ライフサイエンスコーパス: cause

1 from the same causes) but not for discordant causes.

2 6, neurotoxigenic Clostridium baratii type F caused 18 (<0.5%) reported US infant botulism cases.

3 nalysis the use of CPAP did not decrease all-cause 2-week mortality in children 1 month to 5 years of

4 t without the identification of their direct causes (5,6) .

5 ble data suggest that mutations in TBK1 that cause a 50% reduction of TBK1 protein levels are pathoge

6 ate a mechanism by which a single lesion can cause a complex neuropsychiatric syndrome based on that

7 Pathogenic mutations cause a loss of function of the encoded protein Parkin.

8 these results indicate that SGPL1 mutations cause a syndromic form of SRNS.

9 This caused a disruption of Fc-binding and phagocytosis.

10 with a V262F missense mutation in Eda, which caused a milder form of X-linked HED (XLHED), contained

11 first vaccinia virus construct reported that caused a muted innate immune gene expression profile and

12 lator of the pyruvate dehydrogenase complex, caused a profound cell growth inhibition in tumour cells

13 treated with a CB2-specific antagonist that caused a pronounced inhibition of HDM-induced airway inf

14 ited pERK1/2 phosphorylation in all tumours, caused a significant decrease in proliferation in 5/23 (

15 reover, both neonatal and adult THS exposure caused a significant increase in percentage of B-cells a

16 impedes salivary gland invasion 10-fold, and causes a complete absence of liver invasion as mutants f

17 ATP, but not NAD(+), causes a conformational shift to a less compact structur

18 is still commonly regarded as a method that causes a high radiation exposure.

19 loss of DDRGK1 decreases SOX9 expression and causes a human skeletal dysplasia, identifying a mechani

20 to rapid urbanization and industrialization causes a severe global health concern to both ecosystem

21 emerged recently as a global health threat, causing a pandemic in the Americas.

22 ry murine B cells and discovered that RAG1/2 causes aberrant insertions by releasing cleaved antibody

23 e inhibits piwi-interacting RNA trimming and causes accumulation of untrimmed piwi-interacting RNA in

24 pha (PML-RARalpha) oncofusion protein, which causes acute promyelocytic leukemia, inhibits TNFalpha i

25 regulatory elements in diploid organisms may cause allele specific expression (ASE) - unequal express

26 ephrocytes, deficiency of the Pals1 ortholog caused alterations in slit-diaphragm-like structures.

27 Specifically, T caused an increase in aggressive behavior, but only amon

28 has enhanced detrital inputs of C to soils, causing an average increase of 1.2 kgCm(-2) (c. 10%) in

29 aureus clonal complex 398 (LA-MRSA CC398) is causing an increasing number of skin and soft tissue inf

30 time from randomisation until death from any cause), analysed in the intention-to-treat population.

31 th a denser clot structure had increased all-cause and cardiovascular mortality risks (log rank P=0.0

32 Risk of all-cause and cause-specific mortality was assessed with Cox

33 etes may be independent risk factors for all-cause and CVD mortality.

34 While numerous studies have addressed causes and consequences of obesity-related adipose tissu

35 s relative to energy intake, we explored the causes and consequences of variation in body mass of wil

36 ody-mass index (BMI), according to age, sex, cause, and BMI in 195 countries between 1990 and 2015.

37 rceived suffering from early symptom-related causes, attitudes toward early palliative care integrati

38 physiology, with mutations in either protein causing autosomal dominant polycystic kidney disease.

39 of death (i.e., siblings dying from the same causes) but not for discordant causes.

40 chistosomiasis, a neglected tropical disease caused by a chronic infection with parasitic helminths o

41 a rare colon cancer predisposition syndrome caused by a duplication of a noncoding sequence near the

42 exhaustion, occurs during chronic infections caused by a variety of pathogens, from persistent viruse

43 uatamatergic signalling is implicated may be caused by aberrant salience leading to a change in the n

44 reduction in the initiation of BCR signaling caused by actin alteration is associated with a decrease

45 fide-bonded oligomers at neutral pH that are caused by activation and thiol deprotonation of beta-sub

46 t is generally believed that RASopathies are caused by altered levels of pathway activation, the sign

47 The large scale seepage reported here is not caused by anthropogenic warming.

48 d not establish the proportion of casualties caused by AXO from unplanned explosions at munitions sit

49 PO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.

50 Melioidosis, caused by Burkholderia pseudomallei, is endemic in north

51 hilic peptide with rapid fungicidal activity caused by C. neoformans.

52 hern forest carbon balance to climate change caused by changes in forest mortality.

53 ance of the respiratory eggshell ridges, are caused by changes in the spatial distribution of inducti

54 This rule change is caused by cocaine-exacerbated D1-cAMP/protein kinase A d

55 rum of human diseases called ciliopathies is caused by defective primary cilia morphology or signal t

56 man syndrome (AS) is a neurogenetic disorder caused by deletion of the maternally inherited UBE3A all

57 Spinal Muscular Atrophy (SMA) is caused by diminished Survival of Motor Neuron (SMN) prot

58 was mostly explained by periodic inhibition caused by free ammonia due to periodic transient pH upsh

59 rocytes of Alexander disease (AxD), which is caused by heterozygous mutations in the GFAP gene, which

60 ants with diffuse white matter injury (DWMI) caused by hypoxia.

61 r in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function.

62 acterized by fungal and bacterial infections caused by impaired generation of TH17 cells; meanwhile,

63 d and lymphatic vessel (LV) disorder that is caused by inherited inactivating mutations of the RASA1

64 comes in patients with acute ischemic stroke caused by intracranial proximal occlusion.

65 t persistent cardiorespiratory abnormalities caused by LT-IH are mediated by epigenetic re-programmin

66 idly progressive neurodegenerative disorders caused by misfolding followed by aggregation and accumul

67 ease is a disorder of copper (Cu) misbalance caused by mutations in ATP7B.

68 Axenfeld-Rieger syndrome is caused by mutations in PITX2 or FOXC1 and aniridia is ca

69 RP is frequently caused by mutations in Rhodopsin; in some animal models,

70 g and respiratory disease.Cystic fibrosis is caused by mutations in the CFTR chloride channel, leadin

71 RTT) is a debilitating neurological disorder caused by mutations in the gene encoding the transcripti

72 is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2

73 fections, and cystic fibrosis (CF), which is caused by mutations of the cystic fibrosis transmembrane

74 on, due to a disruption of podosome rosettes caused by myosin-IIA overassembly, and a myosin-independ

75 s an autosomal recessive disorder frequently caused by non-assembly of dynein arm motors into cilia a

76 Increased Rac1 activity caused by OGD/ischemia contributes to neuronal death in

77 nvolvement but was subject to attrition bias caused by passive follow-up.

78 mutations in PITX2 or FOXC1 and aniridia is caused by PAX6 mutations.

79 the spectrum of autistic disorders - whether caused by rare highly penetrant mutations or sporadic fo

80 e resected, remaining hotspots may have been caused by residual lymphatic flow after resection.

81 ), one of nine inherited, incurable diseases caused by similar mutations.

82 then be understood in terms of stabilization caused by spin-coupling augmented by dispersion, polariz

83 Toxic shock syndrome (TSS) is caused by staphylococcal and streptococcal superantigens

84 K2 overexpression partly rescues the defects caused by suppression of FGF signalling.

85 ifference in k0 is due to a tunneling effect caused by the adsorption of the electrolytes on the elec

86 E STATEMENT Spinal muscular atrophy (SMA) is caused by the loss of motor neurons, but astrocyte dysfu

87 ra is a severe dehydrating illness of humans caused by toxigenic strains of Vibrio cholerae O1 or O13

88 ment in Id2/Id3 double-knockout mice that is caused by unchecked expansion of invariant NKT (iNKT) ce

89 fancy, can suffer from lifelong debilitation caused by underdeveloped maxillae.

90 cute respiratory distress syndrome (ARDS) is caused by widespread endothelial barrier disruption and

91 ; in contrast BVES and CAP2 murine knockouts caused cardiac conduction defects.

92 Slow toxicodynamic recovery caused carry-over toxicity in subsequent exposures, ther

93 This amount of heating alone did not cause cell death.

94 Eliminating PEPD causes cell death and tumor regression due to p53 activa

95 or inhibitor in the presence of trastuzumab, caused cells to regain an epithelial phenotype.

96 sample volumes without loss of rare disease-causing cells.

97 Hydrothermal treatment caused changes in the phenolic content improved the doug

98 Administration of nitroglycerin causes changes in the systemic and coronary circulation

99 Mutations in this gene cause childhood blindness, in which the a- and b-wave re

100 cular aspects of the regulatory cascade that causes chronic infection.

101 these interactions are disrupted by deafness-causing Cib2 mutations.

102 ate set at 250 mL/min was not more likely to cause clotting compared with 150 mL/min (hazards ratio,

103 separating clusters from single cells and/or cause cluster damage or dissociation during processing.

104 l tissues and can treat microvessels without causing collateral damage to the surrounding tissue.

105 Notably, 12 was able to cause concentration-dependent inhibition of cell prolife

106 Loss of ClpC repression in MD mutants causes constitutive activation and severe cellular toxic

107 his process is 'hijacked' by drug addiction, causing cue-induced cravings and relapse.

108 transmembrane regulator (CFTR) mutation that causes cystic fibrosis.

109 se stresses usually occur simultaneously and cause damages that exceed single stresses.

110 ation in auditory and vestibular hair cells, causing deafness and balance defects.

111 All-cause death and incident chronic kidney disease were sec

112 diovascular events (MACE, a composite of all-cause death, nonfatal myocardial infarction [MI], heart

113 observed for the two measures with late all-cause death.

114 in the Earth's crust and release waves that cause destructive shaking.

115 Ebola virus causes devastating hemorrhagic fever outbreaks for which

116 analogous to the most severe dry/heat spells causing dieback in the late 20th century.

117 biological processes used by A. baumannii to cause disease are not well defined, but recent research

118 7 influenza A viruses are able to infect and cause disease in mammals without prior adaptation and th

119 of high-performance nanomaterials that will cause disruptive improvements in the field of biosensing

120 51 activity slows replication elongation and causes double-strand breaks.

121 emonstrate that short-wavelength deformation causes drainage directions to diverge from long-waveleng

122 Here, we provide evidence that hypoxia causes economic impacts on a major fishery.

123 tic diseases for which obesity is the direct cause (eg, nonalcoholic fatty liver disease) or is a sig

124 Traumatic brain injury (TBI) causes extensive neural damage, often resulting in long-

125 er 500 A.D., the NAO may indicate a specific cause for the punctuated history of migrations in Late A

126 ents; gallic acid and carnosic acid were the cause for the synthetic lethality.

127 hepatitis B virus (HBV), or a noninfectious cause for their ALF.

128 tematic understanding about their extent and causes for any one biological system.

129 rent pulmonary TB may have the potential for causing harmful postvaccination immunologic (Koch-type)

130 term hypoxia exposure, we found that hypoxia caused heart dysfunction.

131 in-binding domain (ABD) of beta-III-spectrin causes high-affinity actin binding and decreased thermal

132 ingly compounded by partner drug resistance, causing high failure rates of artemisinin combination th

133 uman respiratory viruses to wild great apes, causing high morbidity and, occasionally, mortality.

134 Many viral infections cause host shutoff, a state in which host protein synthe

135 Spry2 deletion in the adult mouse beta-cell caused hyperglycemia and hypoinsulinemia.

136 Depletion of RNF146 caused hypersensitivity to LPS-induced TNF-alpha product

137 s in winter with rainfall (rain-on-snow) can cause 'icing', restricting access to forage, resulting i

138 Given the absence of external causes in vitro, the interplay of structurally different

139 Dengue can cause increased vascular permeability that may lead to h

140 In parallel, Nlrp12 deficiency in mice caused increased basal colonic inflammation, which led t

141 NRP1 shRNA expressing KRAS (mt) tumor cells caused increased cell viability by decreasing SMAD2 phos

142 n of normal HA catabolism in Hyal2(-/-) mice causes increased HA, which may promote endothelial-to-me

143 Phosphorylation causes increases in radius, protein accessibility and st

144 ature apoptotic destruction of erythroblasts causing ineffective erythropoiesis.

145 ns, mutations in the NMD factor gene, UPF3B, cause intellectual disability (ID) and are strongly asso

146 trol [3] prey, as well as to exhaust prey by causing involuntary fatigue through remote activation of

147 complication due to the variety of bacteria causing it, their resistance against classical antibioti

148 The application of pressure to the complex causes its time-dependent dissociation and the loss of b

149 on of populations from rural to urban living causes landscape changes and alters the functionality of

150 vulnerability when abnormal experience could cause lasting damage to the developing brain.

151 respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized

152 as a model organism Ceratonova shasta, which causes lethal disease in salmonids.

153 It causes lymphomas in individuals with acquired and innate

154 Drought can cause major damage to plant communities, but species dam

155 ities and ocean warming has the potential to cause major distributional shifts, particularly in polar

156 umulation of extremely large amounts of GFAP causes many molecular changes in astrocytes, including p

157 Rather, inhibition of ATP synthesis caused massive spontaneous vesicle exocytosis, followed

158 In the heart, fibrosis causes mechanical and electrical dysfunction and in the

159 However, the underlying disease-causing mechanism remains uncertain.

160 ive mutations in WD repeat domain 62 (WDR62) cause microcephaly and a wide spectrum of severe brain m

161 Dengue virus infection typically causes mild dengue fever, but, in severe cases, life-thr

162 rofound RPE and retinal damage at doses that caused minimal effects in wild-type mice, and adoptive t

163 As GI TB can cause morphological alterations in and around the small

164 on had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P

165 ted hazard ratio for acute rejection and all-cause mortality at 3 years in recipients who have experi

166 The primary endpoint was all-cause mortality at 30 days.

167 disease death, cardiovascular death, and all-cause mortality by 28% (P=0.020), 25% (P=0.009), and 18%

168 ssium values collected at follow-up with all-cause mortality in a prospective and consecutive cohort

169 colonization by two bacterial pathogens that cause mortality in neonates.

170 All-cause mortality in the entire Medicare population from 2

171 The primary outcome was all-cause mortality until 28 days.

172 All-cause mortality was higher for nonadherent patients (haz

173 n nonfermented milk intake and increased all-cause mortality was recently reported, but overall, the

174 ons between intake of dairy products and all-cause mortality with an emphasis on nonfermented milk an

175 ted cardiac arrest), its components, and all-cause mortality with the use of multivariable Cox models

176 88 for ADA HbA1c clinical categories for all-cause mortality.

177 The primary outcome was all-cause mortality; myocardial infarction, revascularizatio

178 A disease-causing mutation in human STN1 engenders a selective def

179 ucomas have strong genetic bases and disease-causing mutations have been discovered in several genes.

180 Polymicrobial sepsis in mice causes myocardial dysfunction after generation of the co

181 cardiomyocytes induced murf1 expression and caused myofibril disarray, whereas inhibiting Calcineuri

182 th toxins are equally impaired in ability to cause necrotizing myositis.

183 ficial for endosperm nutritional quality but cause negative pleiotropic effects for reasons that are

184 eat expansion in the deubiquitinase ataxin-3 causes neurodegeneration in Spinocerebellar Ataxia Type

185 n prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative dis

186 Escherichia coli is a leading cause of bacterial mastitis in dairy cattle.

187 Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide.

188 Glaucoma is a leading cause of blindness worldwide, and is characterized by pr

189 We sought the genetic cause of cardiac, vertebral, and renal defects, among ot

190 ia, acquired scarring or both - are a common cause of childhood hypertension and renal failure.

191 ic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide.

192 deficiency has been reported as a monogenic cause of common variable immune deficiency with features

193 duced lung function and is the third leading cause of death globally.

194 butes to cardiovascular disease, the leading cause of death in the United States.

195 The precise cause of ET is unknown, however pathological oscillation

196 ry, somatic mutations in MAP2K1 are a common cause of extracranial AVM.

197 us A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldw

198 Acinetobacter baumannii is a common cause of health care associated infections worldwide.

199 Dilated cardiomyopathy (DCM) is an important cause of heart failure.

200 encoding sarcomeric proteins are the leading cause of inherited primary cardiomyopathies.

201 a (Aspergillus fumigatus) is the most common cause of invasive aspergillosis, a frequently fatal lung

202 Glaucoma is the leading cause of irreversible blindness worldwide.

203 The primary cause of KOS is autosomal recessive mutations in the gen

204 iver injury and it is the second most common cause of liver failure.

205 is a debilitating mental illness and a major cause of lost productivity worldwide.

206 The cause of mesial temporal lobe epilepsy (MTLE) is often u

207 y 30, while infection/ sepsis is the leading cause of mid-term mortality.

208 cteriaceae have recently become an important cause of morbidity and mortality due to healthcare-assoc

209 Bloodstream infections are a leading cause of morbidity and mortality in the United States an

210 infection in the United States and a leading cause of morbidity and mortality.

211 The leading cause of mortality in HFpEF is sudden death, but little

212 of the MAP kinase pathway in microglia as a cause of neurodegeneration and this offers opportunities

213 t frequent, yet under-recognised, infectious cause of newborn malformation in developed countries.

214 RRK2 represent the most common known genetic cause of PD.

215 Streptococci are not an infrequent cause of periprosthetic joint infection (PJI).

216 calcitrant to antibiotic therapy and a major cause of persistent and recurrent infections.

217 erulonephritis or interstitial nephritis, as cause of renal failure, represented the only predictive

218 ates suggests altered function as the likely cause of retinal pathology.

219 the retina is essential to understanding the cause of rhegmatogenous retinal detachment and vitreoret

220 taphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired

221 Enterovirus A71 (EV-A71) is the major cause of severe hand, foot, and mouth disease and viral

222 essential for cortical development, but the cause of this neurotropism remains obscure.

223 lopment of early dermatologic reactions, and cause of treatment discontinuation were annotated.

224 umococcal diseases (IPDs) remain the leading cause of vaccine-preventable childhood death, even thoug

225 ary embolism (PE) is a serious and prevalent cause of vascular disease.

226 man astroviruses are recognized as a leading cause of viral diarrhea worldwide in children, immunocom

227 r photoreceptor survival, and is the leading cause of vision loss in the elderly.

228 Inherited retinal disease is a common cause of visual impairment and represents a highly heter

229 onged remission is less common than in other causes of childhood onset epilepsy.

230 cess mortality risk was found for concordant causes of death (i.e., siblings dying from the same caus

231 s or those not undergoing surgery, competing causes of death may diminish the benefit, and there is n

232 sease (p = 0.003), possibly due to competing causes of death over this dose interval.These results co

233 In general, causes of death responsible for more YLLs overall also c

234 The contribution of non-respiratory causes of death to global influenza-associated mortality

235 median time from diagnosis to death, and the causes of death.

236 laboratory evaluations to exclude secondary causes of disease.

237 h hepatitis C virus (HCV) is one of the main causes of hepatocellular carcinoma.

238 p A Streptococcus (GAS) is among the top ten causes of infection-related mortality in humans.

239 ve coding suggests that the brain infers the causes of its sensations by combining sensory evidence w

240 guishing cardiac amyloidosis (CA) from other causes of myocardial thickening with, however, scarce da

241 iques have provided limited insight into the causes of persistent postoperative seizures in patients

242 eteorological conditions are suspected to be causes of preterm birth.

243 ntral goal in biochemistry is to explain the causes of protein sequence, structure, and function.

244 All causes of renal allograft injury, when severe and/or sus

245 is now recognized as one of the most common causes of systemic amyloidosis in North America.

246 Here, we studied causes of uncertainty among 16 crop models in predicting

247 Contemporary data for causes of vision impairment and blindness form an import

248 Prevalence and main causes of vision loss.

249 However, many other potential causes of white matter signal abnormalities can mimic th

250 er understand the behavior of the flatulence-causing oligosaccharides in cowpea seeds during isotherm

251 a(2+) influx via TRPC6 or Orai1 channels and caused only a minor inhibition of P2X1-dependent Ca(2+)

252 m the regressions of shape on some exogenous cause or effect of form.

253 sociated with reduced risk of death from any cause or from cancer for patients whose tumors did not c

254 nd limb was transected at postnatal day 8 to cause paralysis to that limb.

255 small number of genes have been reported to cause PCH, and the vast majority of PCH cases are explai

256 Short- and medium-wavelength UV light can cause photo-lesions in DNA origami.

257 reports, we did not detect a decline in all-cause pneumonia in older adults in any country.

258 el of AxD that is heterozygous for a disease-causing point mutation (Gfap(R236H)(/+)) (and thus expre

259 ng that can impart treatment resistance, and cause problematic off-target effects.

260 s unclear at what levels liver fluke burdens cause production losses.

261 Oncogenic Ras causes proliferation followed by premature senescence in

262 inase activity decreases SH3-GK interaction, causing PSD-95 to adopt an open conformation.

263 ii) has emerged as a dangerous pathogen that causes rare but life-threatening infections.

264 .Arg90His substitution, which is reported to cause reduced reactive oxygen species (ROS) production,

265 This gain-of-function CRY1 variant causes reduced expression of key transcriptional targets

266 at reduced expression of either TSC1 or TSC2 causes reduced pigmentation through mTORC1 activation, w

267 ly in colorectal cancer than in melanoma and causes resistance only in the former.

268 dogs is a unique example of multiple disease-causing retrocopies of the same parental gene in a mamma

269 of Schistosoma mansoni, the blood fluke that causes schistosomiasis, ranked among the most prevalent

270 ricting and destabilizing the membrane neck, causing scission.

271 Excess Phosphorus (P) in agriculture is causing serious environmental problems like eutrophicati

272 nergy consumption, disrupted agriculture and caused severe human discomfort.

273 amounts of CO2 and CH4 into the atmosphere, causing severe global warming and subsequent mass extinc

274 st amount of added master alloy, ultrasonics caused significant additional grain refinement compared

275 t of four kinases AURKB, NEK1, TTK, and WEE1 causes simulated HeLa cells to accumulate in the M phase

276 , the ubiquitous carcinogen in sunlight that causes skin cancer.

277 y higher than the general population for all causes (SMR 5.7, 95% CI 5.5-5.8), particularly non-AIDS

278 Risk of all-cause and cause-specific mortality was assessed with Cox proportio

279 ve index mismatches between media and sample cause spherical aberrations that often limit penetration

280 We show that loss of RER in B. subtilis causes strand- and sequence-context-dependent GC --> AT

281 h doses, staple dissociation increases which causes structural disintegration.

282 energy calculations, the Gly1629Glu mutation causes structural perturbation in the A2 domain and ther

283 -hospital cardiac arrest of presumed cardiac cause that had been included in the TTM-trial.

284 pact, but additionally a dynamical one: They cause the Lindemann criterion to fail in 2D in the sense

285 ns in the MCOLN1 gene, which encodes TRPML1, cause the neurodegenerative lysosomal storage disorder m

286 Mutations in ATP7B cause the potentially fatal hepatoneurological disorder

287 RNA molecules cause the proteins involved in the formation of germ gra

288 round LanFTc1, suggesting that this deletion caused the loss of vernalization response.

289 tion in the penultimate MftA Val-29 position causes the accumulation of an MftA** minor product.

290 (TRIF) and nuclear factor kappaB (NF-kappaB) causes the apoptosis of MDCC-MSB1 cells.

291 neurons in the central nervous system (CNS), causing the adult-onset degenerative disease amyotrophic

292 tivity and the particular Leishmania species causing the disease can lead to variable performance.

293 pathways through which clozapine may act to cause this serious adverse effect.

294 We determined that selinexor causes thrombocytopenia by blocking thrombopoietin (TPO)

295 us, expression of a 5' extended mRNA isoform causes transcriptional interference at the downstream pr

296 narrow luminal sections without potentially causing trauma to tissue with a traditional OCT endoscop

297 Stacking both beneficial traits caused undesirable branching and sterility due to epista

298 liferation of retinal blood vessels commonly causes vision impairment in proliferative retinopathies,

299 an cells are frequently exposed to stressors causing volume changes.

300 Climate change is causing warmer and more variable temperatures as well as