ライフサイエンスコーパス: caveolin-1

1 , is essential for normal oligomerization of caveolin 1.

2 mselves can still interact in the absence of caveolin 1.

3 colocalized with clathrin far more than with caveolin-1.

4 D1) cofactor during endolysosomal sorting of caveolin-1.

5 ins rich in the membrane raft marker protein caveolin-1.

6 ediated stabilization of endothelial surface caveolin-1.

7 r the lipid raft markers ganglioside GM1 and Caveolin-1.

8 se to the Ca(2+) signal, was also reduced by caveolin-1.

9 impaired the anti-proliferative function of caveolin-1.

10 uired a functional scaffolding domain within caveolin-1.

11 re positive for type I markers, T1alpha, and caveolin-1.

12 harmacologic inhibition of ERKs or silencing caveolin-1.

13 nic fibroblasts (MEFs), which do not express caveolin-1.

14 he transmembrane domain (residues 96-136) of caveolin-1.

15 e structures might be involved in delivering caveolin-1.

16 n impaired the antiproliferative function of caveolin-1.

17 detergent-resistant membranes (rafts) and to caveolin-1.

18 surface augmented degradation like wild-type caveolin-1.

19 NA interference (RNAi)-mediated depletion of caveolin 1/2 or flotillin had no effect on ATP7A localiz

20 We found that caveolin-1, a structural protein component of caveolar m

21 ncrease in Ca(2+) release in the presence of caveolin-1 activated protein kinase C, which accelerated

22 Caveolin-1 acts as a scaffolding protein to functionally

23 Functional studies demonstrate that caveolin-1 acts as an endogenous inhibitor of Nrf2, as s

24 tor light responses, indicating that lack of caveolin-1 affects photoreceptor function in a non-cell-

25 Expression of DN caveolin-1 also reduced RVFV infection significantly, wh

26 by the binding of the scaffolding domain of caveolin-1 (amino acids 82-101) to the caveolin-binding

27 by the binding of the scaffolding domain of caveolin-1 (amino acids 82-101) to the caveolin-binding

28 svascular pumping required the expression of caveolin 1 and annexin A1.

29 The CAV1/CAV2 (caveolin 1 and caveolin 2) genomic region previously was

30 ive endocytosis with increased expression of caveolin 1 and caveolin 2.

31 The core interactions between caveolin 1 and cavin 1 are independent of cavin 2, cavin

32 On the contrary, eNOS, Caveolin-1 and -2 expression were significantly increase

33 ith c-Abl, increased phosphorylation of both caveolin-1 and c-Abl and abolished the inhibitory effect

34 ative stress-induced phosphorylation of both caveolin-1 and c-Abl, which is the major kinase of caveo

35 R on oxidant-induced phosphorylation of both caveolin-1 and c-Abl.

36 ctures formed from a complex of the proteins caveolin-1 and caveolin-2.

37 aveolae, modulates the oncogenic function of caveolin-1 and cooperates with caveolin-1 to enhance pan

38 ial cells resulted in an increased amount of CAVEOLIN-1 and decreased cell proliferation.

39 a-mediated endocytosis, and RNAi targeted to caveolin-1 and dynamin, drastically reduced RVFV infecti

40 tored in double knockout mice that lack both caveolin-1 and eNOS.

41 this study, we show that KSR1 interacts with caveolin-1 and is responsible for MEK and ERK redistribu

42 In cell culture studies, membranous caveolin-1 and nuclear p53 expression was greater in rep

43 Caveolin-1 and p53 expression was decreased in bone in S

44 rat serum significantly down-regulated both caveolin-1 and p53 in senescent and nonsenescent cells.

45 sion molecule-1 and the transcytosis protein Caveolin-1 and promoting endothelial transcytosis.

46 further demonstrate that ShcA interacts with Caveolin-1 and the costameric protein plasma membrane Ca

47 aled the physical interaction of cavin-1 and caveolin-1 and their colocalization in pancreatic cancer

48 Correspondingly, significant increases of caveolin-1 and vascular endothelial growth factor (VEGF)

49 .g., matrix metalloproteinases, IL-8, PDGFs, caveolin 1, and lysyl oxidase), several of which were as

50 nto polarized trophoblasts that is clathrin, caveolin-1, and dynamin II independent but requires inta

51 in-1 and c-Abl, which is the major kinase of caveolin-1, and endocytosis of albumin in human umbilica

52 ment of cavin-1 on the prognostic potency of caveolin-1, and showed that combination of cavin-1 with

53 t is homologous to the Src-binding domain of caveolin-1, and this region is required for SSeCKS-Src i

54 of the Na(+),K(+)-ATPase with ankyrin B and caveolin-1 are expected to result in changes in plasma m

55 Caveolin-1 associates with the endo/lysosomal machinery

56 ound in caveolae and directly phosphorylated caveolin-1 at Tyr14 in vitro and in vivo This modificati

57 vin-1/-2/-3/-4 and caveolin-1) in the cavins/caveolin-1 axis were screened by immunohistochemistry in

58 re and driver-gene mutations, and the cavins/caveolin-1 axis.

59 The caveolin-1 bound fatty acids were immunoprecipitated by

60 investigated the fatty acids in caveolae and caveolin-1 bound fatty acids.

61 The effect required caveolin-1 but was observed in cells depleted of clathri

62 NKCC2 endocytosis by 39 +/- 4% and silencing caveolin-1 by 29 +/- 4%.

63 nsive element (ARE) after down-regulation of caveolin-1 by small interfering RNA or overexpression of

64 A heterozygous caveolin-1 c.474delA mutation has been identified in a f

65 A heterozygous Caveolin-1 c.474delA mutation has been identified in a f

66 in the pathogenesis of PAH in patients with caveolin-1 c.474delA mutation.

67 in the pathogenesis of PAH in patients with caveolin-1 c.474delA mutation.

68 Caveolin 1 (Cav-1) is a plasma membrane-associated prote

69 1 enzyme, together with the scaffold protein caveolin 1 (CAV-1), also acts as a negative regulator of

70 d overexpression of an MLR scaffold protein, caveolin-1 (Cav-1) (via a synapsin promoter, SynCav1), i

71 Caveolin-1 (Cav-1) ablation results in loss of caveolae

72 mily, is largely different from better known caveolin-1 (Cav-1) and thus might play distinct function

73 Caveolin-1 (Cav-1) binding to eNOS holds eNOS in an inac

74 Caveolin-1 (Cav-1) gene inactivation interferes with cav

75 Hence, this study evaluated the role of caveolin-1 (Cav-1) in modulating P2Y2R subcellular distr

76 cells to assess the role of cholesterol and caveolin-1 (CAV-1) in the diffusion, expression, and fun

77 Caveolin-1 (Cav-1) interacts with and mediates protein t

78 es this gap in knowledge by identifying that caveolin-1 (Cav-1) is a candidate mechanism-based biomar

79 Caveolin-1 (Cav-1) is a key organizer of membrane specia

80 We hypothesized that caveolin-1 (Cav-1) participates in IOP maintenance via m

81 nanoparticles containing siRNA targeting the caveolin-1 (Cav-1) transcript caused a reduction of the

82 ions in the caveolar structural protein gene Caveolin-1 (CAV-1) were identified in two patients with

83 Caveolin-1 (Cav-1), a major component of caveolae, is a

84 Caveolin-1 (CAV-1), a structural protein of the cell mem

85 One LD coat protein is caveolin-1 (Cav-1), an essential component for caveola a

86 lasma membrane in DM, which colocalized with caveolin-1 (Cav-1), the key structural protein of caveol

87 this study we show that Dsg2 associates with caveolin-1 (Cav-1), the major protein of specialized mem

88 titioning into caveolae and association with caveolin-1 (Cav-1).

89 Caveolin 1 (Cav1) is a required structural component of

90 e-like polygonal structures [7, 8] formed by caveolin 1 (Cav1) or Cav3 and one of the cavin proteins

91 We hypothesized that caveolin 1 (CAV1), a well-known eNOS interactor, regulat

92 ding protein and main component of caveolae, caveolin 1 (cav1), which was present in each epicardial

93 d indirectly through another miR-204 target, Caveolin 1 (CAV1).

94 e found that a fully functional construct of caveolin-1 (Cav1(62-178)) was a monomer in dodecylphosph

95 idomic and gene array analyses revealed that caveolin-1 (CAV1) deficiency results in altered cellular

96 Caveolin-1 (Cav1) drives the formation of flask-shaped m

97 ies have revealed significant association of caveolin-1 (Cav1) gene variants with increased risk of c

98 Owing to the important role of caveolin-1 (CAV1) in TGF-beta receptor internalization a

99 holesterol-binding integral membrane protein caveolin-1 (Cav1) into the membrane, however, the precis

100 erapeutic stress-resistant tumor clones, and caveolin-1 (CAV1) is a main regulator of numerous signal

101 Caveolin-1 (CAV1) is a multifunctional protein and a maj

102 Caveolin-1 (Cav1) is a scaffolding protein that serves t

103 Caveolin-1 (Cav1) is an essential component of caveolae

104 Caveolin-1 (CAV1) is an essential component of caveolae

105 Caveolin-1 (Cav1) is an integral membrane, scaffolding p

106 The plasma membrane organizing protein caveolin-1 (Cav1) is increased in a variety of cancers,

107 Caveolin-1 (CAV1) is the defining constituent of caveola

108 Caveolin-1 (Cav1), a major Src kinase substrate phosphor

109 with hereditary hemorrhagic telangiectasia), caveolin-1 (CAV1), and a gene (KCNK3) encoding a two-por

110 show that the lipid raft-associated protein caveolin-1 (CAV1), in analogy with its previously descri

111 The absence of PTEN leads to caveolin-1 (CAV1)-dependent beta-catenin transcriptional

112 These data support a role for caveolin 1, caveolin 2, or both in POAG and suggest that

113 Notably, caveolin-1, caveolin-2, and annexin A2, which are protei

114 ischemic penumbra of rat brains, and whether caveolin-1 changes correlated with reduced brain injury

115 odification regulated the generation of TIE2/caveolin-1 complexes and was essential for TIE2/caveolin

116 on and confocal microscopy demonstrated TIE2/caveolin-1 complexes in the nucleus, and using inhibitor

117 ucture analysis of a functional construct of caveolin-1, containing the intact C-terminal domain, was

118 The central portion of caveolin-1 contains two helices (H1 and H2) connected by

119 o characterize the structure and dynamics of caveolin-1 (D82-S136; Cav182-136) in a DMPC bilayer usin

120 signaling to RhoA is galectin-3 and phospho-caveolin-1 dependent and promotes the formation of trans

121 lmonary arteries via elastase inhibition and caveolin-1-dependent amplification of BMPR2 signaling.

122 In vitro, syndecan-2 promoted caveolin-1-dependent internalization of TGF-beta1 and Tb

123 ve been shown to impair leptin signaling via caveolin-1-dependent mechanisms.

124 de-in integrin signaling stimulating phospho-caveolin-1-dependent RhoA activation, actin reorganizati

125 n-2 exerts antifibrotic effects by promoting caveolin-1-dependent TGF-beta1 and TbetaRI internalizati

126 ERK as a KSR1 mutant unable to interact with caveolin-1 does not efficiently mediate growth factor-in

127 in-depth functional experiments showed that caveolin-1-enhanced aggressiveness of pancreatic cancer

128 echanism that involves recruitment of KIT to caveolin-1-enriched microdomains.

129 ggests a bidirectional crosstalk between the caveolin-1/ERK and Wnt/beta-catenin pathways in mechanot

130 e show that there is interaction between the caveolin-1/ERK and Wnt/beta-catenin signaling pathways i

131 Caveolin-1 exhibits a stage-dependent, functional fluctu

132 We identified caveolin-1 expression as a crucial step in adipose cell

133 ial epithelial cells of asthmatics had lower caveolin-1 expression compared with control cells.

134 In contrast, manipulation of caveolin-1 expression did not affect the actions of E2 o

135 s seen with modest weight gain, may increase caveolin-1 expression in adipose tissue.

136 Increased caveolin-1 expression in turn impairs leptin signaling a

137 We demonstrate that a lack of caveolin-1 expression inhibits oncogenic K-Ras (K-Ras(G1

138 at the mRNA and protein levels, and that low caveolin-1 expression is associated with poor survival.

139 human sample analysis in which we show that caveolin-1 expression is dramatically down-regulated in

140 Cavin-1 stabilizes caveolin-1 expression or activity by inhibiting its inte

141 Also shRNA lentivirus knockdown of caveolin-1 expression prevents rapid internalization of

142 mature senescence through down-regulation of caveolin-1 expression to progress from premalignant lesi

143 Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell sene

144 cancer was found to be largely dependent on caveolin-1 expression, which highlights the critical rol

145 human white preadipocytes, leptin increased caveolin-1 expression, which in turn impaired leptin cel

146 e expansion response correlated with initial caveolin-1 expression.

147 ted (125)I-CXCL1 endocytosis as knockdown of caveolin-1 failed to inhibit ligand internalization.

148 emodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis' by Goet

149 po-osmotic tension induced the dispersion of caveolin-1 from the caveolae, possibly through flattened

150 Here we studied how this mutation alters caveolin-1 function using patient-derived fibroblasts.

151 Here we studied how this mutation alters caveolin-1 function, using patient-derived fibroblasts.

152 Ligand 1 will permit targeted study of caveolin-1 function.

153 Similarly, caveolin-1/galectin-3-dependent EGF signaling induces mo

154 was to screen subjects for variation in the Caveolin-1 gene (Cav1), previously shown to correlate wi

155 Like mice lacking caveolin-1 globally, (RPE)CAV1(-/-) mice developed a nor

156 Here, we show that the scaffolding protein caveolin-1 has a profound effect on receptor-driven Ca(2

157 Caveolin-1 has been primarily described as a major compo

158 Caveolin-1 has emerged as a critical regulator of signal

159 e formation of lipid rafts and activation of caveolin-1; however, no such observations were made upon

160 fatty acids were immunoprecipitated by anti-caveolin-1 IgG and analyzed with GC/MS.

161 roximately one-quarter of the density of the caveolin-1 in a flask-shaped caveola.

162 The caveolin-1 in a flattened caveola is assumed to have app

163 tion of Sirt1 expression or re-expression of caveolin-1 in caveolin-1 null MEFs restores reactive oxy

164 Expression of mutated caveolin-1 in caveolin-1-null mouse fibroblasts failed t

165 Finally, we show that overexpression of caveolin-1 in colon cancer cells inhibits oxidant-induce

166 report that, although DARC co-localizes with caveolin-1 in endothelial cells, caveolin-1 is dispensab

167 extracellular domain and co-sedimented with caveolin-1 in lipid rafts.

168 critical role of the final 20 amino acids of caveolin-1 in modulating fibroblast proliferation by dam

169 critical role of the final 20 amino acids of caveolin-1 in modulating fibroblast proliferation throug

170 esults reveal a novel role for intracellular caveolin-1 in modulating phagolysosomal function.

171 Cavin-1 expression is associated with caveolin-1 in pancreatic cancer tissue samples and cell

172 Overexpression of caveolin-1 in ST2 cells resulted in increased expression

173 and formed a continuous population with the caveolin-1 in the caveolae of cells under isotonic cultu

174 of this study was to investigate the role of caveolin-1 in treadmill-exercise-induced angiogenesis in

175 ive critical molecules (cavin-1/-2/-3/-4 and caveolin-1) in the cavins/caveolin-1 axis were screened

176 the EPA-induced lipid raft disorganization, caveolin-1 inactivation, and cellular cytotoxicity were

177 The proportion of one-quarter-density caveolin-1 increased after increasing the tension of the

178 Overexpression of caveolin-1 increased receptor-phospholipase C coupling,

179 In addition, overexpression of caveolin-1 induces stress induced premature senescence i

180 bitor groups received an IP injection of the caveolin-1 inhibitor, daidzein (0.4 mg/kg), every 24 h f

181 demonstrate that the combination of TIE2 and caveolin-1 inhibitors resulted in significant radiosensi

182 Furthermore, abolishing the KSR1-caveolin-1 interaction increases growth factor demands t

183 nd suggests that the interruption of cavin-1/caveolin-1 interaction is a promising therapeutic strate

184 show that the lipid raft scaffolding protein caveolin-1 interacts with the STIM1-Orai1 complex to inc

185 Our results reveal that caveolin-1 is a bimodal regulator of receptor-dependent

186 We demonstrate that caveolin-1 is a direct binding partner of Nrf2, as shown

187 These results suggest that caveolin-1 is a mediator of nonestrogenic SPI effects on

188 Caveolin-1 is a target for academic and pharmaceutical r

189 Caveolin-1 is an essential structural protein of caveola

190 Caveolin-1 is an integral membrane protein of plasma mem

191 Caveolin-1 is an integral membrane protein that is the p

192 ytosis-like process in endothelial cells and caveolin-1 is dispensable for CXCL1 internalization.

193 alizes with caveolin-1 in endothelial cells, caveolin-1 is dispensable for DARC-mediated (125)I-CXCL1

194 The interaction between KSR1 and caveolin-1 is essential for optimal activation of ERK as

195 While caveolin-1 is known to participate in a myriad of vital

196 These data show that caveolin-1 is necessary for optimal KSR1-dependent ERK a

197 Caveolin-1 is the primary structural component of endoth

198 In contrast, in caveolin-1 KD (Cav1-KD) cells, >87% of adiponectin-induc

199 alpha(i/o) coupling in brown adipocytes from caveolin-1 knock-out mice or in wild type adipocytes tre

200 tosis required dynamin but was unaffected by caveolin-1 knockdown or cholesterol depletion.

201 nt of endothelial nitric oxide synthase from caveolin-1, leading to an impairment of nitric oxide sig

202 After oxidative stress, caveolin-1 limits the movement of Nrf2 from caveolar mem

203 Therefore, by inhibiting Sirt1, caveolin-1 links free radicals to the activation of the

204 Thus, by inhibiting Nrf2-mediated signaling, caveolin-1 links free radicals to the activation of the

205 id compositions of caveolae and acylation of caveolin-1 may be important for caveolae formation and f

206 d TRPV5 activity by impairing dynamin-2- and caveolin-1-mediated endocytosis of TRPV5.

207 m of RVFV MP-12 uptake is dynamin-dependent, caveolin-1-mediated endocytosis.

208 reted by senescent fibroblasts following the caveolin-1-mediated inhibition of Sirt1.

209 The caveolin-1-mediated secretion of IL-6 by senescent fibro

210 mbrane of microvascular endothelial cells in caveolin 1(-/-) mice is much more susceptible to acute r

211 Thus, overall, whereas a direct caveolin 1/Na,K-ATPase interaction is confirmed, the lac

212 beit with a low molar stoichiometry (1:15-30 caveolin 1/Na,K-ATPase).

213 eolin-1 complexes and was essential for TIE2/caveolin-1 nuclear translocation.

214 expression or re-expression of caveolin-1 in caveolin-1 null MEFs restores reactive oxygen species-in

215 nd premature senescence in wild-type but not caveolin-1 null mouse embryonic fibroblasts (MEFs).

216 -regulation of NQO1, an Nrf2 target gene, in caveolin-1-null MEFs and the activation or inhibition of

217 nd shows that impaired tumor angiogenesis in caveolin-1-null mice is, at least in part, the result of

218 Consistent with these data, caveolin-1-null mice overexpressing K-Ras(G12D) display

219 K-Ras(G12D)-induced premature senescence in caveolin-1-null mice results in the formation of more ab

220 r senescence in the lung of wildtype but not caveolin-1-null mice.

221 ride (L-NAME), including the reversal of the caveolin-1-null mouse angiogenic phenotype.

222 nucleus before and after oxidative stress in caveolin-1-null mouse embryonic fibroblasts (MEFs), whic

223 Expression of mutated caveolin-1 in caveolin-1-null mouse fibroblasts failed to induce forma

224 vital cellular processes, structural data on caveolin-1 of any kind is severely limited.

225 small, high-affinity, selective disrupter of caveolin-1 oligomers.

226 y examining the impact of membrane rafts and caveolin-1 on the differential signaling of mouse beta(3

227 Phosphorylation of caveolin-1 on tyrosine 14 promotes the sequestration of

228 YD1) and purified human Src kinase and human caveolin 1 or interactions between these proteins in nat

229 ma membrane domains structurally composed of caveolin-1 or -3 along with other proteins.

230 r or small interfering RNAs (siRNAs) against caveolin-1 or Tie2 inhibited their trafficking.

231 Neuron-specific caveolin-1 overexpression improves motor function and pr

232 white preadipocytes, which was prevented by caveolin-1 overexpression.

233 2 cells exhibited a strong association among caveolin-1, p53, and mouse double minute 2 homologue (md

234 were associated with down-regulation of the caveolin-1/p53-mediated senescence pathway in bone.

235 Our findings suggest that the caveolin-1 pathway is involved in the regulation of VEGF

236 of a mutant form of Nrf2 that cannot bind to caveolin-1 (Phi-->A-Nrf2) hyperactivates ARE and inhibit

237 ck down of c-Abl significantly decreased the caveolin-1 phosphorylation after H2O2 exposure and aboli

238 on of AMPK inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis, and this eff

239 However, the regulatory mechanism of caveolin-1 phosphorylation remains unclear.

240 ly unexpected role for AMPK in inhibition of caveolin-1 phosphorylation under oxidative stress.

241 , ILK, and Src-dependent RhoA activation and caveolin-1 phosphorylation.

242 d galectin-3 also mediate EGF stimulation of caveolin-1 phosphorylation.

243 lished the inhibitory effect of AICAR on the caveolin-1 phosphorylation.

244 lished the inhibitory effect of AICAR on the caveolin-1 phosphorylation.

245 Phosphorylation of caveolin-1 plays a fundamental role in the mechanism of

246 and showed that combination of cavin-1 with caveolin-1 predicted worse survival in pancreatic cancer

247 olar deformation by measuring the density of caveolin-1 projected onto a two-dimensional (2D) plane.

248 oint mutation in the transmembrane domain of caveolin-1 (proline 132 to leucine) has deleterious effe

249 oximately 2.5-fold) or decrease (by half) of caveolin-1 protein levels in RPE cells in culture was su

250 We show that halving caveolin-1 protein levels significantly alkalinized lyso

251 This frameshift mutation leads to a caveolin-1 protein that contains all known functional do

252 This frameshift mutation leads to caveolin-1 protein that contains all known functional do

253 Each caveola contains approximately 150 caveolin-1 proteins.

254 o reduced levels of occludin, claudin 5, and caveolin 1, proteins central to blood-brain-barrier inte

255 Phosphorylation of tyrosine 14 on caveolin-1 regulates CRAC channel-evoked c-fos activatio

256 a subcutaneous xenograft model that stromal caveolin-1 remodels the intratumoral microenvironment, w

257 cancer cells, which could not be restored by caveolin-1-rescue construct.

258 Complete backbone assignments of caveolin-1 (residues 62-178) were made, and it was deter

259 y small interfering RNA or overexpression of caveolin-1, respectively.

260 ression of wild-type caveolin-1 with mutated caveolin-1 restored the ability to form caveolae.

261 ression of wild type caveolin-1 with mutated caveolin-1 restored the ability to form caveolae.

262 Interestingly, overexpression of caveolin-1 restores cellular senescence in both A549 and

263 These studies define a galectin-3/phospho-caveolin-1/RhoA signaling module that mediates integrin

264 -induced IL-8 responses via the formation of caveolin-1-rich "signaling hubs" in the corneal cells th

265 esponsible for MEK and ERK redistribution to caveolin-1-rich fractions.

266 nd prevents the translocation of ICAM-1 into caveolin-1-rich membrane domains.

267 ion and induces translocation of ICAM-1 into caveolin-1-rich membrane domains.

268 Treatment with the caveolin-1 scaffolding domain peptide (CSP) reversed the

269 her, inhibition of Src kinase activity using caveolin-1 scaffolding domain peptide suppressed bleomyc

270 reveal that structurally distinct domains of caveolin-1 selectively regulate the ability of local cal

271 extent of caveolar formation and the role of caveolin-1 signalling were evaluated by immunohistochemi

272 ey show, for the first time, that organellar caveolin-1 significantly affects tissue functionality in

273 o disrupt membrane rafts or transfected with caveolin-1 siRNA, the cyclic AMP response to the beta(3)

274 We also identified IL-6 as a caveolin-1-specific cytokine that is secreted by senesce

275 Therefore, eliminating caveolin-1 specifically impairs phagolysosomal degradati

276 Here we explored mice lacking caveolin-1 specifically in the retinal pigment epitheliu

277 cking of the microdomain-associated proteins caveolin-1, syntaxin-6, and multidrug resistance protein

278 ydrophobic domain (FQRQVWLLF) interacts with caveolin 1 targeting Kv1.3 to caveolar rafts.

279 A mutant form of caveolin-1 that fails to reach the cell surface augmente

280 can be increased by blocking its binding to Caveolin-1, the main coat protein of caveolae, using a h

281 and-induced TIE2 trafficking is dependent on caveolin-1, the main component of caveolae.

282 w concentrations of cyclodextrin also caused caveolin-1 to accumulate on late endosome/lysosomal memb

283 c function of caveolin-1 and cooperates with caveolin-1 to enhance pancreatic cancer aggressiveness.

284 mbrane and acts synergistically with phospho-caveolin-1 to promote integrin-dependent matrix remodeli

285 mouse fibroblasts, where it colocalizes with caveolin-1, under resting conditions.

286 ession of p53 and p21, whereas, knockdown of caveolin-1 using shRNA led to increases in mdm2 and elim

287 The caveolin-1/VEGF signaling pathway may be a potential tar

288 cally to augmented interaction of BMPR2 with caveolin-1 via elafin-mediated stabilization of endothel

289 hly enriched with saturated fatty acids, and caveolin-1 was acylated by palmitic acid and stearic aci

290 Unexpectedly, GC/MS analysis indicated that caveolin-1 was not acylated by myristic acid; instead, i

291 Endogenous caveolin-1 was recruited to maturing phagolysosomes in R

292 The one-quarter-density caveolin-1 was soluble in detergent and formed a continu

293 The distinct, dispersed lower-density caveolin-1 was soluble in detergent and increased after

294 Further, in cells lacking caveolin-1, we observed an accumulation of KCa2.3 at the

295 and related membrane protein distributions (caveolin-1) were obtained.

296 membranes and the interaction of Sirt1 with caveolin-1, which lead to inhibition of Sirt1 activity.

297 Cavin 1 forms trimers and interacts with caveolin 1 with a molar ratio of about 1ratio4.

298 that K-Ras(G12V) promotes the interaction of caveolin-1 with MTH1, which results in inhibition of MTH

299 However, coexpression of wild-type caveolin-1 with mutated caveolin-1 restored the ability

300 However, co-expression of wild type caveolin-1 with mutated caveolin-1 restored the ability