ライフサイエンスコーパス: cell biological

1 r polyglutamine-associated developmental and cell biological abnormalities, particularly those with e

2 ub-circuits of the GRN control five distinct cell biological activities, each part of the complex EMT

3 tream targets that participate in a range of cell biological activities.

4 inary insight into potential windows of stem cell biological activity and identified clinical assessm

5 Recent structural, biochemical, and cell biological advances suggest that the catalyzed conv

6 Genetic, biochemical, and cell biological analyses demonstrate that the ECH/YIP4 c

7 Biochemical and cell biological analyses demonstrate these mutations inf

8 h that included structural, biochemical, and cell biological analyses revealed two distinct chemotype

9 tive band in prion-infected mice, subsequent cell biological analyses uncovered a surprisingly coordi

10 Using biochemical, molecular modeling and cell biological analyses, we have investigated the inter

11 Moreover, cell biological analysis established that Syndecan1 is a

12 Biochemical and cell biological analysis indicate that the Zn1 and Zn2 d

13 Cell biological analysis indicates that MAP7 promotes br

14 hnical challenges associated with performing cell biological analysis of the delicate filopodial stru

15 rm cells to carry out a detailed genetic and cell biological analysis of the resulting ovarian tumor

16 Cell biological analysis revealed that ALIX and AMSH3 co

17 Cell biological analysis reveals that Pkd1l1 and Pkd2 lo

18 Here, using an array of biophysical, cell biological and behavioural assays we have character

19 Cell biological and biochemical analysis demonstrated th

20 In combination with other cell biological and biochemical approaches, a robust and

21 nowledge related to the genetic, epigenetic, cell biological and biochemical aspects of BDNF biology

22 A variety of cell biological and biochemical assays was employed to d

23 Our data reveal the cell biological and biochemical basis of the obligate re

24 Here we integrate optical tweezers with cell biological and biochemical methods to test the prev

25 By cell biological and biochemical methods, we demonstrate

26 Cell biological and biophysical experiments with primary

27 nin signaling mechanisms in beta cells using cell biological and electrophysiological approaches.

28 n described that confer a range of molecular cell biological and functional phenotypes.

29 Cell biological and genetic analyses of these SH3 partne

30 To address this question, we applied cell biological and genetic analyses to investigate guar

31 y of open and closed mitosis will complement cell biological and genetic approaches aimed at decipher

32 und accumulation-we applied a combination of cell biological and genetic approaches.

33 Cell biological and genetic evidence has implicated the

34 Fusarium graminearum was investigated using cell biological and genetic methods.

35 physical autonomy from the nucleus has both cell biological and genetic ramifications.

36 Next, we cover the cell biological and molecular aspects of PIN function, i

37 Here, we have used biochemical, cell biological and molecular genetic approaches to demo

38 Here we use genetic, cell biological and molecular studies in Caenorhabditis

39 Many new insights from cell biological and molecular studies provide opportunit

40 Here we use genetics, cell biological and pharmacological tools to demonstrate

41 nd hypomorphic alleles and performed in vivo cell biological and physiological analysis.

42 activity and animal behavior, as well as for cell biological and physiological applications requiring

43 Based on important cell-biological and biochemical results concerning the s

44 nces provide provocative insights into these cell-biological and molecular changes, which have implic

45 Cell-biological and molecular evidence is consistent wit

46 d employ Ca2+ imaging, electrophysiological, cell biological, and biochemical approaches to describe

47 regates based on morphological, biophysical, cell biological, and biochemical criteria, suggesting th

48 Based upon genetic, cell biological, and biochemical data, we propose that O

49 These results provide genetic, cell biological, and biochemical evidence that a princip

50 Our structural, cell biological, and biochemical findings identify loop>

51 Two essential models that integrate genetic, cell biological, and biochemical information have been p

52 In sum, this study utilizes computational, cell biological, and biochemical methods to present a mo

53 Genetic, cell biological, and biochemical studies suggest that re

54 oach that includes biophysical, biochemical, cell biological, and bioinformatics methods to study the

55 Employing biochemical, cell biological, and biophysical approaches, we demonstr

56 ypes are not equivalent, and recent genetic, cell biological, and biophysical evidence suggests how t

57 Emerging studies of the structural, cell biological, and functional defects caused by rare m

58 Using biochemical, cell biological, and genetic approaches we demonstrate t

59 By combining molecular, cell biological, and genetic approaches, we show that ST

60 Gene disruption, cell biological, and immunolocalization studies show tha

61 Based on a combination of biochemical, cell biological, and molecular dynamics simulation appro

62 tional profiling, combined with biochemical, cell biological, and physiological phenotyping, identifi

63 ts in significantly different developmental, cell biological, and signaling phenotypes from those see

64 Using unbiased biochemical, cell-biological, and genetic approaches, we have tested

65 In this study, we took a cell biological approach, observing the dynamics of fluo

66 Using a cell biological approach, we show that the two Streptomy

67 conundrum using genetic, physiological, and cell biological approaches and identified the operation

68 Using a combination of cell biological approaches and in vitro reconstitution o

69 We argue that biochemical and cell biological approaches are also required, because se

70 rt outlook into how combined biophysical and cell biological approaches might lead to the identificat

71 Genetic, genomic, biochemical, and cell biological approaches possible in the powerful Sacc

72 omain, we used biophysical, biochemical, and cell biological approaches to examine the two major prod

73 tor Rfx2, we used bioinformatics and in vivo cell biological approaches to gain insights into the mol

74 We used genetic, physiological and cell biological approaches to show that reorganisation o

75 mutations, a combination of biophysical and cell biological approaches were applied to evaluate the

76 he central role of morphology comparisons in cell biological approaches, few statistical tools are av

77 erse genetics, complementation analyses, and cell biological approaches, we assessed the in vivo func

78 Using pharmacological and cell biological approaches, we demonstrate that IRAP lig

79 combination of structural, biochemical, and cell biological approaches.

80 combination of transcriptomic, genomic, and cell biological approaches.

81 Here, using cell-biological approaches, we have dissected basic prin

82 Although genetic and cell biological aspects have been elucidated, the molecu

83 ew findings provide fundamental insight into cell biological aspects of AQP2 function and may be rele

84 Using proteomic biochemical and cell biological assays combined with time-lapse imaging

85 Cell biological assays in C. elegans neurons show that N

86 This system enables many types of cell biological assays that have been performed with imm

87 By combining cell biological assays with cross-linking mass spectrome

88 characterized by a range of biochemical and cell biological assays, including a novel high-throughpu

89 In cell biological assays, the actin cross-linking domain (

90 bined this with biochemical measurements and cell biological assays.

91 ated by flow cytometry analysis and in vitro cell biological assays.

92 ce that may be useful for fluorescence-based cell biological assays.

93 Recent advances highlight important cell biological atherogenic processes, including mechano

94 ey inherited developmental, biochemical, and cell biological attributes.

95 These results suggest a cell biological basis for ITIM receptor signaling and es

96 The cell biological basis for the formation of rods is well

97 We investigated the cell biological basis for the remarkable selectivity and

98 Taken together, our results provide a cell biological basis for the role of PKCtheta clusterin

99 Our findings provide a biochemical and cell biological basis for the understanding of the patho

100 tion in some cases, though the mechanism and cell biological basis for this requirement remain unknow

101 They also provide a cell biological basis of centromere drive and karyotype

102 ganglion cells as a model to investigate the cell biological basis of radial migration and the conseq

103 ues has enabled investigators to explore the cell biological basis of the inhibitory response.

104 CD133 has been linked on a cell biological basis to stem cell-fate decisions in hum

105 In exploring the cell biological basis underlying this behavior, we have

106 m3 in morphogenesis, and they also provide a cell-biological basis for the role of Pitx transcription

107 ar basis of XIAP in the regulation of cancer cell biological behavior remains largely unknown.

108 however, it is also involved in other cancer cell biological behavior.

109 Here, we use cell biological, biochemical, and computational techniqu

110 We show using cell biological, biochemical, and genetic analyses that

111 consequences of these mutations by genetic, cell biological, biochemical, and spectroscopic approach

112 rsal tissues in Xenopus laevis embryos using cell biological, biophysical and embryological technique

113 and use of a wealth of experimental data in cell biological calculations.

114 t of HER2 overexpression on disease-relevant cell biological changes in these BC.

115 ment, offering a link between structural and cell biological characterisation.

116 Here, we report the biochemical and cell biological characterization of the rest of the yeas

117 We found 40 cell-biological characters that captured the phenotypic

118 However, the range of substrates and cell biological consequences of AMPylation remain poorly

119 r bending membranes are evident in different cell biological contexts across eukaryotic phyla.

120 ta has been documented in various tissue and cell biological contexts, yet the underlying mechanisms

121 ates that toxicity arises only in particular cell biological contexts.

122 e and determine microtubule orientation, the cell biological correlate of neurite polarization.

123 Here, we integrate genetic, structural, and cell biological data into an updated overview of yeast s

124 Complementary biochemical and cell biological data refine and consolidate the interact

125 Although a vast body of genetic and cell biological data regarding Mlh1-Mlh3 is available, m

126 llectively, our structural, biochemical, and cell biological data suggest that multiple anillin-actin

127 Genetic, biochemical, and cell biological data suggest that UCN suppresses ectopic

128 This study presents biochemical and cell biological data that further elucidate the mechanis

129 hatase oxidation in signal transduction, the cell biological details of reactive oxygen species-catal

130 man stem cells can also drive biomedical and cell biological discoveries in a human model system, whi

131 gnitive experience importantly regulates the cell biological effects of HDACi administration, however

132 in disease pathogenesis, we investigated the cell biological effects of increased TMEM106B expression

133 In the present study, we characterized the cell biological effects of these mutants using human emb

134 COSAN elicits a range of cell biological effects, including altered cell morpholo

135 thogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, t

136 ocess that requires the coordination of many cell biological events.

137 se platelets through a series of fascinating cell biological events.

138 The cell-biological events that guide early-embryonic develo

139 We provide genetic and cell biological evidence for the role of ADP-ribosylatio

140 Genetics and cell biological evidence indicate that ZapD requires Fts

141 Genetic, biochemical, and cell biological evidence suggests that MYB2 functions as

142 Here we provide biochemical, genetic, and cell biological evidence that the microtubule-bundling p

143 hat have been discovered through genetic and cell biological examination of this pathway.

144 een probed through genetic, biochemical, and cell biological experimentation as well as by mathematic

145 Genetic and cell biological experiments indicate a critical role of

146 Biochemical and cell biological experiments revealed that trehalose alte

147 Biochemical and cell biological experiments suggest that PI(3,5)P(2) rec

148 he data for this model come from genetic and cell biological experiments.

149 ct motility parameters from a diverse set of cell-biological experiments in an automated and user-fri

150 These findings provide a common cell biological explanation for the decreased stimulator

151 associated disorders are unified by a common cell biological feature: the deposition of the culprit p

152 s generated by Hmg1p and Hmg2p have distinct cell biological features determined by the transmembrane

153 This study reveals novel cell biological features that may contribute to the mech

154 mportant pathogens and symbionts with unique cell biological features.

155 e be a thorough understanding of the general cell biological function of inclusions and their potenti

156 ngs indicate that gamma-RIMs are involved in cell biological functions distinct from the regulation o

157 To better apprehend gamma/delta T cell biological functions in the periphery, it appears c

158 T cells use the endocytic pathway for key cell biological functions, including receptor turnover a

159 roteins tasked with the execution of crucial cell biological functions.

160 ole of GOLPH3 in N-glycosylation to regulate cell biological functions.

161 ling molecules that have widespread roles in cell biological functions.

162 e targets and then correlated these with the cell biological impact.

163 binds to and destabilizes microtubules using cell biological, in vitro, and structural approaches.

164 is of coupled variables is a core concept of cell biological inference, with co-localization of two m

165 What is the minimal set of cell-biological ingredients needed to generate a Golgi a

166 Therefore, to gain genetic and cell biological insight into FXTAS, we examined the effe

167 Two recent studies provide important cell biological insights into the subcellular sites of N

168 Genetic and cell biological interactions suggest that CALF-1 couples

169 ew, we propose that as a result of the tight cell biological interconnection of axons and myelin, dam

170 rabbit an excellent model for gene therapy, cell biological intervention, progenitor cell transplant

171 involved in Abeta production has facilitated cell biological investigations on APP processing and adv

172 elity of DNA synthesis, and raise intriguing cell biological issues with regard to nucleotide pool co

173 of the ontology to the continuously growing cell biological knowledge.

174 s perform functions that might be considered cell-biological, like fluid secretion and cell volume re

175 ains physiological operation within inherent cell biological limitations.

176 The early cell biological literature is the resting place of false

177 cells that are adapted to the use of certain cell biological machinery, but also of highlighting the

178 compartments makes the use of decentralized cell biological machines necessary.

179 ed to effectively and rapidly pattern living cells, biological macromolecules, and biomaterials.

180 tructure of the mitotic spindle, providing a cell biological mechanism for its aneugenic activity, an

181 To elucidate the molecular and cell biological mechanism for trans-enhancement, we perf

182 This cell-biological mechanism may mediate such cell transiti

183 y regulation of axonal mitochondria as a new cell-biological mechanism that helps determine the regen

184 n human, mouse and zebrafish, which describe cell biological mechanisms fundamental to the growth and

185 rent vulnerabilities to OGD recruit distinct cell biological mechanisms in response to insult, and th

186 tional decay during aging in humans, but the cell biological mechanisms responsible for this process

187 d to deafness has provided insights into the cell biological mechanisms that control hair cell develo

188 rent understanding of developmental cues and cell biological mechanisms that establish polarity in ne

189 Genetic and cell biological mechanisms that regulate stomatal develo

190 * Genetic and cell biological mechanisms that regulate stomatal develo

191 on occurs within primary cilia, although the cell biological mechanisms underlying both Shh signaling

192 Membrane trafficking is key to the cell biological mechanisms underlying development.

193 Several studies have identified cell biological mechanisms underlying extrusion of cells

194 t has diverged significantly at the level of cell biological mechanisms.

195 Cell-biological mechanisms mediating delamination are, h

196 Recently, genetic and cell biological methods have provided insights into sequ

197 We have used various biochemical and cell biological methods to study the dynamics of clamp a

198 Based on these and previous cell biological observations, we suggest that Pch2 impac

199 ut my scientific journey to the synapse, the cell biological one, but also a metaphorical synapse-my

200 Autophagy is a cell biological pathway affecting immune responses.

201 d our understanding of the developmental and cell biological pathways that contribute to palate closu

202 processes that play important roles in many cell biological pathways, including intracellular transp

203 Despite distinct patterns of biochemical and cell-biological perturbations, V60L and I90M each attenu

204 By integrating cell biological, pharmacological, and genetic approaches

205 this Perspective, I provide a broad view of cell biological phenomena in bacteria, the technical cha

206 in vitro and in vivo study of these classic cell biological phenomena.

207 ules-associated with evolutionary changes in cell-biological phenotypes.

208 In this review, we discuss the cell biological principles of endosomal trafficking, the

209 The cell biological principles that govern innate immune res

210 Together, these results illustrate use of cell-biological principles to enable expansion of the ve

211 ng with the clonable SNAP tag, a widely used cell biological probe to visualize fusion proteins by fl

212 le reaction may be useful for creating novel cell biological probes, diagnostics, or therapeutics tha

213 e-organizing center, as an early step in the cell biological process underlying NK cell cytotoxicity.

214 Autophagy is a fundamental cell biological process whereby eukaryotic cells form me

215 es represent the end products of a multistep cell-biological process termed the invasion-metastasis c

216 Metastasis is a multistep cell-biological process, which is orchestrated by many f

217 ecent studies have advanced our views of the cell biological processes and crucial proteins that driv

218 ontraction in nonmuscle cells underlies many cell biological processes and is based on contractility

219 f microtubule dynamics is essential for many cell biological processes and is likely to be variable b

220 ay, overt or covert mechanical forces govern cell biological processes and produce sensations.

221 oration is shedding new light on interesting cell biological processes and suggesting novel therapeut

222 ndance can profoundly limit the precision of cell biological processes from secretion to metabolism.

223 w the protocol can be adapted to study other cell biological processes in aging neurons.

224 evel programs of gene expression to discrete cell biological processes in vivo remain poorly understo

225 They are involved in key cell biological processes including vesicle trafficking,

226 Our understanding of cell biological processes involved in regulating aging h

227 ighlighting examples wherein the fundamental cell biological processes of protein synthesis and degra

228 Several cell biological processes play a role in the regulation

229 are fundamentally important for a variety of cell biological processes ranging from cytoskeletal dyna

230 iochemical mediators that act in a myriad of cell biological processes remain poorly understood.

231 ,5)P2 production may be coupled to important cell biological processes such as membrane trafficking o

232 that have previously shed light on critical cell biological processes that are perturbed by single-g

233 icates the manipulation and visualization of cell biological processes that control synaptic function

234 imaging provides intriguing insight into the cell biological processes that mold embryonic tissues in

235 aradigm for understanding genomic control of cell biological processes that span from early cell morp

236 made towards understanding how the distinct cell biological processes that together drive apical con

237 usion is essential in a myriad of eukaryotic cell biological processes, including the synaptic transm

238 one of the preferred metazoans for studying cell biological processes, such as ERAD.

239 coordinate the timing and execution of these cell biological processes.

240 ans to discover small molecules that perturb cell biological processes.

241 rstood, despite its clear importance in many cell biological processes.

242 ms by which motors contribute to fundamental cell biological processes.

243 imulation technique to provide insights into cell biological processes.

244 that regulate and execute developmental and cell biological processes.

245 model systems for understanding fundamental cell biological processes.

246 tools may transform our view of fundamental cell biological processes.

247 orylation of Cdk targets involved in several cell biological processes.

248 advances made specifically in the following cell biological processes: (1) cytoskeletal-related proc

249 our current understanding of the underlying cell-biological processes in the Golgi.

250 library development targeting the underlying cell-biological processes.

251 nt impediment to the optical control of most cell-biological processes.

252 thelial-to-mesenchymal transition (EMT) is a cell biological program that confers mesenchymal traits

253 ow cancer cell behavior can be modified by a cell-biological program called the epithelial-to-mesench

254 basis for this observation, we examined the cell biological properties of sacsin.

255 results are interpreted with respect to the cell biological properties of TRiC and suggest that in v

256 he Hippo pathway is regulated by fundamental cell biological properties, such as polarity and adhesio

257 re invisible to contemporary haploid-centric cell biological, proteomic, and functional genomics appr

258 w nuclear size is regulated is a fundamental cell-biological question with relevance to cancers, whic

259 hodology that can be applied to a variety of cell biological questions or used within a clinical sett

260 spectrometry-based lipidomics in addressing cell biological questions.

261 olution investigations of a broad variety of cell biological questions.

262 scopy ultrastructure, which can help address cell biological questions.

263 exchange, selective ion exchange, and whole-cell biological reduction) and emerging (catalysis) perc

264 pplications of biochemical, biophysical, and cell biological research.

265 microscopy, has become an important tool in cell biological research.

266 th applications in nutritional, medical, and cell-biological research.

267 strate, for the first time, that neural stem cell biological responses to laminin are dependent on to

268 mes have long been proposed to play multiple cell biological roles in cancer.

269 s within the body, extending its function to cell biological roles such as mediating cellular recepto

270 ng a series of mutants to examine Abl's many cell biological roles.

271 Mitotic chromosomes were one of the first cell biological structures to be described, yet their mo

272 ries, an activity that has been suggested by cell biological studies but had not been directly measur

273 Cell biological studies confirmed OCTN1-mediated transpo

274 A recent series of genetic and cell biological studies have shed light on the question-

275 When combined with genetic, biochemical, and cell biological studies in Chlamydomonas reinhardtii, th

276 hysical properties in solution and conducted cell biological studies in mammalian cells.

277 Cell biological studies indicate that Arc/Arg3.1 protein

278 Biochemical and cell biological studies of how bacteria and other microo

279 have performed single-molecule motility and cell biological studies of Khc-73.

280 opy (cryo-EM), biophysical, biochemical, and cell biological studies of the interaction between the C

281 Mutant TIA1 was characterized by cell biological studies on HeLa cells, including quantif

282 Genetic and cell biological studies over almost 2 decades have revea

283 In the case of cilia and flagella, multiple cell biological studies show that microtubule diversity

284 rmatic analyses coupled with biochemical and cell biological studies suggest that parasitic protozoa

285 ide range of bioanalytical, biophysical, and cell biological studies where individual DNA strands are

286 f both cell types has hampered molecular and cell biological studies, which often require large quant

287 ther proteins with genetic, biochemical, and cell biological studies.

288 d model for developmental, physiological and cell biological studies.

289 r pathway that may be of interest for future cell biological studies.

290 Biochemical, molecular, and cell-biological studies reveal that PITPNC1 promotes mal

291 sors for a variety of applications including cell-biological studies, substance detection, and diseas

292 ticipation of TBK1 in a myriad of additional cell biological systems in normal and pathophysiologic c

293 ng and elucidating the complex mechanisms of cell biological systems.

294 ing to study using traditional molecular and cell biological techniques alone.

295 with electrophysiological, biochemical, and cell biological techniques, to identify a clinically rel

296 gation of cytoneme regulation using standard cell biological techniques.

297 comprehensive synthesis of evolutionary and cell-biological thinking is lacking.

298 d C3H mice using proteomic, biochemical, and cell biological tools.

299 ttings facilitates an accurate evaluation of cell biological variability.

300 tumor-suppressor inactivation and reveals a cell-biological vulnerability for TNBCs lacking therapeu