ライフサイエンスコーパス: cecum

1 ll intestine (duodenum) and large intestine (cecum).

2 f mice, affecting mainly the right colon and cecum.

3 losely reflected its ability to colonize the cecum.

4 was impaired in its ability to colonize the cecum.

5 senger RNA and/or protein were determined in cecum.

6 type I collagen, and cytokine expression in cecum.

7 undant in surface columnar epithelium in the cecum.

8 s associated with IL-27p28 expression in the cecum.

9 nstream signaling gene expression within the cecum.

10 n epithelial cells of the proximal colon and cecum.

11 direct inoculation of P. aeruginosa into the cecum.

12 , one in the ascending colon, and one in the cecum.

13 sa and various virulence components into the cecum.

14 f epithelial proliferation at the tip of the cecum.

15 throughout the gut epithelium, including the cecum.

16 of Paneth cells, and absence of mucus in the cecum.

17 To be effective they must reach the cecum.

18 a disease-protective role for IL-17A in the cecum.

19 or its various components directly into the cecum.

20 terocytes of duodenum, proximal jejunum, and cecum.

21 ated with pathology (lesion severity) in the cecum.

22 numbers of E. coli bacteria adhering to the cecum.

23 ific domains were present in the stomach and cecum.

24 red midgut-hindgut union and agenesis of the cecum.

25 ater stages of development take place in the cecum.

26 cecum, and colon and were most severe in the cecum.

27 ng colon hanging down in the pelvis from the cecum.

28 forestomach, antrum, pylorus, duodenum, and cecum.

29 rming, uncultivated inhabitant of guinea pig cecum.

30 y of aberrant crypt foci was observed in the cecum.

31 and decreased neutrophil infiltration in the cecum.

32 the intestine but developed SPs only in the cecum.

33 rkedly inhibited the formation of SPs in the cecum.

34 lonic tumorigenesis, most notably within the cecum.

35 rates a two-centimeter ulcerated mass in the cecum.

36 raintestinal growth but not in growth in the cecum.

37 of ca. 90% of normal microbial taxa from the cecum.

38 lonoscopy by infusing fresh donor feces into cecum.

39 not trigger overt inflammation in the murine cecum.

40 nects both segments at 80 cm proximal to the cecum.

41 duodenum, ileum, jejunum and colon, and the cecum.

42 small bowel mucosa from the duodenum to the cecum.

43 growth and toxin production in the colon and cecum.

44 r localized in the mucus layer of the murine cecum.

45 (4.0 +/- 0.4 versus 3.6 +/- 0.3) or for the cecum (4.6 +/- 0.3 versus 4.0 +/- 0.3).

46 and inflammatory cytokine expression in the cecum 5 days after infection of mice.

47 of measured bile acids in serum (81.2%), the cecum (97.7%), and the rectum (97.5%).

48 was assessed using a rabbit sidewall defect-cecum abrasion model, where it was applied to both injur

49 Furthermore, we show evidence that the cecum acts a biological sump holding large concentration

50 However, in the cecum, advancing ENCCs pause for approximately 12 h, and

51 Autophagy was induced in small intestine and cecum after infection with S typhimurium, and required A

52 A was lethal to mice when injected into the cecum after partial hepatectomy.

53 at the hepatic flexure in 4 patients (36%), cecum and ascending colon (4 pts, 36%), rectosigmoid (2

54 ded laterally, overlying the position of the cecum and ascending colon.

55 e lumen and mucosal surface of the colon and cecum and causes crypt hyperplasia and mucosal inflammat

56 tures with EPEC, colonizes mice in colon and cecum and causes inflammation, but typically little or n

57 a led to parasite invasion of the intestinal cecum and cecal tonsils.

58 highest concentration of CYP2Cs occurred in cecum and colon (cecum >/= proximal colon >> distal colo

59 transcripts were expressed at high levels in cecum and colon and at lower levels in small intestine.

60 hich colonizes primarily the surfaces of the cecum and colon and causes transient mucosal inflammatio

61 re alpha-defensins are abundant in MMP7(-/-) cecum and colon due to luminal proteolytic activation by

62 The cecum and colon had immunoreactivity for neuronal TRPA1,

63 communities associated with the mucus of the cecum and colon is an important early step in GI tract c

64 similar colonization levels of WT(Hc) in the cecum and colon of both B6 and IL-10(-/-) mice.

65 icantly improves pathological changes in the cecum and colon of C. difficile-infected mice and reduce

66 olonization levels of WT H. hepaticus in the cecum and colon of male mice were approximately 1,000-fo

67 Despite colonization of the cecum and colon tissues by C. fetus in SCID mice, no les

68 R, IL-22 binding protein, and IL-23R between cecum and colon, a finding that may help explain why the

69 tive processing were identified in MMP7(-/-) cecum and colon, and proteinases of host and microbial o

70 In the cecum and colon, approximately 20% of the luminal epithe

71 Distal gut tissues such as cecum and colon, however, have proved considerably more

72 ies in the outer (loose) mucus layer, in the cecum and colon, starting at day 1 p.i.

73 ly few and in the lower small intestine, the cecum and colon, virtually no IGLEs survived capsaicin t

74 se in constitutive ICAM-1 expression in both cecum and distal colon.

75 = 0.9626) between competitive indices in the cecum and fecal samples of CBA mice at 30 days after inf

76 ral layers of the jejunum, ileum, colon, and cecum and in HT-29, T-84, T98G, and Bon cell lines.

77 C. jejuni during colonization of the chicken cecum and in two different in vitro growth phases using

78 or E. maxima, that preferentially infect the cecum and jejunum, respectively.

79 wever, an El Tor TCP(-) strain colonized the cecum and large bowel almost as well as the wild-type st

80 of viable cells were also recovered from the cecum and large bowel.

81 e in total bacterial number was noted in the cecum and large intestine with 10x LD(50) S. enterica se

82 y after weaning, then quickly retreat to the cecum and large intestine.

83 e to control or single-agent therapy) in the cecum and liver but not in the subcutis.

84 increased rates of tumor development on the cecum and metastasis to the liver, as compared with sali

85 lower ileum) and the large intestine (i.e., cecum and mid-colon/rectum).

86 ne resulted in decreased colonization of the cecum and Peyer's patches of the terminal ileum and colo

87 a cecum from a donor, and then removing the cecum and placing it into the recipient's peritoneal cav

88 r S. typhimurium to efficiently colonize the cecum and PP and subsequently cause systemic typhoid-lik

89 eloped colitis in all segments of the colon (cecum and proximal and distal colon).

90 entire gut, we have found that ENCCs in the cecum and proximal colon behave uniquely.

91 rands; ENCCs initially migrating through the cecum and proximal colon fragment from the main populati

92 -infection, with pronounced pathology in the cecum and proximal colon marked by infiltration of neutr

93 with electrodes chronically implanted in the cecum and proximal colon or in vitro in distal colon; fe

94 tern of migration to distinct regions of the cecum and proximal colon.

95 ly implanted intraparietal electrodes in the cecum and proximal colon.

96 ssue repair in order to seal off the injured cecum and reduce bacterial spread as well as ameliorate

97 In the cecum and sigmoid colon, but not in the rectum, the prol

98 ith Salmonella enterica serovar typhimurium; cecum and small-intestine tissues were collected for imm

99 , but inflammatory changes may extend to the cecum and terminal ileum.

100 rol) after a barrier was laid in between the cecum and the abdominal wall.

101 ates of intestinal cell proliferation in the cecum and the distal colon were culture positive signifi

102 c and Kras yielded microadenomas in both the cecum and the proximal colon, which progressed to macroa

103 e in tumor incidence and multiplicity in the cecum and the proximal colon.

104 d 48 hours after their introduction into the cecum and their PA-I expression was assessed.

105 from antigen sampling M cells in the rabbit cecum and tonsils.

106 cecal mucus isolated directly from the mouse cecum and, like its parent, survived well after reaching

107 neurons in the lateral DMV projecting to the cecum and/or proximal colon.

108 The cecums and large intestines were studied for numbers of

109 terms of the number of CFU/organ (colon and cecum) and in terms of the amount of hyperplasia, as mea

110 irradiated sites (rectosigmoid, sigmoid, and cecum), and nonirradiated sites (the rest of the colon).

111 hic bladders, between which there is an open cecum, and a blindly ending colon hanging down in the pe

112 to the absorptive epithelial cells in ileum, cecum, and colon along with TRPV6.

113 Lesions were seen in distal ileum, cecum, and colon and were most severe in the cecum.

114 lesions simultaneously affecting the liver, cecum, and colon are associated with natural infection o

115 omplete (organ plus luminal contents) ileum, cecum, and colon of MMP7-null and wild-type mice were an

116 rous animals, specialized organs (the rumen, cecum, and colon) have evolved that allow highly efficie

117 in four intestinal regions (jejunum, ileum, cecum, and colon) of outbred Swiss Webster (SW) mice.

118 s present in rat duodenum, proximal jejunum, cecum, and colon, and a 6.5-kilobase transcript is prese

119 ays), and epithelial infection in the ileum, cecum, and colon.

120 ies were taken at 20 cm from the anal verge, cecum, and descending colon.

121 atively abundant in the SO, duodenum, ileum, cecum, and distal colon, with fewer neurons and nerve fi

122 -fold) of the gastrointestinal tract (ileum, cecum, and feces) and visceral organs (bursa and spleen)

123 limited to the corpus allatum (CA), gastric cecum, and malpighian tubules.

124 r H. hepaticus colonization of the liver and cecum, and microscopic morphometric evaluations of the l

125 The mutant was outcompeted in the ileum, cecum, and midcolon, suggesting that Lpf contributes to

126 orphological regions: foregut, prececal gut, cecum, and postcecal gut.

127 otuberculosis localizes to the distal ileum, cecum, and proximal colon of the gastrointestinal tract

128 n the metabolic state of the terminal ileum, cecum, and sigmoid colon.

129 ypt foci was larger in the colon than in the cecum, and the highest frequency of aberrant crypt foci

130 CFTR Cl(-) channel, were reduced in jejunum, cecum, and trachea of Nkcc1(-/-) mice, indicating that N

131 uding the stomach, duodenum, jejunum, ileum, cecum, appendix, colon and rectum.

132 osal barrier function may be enriched in the cecum as a result of metabolic differences of the surrou

133 group, the incidence of tumor growth on the cecum as well as the frequency of hepatic metastasis was

134 sterol but reduced coprostanol levels in the cecum, as well as elevated atherogenic lysophosphatidylc

135 oxide synthase, and gamma interferon in the cecum, as well as elevated Th1-associated serum immunogl

136 hat inflammatory changes first appear in the cecum, ascending and transverse colon of 3-wk-old mutant

137 colon, sigmoid colon, or rectum vs appendix, cecum, ascending colon, hepatic flexure, or transverse c

138 ncer was defined as any tumor arising in the cecum, ascending colon, hepatic flexure, or transverse c

139 colon, sigmoid colon, or rectum vs appendix, cecum, ascending colon, hepatic flexure, or transverse c

140 ia and mucosal inflammation in the colon and cecum at 2 but not 6 weeks, whereas B-cell-deficient mic

141 rked to severe inflammation in the colon and cecum at days 7 and 28 and intense inflammation of the s

142 antibodies and lectins to Peyer's patch and cecum biopsy specimens from three normal individuals and

143 Car1(CreER) KI caused tumor formation in the cecum but did not yield adenomas in the proximal colon.

144 ntribute to defense against infection in the cecum but not extracolonically at this stage of Salmonel

145 o the intestinal epithelium in the ileum and cecum but not in the colon.

146 hibited a defect for the colonization of the cecum but not of the Peyer's patches, mesenteric lymph n

147 the cecum while butyrate was present in the cecum but not the ileum.

148 in the intestinal cells and in the lumen of cecum, but it can be released through the tegumental sur

149 educed constitutive ICAM-1 expression in the cecum, but not in the distal colon.

150 cAMP-stimulated epithelial cells of NBC1-/- cecum, but pH(i) regulation during sodium removal and re

151 of bioluminescent bacteria localized in the cecum by 3 h postinfection, indicating that the cecum is

152 ned as the time when removal of the necrotic cecum by rescue surgery is no longer effective.

153 ersistent colonization of WT H. hepaticus in cecum, colon, and jejunum but only transient colonizatio

154 cells of duodenum, jejunum, ileum, stomach, cecum, colon, and kidney proximal tubule S 3 segments.

155 the hamsters were sacrificed, and each whole cecum, colon, and rectum was stained with 0.2% methylene

156 s of the digestive tract, including stomach, cecum, colon, and rectum, or other mouse tissues such as

157 vated levels of Th2 cytokines and diminished cecum colonization after wild-type challenge.

158 ecal EHEC sIgA, with pVAX-56.2 reducing EHEC cecum colonization.

159 The liver- and cecum-colonizing abilities of the strains was estimated

160 Reg) cells are enriched in the healthy human cecum compared to the terminal ileum and sigmoid colon,

161 -fold reduction in colonization of the chick cecum compared to wild-type C. jejuni strain 81-176.

162 tration and pH to elicit invasion, while the cecum contained no detectable formate.

163 d that among extrahepatic tissues, colon and cecum contained the highest amount of CYP2Cs.

164 microbiota transplantation by oral gavage of cecum content obtained from donor CTRL- or HFD-treated m

165 elected Gram-negative bacteria obtained from cecum content of HFD+BDL-treated mice.

166 sensitivity), then given fungicide and donor cecum content via oral gavage.

167 Cells of M. polyspora were harvested from cecum contents by sedimentation in a Ficoll gradient and

168 In situ hybridization of cecum contents with fluorescently labeled oligonucleotid

169 ed in the intestinal tract (duodenum, ileum, cecum, distal colon), but not in the esophagus or stomac

170 However, the cecum draining lymph node (cLN), the gut tissue, and the

171 Upon infection with the cecum-dwelling nematode Trichuris muris, the majority of

172 of gamma interferon expression in the murine cecum early (12 h) after serotype Typhimurium infection

173 antation, involved ligating and puncturing a cecum from a donor, and then removing the cecum and plac

174 rmation of gastrointestinal buds such as the cecum from the midgut, but the mechanisms regulating thi

175 ation of CYP2Cs occurred in cecum and colon (cecum >/= proximal colon >> distal colon), with lower le

176 all tissues examined from adult mice (brain, cecum, heart, kidney, liver, lung, spleen, and Peyer's p

177 cancer risk for smoking in subsites from the cecum (HR = 1.41) to the proximal colon (excluding the c

178 = 1.41) to the proximal colon (excluding the cecum; HR = 1.27) to the distal colon (HR = 1.04; P for

179 ween B6 QTL on Chr. 8 and 18 contributing to cecum hyperplasia were particularly striking.

180 lves response to fecal contents and necrotic cecum in addition to microbial challenge, in this study,

181 right-sided sigmoid colon as air within the cecum in children suspected of having abnormalities such

182 splanted by attachment to the surface of the cecum in control and liver-specific IGF-I-deficient (LID

183 uced, especially in the distal ileum and the cecum in experimental cirrhosis with BT (excluding PVL).

184 r 6 - 12 months old, and in the duodenum and cecum in older animals at a lower frequency.

185 acterial spread, possibly by sealing off the cecum in the cecal ligation and puncture (CLP) model of

186 immune response of the chronically infected cecum in unprecedented detail.

187 the adherence of the E. coli isolates to the cecum in vivo following host catabolic stress.

188 trate measurements suggested that the murine cecum is a nitrate-limited environment.

189 Colonic ischemia isolated to the cecum is a rare entity.

190 lopment of these intestinal neoplasms in the cecum is driven by the interplay between genetic changes

191 um by 3 h postinfection, indicating that the cecum is not only a major colonization site of EPEC but

192 data suggest that colonization of the murine cecum is required for efficient fecal shedding in mice.

193 mouse embryos have agenesis of the embryonic cecum, lacking both mesenchymal expansion and an epithel

194 bile salt levels, and urobilinogen levels in cecum, large intestine, and feces.

195 ted with shortening of colon length, reduced cecum length, decreased crypt heights, and increased sev

196 uced by cecal ligation and puncture with the cecum ligated below the cecal valve at 25%, 50%, and 75%

197 tal animal models, particularly the model of cecum ligation and puncture (CLP).

198 eceptor 2-/- mice were divided into sham and cecum ligation and puncture groups.

199 Mice were also subjected to cecum ligation and puncture, a model used to induce peri

200 severe polymicrobial sepsis was induced with cecum ligation and puncture.

201 abetic mice with mild sepsis (MS) induced by cecum ligation and puncture.

202 ham animals underwent laparotomy but without cecum ligation and puncture.

203 y relevant model of sepsis, was generated by cecum ligation and puncture.

204 Using an animal model of sepsis, cecum ligation, and puncture, we observed that mice beca

205 some (Chr.) 3 contributed to lesions in both cecum [logarithm of odds ratio (LOD) = 14.6)] and colon

206 on pattern, including developing stomach and cecum, many craniofacial regions and areas in the centra

207 ds, Fgf10 expression is found throughout the cecum mesenchyme.

208 nt bacterial clones that were present in the cecum, mesenteric lymph nodes, and spleen 5 days postinf

209 erminal ileum but normal colonization of the cecum, mesenteric lymph nodes, and spleen.

210 222 patients from the endoscopically normal cecum, midtransverse colon, and rectum.

211 uptake, the most common areas of uptake were cecum (n = 65), sigmoid (n = 60), and ascending colon (n

212 type strain NRRL YB-4349, CBS 9733, from the cecum of a horse).

213 II-positive cells was seen in the colon and cecum of animals undergoing the disease.

214 on of clones that overexpress Tiam1 into the cecum of athymic mice resulted in tumor growth in the sp

215 otype Typhimurium to colonize the spleen and cecum of BALB/c mice 5 days after infection.

216 tration varied in the duodenum, jejunum, and cecum of chicken intestine, and the inhibitory effect of

217 bacterium naturally colonising the rumen and cecum of herbivores where it utilizes an enigmatic mecha

218 Ileum and cecum of Lewis rats were subserosally injected with pept

219 s, and were nonlethal when injected into the cecum of mice after 30% surgical hepatectomy.

220 y to induce mortality when injected into the cecum of mice after a 30% hepatectomy.

221 r the introduction of P. aeruginosa into the cecum of mice after a 30% hepatectomy.

222 ulosis mutants that failed to survive in the cecum of mice after orogastric inoculation.

223 ncreased in vivo by local factors within the cecum of mice in response to surgical stress.

224 d in the intestinal tract, is induced in the cecum of mice resistant to Trichuris muris infection.

225 uris induced an elevated Th1 response in the cecum of naive wild-type mice and accelerated colitis in

226 n cancer cells growing orthotopically in the cecum of nude mice expressed a high level of EGF, EGFR,

227 ur when P. aeruginosa is introduced into the cecum of sham operated control mice.

228 hepatectomy, strains were retrieved from the cecum of sham-operated and hepatectomy-treated mice 24 a

229 fatty acids (SCFAs) present in the ileum and cecum of streptomycin-treated mice and untreated control

230 and 0.5-1cm wide pouch that extends from the cecum of the large bowel.

231 shable from human GISTs were observed in the cecum of the mutant mice with high penetrance.

232 eated mice differed greatly from that of the cecum of the same mice, primarily among families of the

233 cterial populations inhabiting the ileum and cecum of TLR- and MyD88-deficient mice.

234 The colons and cecums of 62 Apc1638N/+ mice were evaluated for the spon

235 robiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% i

236 t was able to survive in the GI tract (i.e., cecum) of mice, albeit in numbers somewhat less than tho

237 In the cecum, only a putative QTL on Chr 11 was associated with

238 in the small intestine, but not those in the cecum or colon, stabilized and persisted for at least 72

239 utathione and protein carbonyl levels in the cecum or colon.

240 wild-type strain in the ileum but not in the cecum or mid-colon, raising the possibility that CadA ne

241 affixed to the serosal side of the stomach, cecum, or liver of anesthetized rats (n = 6 each tissue)

242 (P < 0.0079) and trended to be higher in the cecum (P < 0.15) in the HhcdtBm7-colonized male mice ver

243 us slow acetylator congenic hamsters in both cecum (P = 0.0352) and colon (P = 0.0006).

244 en near-neutral posterior midgut and gastric cecum (pH 7-8).

245 m tissue-adhered and luminal bacteria of the cecum, proximal colon, and distal colon, which allowed u

246 dentical laparotomy but without ligation and cecum puncture.

247 is, expression of villin in the duodenum and cecum requires different regulatory sequences than the r

248 Microbial DNA analyses in feces and cecum revealed transplantation of donor microbial commun

249 average height of proliferating cells in the cecum, sigmoid colon, and rectum and increases cell prol

250 Biopsy specimens from the cecum, sigmoid colon, and rectum were collected at basel

251 t with streptomycin altered the SCFAs in the cecum, significantly decreasing the concentration of ace

252 are like other carbohydrates that reach the cecum, such as nonstarch polysaccharides, sugar alcohols

253 Nevertheless, they had smaller cecum suggesting a mildly compromised intestinal develop

254 cause defects in colonization of the murine cecum, suggesting roles for one or more effector Yops in

255 d in higher propionate concentrations in the cecum than did no supplementation (P < 0.05).

256 expression were significantly higher in the cecum than in distal colon, a finding that cannot be exp

257 e peroxidase activity was normally higher in cecum than in distal colon, and this difference was sign

258 at Helicobacter organisms concentrate in the cecum, the preferred site of tumor development.

259 MET-1 also preserved cecum tight junction protein expression, and reduced S.

260 es of withdrawal of the colonoscope from the cecum to the anus (range, 3.1 to 16.8 minutes for proced

261 nic surface, was manually extracted from the cecum to the descending colon.

262 cells in colonic crypts distributed from the cecum to the rectum support transgene expression.

263 lammation, which extended diffusely from the cecum to the rectum, was localized to the lamina propria

264 atory lesions in the area extending from the cecum to the rectum.

265 or (VEGF) as well as vessel abundance in the cecum tumors was dependent on the levels of serum IGF-I.

266 eeks of age and showed more pathology in the cecum (typhlitis) than we observed with E. faecalis-indu

267 ted in the small intestine but pass into the cecum unchanged, where they are selectively utilized by

268 to show typical organization of the damaged cecum wall.

269 de 3D endoluminal fly-through from rectum to cecum was 76.6% +/- 4.8% (range, 63%-92%); coverage was

270 Colonoscopy to the level of the cecum was completed in 97.0 percent of the patients.

271 The necrotic cecum was excised 10 hours thereafter, and the survival

272 In additional rats, the necrotic cecum was excised at 20 hours after CLP following AM/AMB

273 In additional animals, the necrotic cecum was excised at 20 hrs after cecal ligation and pun

274 In additional animals, the necrotic cecum was excised at 20 hrs after cecal ligation and pun

275 The necrotic cecum was excised at 20 hrs post-CLP, and 10-day surviva

276 filling blind loop (SFBL) was created or the cecum was excluded from the fecal stream in specific pat

277 Bacterial DNA from the cecum was extracted for deep metagenomic sequencing.

278 The cecum was identified and scored using an abrasive pad un

279 ve enteric bacilli adherent to the ileum and cecum was less in the protein-malnourished rats than in

280 The cecum was ligated and punctured to produce abdominal sep

281 gation and puncture (CLP) model, whereby the cecum was partially ligated and punctured nine times wit

282 Colonoscopy to the cecum was performed in 154 of these persons at a mean of

283 harvested from the chicken intestinal lumen (cecum) was compared with that of a late-log-phase LB bro

284 Contents of the cecum were analyzed for bacterial 7 alpha-dehydroxylase

285 The colon and cecum were collected for histopathology.

286 Average Po2 values in the lumen of the cecum were extremely low (<1 mm Hg).

287 143 had MR images in which the appendix and cecum were identifiable in the sagittal plane.

288 stomach, the first 8 cm of duodenum, and the cecum were prepared as wholemounts and were processed wi

289 e liver, spleen, mesenteric lymph nodes, and cecum were sequentially harvested and cultured.

290 The pathologic changes in the cecum were similar in both groups except for the lack of

291 s of perfused gut organs (stomach, duodenum, cecum) were prepared, counterstained with Cuprolinic blu

292 ion in all small intestinal segments and the cecum when compared with chow (p <.05).

293 neutrophil infiltration in lung, liver, and cecum, when compared with vehicle treatment.

294 appeared normal but were up-regulated in the cecum, where GISTs were commonly found.

295 ds, seminal vesicles, bone marrow cells, and cecum, where it was the major K-Ras isoform expressed.

296 n the ileum but low or not detectable in the cecum while butyrate was present in the cecum but not th

297 rimarily in the distal half of the colon and cecum with lower levels detectable in the proximal colon

298 ks to months, predominantly in the colon and cecum, with lower concentrations of bacteria present in

299 y procedures, the capsule does not reach the cecum within recording time.

300 Removal of the injury source, ligated cecum, within 6 h of the initial insult resulted in incr