ライフサイエンスコーパス: cell activation

1 ISTA (V-domain Ig-containing Suppressor of T cell Activation).

2 Th1 cell polarization and cytotoxic CD8(+) T cell activation.

3 played allergen on VLPs failed to cause mast cell activation.

4 iperacillin and the threshold required for T cell activation.

5 rticularly those that depend on Ag-induced T cell activation.

6 CR stimulation and is required for optimal T cell activation.

7 nucleotide synthesis or nucleotide-dependent cell activation.

8 its role as a novel regulator of naive CD4 T-cell activation.

9 it MYD88/p100 signaling as a regulator for B-cell activation.

10 e effects of TGF-beta on IL-33-mediated mast cell activation.

11 perate and thus enhance the sensitivity of T cell activation.

12 ucuronidase heparanase that increase upon NK cell activation.

13 show how the mutations function to improve T-cell activation.

14 1 even when stimulated by antigen-specific T cell activation.

15 ew insights into antigen properties and MAIT cell activation.

16 to how physiological cues may influence stem cell activation.

17 contribute to the endogenous pathway of iNKT cell activation.

18 e role of DNA methylation in regulating mast cell activation.

19 on (DR) as the results of hepatic progenitor cell activation.

20 lter immune effector cell numbers or myeloid cell activation.

21 itical NKp30 ligand B7-H6 thus inhibiting NK cell activation.

22 CD8+ T cells, and CD4/CD8 ratio) and CD4+ T-cell activation.

23 ustion by regulating Pdcd1 expression upon T cell activation.

24 w downstream events can ultimately lead to T cell activation.

25 cterial infections by controlling effector T cell activation.

26 rabinose residues, decreased the extent of B cell activation.

27 attempted limitation of pathogenic CD8(+) T-cell activation.

28 propose plays a crucial role in regulating T cell activation.

29 clinical disease and signs of chronic immune cell activation.

30 tumor microenvironment promotes malignant B cell activation.

31 ) is required for gastric colonization and T-cell activation.

32 ants with stronger suppression of in vitro T cell activation.

33 l d 1 displayed on VLPs fails to induce mast cell activation.

34 s production of reactive oxygen species upon cell activation.

35 esenting cells (APCs) and induce alphabeta T-cell activation.

36 fector cell differentiation by controlling B cell activation.

37 costimulation similarly increased human iNKT cell activation.

38 mobilization and to the attenuation of mast cell activation.

39 nt antigens, leading to systemic and local T cell activation.

40 nization properties diminishes pAg-induced T cell activation.

41 effect of CXCL4 in modulating DC-mediated T cell activation.

42 cross-present capsid antigen during CD8(+) T-cell activation.

43 nd kinase activity are induced upon CD4(+) T cell activation.

44 that can clinically inhibit Vgamma9Vdelta2 T cell activation.

45 ma) against EBV-infected cells, enhancing NK cell activation.

46 CD80 and CD86), is a negative regulator of T-cell activation.

47 , where it rapidly disassociated following T-cell activation.

48 ) on TCR-ligand interaction and subsequent T cell activation.

49 eton in regulating force generation during T-cell activation.

50 ng, costimulatory pathways are involved in T cell activation.

51 13 production in lung tissue, as well as TH2 cell activation.

52 ional programs that are a hallmark of immune cell activation.

53 degranulation, IVIG attenuated post-ICH mast cell activation.

54 igins induced cytokine production and immune cell activation.

55 fluorescence in situ hybridization during T-cell activation.

56 ructure has been shown to be important for T cell activation.

57 and NFAT translocation, a measure of full T-cell activation.

58 nt of pAg sensing that ultimately leads to T cell activation.

59 l guanosine triphosphate protein linked to T-cell activation.

60 fall in oxygen levels might initiate Type I cell activation.

61 promote hyperplasia, fibrosis, and vascular cell activation.

62 on regulatory or effector T cells reduces T cell activation.

63 For full T-cell activation, 2 signals must be received, and ligands

64 enhanced inflammation, stronger endothelial cell activation, a more disturbed vascular integrity, an

65 However, although NKp65 utilizes Syk for NK cell activation, a physical association of Syk with the

66 ong antigen dispersal, DC positioning, and T cell activation after protein immunization.

67 et cells led to a significant increase in NK cell activation against said target cells.

68 yndrome, which is characterized by massive T cell activation and a predominant Th1 profile of cytokin

69 with avoidance of humoral immunity, i.e., B cell activation and antibody neutralization.

70 ght to determine the mechanisms that drive B cell activation and antibody production during chronic a

71 mulates the CD27 pathway, which results in T-cell activation and antitumor activity in tumor models.

72 eased B regulatory cell [Breg] counts, and B cell activation and apoptosis) is specifically associate

73 Since inhibitory receptors control NK-cell activation and are necessary for MHC-I-dependent ed

74 stigated their role in alloantigen-induced T cell activation and asked whether their absence might im

75 Expression of genes associated with B cell activation and class switch recombination was measu

76 significantly increased tumor-infiltrating T-cell activation and cytotoxicity and decreased the frequ

77 apidly decreased liver inflammation and MAIT cell activation and cytotoxicity, and increased the MAIT

78 nflammatory response led to deficient immune cell activation and delayed bacterial clearance.

79 ostimulatory interactions are required for T cell activation and development of an effective immune r

80 BAFF, IL-2, and IL-21 induce memory and DN B cell activation and differentiation has implications for

81 naling and metabolic pathways critical for T-cell activation and differentiation into Th1 and Th17 su

82 Immune cell activation and differentiation occurs concurrently

83 n naive CD8(+) T cells plays a key role in T cell activation and differentiation.

84 eir protein-coding target RNAs involved in T-cell activation and differentiation.

85 le for cyclin-dependent kinase 5 (Cdk5) in T-cell activation and effector function, but the contribut

86 +) T regulatory (Treg) cells suppress immune cell activation and establish normal immune homeostasis.

87 c cells (DCs), and is required for optimal T-cell activation and expansion.

88 ng in adoptively transferred CTLs enhances T cell activation and IFN-gamma production in vitro, leadi

89 pha production, resulting in superior immune cell activation and increased immunotherapeutic properti

90 igen presentation thereby preventing early T cell activation and interferes with diapedesis.

91 n of transcriptional programs that inhibit T cell activation and maintain tolerance.

92 d CD70, all of which are related to memory T cell activation and maintenance.

93 onocyte exosome release reverses endothelial cell activation and monocyte chemotaxis.

94 aling in HLA class I Ab-mediated endothelial cell activation and monocyte recruitment.

95 Using NK cell activation and NK cytotoxicity assays, we compared

96 cytokine that potently promotes endothelial cell activation and pathological angiogenesis in our pre

97 tein) chromatin regulator is controlled by B cell activation and potentiates steady-state and postimm

98 or autophagy in the regulation of microglial cell activation and pro-inflammatory molecule secretion,

99 f Mer in dendritic cells promotes enhanced T cell activation and proinflammatory cytokine production.

100 pensate for the lack of Cdc42 in TLR-induced cell activation and proliferation, so the two proteins p

101 serine/threonine kinase, is involved in TH2 cell activation and proliferation.

102 n in FMDV carriers suggested inhibition of T cell activation and promotion of Th2 polarization.

103 nflammatory mediators leading to mononuclear cell activation and recruitment could underlie the abnor

104 Furthermore, we observed pan-T-cell activation and redistribution from the circulation

105 that human IL-6 is important for efficient B-cell activation and selection.

106 rbon receptor (AhR) is highly induced upon B cell activation and serves a critical role in regulating

107 -derived macrophages were able to suppress T-cell activation and showed restored antimycobacterial ac

108 t use iPS cell factors and thus differs from cell activation and signaling-directed (CASD) reprogramm

109 Liver sinusoidal endothelial cell activation and stellate cell activation was increas

110 tory receptor with a central role in myeloid cell activation and survival.

111 cts with FcmuR on B cells to support early B cell activation and the development of long-lived humora

112 rtant for controlling the decision between T cell activation and tolerance via Cbl-b.

113 ubtilis EPS can be used to broadly inhibit T cell activation and, thus, control T cell-mediated immun

114 ts, (c) TCR signal transduction leading to T cell activation, and (d) TCR degradation.

115 increased germinal center (GC) responses, T cell activation, and AC accumulation within GCs.

116 development of lymphadenopathy and CD4(+) T cell activation, and autoimmunity that mainly targeted s

117 canonical domains for antigen recognition, T cell activation, and costimulation.

118 te expression profiles during drug-induced T cell activation, and expression of each receptor was enh

119 instructed TNFalpha expression, endothelial cell activation, and intratumoral T-cell infiltration.

120 d reactive oxygen species production, immune cell activation, and local hepcidin expression.

121 lipoproteins and phospholipids, endothelial cell activation, and macrophage infiltration/activation

122 gamma response, CD16-mediated natural killer cell activation, and monocyte/macrophage activation.

123 MHC class I expression, impaired cytotoxic T cell activation, and poor patient prognosis.

124 nge by 84% to 90%, as well as diarrhea, mast cell activation, and TH2 cytokine responses and serum al

125 induced hypertension, vascular injury, and T-cell activation; and gammadelta T cells are associated w

126 with biased capacity for CD4(+) and CD8(+) T cell activation are asymmetrically distributed in lymph

127 s has illustrated that important facets of T-cell activation are controlled at the level of translati

128 l receptor (TCR) triggering and subsequent T-cell activation are essential for the adaptive immune re

129 endent ILC2 expansion, and IL-33-driven mast cell activation are necessary for induction of type 2 im

130 criminate self- and foreign antigen before T cell activation are unresolved.

131 Whereas metabolic changes occurring during T cell activation are well characterized, the metabolic de

132 o inhibit the unintentional Vgamma9Vdelta2 T cell activation as a consequence of aminobisphosphonate

133 tion genes, which correlated (r=0.78) with T-cell activation as measured by CD8-positive expression.

134 deal molecule to improve early pathways of B cell activation, as it links innate and adaptive immunit

135 hat lymphostatin is likely to act early in T cell activation, as stimulation of T cells with concanav

136 of antibodies that block these pathways in T-cell activation assays.

137 y kinase Lck sets a critical threshold for T cell activation because it phosphorylates the TCR comple

138 In addition, a restraint on T cell activation by CD6 was revealed in primary T cells e

139 he molecular mechanisms for hepatic stellate-cell activation by HCV-infected hepatocytes are underexp

140 of 76 kDa (SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell rece

141 b1) restrains PD-1 expression induced upon T cell activation by recruiting a nucleosome remodeling de

142 e investigated a mechanism for suppressing T cell activation by stimulating a natural inhibitory rece

143 The approach of biasing cell activation by tuning signaling thresholds and outpu

144 y a new role for T cell TRAF3 in promoting T cell activation, by regulating localization and function

145 ere are conditions in which Vgamma9Vdelta2 T cell activation can be considered inappropriate for the

146 ytotoxicity response from a polyfunctional T cell activation caused hepatotoxicity and the rapid indu

147 We undertook translatome analysis of CD8 T-cell activation, combining polysome profiling and microa

148 several genes involved in TCR signaling and cell activation, confirming its role as a novel regulato

149 ) cells specifically inhibited TH1 and CD8 T cell activation consistent with their co-localization wi

150 that titrating PD-1 expression during CD8 T cell activation could have important ramifications in va

151 r the rFlaA:Betv1 conjugate and analyzed for cell activation, cytokine secretion, and metabolic state

152 to the RBC cell surface strongly inhibited B cell activation, cytokine secretion, and proliferation.

153 We demonstrated that while ICH induced mast cell activation/degranulation, IVIG attenuated post-ICH

154 ndothelial cell capillarization and stellate cell activation demonstrates allograft injury in proximi

155 , and pathogenic infections can all affect T cell activation, differentiation, and the kinetics of gr

156 Binding CD33 restricts cell activation/differentiation; however, natural ligand

157 In conclusion, progenitor cell activation differs between PSC and PBC and is chara

158 nt knowledge about the various types of mast cell activation disorders, their treatment, and areas of

159 T cell activation drives proliferation but also reverses l

160 n about their capacity to influence CD4(+) T-cell activation during a primary or secondary response t

161 insight into the mechanisms underlying CD8 T cell activation during infection, which may be useful in

162 Glutamine had no effect on granule cell activation earlier, during epilepsy development.

163 reochemical and energetic influences on MAIT cell activation, enabling design of a water stable synth

164 CD177-driven cell activation enhanced surface beta2 integrin expressi

165 Our data suggest there is a unique B cell activation environment within NP that is distinct f

166 tedly, however, we observed increased immune cell activation following administration of PapMV to com

167 which the pericardial AT coordinates immune cell activation, granulopoiesis, and outcome after MI.

168 tic landscape in response to Ag during CD4 T cell activation have not been well characterized.

169 M-resistant BALB/c mice leads to amplified T cell activation, higher serum gamma interferon (IFN-gamm

170 are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain

171 By directly comparing inflammatory cell activation in a 4 mm ear injury during regeneration

172 holangiocytes promoted quiescent mesenchymal cell activation in a platelet-derived growth factor (PDG

173 The cell surface receptor CD6 regulates T cell activation in both activating and inhibitory manner

174 lopment, and significantly increased granule cell activation in both control and chronically epilepti

175 allergy is associated with IgE-mediated mast cell activation in conjunctival tissue leading to the re

176 xpression is reduced during hepatic stellate cell activation in culture and in a mouse model of alcoh

177 red the capability of Fel d 1 to induce mast cell activation in its free form versus displayed on VLP

178 possible employment of impedance to assess T cell activation in label-free.

179 suppressed expression of markers of stellate cell activation in livers of mice fed a diet rich in tra

180 he specific neoantigen qualities promoting T-cell activation in long-term survivors, we discovered th

181 or neutrophils in restraining autoreactive B cell activation in lupus.

182 ssed based on helper T-cell and regulatory T-cell activation in mice.

183 of hepatocyte fate characterized progenitor cell activation in PBC versus PSC.

184 e I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known,

185 s have suggested that it also inhibits glial cell activation in rodents, and may alter opioid-mediate

186 says, and the variant was found to silence T-cell activation in seven of the eight blood donors who r

187 However, exacerbated mast cell activation in Sucnr1(-/-) mice did not contribute t

188 in nonatopic, nonallergic adults was muted T-cell activation in the peripheral blood and inflammatory

189 hage/T cell infiltration in the kidney and T cell activation in the renal draining lymph nodes.

190 Ang II-induced T-cell activation in the spleen and perivascular adipose t

191 ot affect HIV-1 gene expression induced by T cell activation in these rCD4s.

192 s observation correlated with increased mast cell activation in vitro and in vivo.

193 MSDC-0602 directly reduced hepatic stellate cell activation in vitro, and MSDC-0602 treatment or hep

194 vivo, and maximal FcepsilonRI-mediated mast cell activation in vitro.

195 f these mechanisms as important in driving T cell activation in vivo.

196 IL-27R was shown to suppress T cells activation in atherosclerosis, however it's possib

197 beta-dependent Treg-cell suppression of mast cell activation, in the absence of modulation of T- or B

198 haracterized by tissue eosinophilia and mast cell activation, including abundant production of prosta

199 with an hCD22 ligand were shown to prevent B cell activation, increase cell death, and induce toleran

200 IBDM, proliferation, fibrosis, and vascular cell activation increased.

201 at concentrations that triggered similar NK cell activation, indicating that cell-associated gp350(+

202 patocyte MPC2 deletion also limited stellate cell activation indirectly by affecting secretion of exo

203 In secondary lymphoid organs, Ag-driven B cell activation induces terminal maturation and Ig isoty

204 Importantly, T cell activation induces the expression of Hili in CD4(+)

205 ts the importance of monitoring peripheral T cell activation inhibitor-mitochondrial expression, LBP

206 Peripheral and intragraft expressions of T cell activation inhibitor-mitochondrial were stable in l

207 Cell activation is a vital step for T-cell memory/effect

208 h optimal stroma permeabilization and immune cell activation is able to markedly increase therapy res

209 T cell activation is an energy-demanding process fueled by

210 Mast cell activation is common and possibly necessary for mai

211 The mast cell activation is negatively regulated by an inhibitory

212 istocompatibility complex (p/MHC) leads to T-cell activation is not yet fully understood.

213 er of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environment

214 1 (MR1) participation, is required for MAIT cell activation; iv) MAIT cell responses to SEB can occu

215 mal traffic in TCR signal transduction and T cell activation leading to IL-2 production.

216 First, peripheral blood CD4(+) and CD8(+) T-cell activation levels initially decreased in M- partici

217 ant target proteins UL83 or UL123, and the T-cell activation marker interferon-gamma (IFN-gamma).

218 romatic flow cytometry was used to analyze T-cell activation markers (CD107, CD154, interleukin-2 [IL

219 f the TH2-polarizing cytokine IL-4 and the T-cell activation markers CD69 and CD62L.

220 -CD40/CpG treatment led to upregulation of T cell activation markers in draining lymph nodes.

221 eceptors, antimicrobial peptides, monocytoid cell activation markers, and numerous genes annotated as

222 d anticoagulation, fibrinolysis, endothelial cell activation, matricellular protein release, and tiss

223 adducts accompanied by evidence of stellate cell activation, matrix remodeling, and fibrosis (P < 0.

224 r organization, and changes in LADs during T-cell activation may provide an important additional mode

225 ids on the cell surface and thereby regulate cell activation, migration, adhesion, and signaling.

226 tibody production, cytokine secretion, and T-cell activation; moreover, B cell misregulation is impli

227 e expression, fragmented mitochondria, glial cell activation, muscle atrophy, weight loss, and reduce

228 ite maraviroc prophylaxis showed increased T-cell activation, naive T-cell skewing, and elevated seru

229 ng with 12 signatures tracking CD8 and CD4 T-cell activation, natural killer cells, and IFN activatio

230 perturbation promoted downstream endothelial cell activation, neutrophil accumulation, endothelial ce

231 Disordered mast cell activation occurs when mast cells are pathologicall

232 In DAOY cells, activation of TRPC4-containing channels resulted

233 es, costimulatory molecule expression, and T-cell activation on L lactis G121 challenge.

234 We show that GABA cell activation only promotes cataplexy attacks associat

235 tive FPIES suggest low-grade intestinal mast cell activation or increased mast cell load.

236 l VACV intranasal challenge, or defects of T cell activation or T cell homing to the site of inoculat

237 s a prominent role for the CD16-dependent NK cell activation pathway in the complex array of factors

238 Molecular intermediates in T-cell activation pathways are crucial targets for the the

239 d eosinophilic airway inflammation and a TH2 cell activation phenotype that was not different from th

240 Vgamma9Vdelta2 T cell activation plays an important role in antitumor and

241 Antigen solution structures, MAIT cell activation potencies (EC50 3-500 pM), and chemical

242 T cell activation profiles, the extent of B cell activation prior to ART did not correlate with HIV

243 ity is observed under conditions where the T cell activation probability is low.

244 Interestingly, unlike for T cell activation profiles, the extent of B cell activatio

245 e show that type I IFNs support robust CD8 T cell activation (proliferation and IFN-gamma and granzym

246 c cells in vivo and in vitro, IVM impaired T-cell activation, proliferation, and cytokine production

247 stimulation of ILC2s with NMU induced rapid cell activation, proliferation, and secretion of the typ

248 Thus, B cell activation prompts a temporal switch from canonical

249 ylated CD6 cytoplasmic Y662 residue during T cell activation, providing an activating signal to T cel

250 rdings in behaving mice, we show that orexin cell activation rapidly recruits GAD65LH neurons.

251 FcgammaRIIB-mediated inhibition of effector cell activation requires direct ligation to an activatin

252 B-cell activation seemed to play a role in B-cell lymphoma

253 totic signaling pathways, the noncytotoxic T cell activation showed extended proliferative, metabolic

254 nate proinflammatory response or increased T cell activation/skewing display a more impaired behavior

255 Immune cell activation stimulates neuronal circuits that regula

256 h depression of serum markers of the myeloid cell activation, such as CCL5, CCL11, and C-X-C motif ch

257 over-representation of genes relevant for T cell activation, such as CD40L, IRAK1, IRAK2, STAT1, and

258 way, or the loss of negative regulators of T cell activation, such as the E3 ubiquitin ligase Cbl-b,

259 been proposed to interpret acute MCT in mast cell activation syndrome (MCAS).

260 tment in the last decade, many areas of mast cell activation syndrome are in need of research.

261 g clonal mast cell disorder (monoclonal mast cell activation syndrome or systemic mastocytosis) and t

262 Mast cell activation syndrome refers to a group of disorders

263 ystemic mastocytosis but not monoclonal mast cell activation syndrome.

264 flammatory cytokines, and evidence of innate cell activation that included neutrophil extracellular t

265 reg cell TCR repertoire led to marked immune cell activation, tissue inflammation, and an ultimately

266 ses while maintaining low levels of CD4(+) T-cell activation to avoid the generation of target cells

267 and morphological events occurring during T-cell activation to model force generation and to reveal

268 d levels of serum tryptase, a marker of mast-cell activation, to a greater extent than did placebo (d

269 ion of CD22 ligands in RBCs should abolish B cell activation toward its cognate Ag on the surface of

270 ensitive to apoptosis but also accelerated T cell activation under phorbol 12-myristate 13-acetate/io

271 d endocytic lipid antigen presentation for T cell activation upon benzo[a]pyrene exposure.

272 ese cells, including several mediators of NK cell activation (VAV3 and LYN) and a large array of NK r

273 hat IVIG will attenuate the ICH-induced mast cell activation via FcgammaRIIB/SHIP1 pathway, resulting

274 ies to expand myeloma-specific T cells and T-cell activation via PD-1/PD-L1 blockade are currently be

275 hat during homeostasis, FRCs also suppress T cell activation via producing high level of prostaglandi

276 n into polarized MPhis that mediate stellate cell activation via TGF-beta.

277 V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoi

278 into secondary lymphoid organs nor initial T cell activation was affected by Dll1/4 loss.

279 T cell activation was again dependent on type I IFNs produ

280 Hepatic stellate cell activation was detected by immunofluorescence.

281 Endothelial cell activation was evaluated by quantifying nuclear fac

282 dal endothelial cell activation and stellate cell activation was increased in patients with non-HLA a

283 B-cell activation was modulated by 9cRA, reducing the expr

284 This T-cell activation was not indiscriminate because we observ

285 However, B cell activation was only partially normalized post-ART,

286 T cell activation was reduced with DMF treatment, especial

287 We demonstrate the persistence of T-cell activation well beyond viral clearance and detect E

288 signatures of innate immunity and dendritic cell activation were highly associated with protection i

289 volved in glycolysis, gluconeogenesis, and T cell activation were unaffected.

290 molecule that suppresses CD4(+) and CD8(+) T cell activation when expressed on antigen-presenting cel

291 Recently, they have been implicated in T cell activation, where small numbers of antigenic recept

292 gonism also increased markers of endothelial cell activation, which was partially reduced by genetic

293 , senescence, fibrosis, and hepatic stellate cell activation, which were reduced in Hdc(-/-) HFD mice

294 While HCV-specific CD8 T-cell activation with cytolytic and antiviral effects was

295 nderlying mechanisms by which MIA leads to T cell activation with increased IL-17a in the maternal ci

296 Cytoplasmic RNA granules are formed upon cell activation with mitogens, including stress granules

297 itive signaling modalities that control mast cell activation, with an emphasis on novel FcepsilonRI r

298 n to unparalleled levels and avoids global T-cell activation within resting CD4+ T-cells.

299 t PD-L1 may result from the high degree of T-cell activation within the highly immunogenic milieu of

300 g and balancing the requirement for cortical cell activation without uncontrolled cell proliferation.