causal effect of smoking during pregnancy on risk of sev

62 We found evidence consistent with a causal effect of smoking initiation on schizophrenia ris

63 r susceptibility, in addition to inferring a causal effect of smoking on mLOY.

64 We estimated the causal effect on proximal measures, such as website page

65 ether being sentenced to prison itself has a causal effect on the probability of a subsequent return

66 However, this does not confirm a causal effect.

67 We detected 14 paths with potential causal effects by MR, following pathway-based sensitivit

68 e biased estimates of mortality-and often of causal effects even when the true effect was null.

69 Attribution of the primary outcome to causal effects of intervention in the present subsample

70 Estimating causal effects of local air pollution on daily deaths: e

71 Insights from experimental studies support causal effects of maternal obesity on offspring outcomes

72 ental variables to test for and estimate the causal effects of modifiable risk factors on outcomes.

73 riants as instrumental variables to estimate causal effects of risk factors on outcomes.

74 The assumptions needed to transport causal effects to a specific target population must be c

75 Estimation of causal effects using observational data continues to gro

76 g-formula correctly estimated mortality and causal effects when all inputs were from the target popu

77 els (ABMs) are 2 approaches used to estimate causal effects.

78 unconfounded markers of exposures to examine causal effects.

79 assumptions, estimates can be interpreted as causal effects.

80 To use UK Biobank data to report causal estimates of the association between BMI and card

81 the genetic risk score was applied to derive causal estimates using a mendelian randomization approac

82 quired to obtain more precise (and unbiased) causal estimates.

83 Our results provide causal evidence for the involvement of the cerebellum in

84 However, causal evidence for the way oscillatory activity shapes

85 at much faster timescales (>5 Hz); however, causal evidence for this relationship is currently lacki

86 ese neurons, we provide both correlative and causal evidence that the nervous system uses millisecond

87 in V1 paired with recording in MT to provide causal evidence that the relationship between V1 and MT

88 A field experiment provides causal evidence that working adults report greater happi

89 The present study provides the first causal evidence to indicate that this region is critical

90 tic plant species Canarina eminii to explore causal explanations for this pattern.

91 vidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later

92 e proof that the atopic march is the primary causal factor in childhood allergic disease.

93 Sleep difficulties might be a contributory causal factor in the occurrence of mental health problem

94 provides strong evidence that insomnia is a causal factor in the occurrence of psychotic experiences

95 iology based on the timing of the insult and causal factor.

96 combined with changing land-use regimes are causal factors in species' range shifts and are importan

97 r viral proteins are commonly thought as the causal factors, we are interested in the alternative pos

98 ign credit for any particular outcome to the causal features which preceded it.

99 thologue of TERMINAL FLOWER1 (FvTFL1) as the causal floral repressor.

100 r, linking common variants to genes that are causal for CKD etiology remains challenging.

101 finding that mutations in the MAGI2 gene are causal for congenital SRNS.

102 to the functional mPFC deactivation that is causal for the pain phenotype and represents a cellular

103 ined post-Golgi trafficking processes proved causal for this phenotype and might be due to lack of di

104 We used causal forest modelling, which identifies HTEs, using a

105 cognitive and behavioural flexibility make a causal functional contribution to the hierarchical gener

106 The causal gene and underlying mechanism remain unresolved.

107 OsHAC4 is the causal gene for the As(V)-hypersensitive phenotype.

108 offers an alternative approach to candidate causal gene identification for variants with cell state-

109 IDENTITY1 (LMI1) gene of Arabidopsis is the causal gene underlying the l-D1 locus.

110 ibution, an R package that assigns candidate causal gene(s) to a risk variant identified by a genetic

111 Identifying the causal genes has benefited enormously from advances in h

112 modifier loci have been detected in plants, causal genes have remained elusive.

113 To test the hypothesis that the missing causal genes in HCM is, in part, because of an oligogeni

114 te the utility of Variant Ranker to identify causal genes using real and synthetic datasets.

115 ns among all 44 TGCT risk SNPs and candidate causal genes.

116 on variation, is warranted to understand the causal genetic basis of AF.

117 , and were able to assign a causal or likely causal germ line mutation in 86 patients (48.0%), involv

118 ohort study comparing risks of death in five causal groups (suicide, drug-related or alcohol-related,

119 iable analysis to estimate a cohort-specific causal hazard ratio for the association between BMI and

120 ancer, we estimated the cumulative number of causal HPV infections by age, stratified by HPV genotype

121 ages, the age at which women acquire their "causal" HPV infection that develops into cervical cancer

122 A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium

123 ents with prior stent implantation, VLST was causal in 20% of MI cases and presented more often as ST

124 studies to lead to associations that are not causal in nature.

125 ssumptions required to draw internally valid causal inference in a specific study sample.

126 We describe a simplified model of causal inference in multisensory speech perception (CIMS

127 e adoption of a more circumspect approach to causal inference in the neuroscience of stress.

128 ealth research: how to address challenges to causal inference posed by wealth's cumulative nature and

129 Using causal inference testing, we searched causal variants ac

130 The CIMS model uses causal inference to provide a computational framework fo

131 es for disease-associated variants, and test causal inference.

132 on control, and retrospective 'sense-making' causal inferences.

133 nd preparation periods with a strong Granger-causal influence from ACC to FEF.

134 Here, we investigated the causal influence of two major stress neuromodulators, co

135 ments, the adult had a significant (Granger) causal influence on infants' neural activity, which was

136 ether predictive activation patterns reflect causal influence within circuits.

137 cotine involvement, consistent with possible causal influence.

138 icity matched controls to identify potential causal initiating infections.

139 Utilization of causal interaction data enables mechanistic rather than

140 S to systematically investigate long-latency causal interactions between right-hemisphere motor areas

141 new ways and then by assessing the principal causal interactions between the primary, genetically bas

142 btained an effect estimate, which can have a causal interpretation under specific assumptions, of bir

143 Here, we show the causal involvement of the right temporoparietal junction

144 hizophrenia, but whether the relationship is causal is not known.

145 We demonstrate a causal link between BCGM divergence and expression diffe

146 these strategies, we were able to provide a causal link between DEE and the following genes: NTRK2,

147 This observation is the first to document a causal link between Dhb formation and protein cross-link

148 Our results support a causal link between dysregulation of a miRNA target and

149 these correlations cannot be used to infer a causal link between food web connectance and habitat inv

150 this issue of the JCI, Ando et al. provide a causal link between histamine-releasing factor (HRF) int

151 A causal link between metal contamination and siderophore

152 oach to address this problem and establish a causal link between the power fluctuations of electrophy

153 This study further substantiates a causal link between the V307L KCNQ1 mutation and pro-arr

154 We here identify a causal link between these two features of declarative me

155 is presumptively transplacental, although a causal link explaining the interval delay between matern

156 Although researchers established the causal link with FMRP loss >;25 years ago, studies conti

157 necessary to further characterize potential causal links between DUP, striatal circuitry and clinica

158 tic regulation of puberty timing and support causal links with cancer susceptibility.

159 egeneration, nominating a causal variant and causal mechanism for allele-specific expression and dise

160 the tablet's inert ingredients as a possible causal mechanism.

161 identifying subtypes of asthma to understand causal mechanisms and translating this knowledge into pe

162 ry epigenomic datasets provided evidence for causal mechanisms at several loci, including at a previo

163 t risk factor for subsequent asthma, but the causal mechanisms remain obscure.

164 otential of computational tools to elucidate causal mechanisms underlying loss of protein function in

165 d genetic variants can lead to understanding causal mechanisms, and to disentangling reverse causatio

166 Partial correlations and causal mediation analyses (mediation R package) were the

167 erol, and TRIB1 for triglycerides) that were causal mediators for the corresponding traits, as well a

168 biota studies and enabling identification of causal microbes.

169 ociated with only a subset of strains within causal microbial groups.

170 set for alcohol dependence and identify the causal miRNAs for alcohol-dependency in patients which w

171 We also identified likely causal missense variants in a gene implicated in primary

172 Here, we introduce dynamic causal modeling (DCM) for optogenetic fMRI experiments-w

173 Previously, dynamic causal modeling (DCM) indicated that mid LPFC integrates

174 underlying neurophysiology, we used dynamic causal modeling for cross-spectral density and estimated

175 We used causal modeling to estimate the impact of local air poll

176 The claims that learning systems must build causal models and provide explanations of their inferenc

177 elop empirical and theoretical links between causal models of this transformation and more traditiona

178 f movement variability, combined with simple causal models, can uncover the circuit structure of sens

179 etermine parameter estimates for the dynamic causal models, which were compared between groups.

180 We identified a causal mutation in 1 of 14 genes in 50% (353/710).

181 We identified a likely causal mutation in the majority of these families (21 of

182 uman arthritis and decreased height, but the causal mutations are still unknown.

183 obtain near base-pair resolution, resolving causal mutations in developmental enhancers, validated t

184 l step towards the identification of disease-causal mutations of gene regulatory elements.

185 WD40 domain of TRAF7, the same location for causal mutations of meningiomas.

186 omes postrenal transplantation, although the causal nature of this relationship remains unclear.

187 The datasets were integrated to identify a causal network describing PKA signaling that explains va

188 measured outcome determinants, even when the causal network linking variables is identical.

189 sparse activation patterns that reflect the causal neuron-behavior relationship.

190 encoding the scaffolding protein Nbeal2, are causal of gray platelet syndrome (GPS), a rare recessive

191 est that vitamin D deficiency is potentially causal of sero-negative RA and provide new insights into

192 mics are a critical axis of manipulation for causal optogenetic studies.

193 ma (HCC) has generated controversy about the causal or incidental nature of this association and the

194 ction; and (2) the genetic pleiotropy follow causal or independent model.

195 -exome sequencing, and were able to assign a causal or likely causal germ line mutation in 86 patient

196 results provide novel insight into promising causal paths to and from glucose and type 2 diabetes and

197 s prevalence is increasing and may be on the causal pathway between noise and cardiovascular disease,

198 inine and osmolality may be colliders on the causal pathway from arsenic exposure to obesity, as comm

199 However, the directionality of the causal pathway remains unknown.The objectives of this st

200 ence that methylation is likely to be on the causal pathway to disease in later life.

201 es an AP2-like transcription factor, but the causal polymorphism of the domestication traits remained

202 making those prime candidates for phenotype-causal polymorphisms.

203 mental methods that produce context-specific causal predictions.

204 of 400 mg DSM265 was well tolerated and had causal prophylactic activity when given 1 day before CHM

205 res, these results provide new support for a causal rather than bystander role for myeloperoxidase in

206 Mendelian randomization showed no causal relation between H. pylori genetic risk score and

207 the gut microbiota and obesity in humans, a causal relationship and the underlying mechanism remain

208 Stimulation data indicated the causal relationship between (i) superior-temporal gyrus

209 randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive functi

210 This study investigates the causal relationship between adiponectin levels and metab

211 These results demonstrate a causal relationship between complement dysregulation and

212 entromedial prefrontal cortex (vmPFC), but a causal relationship between dysregulation of these areas

213 changes in body weight, lending support to a causal relationship between loss of CB1 in adipocytes an

214 Their findings reveal what could be the causal relationship between multiple pathogenic pathways

215 Knowledge about the causal relationship between objects has been studied ext

216 Mendelian randomization analysis suggests a causal relationship between pro-ENK level and deteriorat

217 The causal relationship between RA and AD was assessed using

218 h using an unobtrusive method to establish a causal relationship between strategy and choice, randoml

219 The causal relationship between systolic blood pressure (SBP

220 Here, we show a clear causal relationship between the freeze-concentration eve

221 role models for healthy behaviours assumes a causal relationship between their health behaviours and

222 Under the assumption of a causal relationship between timing of ANS and mortality,

223 Structure-function analysis reveals a causal relationship between tubulin structure and MT sta

224 Although a causal relationship between Zika virus (ZIKV) and microc

225 Despite the causal relationship established between malignant mesoth

226 mproved capability to resolve the timing and causal relationship of events in the geologic record.

227 However, because of its causal relationship with severe congenital malformations

228 ce (CAMP) has long been proposed as having a causal relationship with the end-Triassic extinction eve

229 oimmunity in patients with CSU from level 1 (causal relationship) to level 5 (causality not likely).

230 ings with computational modeling, we infer a causal relationship, namely that changes in white matter

231 reased impulsive action, thus establishing a causal relationship.

232 Further studies are needed to confirm a causal relationship.

233 functional measurements-to parameterize the causal relationships among regions of a distributed brai

234 Establishing causal relationships between specific features of sleep

235 chnical advance towards the establishment of causal relationships between the chemistry and microbial

236 Whether these associations represent causal relationships remains uncertain.

237 Whether these associations are causal remains to be seen.

238 These results have motivated a generation of causal research conducted using bench, clinical, and pop

239 evidence suggests that HDL-cholesterol is a causal risk factor for AMD risk and that increasing HDL-

240 protein(a) concentration are independent and causal risk factors for coronary heart disease.

241 s have facilitated a better understanding of causal risk factors, elucidated underlying biology and i

242 provide evidence that the HD signal plays a causal role as a neural compass in navigation.

243 as the site for negative behaviors, and the causal role for CeA circuits underlying appetitive behav

244 onjugated antibody to Mac1, we demonstrate a causal role for microglia in the development, but not ma

245 hether DNA methylation plays a mediating and causal role in associations between maternal vitamin B12

246 suggested to SRF that gut microbiota have a causal role in carbohydrate-induced hypertriglyceridemia

247 However, identifying brain areas that play a causal role in decision making has proved challenging.

248 al copies of a gene is related to the gene's causal role in disease.

249 specific histone acetylation to assess their causal role in gene expression and cellular and behaviou

250 hesis that SIRT1 may actually play a crucial causal role in overload-induced hypertrophy of skeletal

251 contrast, ritual human sacrifice does play a causal role in promoting and sustaining the evolution of

252 Our results show that V5/hMT+ plays a causal role in tactile direction processing, and strengt

253 target organs and is hypothesized to have a causal role in TCDD-induced toxicity.

254 suggest that the alpha'3 compartment plays a causal role in the behavioral response to novel and fami

255 ergy suggests that the microbiome may have a causal role in the development of food allergy.

256 renin-angiotensin-aldosterone system plays a causal role in the development of hypertension, atherosc

257 learning rates, thereby demonstrating their causal role in the learning process.

258 man clinical studies suggest it might have a causal role in these diseases.

259 i.e., small HDL triglycerides, might have a causal role of elevating glucose levels.

260 To investigate the causal role of hypoadiponectinemia in GDM, adiponectin g

261 n animal models have produced evidence for a causal role of intestinal microbiota in the etiology of

262 Findings do not provide strong support for a causal role of maternal smoking during pregnancy in offs

263 be useful in the further elucidation of the causal role of reflux in erosive tooth wear.

264 While a causal role of these mutations cannot be established dir

265 itro [3, 4] and in vivo [5, 6], suggesting a causal role of theta activity for the formation of compl

266 Our results suggest that PPC plays a causal role specifically in visual decision making and m

267 Mechanistic investigations demonstrated causal roles for CADM1, SPHK1, and YAP/TAZ in mediating

268 able (and not novel), but their theory lacks causal specificity.

269 entire dataset to investigate the underlying causal structure of hair disorders.

270 meters drawn from distinct populations whose causal structures and baseline outcome risks differ.

271 weight with academic performance may not be causal, suggesting that interventions should focus on th

272 wever, whether this association results from causal teratogenic effects or from confounding influence

273 Here, we put this hypothesis to a rigorous, causal test by combining the FCM with a transcranial mag

274 illustration, if findings presented here are causal, that would suggest that if Christchurch, New Zea

275 If the observed association is causal, the number needed to harm for severe AKI followi

276 aureus, opening prospects for diagnosis and causal therapy of asthma.

277 sis may include factors that are proximately causal, upstream risk activators, and risk markers.

278 ntotemporal lobar degeneration, nominating a causal variant and causal mechanism for allele-specific

279 nd makes no distributional assumption on the causal variant effect sizes while accounting for linkage

280 ethods using 21 exomes for which the disease causal variant has been previously established through t

281 The majority of families with a causal variant identified have a nonunique variant.

282 The most likely causal variant identified was a novel missense variant i

283 H oxidase (NOX2), as the putative underlying causal variant that drives a strong SLE-associated signa

284 s a widely used approach for identifying the causal variant(s) at disease-associated loci.

285 studies in beta cell lines, we localize the causal variant(s) at this locus to a 5 kb region that ov

286 To discern the true causal variant(s), a variety of statistical fine-mapping

287 intron of the PHACTR1 gene, as the putative causal variant.

288 Using causal inference testing, we searched causal variants across eight cardiometabolic traits (BMI

289 ally, we identified a set of high-confidence causal variants and showed that these were more enriched

290 neity in linkage disequilibrium (LD) between causal variants and SNPs biases ID estimates, and we dev

291 ther populations even when choosing the same causal variants and that biases in any direction are pos

292 lution, which precludes investigation of the causal variants and their molecular mechanisms.

293 However, because causal variants are difficult to identify, and cis-eQTLs

294 equencing utilized for the identification of causal variants has discovered coding mutations in some

295 However, many causal variants have yet to be identified, and a large p

296 Causal variants that aggregate in families usually have

297 ons, but we could also directly identify the causal variants that were validated through complementat

298 ing resolves 23 signals to one or two likely causal variants.

299 des a powerful resource for the discovery of causal variants.

300 spring systemic cardio-metabolic profile are causal, via intrauterine mechanisms, or due to shared fa