ライフサイエンスコーパス: cell cluster

1 hen sink under the surface to form a compact cell cluster.

2 regulation of dendritic cell/natural killer cell cluster.

3 or and interfacial deflection in a simulated cell cluster.

4 a lack of directional movement by the border cell cluster.

5 also required for organization of the border cell cluster.

6 asymmetry and delamination of an epithelial cell cluster.

7 HMVEC were not able to invade the malignant cell cluster.

8 e progeny of each neuroblast-ganglion mother cell cluster.

9 ed by two central cells within the migratory cell cluster.

10 actions determine the emergent properties of cell clusters.

11 ng of cell functions in isolated and grouped cell clusters.

12 y and reliably to formation of proliferating cell clusters.

13 ible, and ordered envelopes that encased the cell clusters.

14 mipara but with a greater propensity to form cell clusters.

15 3 proteins were strongly expressed in the OA cell clusters.

16 the failure to detect viral genomes in the T-cell clusters.

17 ue to the emergence of periportal islet-like cell clusters.

18 rns in cell cycle activity within epithelial cell clusters.

19 focused within the cytochrome oxidase dense cell clusters.

20 e and a release of individual cells or small cell clusters.

21 evels than the other Slouch-positive founder cell clusters.

22 ecules, and the generation of haematopoietic cell clusters.

23 solated, single BCE cells, as well as in BCE cell clusters.

24 ere members of discrete horizontal or radial cell clusters.

25 served only when NP cells form CDH2 positive cell clusters.

26 loss of CDH2 expression and ability to form cell clusters.

27 induced changes in the proportions of some B cell clusters.

28 ctable in most chondrocytes, particularly in cell clusters.

29 bronectin matrix disruption and dispersal of cell clusters.

30 nfined spaces such as the medium surrounding cell clusters.

31 ution, the dynamics of force transmission in cell clusters.

32 ng-controlled phenotypes as a consequence of cell clustering.

33 evels of eDNA and a concomitant reduction in cell clustering.

34 r extracellular matrix-dependent endothelial cell clustering.

35 ulations, like confluent cell monolayers and cell clustering.

36 te that neogenin mediates netrin-1-dependent cell clustering.

37 eir patterned distribution by promoting stem cell clustering.

38 taining, imaging noise, cell morphology, and cell clustering.

39 In cell clusters, 3 microm TTX induced longer AP interpulse

40 ies are concentrated in the A1 and caudal C1 cell cluster (A1/C1) in the ventrolateral medulla, a reg

41 ltifocal aberrant crypt-containing endocrine cell clusters (ACECs) that contain crypt EC cell microtu

42 We directly observed multicolored tumor cell clusters across major stages of metastasis, includi

43 velopment in culture, also forms embryogenic cell clusters after TSA treatment.

44 Polarized secretory cells cluster all Ca2+ signaling proteins, including GPC

45 The directed migration of the cell cluster along the path of Sdf1a chemokine requires

46 innata sequestered Se in localized epidermal cell clusters along leaf margins and tips, concentrated

47 These cell clusters also have differential adhesive properties

48 novel subtypes, pseudo-temporal ordering of cells, clustering analysis, etc.

49 complete graph in which a node represents a cell cluster and an edge between a pair of nodes defines

50 Ai resulted in disorganization of the border cell cluster and impaired migration.

51 blishes a boundary between the motile border cell cluster and its non-invasive epithelial neighbors t

52 its in calcium-dependent N-cadherin-mediated cell clustering and cell-substratum adhesion, and primar

53 regulate DC-SIGN expression and promote DC-T-cell clustering and HIV-1 spread.

54 edundantly with Spitz to control R8 spacing, cell clustering and survival.

55 ch SDF-1 gradients first promote endothelial cell clustering and then EphB2 and EphB4 critically cont

56 every enthesis; the most common changes were cell clustering and/or fissuring (in 76% of entheses).

57 lets compared with sub-islet-sized endocrine cell clusters and among pancreatic lobes.

58 wander across the surface instead of forming cell clusters and biofilms.

59 y also showed upregulation of VLA-4-positive cell clusters and BMD cells at the metastatic sites, pro

60 hymal transition (EMT) enables scattering of cell clusters and disseminates motile cells to distant l

61 nd tested our method on both coverslip-grown cell clusters and filter-grown intact monolayers.

62 direct contact of mouse submandibular (mSMG) cell clusters and hHF-MSCs was not required for mSMG cel

63 Silencing hnRNP A2/B1 induced formation of cell clusters and increased proliferation.

64 Cell clusters and migrating cells reacted to pgp 9.5, an

65 particle-based simulation model for adhesive cell clusters and monolayers.

66 pressure that leads to clonality of these B-cell clusters and opens the possibility that infection a

67 agr-dependent reporter was in patches within cell clusters and oscillated with time.

68 e provides a purification step by entrapping cell clusters and other impurities within its fibers.

69 1+ embryonic precursors also results in stem cell clusters and paracrine tumours.

70 ced proplatelet formation from cultured MKs, cell clustering, and abnormal cortical filamentous actin

71 to neurons and glia, aggregate into ganglion cell clusters, and extend neuronal processes to form a c

72 carotenoid-enriched oil, chromoplasts, small cell clusters, and large cell clusters) were isolated fr

73 lly disseminated clusters, circulating tumor cell clusters, and lung micrometastases frequently expre

74 ion, intravascular emboli, circulating tumor cell clusters, and micrometastases.

75 cell transport studies, guided formation of cell clusters, and tissue engineering.

76 inhibition of FGFR tyrosine kinase inhibits cell clustering; and (iv) FGF2 neutralizing antibody inh

77 Recently, aldosterone-producing cell clusters (APCCs) with high expression of aldosteron

78 Merkel cell clusters appear to have direct access to Fz6-based

79 e of the age of the donor hepatocytes, large cell clusters appeared in juvenile, but only small clust

80 Foci of terminations were related to the cell-cluster architecture of the gracile nuclei in secti

81 that preserve their integrity, and even two-cell clusters are captured efficiently.

82 The B-cell clusters are in close proximity to peripheral node

83 01), whereas the total aldosterone-producing cell cluster area was positively correlated with age (r=

84 l sensory system, composed of four disparate cell clusters, arose from mitotic domain 5 and that mito

85 A cell cluster at the anterior tip of planarian head blast

86 dy to achieve detectable levels within tumor cell clusters at 6 hours after i.v. injection.

87 or-intact BXD2 mouse spleens, MZ precursor B cells clustered at the T cell-B cell border.

88 served in large clusters ( approximately 100 cells/cluster) at the ureteral insertion and along thick

89 In 5 mM K(+) Ringer's, the V(m) of cell clusters averaged -40.0 +/- 4.1 mV (n = 14) and in

90 egulatory volume decrease (RVD) in bile duct cell clusters (BDCCs) from normal and cystic fibrosis (C

91 Individual cell clusters become transfected with a defined shRNA th

92 chemoattractant gradients, the speed of the cell cluster becomes non-monotonic in the cluster's size

93 or Cas function retinal neurons form ectopic cell clusters beyond the inner-limiting membrane (ILM),

94 (HDF)] were assayed for invasion into tumor cell clusters (breast carcinoma, ovarian carcinoma, pros

95 led to the formation of warty lesions, with cell clusters bulging from the epidermal layer, and some

96 Radial clusters accounted for only 23% of cell clusters but >34% of labeled cells.

97 oreactive with free Env cells and Env-target cell clusters but not with fused cells.

98 cell flexibility values, can align and form cell clusters but only when periodic reversals of cell d

99 ution of integrin CD49d to the periphery and cell clustering, but inhibited ERK(1/2) activation and e

100 concentration in pancreatic islets and beta-cell clusters can be explained with a model that uses a

101 J and Pofut1 led to an accumulation of basal cell clusters characterized by the presence of cytokerat

102 strongly responding cell is at one end of a cell cluster, cluster motion is biased toward that cell.

103 In addition, HNT affected border cell cluster cohesion and motility via effects on the JN

104 The time-activity curves for tumor cell clusters, comprising fewer than 10 cells, were deri

105 myocardial BM cell injection formed distinct cell clusters containing donor-derived cells and accumul

106 We find that in pluripotent cells, clustered CpG-islands at genes predict occupancy

107 Circulating tumor cell clusters (CTC clusters) are potent initiators of me

108 Circulating tumor cell clusters (CTC clusters) are present in the blood of

109 tected, whereas neither were observed within cell clusters (CTM), implicating both protection from an

110 We find that just preceding cell cluster delamination, expression of transmembrane i

111 Dynamic regulation of cell clustering depends on the balance between contracti

112 In vivo, expanding cell clusters derived from transplanted FLSPCs had lower

113 lowing the initial influx of immune cells, T cell clusters develop, accelerating the pathology in the

114 ALDH(+)/CD49f(+)/EpCAM(+) tumor and normal cells clustered differently compared with unselected tum

115 patocytes formed cell arrays with individual cell cluster dimensions (150 or 500 microm) correspondin

116 ish the concept that K14(+) epithelial tumor cell clusters disseminate collectively to colonize dista

117 At this leaflet/annulus junction, CD44(+) cells clustered during elongation (11 weeks), extending

118 We found cell clusters embedded in the 3D ECM can exert translati

119 hile not readily apparent at birth, discrete cell clusters emerge over the first postnatal week, yiel

120 bit the T cell-dendritic cell contacts and T cell clustering essential for sustained T cell activatio

121 The As1-4 cells, bilateral serotonergic cell clusters, excited the prolonged A4 burst during the

122 Both single BCE cells and BCE cell clusters exhibited an inwardly rectifying K(+) (Kir

123 ES cell-derived insulin-stained cell clusters expressed insulin mRNA and transcription f

124 pression and increased aldosterone-producing cell cluster expression.

125 To survive, cancer cells cluster extra centrosomes during mitosis, avoiding

126 le NP matrix synthesis patterns by promoting cell clustering for controlled microenvironment conditio

127 Cell cluster formation and nestin expression were abolis

128 minin 1 (L1) is critical for intact salivary cell cluster formation and organization.

129 lthough all MWCNT-alginates lead to enhanced cell cluster formation compared to alginate alone.

130 chorage-independent growth was determined by cell cluster formation in soft agar.

131 into SCID mice resulted in a homogenous germ cell cluster formation in vivo.

132 Consistently, cell cluster formation per unit area on 5 mum wide line

133 o arrest biofilm development at the stage of cell cluster formation we call the maturation-1 stage.

134 Prior to cell division, CD8 T cell-dendritic cell clusters formed in the spleen after live L. monocyt

135 er 7 days, the PECs formed self-regenerating cell clusters, forming villi that resemble intestinal ep

136 ration: (1) initial detachment of the border cell cluster from the follicular epithelium and (2) the

137 subtractive process involving the release of cell clusters from a thick, unstructured biofilm.

138 Here we report that switching preformed cell clusters from procontractile to promigratory cultur

139 Analysis of cell clusters from single NG2 cells revealed that more t

140 lude regular distributions of cells, dynamic cell clusters, gel-like networks, collectively migrating

141 o show that in MAM-exposed rats the abnormal cell clusters (heterotopia) first appear postnatally in

142 is a paracrine chemoattractant during PANC-1 cell clustering: (i) FGF2 is secreted and remains bound

143 Neonatal islet cell clusters (ICCs) from INSLEA29Y transgenic (LEA-tg)

144 to provide high Wg levels to Slouch founder cell cluster II in a temporally specific manner.

145 naling, we have observed that Slouch founder cell cluster II is more sensitive to Wg levels than the

146 detectable during mid-embryogenesis as a 22-cell cluster in the ventral epidermis.

147 usion protein resulted in enhanced in vivo T cell clustering in draining lymph nodes and IL-2 product

148 bed endocrine cell differentiation and islet cell clustering in VEGF-A overexpressing embryos.

149 hat exhibited extensive individual cells and cell clusters in a perivascular and subpial cellular inf

150 controls directed cell protrusions of border cell clusters in a Scar-dependent manner.

151 lture assay using human SKOV3 ovarian cancer cell clusters in collagen as a stimulus for invasion thr

152 While alpha and beta cells formed islet cell clusters in control embryos at E16.5, the increased

153 atrix platform to culture mammary epithelial cell clusters in ECMs of tunable stiffness and confineme

154 We identified larger B-cell clusters in epicardial AT of human patients with co

155 analyzing the shape and distribution of GFP cell clusters in flat wholemount specimens, and by in vi

156 nd that this cell population surrounds tumor cell clusters in M-LN.

157 re, we investigate the role of CDH2 positive cell clusters in preserving healthy, biosynthetically ac

158 d with the occurrence of abnormal basal/stem cell clusters in prostate epithelium of prostate-specifi

159 ly, we demonstrated that formation of PECAM+ cell clusters in response to BV13 was not due to a disru

160 is the presence of a germinal center like B-cell clusters in the allograft.

161 lugs, but not with control CFU-ECs, produced cell clusters in the Matrigel and proliferative lesions

162 pread infection of individual cells or small cell clusters in the subepithelial lamina propria of mon

163 in, and reside in N-cadherin (CDH2) positive cell clusters in vivo.

164 e G(0) stage of the cell cycle, and Sca-1(+) cells cluster in the proximal region of prostatic tubule

165 compared with other organs (P < .001), with cells clustered in areas of active bone formation and re

166 HIV RNA(+) cells clustered in cerebellum tissue but were dispersed

167 for the first time that infiltrating myeloid cells clustered in damaged areas of dystrophic skeletal

168 ease from PC12 cell clusters is presented at cell clusters incubated with the dopamine precursor and

169 agent, L-3,4-dihydroxyphenylalanine, and at cell clusters incubated with the vesicular monoamine tra

170 gle oocytes are lineage-labeled, rather than cell clusters indicative of new oocyte formation.

171 varian tumors involves the invasion of tumor cell clusters into the mesothelial cell lining of perito

172 Based on STRF shape, cells clustered into functional groups that divided the

173 ain translocation time courses of stimulated cells clustered into only two primary modes.

174 The cells clustered into populations of alpha-cells (5%), be

175 rface association of beta-catenin, homotypic cell clustering, invasion through Matrigel, cell migrati

176 Insulin-producing cell clusters (IPCCs) have recently been generated in vi

177 The GABA-sensitive cell cluster is centered on a tegmental (reticular) fiel

178 Here we show that the border cell cluster is compact and round throughout their entir

179 a P2RY8 orthologue, we show that mouse GC B cell clustering is also dependent on FDCs acting to supp

180 Formation of cell clusters is a common morphogenic cell behavior obse

181 ng to demonstrate that polyclonal seeding by cell clusters is a frequent mechanism in a common mouse

182 ing demonstrate that the drug effect on PC12 cell clusters is consistent with previous single-cell ex

183 The integrity of cell clusters is dictated by cell-cell junctions, which

184 single vesicle exocytotic release from PC12 cell clusters is presented at cell clusters incubated wi

185 , we examine how the integrity of epithelial cell clusters is regulated by subcellular forces, protru

186 that lead to the formation of these abnormal cell clusters is unclear.

187 lso suppressed in ex vivo cultures of acinar cell clusters isolated from mouse pancreas bearing targe

188 At the cell cluster level, low intensities of thermal processin

189 onitors TCR signal strength indicates that T cell clustering limits T cell exposure to Ag during acti

190 eration of beta-cells within small endocrine cell clusters located in the regenerating portion of the

191 earlier phenotype observed was that the two cell clusters lose direction and converge at the midline

192 that the sum of forces generated by multiple cell clusters may result in macroscopic deformation.

193 regulates the growth and morphology of these cell clusters; MCAs grow larger and faster in the more r

194 ing in enlarged and densely packed bacterial cell-clusters (microcolonies).

195 This result suggests that circulating tumor cell clusters might be able to better survive chemothera

196 Within these cell clusters, motor neurons receive afferent input and

197 thal-giant-larvae inhibit the rate of normal cell cluster movement suggests that their loss in metast

198 dominant tolerance to porcine neonatal islet cell cluster (NICC) xenografts in mice.

199 long-term survival of neonatal porcine islet cell clusters (NPCC) in chemically diabetic immunocompet

200 nd maturation of porcine neonatal pancreatic cell clusters (NPCCs) microencapsulated in barium algina

201 roperties of the ECM to predict the state of cell clusters of defined shapes and sizes.

202 uce invasion of either single cells or small cell clusters of N-type cells.

203 emonstrate the parallel formation of >20,000 cell clusters of precise size and shape within a thin 2-

204 sential for induction of dermal condensates, cell clusters of precursors for the hair follicle dermal

205 We find that cell clusters of primitive blood islands undergo an inap

206 in, directed biosynthesis only in apical-tip cell clusters of short, procumbent glandular trichomes.

207 o pancreas, with formation of many endocrine cell clusters of the type found in normal islets of Lang

208 ages resulted in increased priming of OT-I T cells [cluster of differentiation 8-positive (CD8(+))] b

209 ree distinct levels of spatial organization: cells, clusters of cells, and collections of clusters.

210 microM) was added to the medium of cultured cells, clusters of PrPC formed on the cell surface, and

211 blasts functioned as a nucleation center for cell clustering on three-dimensional collagen matrices.

212 in-resistant clones were identified as green cell clusters on a spectinomycin medium.

213 oduced by multiple isolated cells as well as cell clusters on soft substrates.

214 ors at an intermediate, mesoscopic, level of cell clusters or domains.

215 Abnormal cell clusters or heterotopias were detected in the margi

216 chick embryonic ventricular CM (3.5 x 10(4) cell clusters per cell chamber) were cultured for 4 days

217 V-1 replication is strongly enhanced in DC-T cell clusters, potentially undermining this process.

218 -photon microscopy revealed that recipient T cells cluster predominantly around lung-resident, donor-

219 that there is no spatial structure, such as cell clustering, present.

220 Furthermore, T cell clustering promotes the upregulation of the CTLA-4

221 to pgp 9.5, and migrating cells, but not the cell clusters, reacted to tyrosine hydroxylase.

222 clusters of >or=3 cells; the percentage of 2-cell clusters remained relatively constant with changing

223 mechanism underlying this synergy within NK cell clusters remains unclear.

224 c map of the visual field, in which adjacent cell clusters represent adjacent points of visual space.

225 is realized by individual cells, rather than cell clusters, representing an alternative to the lobula

226 These results suggest that T cell clustering represents a mechanism that allows conti

227 re, Durdu et al. (2014) show that epithelial cell clusters secrete FGFs into a microlumen, restrictin

228 Many cells cluster signaling complexes in plasma membrane mic

229 logical synapse, with Th1 cells, but not Th2 cells, clustering signaling molecules at the T cell/B ce

230 Hence, cell cluster size can be larger than substrate thickness

231 Area coverage and cell cluster size measurements showed that attachment of

232 ities, donor-to-recipient ratios and initial cell cluster size, and are therefore flawed as universal

233 any morphogenetic behaviors, which depend on cell cluster size.

234 fails and cells proliferate to intermediate cell cluster sizes.

235 2.8-fold increase in the prevalence of beta-cell clusters/small islets at 2 days post-Px contributed

236 ation with an increase in the number of beta-cell clusters/small islets.

237 We argue that the cell cluster speed is a crucial readout of how the clust

238 Maintenance of mitotic cell clusters such as meristematic cells depends on thei

239 isingly, confinement induces EMT even in the cell clusters surrounded by a soft matrix, which otherwi

240 Encapsulated human islet-like cell clusters survived, replicated, and acquired a level

241 tegy for the mechanical stimulation of large cell clusters, taking advantage of dielectrophoresis.

242 methodology is complimentary to other single cell clustering techniques and adds to a growing palette

243 mmunoreactive synapses is much higher in ITC cell clusters than in the BLA or CEA and that microORs t

244 We identified neurons of this cell cluster that suppress mating, but not feeding behav

245 c rejection is the infiltration of ectopic B-cell clusters that are clonal into the transplanted kidn

246 loid parental strain led to slow-sedimenting cell clusters that consisted of just a few cells, thus r

247 er of immobilized cells gives rise to larger cell clusters that eventually develop into the biofilm,

248 erate within distinct islands, forming large cell clusters that eventually fuse during metamorphosis

249 tubes, and spontaneously formed disorganized cell clusters that increased in size in the presence of

250 duced here to explicitly detect and quantify cell clusters that move coordinately in a monolayer.

251 ushantuo microfossils, including symmetrical cell clusters that result from multiple stages of reduct

252 n contrast, strain 129Pt formed a biofilm of cell clusters that were tower-shaped or distinct filamen

253 s a series of early events wherein precursor cells cluster, that is migrate to form cell aggregates,

254 determine the size distribution of adipocyte cell clusters, the percentage of perimeter coverage of t

255 ulation of Myo-II activity within the border cell cluster through localized inhibition of myosin phos

256 By imaging HEK-293 cell clusters through 4.5 mm thick ex vivo rat brain tis

257 operties and can yield functional islet-like cell clusters through intracapsular aggregation that rev

258 he integrated ratio of aldosterone-producing cell cluster to CYP11B2-expressing area was most strongl

259 on at the outer edge of the migrating border cell cluster to resist compressive forces from nurse cel

260 xtract SPs from tissue samples, ranging from cell clusters to brain punches to intact brain regions,

261 lar communication is regulated in epithelial cell clusters to control delamination and migration.

262 ng VE-cadherin antibody, BV13, caused PECAM+ cell clusters to form in cultured allantois explants fro

263 laques (n=30), CD123+ plasmacytoid dendritic cells clustered together with CD11c+ myeloid dendritic c

264 Randomly distributed Golgi puncta in yeast cells cluster toward the growing tip during hyphal forma

265 Consequently, velocity of border cell clusters undergoing guided migration was reduced in

266 We present single-cell clustering using bifurcation analysis (SCUBA), a no

267 nd contact inhibition on the growth of tumor cell clusters using the Cellular Potts Model (CPM) in a

268 ation growth, such as the formation of tight cell clusters versus dispersed colonies, alter the effic

269 and primordial germ cells, Drosophila border cell clusters, vertebrate neural crest migration and ang

270 (+) cells produced only rare, small DPPIV(+) cell clusters, very few of which exhibited a hepatocytic

271 ial distribution of hyperexcitable pyramidal cells (clustered vs uniform), and firing patterns (weakl

272 NK cell clustering was necessary for IFN-gamma production a

273 Formation of B cell clusters was assessed using immunohistochemistry.

274 ant increase in the number of neuroendocrine cell clusters was observed in the lungs of dead transgen

275 ulation of anti-E-cadherin antibody in tumor cell clusters was similarly affected.

276 tant cells comprised only a subset of the 16-cell cluster, we observed strictly cell-autonomous growt

277 to spontaneously-forming adherent epithelial cell clusters, we found that basal force fluctuations we

278 islets and human fetal pancreatic islet-like cell clusters were encapsulated in polytetrafluorethylen

279 beta-cell metabolism, mouse islets and beta-cell clusters were loaded with rhodamine 123 to dynamica

280 adherin-coated surfaces and the formation of cell clusters were slower for zyxin-deficient cells than

281 Encapsulated cell clusters were subsequently transplanted into the pe

282 chromoplasts, small cell clusters, and large cell clusters) were isolated from different types of car

283 pressing cells, called aldosterone-producing cell clusters, were analyzed.

284 postulate that quorum sensing occurs within cell clusters, where signal dispersion might be signific

285 , EPC were able to invade into the malignant cell cluster, whereas HMVEC were not able to invade the

286 Weeks after VSV infection, discrete T-cell clustering with dendritic cells within the lymph no

287 quency and the sizes of isolated recombinant cell clusters with age, indicating that both de novo rec

288 Deletion of the enzyme results in large cell clusters with disordered division patterns, indicat

289 Cell clusters with excess Vangl2 could induce non-autono

290 The finding of cell clusters with stem cells making the transition to c

291 re scattered in the tissue, CD103(-)CD8(+) T cells clustered with CD4(+) T cells and CX3CR1(+) macrop

292 ated mitral cells were located beneath these cell clusters, with scattered neurons in the underlying

293 creating a living array of stably transduced cell clusters within a monolayer of uninfected cells.

294 ly (lbe) gene products mark adjacent cardiac cell clusters within a segment, and their antagonistic i

295 We also detected a few novel or rare cell clusters within the amygdala, medial septum, and in

296 l analysis of NP-implants at day 26 revealed cell clusters within the infrahippocampal cleft as well

297 t, BHK and BHK-AK2 cell implants only formed cell clusters within the infrahippocampal cleft.

298 conversion, and during viral infection, ILC2 cells clustered within inflamed areas and acquired an IL

299 types, with the few differentiated endocrine cells clustered within, or in close proximity to, enlarg

300 diabetic patients receiving fetal pig islet cell clusters xenograft together with a kidney allograft