ライフサイエンスコーパス: causality

1 eficits (reduced posterior-->frontal Granger causality).

2 down inhibition (reduced frontal-->posterior causality).

3 rstanding, whereas neural interventions test causality.

4 min D deficient mice to address the issue of causality.

5 sus statements to update the WHO position on causality.

6 sociations because of confounding or reverse causality.

7 te confounding by tobacco smoking or reverse causality.

8 inly owing to the difficulty in establishing causality.

9 igenetic regulators in the context of cancer causality.

10 probably because of confounding and reverse causality.

11 a neutralizing anti-TNF-alpha Ab, confirming causality.

12 to challenge classic definitions of genetic causality.

13 e in CD4(+) T cells believed to be the major causality.

14 stimator to minimize confounding and reverse causality.

15 ry assays have not been able to confirm this causality.

16 observational nature limits inferences about causality.

17 possible to rule out some effect of reverse causality.

18 in synovial fluid and skin lesions confirmed causality.

19 The statistical analysis cannot establish causality.

20 to chance, residual confounding, or reverse causality.

21 s well as evaluate the potential for reverse causality.

22 of RAS, this study does not provide data on causality.

23 lts may be biased by confounding and reverse causality.

24 iated with gene expression without revealing causality.

25 integrin beta6(-/-) mouse model to study the causality.

26 de novo mutations as an important source of causality.

27 rted as pathogenic in CAKUT did not indicate causality.

28 al studies which limits the ability to infer causality.

29 ation, taking precautions to address reverse causality.

30 ased study designs were used to further test causality.

31 rst 2.6 years of follow-up to reduce reverse causality.

32 , the modified Kramer, was used to determine causality.

33 tudinal design to draw firmer conclusions on causality.

34 tional, no conclusions can be made regarding causality.

35 dentified variants is crucial to demonstrate causality.

36 f an expert assessment of the evidence about causality.

37 sease markers without apriori assumptions of causality.

38 necessary to provide additional evidence of causality.

39 y in CSU with the help of Hill's criteria of causality.

40 an air pollution study provides evidence of causality.

41 ses in K cell spike rates by 1-3 s, implying causality.

42 iagnosis of dementia and to minimize reverse causality.

43 anulysin and interferon-gamma to confirm the causalities.

44 the DILI nomenclature and methods to assess causality, along with the information provided by the Li

45 r BMI as being probably distorted by reverse causality, although it remains possible instead that the

46 We find the strongest enrichment for causality among non-synonymous variants (54x more likely

47 ted causality approaches and for the role of causality analyses in neuroscience as a whole.

48 Linear correlation and Granger causality analyses were performed to investigate functio

49 Granger-causality analysis also supports the latter finding.

50 Spectral Granger-causality analysis revealed that the change in symmetric

51 Using Granger causality analysis, we identified inferior frontal corte

52 Using Granger causality and conditional mutual information analyses, w

53 broadly applicable technology for dissecting causality and connectivity of spatially intermingled but

54 TC levels and periodontitis and to establish causality and directional association.

55 methylation and to make inferences regarding causality and directionality.

56 eriments to field patterns to establish both causality and ecological relevance.

57 RCTs are most useful in determining causality and effectiveness of treatment.

58 To examine causality and elucidate how localized Plexin-B1 stimulat

59 Additional research to establish causality and evaluate interventions is needed for these

60 Further studies are needed to determine causality and generalizability.

61 Further studies are needed to prove causality and its direction.

62 in new-onset paediatric patients to evaluate causality and mechanisms of disease.

63 t many unresolved questions about underlying causality and ordering of associations.

64 studies correlating DILI pathology with its causality and outcome.

65 This raises questions about causality and possible carbonaceous aerosol feedback mec

66 enocarcinoma risk avoids issues with reverse causality and residual confounding that arise in observa

67 iment are more likely to provide evidence of causality and should be prioritized among the body of ev

68 iants not found in controls but of uncertain causality and therefore requiring validation.

69 Traditional methods based on Granger causality and transfer entropy have issues such as diffi

70 Future studies are warranted to determine causality and underlying mechanisms.

71 s challenging because issues such as reverse causality and unmeasured confounding might result in bia

72 s including sampling selection bias, reverse causality, and collider bias have prevented the ability

73 tion has been inappropriately conflated with causality, and it has been claimed that CRP is proathero

74 nidirectional-forcing and true bidirectional causality, and resolve transitive causal chains.

75 ess efforts aimed at disentangling issues of causality, and showcase the shifting research landscape

76 However, we cannot establish causality, and the studies contributing to this review w

77 Here we use the Wiener-Granger causality approach along with well-established cross-cor

78 usality, with implications for other related causality approaches and for the role of causality analy

79 support perceptual learning, formal tests of causality are lacking.

80 when randomized controlled trials to examine causality are not feasible and observational studies pro

81 ng away from the simple assumption of linear causality as proposed in the original amyloid hypothesis

82 riteria on the existing literature to assess causality as the most likely interpretation of this asso

83 analyses may not provide robust evidence of causality, as they are susceptible to confounding, rever

84 After likelihood of causality assessment by established guidelines, six vari

85 Causality assessment for DILI and SJS/TEN was carried ou

86 S/TEN was carried out with the Roussel Uclaf Causality Assessment Method and the Algorithm for Drug C

87 r of cases, and causality with Roussel Uclaf Causality Assessment Method and the Algorithm for Drug C

88 ividually reanalyzed using the Roussel Uclaf Causality Assessment Method.

89 ed before drawing definite conclusions about causality based on Mendelian randomization methodology.

90 Granger causality-based effective (directed) connectivity was us

91 dies, but it has been difficult to establish causality because of the possibility of residual confoun

92 s of our findings are the inability to infer causality because the taxes were implemented at the nati

93 biological conditions are crucial to unravel causalities behind phenotypes of interest.

94 randomization (MR) to infer the direction of causality between BMI and disordered eating in childhood

95 We showed no evidence of causality between BMI and EDs in adulthood in either dir

96 Causality between certain gut microbiota and the develop

97 elusive, our results imply a high degree of causality between clock gene expression and one of the p

98 These simulations thus establish causality between currently unexplained, long timescale

99 Although causality between intermediate filaments and plasticity

100 The bidirectional causality between kidney injury and inflammation remains

101 inverse-variance weighted method to test for causality between later life cognitive ability, educatio

102 While this demonstrates causality between MD hypofunction and cognitive inflexib

103 riment, created a rare opportunity to assess causality between parent and child coverage.

104 is much attention given towards the possible causality between periodontitis and rheumatoid arthritis

105 t and interpretation of statistical tests of causality between phenotypes using genetic instruments.

106 evant animal model that may help clarify the causality between roseolovirus reactivation and diseases

107 an intrinsic consequence of LV dysfunction, causality between SMR and mortality should not be implie

108 Supplementation experiments established causality between specific RCS and browning and allowed

109 In addition, we show that Granger causality between spike trains can be readily assessed v

110 ker castes, making it difficult to establish causality between the molecular mechanisms that underlie

111 egulated LMO2 expression, establishing clear causality between the mutation and oncogene dysregulatio

112 ive model that dispenses with assumptions of causality between the two phenomena and explains mood re

113 undamental properties of Granger-Geweke (GG) causality, both computational and conceptual.

114 These findings suggest causality but this causality should be verified in trial

115 are generally not themselves candidates for causality, but simply act as markers for functional vari

116 tional data, such as confounding and reverse causality, but these have serious limitations.

117 We attempted to infer causality by comparing the effects of maternal versus pa

118 We concede that causality cannot be implied, but our results suggest tha

119 ested), and type II autoimmunity has level 2 causality (causal relationship likely).

120 utoimmunity in patients with CSU has level 3 causality (causal relationship suggested), and type II a

121 The combined odds for causality considering case-control, segregation and brea

122 nly did suppressed alpha power and bottom-up causality correlate with heightened frontal gamma power,

123 id verisimilitude, or else misattribution of causality could compromise policy decisions.

124 Although causality could not be established, delaying LC was asso

125 due to natural disease progression although causality could not be ruled out).

126 M analysis to reveal information about brain causality depends critically on the assumed V0 value use

127 at directly addressed either outcome and any causality dimension, used methods to expedite study sele

128 haly, we included 72 items; for eight of ten causality dimensions (all except dose-response relations

129 To establish this causality, direction of effect, and total genetic burden

130 and most simple (in terms of complexity and causality) discrete state models.

131 unction using both systems biology tools and causality-driven laboratory experimentation will be esse

132 esults; (ii) even if estimated correctly, GG causality estimates alone are not interpretable without

133 Specifically, we show that (i) GG causality estimates can be either severely biased or of

134 To infer causality, experiments in representative models are esse

135 s of action that influence conclusions about causality, exposure-response relationships, susceptibili

136 Assessment Method and the Algorithm for Drug Causality for Epidermal Necrolysis was highly probable o

137 Assessment Method and the Algorithm for Drug Causality for Epidermal Necrolysis, respectively.

138 follow up studies are required to establish causality for identified risk factors.

139 ach that can be used to establish functional causality for noncoding sequence variants identified by

140 ic data will accelerate the determination of causality for novel genes or variants.

141 These data establish direct causality for the contributions of distinct synaptic and

142 mouse models will be necessary to establish causality for these genes.

143 l sampling to elucidate stability, determine causality for translation into biomarker and prevention

144 rate," or "high" and then assigned levels of causality for type I and II autoimmunity in patients wit

145 effect-size distribution and probability of causality for variants with different annotations and jo

146 First, in February 2016, we developed a causality framework that defined questions about the rel

147 ight that we are unable to reliably separate causality from horizontal pleiotropy.

148 Distinguishing causality from mere association typically requires rando

149 betic kidney disease (DKD), but establishing causality from observational data is problematic.

150 are consistently reported, but establishing causality from observational designs can be problematic.

151 Inferring causality from observational studies, however, is subjec

152 eries gene expression data using the Granger causality (GC) model.

153 Treatment-emergent all-causality grade >/= 3 adverse events more common (P < .0

154 The most common all-causality grade 3 and 4 adverse events were pulmonary em

155 All-causality grade 3 or 4 adverse events were 67% for caboz

156 tatus, and left-censoring to explore reverse causality had very little impact on the strength of thes

157 indings provide evidence against the reverse causality hypothesis and strengthen evidence for persona

158 behaviors of the system model; and (iii) GG causality ignores critical components of a system's dyna

159 Among medically evacuated US military combat causalities in Afghanistan, blood product transfusion pr

160 We compare NMHS to Granger causality in analyzing neural circuit recordings and sim

161 are still poorly understood and evidence of causality in children remains scant.

162 An important element in assessing causality in drug-induced liver injury is whether the im

163 le, computer-based instruments for assessing causality in drug-induced liver injury.

164 domization, which may be applied to evaluate causality in increasingly complex networks of omics data

165 as other factors limiting the assumption of causality in Mendelian randomization may exist.

166 n increasingly important tool for appraising causality in observational epidemiology.

167 value," which is related to the evidence for causality in observational studies that are potentially

168 Although we did not establish causality in our analysis, the findings might indicate t

169 establishing a similar approach to determine causality in terms of MMP functions.

170 sensory-driven causal connectivity (Granger causality in the alpha band) during a resting state (eye

171 ing and important challenge is to understand causality in the assembly of "complex" clusters at a mec

172 effect on BMI and provided more evidence for causality in the reverse direction (i.e., an effect of B

173 To examine causality in the reverse direction, MR analyses were use

174 urther studies to help assess directions and causality in these associations.

175 research have made it difficult to establish causality in this complex relationship.

176 tment-emergent adverse events, regardless of causality, in either treatment group (any grade) were fa

177 memory task, we observed significant Granger causality influence from FEF to IT, but not in the oppos

178 signal provided new insight into the dynamic causalities involved in the influence of cognitions on p

179 In Physics, causality is a fundamental postulation arising from the

180 Granger causality is a powerful tool for identifying linear inte

181 This direct causality is incompatible with clinical observations.

182 partments, although any conclusion regarding causality is limited by the cross-sectional nature of th

183 and policy-makers to argue that evidence of causality is necessary before implementing more stringen

184 Although the direct causality is often hard to prove, it is reasonable to co

185 Because causality is ultimately tested in longitudinal cohort st

186 of heart failure have been observed, but the causality is uncertain.

187 l disease is associated with seropositivity, causality is unproven.

188 sociation is causal or what the direction of causality is.

189 ontext of Electromagnetics, the relativistic causality limits the upper bound of the velocity of info

190 Limitations: Reverse causality may have biased the findings; however, results

191 Reverse causality may have resulted in prenatal PBDEs, particula

192 What do frequency-domain causality measures tell us about the functional properti

193 Frequency-domain causality measures, such as those of Geweke, as well as

194 cerns regarding the applicability of Granger causality methods in neuroscience.

195 lity maps of amygdala subregions and Granger causality methods to evaluate task-based intra-amygdaloi

196 Granger causality methods were developed to analyze the flow of

197 societies and suggest that the direction of causality might be inverted.

198 Our research improves causality modeling by combining heterogeneous knowledge,

199 Based on causality networks, we made a functional prediction that

200 ovide statistical meanings to the discovered causality networks.

201 om level 1 (causal relationship) to level 5 (causality not likely).

202 Serious adverse events (all causalities) occurred in 44 patients (13%) of 345 in the

203 Achieving confidence in the causality of a disease locus is a complex task that ofte

204 Causality of alpha activity dynamics was implied by its

205 refers to an analytic approach to assess the causality of an observed association between a modifiabl

206 We used mutants to assess functional causality of candidate genes and constructed a genetic n

207 However, causality of CLA-mediated responses to body fat loss, pa

208 The causality of hepatitis C with respect to the pathogenesi

209 ciated with uterine leiomyomas; however, the causality of MED12 variants, their genetic mode of actio

210 These results indicate that describing the causality of metal effects in terms of kinetics of uptak

211 Our methods accounted for multi-causality of NCDs and for the fact that when risk factor

212 nally validate these new loci and assess the causality of new and established associations between th

213 mine if viral load could provide evidence of causality of pneumonia, we compared viral load in the UR

214 field experiment (n = 3,000), we tested the causality of postural expansion (vs. contraction) on att

215 r study provides evidence for the functional causality of single nucleotide polymorphism rs385076 wit

216 However, unequivocally demonstrating causality of such infections to death is difficult in cr

217 The causality of the APP de novo duplication (which is the f

218 e exhibit seizures and SUDEP, confirming the causality of the de novo mutation in the proband.

219 The causality of the mutation is supported by previous studi

220 We tested the causality of the mutations by comparison to published da

221 urther studies are needed to investigate the causality of these associations and the potential for pu

222 Here, we evaluated the causality of these associations from a genetic perspecti

223 genic factor in sepsis and ICU mortality but causality of these associations has not been demonstrate

224 However, the causality of these associations is unclear.

225 intervention studies are needed to determine causality of these biological and behavioral relations.

226 longitudinal studies are needed to determine causality of these effects.

227 clinical significance, reproducibility, and causality of these findings are disputed.

228 However, the causality of these rare mutations remains unknown.

229 port this function, but the connectivity and causality of these regions in calibrating motor control

230 lenging to demonstrate experimental proof of causality of these risk alleles for renal disease.

231 ated with prognosis, but no proof exists for causality of this association.

232 The causality of this correlation was verified in mice with

233 riving role in the network, exerting Granger causality on the dorsal premotor area.

234 nt with a more careful KZM analysis based on causality - on the comparison of the relaxation time of

235 Although studies have not firmly established causality, onset of regular marijuana use in adolescence

236 onal nature of our study precludes inferring causality or making clinical recommendations, our findin

237 if this reflects pleiotropic effects, direct causality or some shared third factor that links both, f

238 reflect a true inverse association, reverse causality, or differential underreporting in heavier ind

239 The data cannot prove causality owing to the study design.

240 show stronger causal (measured with Granger causality) patterns (G-causes and G-effects) than inhibi

241 If these data reflect causality, PM exposure would be 1 of few AD risk factors

242 These cases, although do not prove causality, point to the need for careful follow-up of re

243 on this analysis, we find that the notion of causality quantified is incompatible with the objectives

244 lying molecular mechanisms through inferring causality relationships mediated by treatment, an optima

245 lying molecular mechanisms through inferring causality relationships mediated by treatment, an optima

246 Because this study is cross-sectional, causality remains to be explored.

247 and cardiovascular disease is clear, though causality remains to be proven in well-controlled prospe

248 g urate levels and cardiometabolic diseases, causality remains uncertain.

249 tributed to the enhanced GLP-1 response, but causality remains unclear.

250 Decisions about causality require systematic assessment to guide public

251 This lack of causality results in separated domains with different (d

252 We argue that evidence of causality should be gauged by a critical evaluation of d

253 These findings suggest causality but this causality should be verified in trials of induced infect

254 Transient Granger causality shows a serial processing of somatosensory inf

255 has been no formal demonstration of disease causality since their discovery.

256 convergent cross mapping, a robust test for causality that does not require correlation, to test alt

257 angles data in a polypeptide is given by the causality that is localized both in time and in space, o

258 s and present examples of complete chains of causality that link individual polymorphisms to changes

259 nal studies intended to produce evidence for causality, the E-value be reported or some other sensiti

260 Although the study design does not establish causality, the findings support potential benefit of air

261 licate these observations and to explore the causality, the underlying pathways, and the long-term ca

262 Regardless of its causality, this change indicates that DNA replication fi

263 were to update and reassess the evidence for causality through a rapid and systematic review about li

264 lines to demonstrate how our system confirms causality through mutant phenotype reversion.

265 (CCM) is a non-linear approach to establish causality, thus, expected to decipher nonlinear causal c

266 ks enable large amounts of information about causalities to be integrated and utilized in probabilist

267 We used Granger causality to analyze predictive relationships among the

268 We also used Granger causality to assess whether omitted variable confounding

269 nometric tools do not allow the direction of causality to be established clearly.

270 The results highlight the potential of causality to detect alteration in blood pressure regulat

271 ms of rare diseases, accurate attribution of causality to detected variants is imperative but imperfe

272 the favoured approach; however, attributing causality to educational intervention proves difficult i

273 We use Granger causality to estimate the relationship between soil mois

274 However, assigning causality to genetic variants associated with a transcri

275 ility of CRISPR/Cas genome editing to assign causality to human mutations in the mouse in <10 wk.

276 individuals using global reasoning on the RN causality to identify key-nodes.

277 For a complete picture of infectious disease causality, transmission effects must be incorporated int

278 ions, there is an urgent need for studies on causality, underlying mechanisms, and effective interven

279 Assuming causality, up to 20% (95% CI 19-22) of violent reoffendi

280 studies for providing mechanisms to explain causality using new methods cannot be overemphasized.

281 Genetic co-heritability and causality via MR was assessed using data from the Intern

282 7 enrolled subjects with suspected DILI, the causality was assessed in 1091 patients, and 899 were co

283 Initial prioritization of variants for causality was by mutation type, whether they were known

284 gnificant (p = 0.002) decline in EMG --> SBP causality was observed in the elderly group, compared to

285 Their causality was then demonstrated by a functional test.

286 for both the exposure and mediator to infer causality-was performed to examine the causal associatio

287 c evidence, satisfying rigorous criteria for causality, we conclude strongly that lowering intake of

288 To test causality, we implemented an exercise intervention that

289 To better establish causality, we next conducted an experiment (n = 704) in

290 To assess causality, we perturbed the function of Tet2, the second

291 Thus, to distinguish between correlation and causality, we used a pharmacogenetic approach.

292 nter-areal interactions, measured as Granger causality, were also dominant between these cortical lay

293 Conventional measures of causality (which compare risks between exposed and unexp

294 an acceleration of false-positive reports of causality, which would impede the translation of genomic

295 for genome engineering studies to establish causality will continue to be frustrated by an inability

296 Although impossible to prove causality with any single approach, MR is a highly cost-

297 -evoked plasticity and to establish links of causality with drug-adaptive behaviors.

298 d to a disproportionate number of cases, and causality with Roussel Uclaf Causality Assessment Method

299 ide important conceptual clarification of GG causality, with implications for other related causality

300 nd it will be difficult to clearly establish causality without appropriate control groups.