ライフサイエンスコーパス: causative

1 is associated with other factors that may be causative.

2 DS angiographic reports were reviewed for causative abnormalities.

3 is of OA may lead to continued exposure to a causative agent and progressive worsening of disease; co

4 Agrobacterium tumefaciens, the causative agent for crown gall disease of plants has pro

5 protozoa Trypanosoma brucei (T. brucei), the causative agent for human African trypanosomiasis (HAT)

6 V) is an emerging human pathogen that is the causative agent for Middle East respiratory syndrome (ME

7 Staphylococcus aureus remains a causative agent for morbidity and mortality worldwide.

8 types A, B, E, and F were identified as the causative agent in 34%, 16%, 17%, and 1% of outbreaks, r

9 la pneumophila, the most commonly identified causative agent in drinking water associated with diseas

10 e status of the infant, and virulence of the causative agent influence the clinical expression of neo

11 development of antibacterial resistance, the causative agent must be identified as rapidly as possibl

12 Legionella pneumophila is the causative agent of a severe pneumonia called Legionnaire

13 Entamoeba histolytica is not a common causative agent of acute appendicitis.

14 ection of the bacterium Vibrio cholerae, the causative agent of acute diarrheal disease in cholera.

15 The parasite Trypanosoma brucei is the causative agent of African sleeping sickness and is know

16 t of Chagas disease; Trypanosoma brucei, the causative agent of African sleeping sickness; and Plasmo

17 al. also described baseline testing for the causative agent of AIDS, the human immunodeficiency viru

18 al defense against Paenibacillus larvae, the causative agent of American foulbrood (AFB) disease.

19 us (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF).

20 espiratory syncytial virus (RSV) is the main causative agent of bronchiolitis, whereas rhinovirus (RV

21 The release of EVs by Trypanosoma cruzi, the causative agent of Chagas disease, has recently been des

22 of their life cycle: Trypanosoma cruzi, the causative agent of Chagas disease; Trypanosoma brucei, t

23 Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), a highly

24 Cryptococcus neoformans var. grubii is the causative agent of cryptococcal meningitis, a significan

25 Cryptococcus neoformans, the causative agent of cryptococcosis, is an opportunistic f

26 l Leishmaniasis, and Leishmania tropica, the causative agent of cutaneous Leishmaniasis with MCs were

27 Dengue virus (DENV) is the causative agent of dengue fever, dengue hemorrhagic feve

28 Among these is Streptococcus mutans, the causative agent of dental caries, the most prevalent chi

29 Rickettsia typhi is the causative agent of endemic typhus, a disease with increa

30 global impact on the equine industry as the causative agent of equine viral arteritis (EVA), a respi

31 Helicobacter pylori, the causative agent of gastric cancer and duodenal and gastr

32 druggable targets in Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (sleepi

33 ied as a hit against Trypanosoma brucei, the causative agent of human African trypanosomiasis.

34 how that infection by Shigella flexneri, the causative agent of human bacillary dysentery, switches o

35 bioactivity against Streptococcus mutans, a causative agent of human dental caries, was detected for

36 on of DCs by Plasmodium falciparum, the main causative agent of human malaria, induces a highly unusu

37 Here, we show that Trypanosoma brucei, the causative agent of human sleeping sickness, has an intri

38 ication.IMPORTANCE Epstein-Barr virus is the causative agent of infectious mononucleosis and infects

39 Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi sarcoma (KS) and multicentric

40 sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi sarcoma (KS), one of the leadi

41 Borrelia burgdorferi, the causative agent of Lyme disease, is transmitted by the t

42 e domains exist in Borrelia burgdorferi, the causative agent of Lyme disease.

43 archetype of fish alloherpesviruses and the causative agent of major economic losses in common and k

44 The causative agent of malaria, Plasmodium, replicates insid

45 pathways are presumed to be absent from the causative agent of malaria, Plasmodium, thus raising the

46 Mayaro virus (MAYV), causative agent of Mayaro Fever, is an arbovirus transmi

47 isolates of the closely related organism and causative agent of melioidosis, Burkholderia pseudomalle

48 resident of the oro- or nasopharynx and the causative agent of meningococcal meningitis and meningoc

49 a zoonotic coronavirus was identified as the causative agent of Middle East respiratory syndrome and

50 ypeable Haemophilus influenzae (NTHI) is the causative agent of multiple respiratory tract infections

51 isfolds to a pathogenic isoform PrP(Sc), the causative agent of neurodegenerative prion diseases.

52 Yersinia pestis, the causative agent of plague, binds host cells to deliver c

53 iction in the bacterium Yersinia pestis, the causative agent of plague.

54 ons of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis cana

55 Poliovirus (PV) is the causative agent of poliomyelitis, a crippling human dise

56 and then classified main pollen grains as a causative agent of pollinosis.

57 Its misfolded isoform PrP(Sc) is the causative agent of prion diseases.

58 Mycobacterium tuberculosis (MTb) is the causative agent of pulmonary tuberculosis (TB).

59 Coxiella burnetii is the causative agent of Q fever, a zoonotic disease that thre

60 Coxiella burnetii, the causative agent of Q fever, establishes a unique lysosom

61 RTANCE Herpes simplex virus 1 (HSV-1) is the causative agent of several pathologies ranging in severi

62 Ophidiomyces ophiodiicola, the causative agent of SFD, has been isolated from over 30 s

63 Entry of ovine herpesvirus 2 (OvHV-2), the causative agent of sheep associated-malignant catarrhal

64 To analyze the causative agent of skin changes in employees of a compan

65 Trypanosoma brucei, the causative agent of sleeping sickness (Human African Tryp

66 proaches to compare energy metabolism in the causative agent of sleeping sickness, Trypanosoma brucei

67 cludes Vaccinia virus and Variola virus (the causative agent of smallpox).

68 HRV is the causative agent of the common cold, which in itself is a

69 as a sexually transmitted disease and as the causative agent of the eye infection trachoma.

70 ribute to infection by L. monocytogenes, the causative agent of the foodborne disease listeriosis, we

71 riant Makona (which emerged in 2013) was the causative agent of the largest outbreak of Ebola Virus D

72 Importantly, F. necrophorum is the primary causative agent of the life-threatening Lemierre's syndr

73 Mycobacterium ulcerans, the causative agent of the neglected tropical disease, Burul

74 The human pathogen Vibrio cholerae, the causative agent of the severe diarrheal disease cholera,

75 Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection, g

76 or growth of Mycobacterium tuberculosis, the causative agent of tuberculosis (TB).

77 ow growth of Mycobacterium tuberculosis, the causative agent of tuberculosis, hinders advancement in

78 Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, which kills 1.8 million

79 ly within a variety of cell types and is the causative agent of tularemia.

80 t of SL-seq in Leishmania donovani, the main causative agent of visceral leishmaniasis in humans, and

81 the interactions of Leishmania donovani, the causative agent of visceral Leishmaniasis, and Leishmani

82 robrachium rosenbergii nodavirus (MrNV), the causative agent of white tail disease (WTD) are associat

83 gative bacterium Bordetella pertussis is the causative agent of whooping cough, a serious respiratory

84 Bordetella pertussis, the causative agent of whooping cough, secretes and releases

85 ation by Bordetella pertussis, the principal causative agent of whooping cough.

86 Moniliophthora perniciosa is the causative agent of witches' broom disease, which devasta

87 However, the causative agent remains unknown for a wide range of dise

88 len monitoring has begun to investigate as a causative agent since 1986.

89 We hypothesized the causative agent to be P ventricosus.

90 The causative agent, measles virus, is a small enveloped RNA

91 The causative agent, SFTS virus (SFTSV), is present in China

92 Its causative agent, the myxozoan Tetracapsuloides bryosalmo

93 component, may point to the microbiome as a causative agent.

94 oral diseases that have yet to be assigned a causative agent.

95 The main causative agents are enterovirus 71 (EV71), coxsackievir

96 d sulfite mills, suggesting yet unidentified causative agents are involved.

97 obally, waterborne organisms are the primary causative agents for the transmission of various forms o

98 n in the viral life cycle.IMPORTANCE HPV are causative agents in a number of human diseases, and curr

99 Influenza A and B viruses are the causative agents of annual influenza epidemics that can

100 Canine influenza viruses (CIVs) are the causative agents of canine influenza, a contagious respi

101 Trypanosoma cruzi parasites are the causative agents of Chagas disease, a leading infectious

102 n described for Leishmania major, one of the causative agents of cutaneous leishmaniasis.

103 pallidum subspecies pertenue (TP) are major causative agents of cutaneous ulcer (CU) in the tropics.

104 E The four serotypes of dengue virus are the causative agents of dengue fever and dengue hemorrhagic

105 an parasites of the genus Leishmania are the causative agents of Leishmaniasis, a disease that can be

106 Plasmodium parasites, the causative agents of malaria, have evolved a unique cell

107 Plasmodium falciparum parasites, the causative agents of malaria, modify their host erythrocy

108 Plasmodium parasites, the causative agents of malaria, possess a distinctive membr

109 sleeping sickness; and Plasmodium spp., the causative agents of malaria.

110 related to mammalian Plasmodium species, the causative agents of malaria.

111 nknown about these phenomena, especially the causative agents of many coral diseases.

112 ice versa.IMPORTANCE A subset of HPV are the causative agents of many human cancers, most notably cer

113 African and American trypanosomes are causative agents of Nagana and Chagas disease respective

114 , and Ravn viruses, all filoviruses, are the causative agents of severe hemorrhagic fever.

115 These parasites are the causative agents of some of the most widespread human di

116 um-shock' implicated VapC toxins as possible causative agents of the observed RNA degradation.

117 l 1,4-benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutaneous leish

118 hogenic Escherichia coli (UPEC), the primary causative agents of urinary tract infections, colonize a

119 antimicrobial susceptibility profiles of the causative agents.

120 that it is necessary to recognize them as a causative allergen of FDEIAn.

121 c pathogens, but capable of rapidly clearing causative and coinfecting pathogens.

122 The protein products of USH2 causative and modifier genes, USH2A, ADGRV1, WHRN and PD

123 the yield of follow-up DSA for detection of causative aneurysms is very low.

124 association between the concentration of the causative anions responsible for the main types of metab

125 vel of importance to the identification of a causative antigen, time relation between exposure and di

126 obstacles, including characteristics of the causative bacillus Mycobacterium leprae: the long incuba

127 he transmission of Mycobacterium leprae, the causative bacillus of the disease.

128 Vibrio cholerae is the causative bacteria of the diarrheal disease cholera, but

129 nization and virulence of the whooping cough causative bacterium Bordetella pertussis Secreted as sol

130 he sorting nexin 14 gene (SNX14) as a strong causative candidate.

131 raits examined, they are not associated with causative changes in the DNA methylome, which appears re

132 t that was rescued when we corrected the MDS causative chromosomal deletion and severe apoptosis of t

133 CAPE accurately identifies causative cis-regulatory variation including expression

134 ariable, underscoring the role of additional causative, contributing, and modifier genes.

135 The causative de novo BRAF mutation was successfully detecte

136 Discriminating the causative disease variant(s) for individuals with inheri

137 Generally, the types of causative DNA damage are associated with replication, tr

138 lowering the dose of, or discontinuing, the causative drug.

139 isease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signa

140 These results support a causative effect of HOTAIR on TRAIL sensitivity.

141 hat this APOE4-driven hyperactivity may be a causative factor driving increased risk of AD among APOE

142 oteasome dysfunction has been suggested as a causative factor in cardiac dysfunction.

143 ved, suggesting replication stress as a root causative factor in CHKi hypersensitivity.

144 production of alpha-synuclein as a possibly causative factor in Parkinson's disease (PD).

145 hat VMA might be a consequence rather than a causative factor in the development of CNV.

146 etative expression of gametogenic genes as a causative factor of UPD, and provide a solid foundation

147 ead to difficulties in finding an underlying causative factor.We report a 12-year-old boy who develop

148 l toxicants and endogenous electrophiles are causative factors for human diseases including cancer.

149 It is probable that causative factors for this less favourable prognosis are

150 ate the unique features of various cells and causative factors of diseases and determine the most eff

151 Protecting neurons from causative factors of secondary injury has been the guidi

152 iple studies have focused on elucidating the causative factors underlying memory defects in Alzheimer

153 s to be effective, we need to understand the causative factors underpinning this rise.

154 conditions, or alternatively that they share causative factors.

155 Stratifying the results for the causative food demonstrates that association of the HLA

156 the BTB-domain-encoding region of RHOBTB2 as causative for a developmental and epileptic encephalopat

157 tion generates a PML-RARalpha fusion protein causative for acute promyelocytic leukemia (APL).

158 s suggest that haploinsufficiency of TBK1 is causative for ALS and FTD regardless of the type of muta

159 Mutations in FUS are causative for amyotrophic lateral sclerosis with a domin

160 Mutations in PNPLA1 have been identified as causative for autosomal recessive congenital ichthyosis

161 Mutations in the profilin 1 (PFN1) gene are causative for familial amyotrophic lateral sclerosis (fA

162 result of a mutant CryAB (alphaB-crystallin) causative for human desmin-related cardiomyopathy were u

163 how that specific structural variants may be causative for quantitative trait loci for germination an

164 A deletion (c.640_644del5) in RNF168, causative for recessive RIDDLE syndrome, had high preval

165 ecreted protein SerpinE2/protease nexin-1 as causative for the highly invasive potential of LRC in me

166 little is known about the allergen molecules causative for type I food allergy in animals, which, lik

167 keratitis and precise identification of the causative fungi and institution of appropriate treatment

168 Since phenotypic identification of the causative fungi is often difficult, time-consuming molec

169 inding protein 43 (TDP-43) is a product of a causative gene for amyotrophic lateral sclerosis (ALS).

170 The discovery of the causative gene for Huntington's disease (HD) has promote

171 ations in type II collagen (COL2A1), but the causative gene in SEMD is not known.

172 rited in an autosomal dominant manner, but a causative gene is yet to be ascertained.

173 Using causative gene network inference to compare the genes re

174 metabolism and further implicate TM6SF2 as a causative gene underlying metabolic disease and trait as

175 No causative gene(s) have been identified so far, resulting

176 g influenced by mutation position as well as causative gene.

177 D) risk loci have been mapped in humans, the causative genes and variants for T1D are largely unknown

178 The causative genes are known for fewer than 40% of PCLD ind

179 , MAK and DHDDS, were not described as major causative genes in other populations.

180 Identification of causative genes in patients with U-HAE is valuable for u

181 of 11 subtypes (ARCI1-ARCI11) based on their causative genes or loci.

182 s to narrow intervals overlapping with known causative genes, demonstrating the potential of diverse

183 sive inheritance and a unique composition of causative genes.

184 talian patients with U-HAE to identify novel causative genes.

185 ntified NPRL2 and NPRL3 as the top candidate-causative genes.

186 urodegenerative disorders with over 50 known causative genes.

187 ease pathways often rely on knowledge of the causative genetic defect, HTI-based screens offer an unb

188 nsformation products have been implicated as causative genotoxic agents, no specific product has been

189 In contrast, the expression of ALS-causative human PFN1 mutants causes a less pronounced ph

190 Furthermore, our results suggest ALS-causative human PFN1 mutants display a partial loss of f

191 thesis through changes in SHMT expression is causative in folate-responsive NTDs.

192 R-loop imbalance is a novel molecular defect causative in TH1 immunodeficiency and genomic instabilit

193 However, the causative link between dysregulated tryptophan metabolis

194 Altogether, this study provides a causative link between TBC1D23 mutations and PCH and sug

195 development, thus implicating ATX/LPA in the causative link of cirrhosis and HCC.

196 In black-grass, while no direct causative link was established linking viral infection t

197 und that this correlation does not reflect a causative link.

198 ave been contradictory regarding whether the causative mechanism is a reduction in number, dysfunctio

199 The causative mechanisms are multifactorial and there are no

200 vo, in the absence of bacteria, and may be a causative microbial signal in SIC.

201 ng GSD Ia and DGS were found but no specific causative mutation for cataract and ONHD.

202 ing in cell dysfunction and death beyond the causative mutation is not well defined.

203 g, and molecular modeling, we identified the causative mutation of the dominant dwarf Ligon lintless

204 However, for most patients with CAKUT, the causative mutation remains unknown.

205 The causative mutation was identified in 37% of families.

206 Inheritance pattern and causative mutation; retinal function as assessed by VA,

207 ns We used this draft to identify the likely causative mutations at the O. tipulae cov-3 locus, which

208 next-generation sequencing (NGS) to identify causative mutations contributing to the association.

209 y the PA genetic risk factors by focusing on causative mutations for PAs.

210 urce has identified a large set of plausibly causative mutations for these disorders.

211 n syndrome (MFS), currently lack a cure, and causative mutations have been identified for only a frac

212 So far, >190 causative mutations have been identified throughout the

213 To date, approximately 40 causative mutations have been identified.

214 on of precision medicine is the concept that causative mutations in a patient's cancer drive its biol

215 ish to confirm 5 novel human F10 variants as causative mutations in affected patients, providing a ra

216 tal renal tubular acidosis has no identified causative mutations in currently known disease genes.

217 rate the clinical utility of WES to identify causative mutations in familial CHD and demonstrate the

218 e been reported to cause RP, discovering the causative mutations in many patients remains a significa

219 ozygosity mapping and WES, we identified the causative mutations in nine of the 33 families studied (

220 Mouse studies that recapitulate causative mutations in the autoimmune disease Aicardi-Go

221 lective and specific cellular effects of the causative mutations.

222 ll, have been erroneously designated as LQTS-causative mutations.

223 n in the thymus and that its perturbation is causative of autoimmune and other immunological diseases

224 rts with DCM-associated mutations and may be causative of DCM.

225 g specific molecular alterations potentially causative of disease.

226 sis in hepatocytes which, in its absence, is causative of TNFR1-mediated inflammation, resulting in h

227 4, more than 20 genes had been identified as causative of, or highly associated with, ALS.

228 r, it is not known whether these changes are causative or a consequence of an underlying ageing proce

229 To what extent this mis-metabolism is causative or a consequence of these diseases is still a

230 Diagnosis of the causative organism has a substantial prognostic importan

231 Recent studies fail to identify a causative organism in more than 50% of cases, which rema

232 cus aureus, which has become the predominant causative organism in the developed world, leads to an a

233 Proper diagnosis of the causative organism is critical, and although culture rem

234 Source of infection, with different causative organisms and temporal changes, might influenc

235 Causative organisms and visual outcomes are similar to t

236 To report the clinical features, causative organisms, and visual acuity (VA) outcomes ass

237 6) in cell lines ectopically expressing APDS-causative p110delta variants and in T-cell blasts derive

238 supports the concept that autoimmunity is a causative parameter that contributes to the various illn

239 The causative pathogen, Mycobacterium tuberculosis (MTB), is

240 in biopsy tissue was performed to identify a causative pathogen.

241 r rapid and accurate identification of these causative pathogens in respiratory infections.

242 ct infections, potential targets include the causative pathogens themselves but also the immune respo

243 r the first 24 hours, sites of infection and causative pathogens were similar in both groups.

244 ity worldwide, but accurate diagnosis of the causative pathology remains challenging.

245 ge-scale network disorder, understanding its causative pathophysiology, and identifying disorder-spec

246 d shorter lifespan in adult flies, while ALS-causative PFN1 mutants display a less toxic effect.

247 ila model expressing human wild-type and ALS-causative PFN1 mutants.

248 Consistently, Kabuki causative point mutations upstream of the JmjC domain do

249 pinulosa, we show that manifestations of the causative polyomavirus (TSPyV) occur during primary infe

250 We analyzed the causative PPI, clinical manifestations, organ involvemen

251 adic solitary meningioma or schwannoma had a causative predisposition mutation.

252 To determine the likelihood of detecting causative recessive mutations by whole-exome sequencing

253 rs and longer follow-up are needed to test a causative relationship between both entities.

254 Here we establish a causative relationship between endogenous glucose storag

255 hypothesized, but studies showing definitive causative relationships between infection and disease su

256 findings were independent of any individual causative risk factor such as body mass index, age, or s

257 These data define a previously undescribed causative role for 3-HAA, which is a product of tryptoph

258 in vitro, and in vivo approach, supporting a causative role for ANGPT1 in disease.

259 o one of these noncoding variants, showing a causative role for DONSON disruption in MMS.

260 Consistent with a causative role for KIAA1109 loss-of-function/hypomorphic

261 tion studies have not been able to explain a causative role for nucleotide variation in its pathogene

262 These findings uncover a possible causative role for the ADAMTS1-NOS2 axis in human TAAD a

263 is in vivo Thus, these studies demonstrate a causative role for whole chromosome loss and the associa

264 ) patients, but whether these changes play a causative role in AD is not clear.

265 To test the idea that SnCs might play a causative role in OA, we used the p16-3MR transgenic mou

266 ect striatal pathway disruption might play a causative role in repetitive behavior of Shank3B mutant

267 sfunction and oxidative stress do not play a causative role in the development of atrophy and contrac

268 s have determined that genes known to have a causative role in the development of PD are expressed in

269 st that dysfunctional microglia might play a causative role in the pathogenesis of neurodegenerative

270 nsistent with the idea that ecdysone plays a causative role in the regulation of the proportion of wi

271 plaques and thrombi but also they may play a causative role in triggering atherosclerotic plaque form

272 Although a causative role of alpha-synuclein (alpha-syn) is well es

273 warrants future investigations regarding the causative role of antibody-mediated autoimmunity in idio

274 d Abeta-positivity might be explained by the causative role of CSVD in Abeta accumulation.

275 To demonstrate a possible causative role of defunct PV neurons in the generation o

276 Our results show, for the first time, the causative role of FOXA2 in a complex congenital syndrome

277 t the mating differentiation, confirming the causative role of Fus3 dynamics in driving cell fate dec

278 Together, our data establish a causative role of let-7 in nonproliferative diabetic ret

279 ough genetic deletion of ATM, suggesting the causative role of SSB accumulation and DDR activation in

280 nephropathy and renal fibrosis; however, the causative role of sustained EGFR activation is unclear.

281 nging to establish which marks actually have causative roles in gene regulation and other processes.

282 y proof-of-concept studies have demonstrated causative roles of gut microbial communities in various

283 LPAI) A(H7N2) virus was identified to be the causative source of an outbreak in a cat shelter in New

284 Among the causative species in Brazil, Leishmania (Leishmania) ama

285 otential health threat and identify putative causative SVOCs that are likely contributing to this act

286 risingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to

287 understood only partially and the methods of causative treatment are limited.

288 c respiratory viruses.IMPORTANCE PF has many causative triggers, including severe respiratory viruses

289 A causative understanding of genetic factors that regulate

290 Understanding causative variant segregation is extremely important, ev

291 an inability of footprinting to identify the causative variant within a haplotype.

292 e-genome sequencing was used to identify the causative variant.

293 ay a foundation for future identification of causative variants and genes for CAD.

294 The lack of tools to identify causative variants from sequencing data greatly limits t

295 owever, in a series of patients with HAE, no causative variants have been described, and the pathophy

296 le progress has been made searching for risk-causative variants in candidate genes; therefore, more c

297 Yield of causative variants in hypertrophic cardiomyopathy (HCM)

298 We find that PVP accurately identifies causative variants in whole exome and whole genome seque

299 strate the performance of PVP in identifying causative variants on a large number of synthetic whole

300 nctional annotation can identify potentially causative variants, even when genomic data are limited.O