ライフサイエンスコーパス: cell cycle checkpoint

1 specific mitotic arrest mediated by the Mad2 cell cycle checkpoint.

2 Rad3 related) and CHK1 kinases to induce the cell cycle checkpoint.

3 bition of ATR or CHK1, but also defects G2-M cell cycle checkpoint.

4 grade signals to specifically enforce a G1-S cell cycle checkpoint.

5 system ensures mitotic entry independent of cell cycle checkpoint.

6 regulation of the DNA damage-induced G(2)/M cell cycle checkpoint.

7 3C which involves the disruption of the G2/M cell cycle checkpoint.

8 signaling pathway in the regulation of this cell cycle checkpoint.

9 ncurring DNA damage and without activating a cell cycle checkpoint.

10 arrest, probably because of activation of a cell cycle checkpoint.

11 esults in defective recovery from the G(2)/M cell cycle checkpoint.

12 n of cellular DNA damage and activation of a cell cycle checkpoint.

13 Gln checkpoint and before the mTOR-mediated cell cycle checkpoint.

14 genetic alterations that deregulate the G1/S cell cycle checkpoint.

15 on, rather than an indirect consequence of a cell cycle checkpoint.

16 tial mediator of the DNA damage response and cell cycle checkpoint.

17 step in the initiation and amplification of cell cycle checkpoint.

18 f cyclin-dependent kinases 2 and 4/6 at G1/S cell-cycle checkpoint.

19 s normally triggers a precise precytokinesis cell-cycle checkpoint.

20 in sensing general DNA damage and mediating cell-cycle checkpoint.

21 ontrol of DNA damage repair and signaling to cell cycle checkpoints.

22 g in ATM/Chk2 inactivation and abrogation of cell cycle checkpoints.

23 pigenetic silencing of CDKN1A and release of cell cycle checkpoints.

24 t timer to trigger the MBT and activation of cell cycle checkpoints.

25 DDR) activates downstream pathways including cell cycle checkpoints.

26 ns, including DNA breaks, and can compromise cell cycle checkpoints.

27 M/Chk2 and ATR/Chk1 pathways and appropriate cell cycle checkpoints.

28 ive proteins and reverses DNA damage-induced cell cycle checkpoints.

29 critical residues of EBNA3C in bypassing the cell cycle checkpoints.

30 n the initiation of both DNA replication and cell cycle checkpoints.

31 cluding the initiation of DNA damage-induced cell cycle checkpoints.

32 ously described, but also regulates multiple cell cycle checkpoints.

33 ut the genome and have activated ATM and ATR cell cycle checkpoints.

34 ontrols progression of mitosis by activating cell cycle checkpoints.

35 mosome instability in cancer cells that lack cell cycle checkpoints.

36 nous cell divisions without growth phases or cell cycle checkpoints.

37 n actionable dependence on ATR/CHK1-mediated cell cycle checkpoints.

38 oprotein from HPV degrades p53 and abrogates cell cycle checkpoints.

39 enome integrity by regulating DNA repair and cell cycle checkpoints.

40 Human cells contain G1 and G2 cell cycle checkpoints.

41 cute homology-directed DNA damage repair and cell cycle checkpoints.

42 rades the tumor suppressor p53 and abrogates cell cycle checkpoints.

43 ncluding the onset of bulk transcription and cell-cycle checkpoints.

44 response to DNA damage and is essential for cell-cycle checkpoints.

45 nment, as well as an amplification of G(1)/S cell-cycle checkpoints.

46 tors that normally coordinate DNA repair and cell-cycle checkpoints.

47 pt and irreversible nature of three specific cell-cycle checkpoints.

48 ponse and, in particular, intra-S and G(2)/M cell-cycle checkpoints.

49 nonical regulatory mechanisms that establish cell-cycle checkpoints.

50 s illegitimate joining of DSBs and activates cell-cycle checkpoints.

51 y M. oryzae requires two independent S-phase cell-cycle checkpoints.

52 lar oncogenes need to circumvent DDR-induced cell-cycle checkpoints.

53 protein involved in DNA repair pathways and cell-cycle checkpoints.

54 These include altered cell cycle checkpoints, aberrations of the centrosome, a

55 it a hypersensitivity to ionizing radiation, cell cycle checkpoint abnormalities, and impaired end-jo

56 tify strong synergistic interactions between cell-cycle checkpoint-abrogating Chk1- and MK2 inhibitor

57 The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent a

58 Activation of ATM/ATR triggers cell cycle checkpoint activation and adaptive responses

59 e same DNA damage response pathway to effect cell cycle checkpoint activation and apoptosis.

60 horylation, induced PARP cleavage, abrogated cell cycle checkpoint activation and attenuated the form

61 Hus1-Rad1 complex is known to participate in cell cycle checkpoint activation and DNA repair.

62 Arrest results from cell cycle checkpoint activation due to persistent signa

63 provide an example of how the transition to cell cycle checkpoint activation during development is a

64 umerous substrates important for DNA repair, cell cycle checkpoint activation, and apoptosis.

65 rivaled by marked activation of DNA damage, cell cycle checkpoint activation, and mitotic catastroph

66 tranded DNA and may determine telomere size, cell cycle checkpoint activation, and, ultimately, tempe

67 during DNA damage response and ATM-dependent cell cycle checkpoint activation.

68 rous substrates implicated in DNA repair and cell cycle checkpoint activation.

69 homologous recombination and damage-induced cell cycle checkpoint activation.

70 on of Mcm10 leads to chromosome breakage and cell cycle checkpoint activation.

71 trol ultimately causes extensive DNA damage, cell-cycle checkpoint activation and cell death whereas

72 Consequently, GSCs exhibit rapid G2-M cell-cycle checkpoint activation and enhanced DNA repair

73 WAC-dependent transcription is important for cell-cycle checkpoint activation in response to genotoxi

74 ular functions, including DNA damage repair, cell-cycle checkpoint activation, gene transcriptional r

75 The 9-1-1 complex facilitates cell cycle checkpoint activity and coordinates this acti

76 reduces IR-induced apoptosis by influencing cell-cycle checkpoint activity, potentially allowing for

77 ion has been shown to trigger a rapid G(2)/M cell cycle checkpoint after DNA damage stress and a spin

78 broblasts demonstrated a defective G(0)/G(1) cell cycle checkpoint after gamma-irradiation.

79 nonhomologous end-joining and regulation of cell-cycle checkpoints after DNA damage.

80 It partially abolished the G2 cell cycle checkpoint and caused DNA replication stress

81 AKT, activation of the p53 tumor suppressor cell cycle checkpoint and cell death.

82 ologous recombination DNA repair and Chk1 in cell cycle checkpoint and DNA repair, creating opportuni

83 E7 abrogates the G1 cell cycle checkpoint and induces genomic instability, b

84 g that ATM mediates the effect of miR-421 on cell cycle checkpoint and radiosensitivity.

85 These events are required for cell cycle checkpoint and repair responses to ionizing r

86 ry syndrome that implicates dysregulation of cell cycle checkpoint and T cell signaling.

87 d enrichment of DNA replication, cell cycle, cell cycle checkpoint and TNF pathways in selinexor trea

88 BRCA1 E3 ligase activity regulates the G2/M cell cycle checkpoint and, thus, contributes to maintena

89 BRCA1 E3 ligase activity regulates the G2/M cell cycle checkpoint and, thus, contributes to maintena

90 The mammalian MMR proteins also activate cell cycle checkpoints and apoptosis in response to pers

91 d in the regulation of the G(1)-S and G(2)-M cell cycle checkpoints and death receptor/apoptosis sign

92 /2-bound genes involved in the regulation of cell cycle checkpoints and DNA damage response.

93 karyotic genomic integrity is safeguarded by cell cycle checkpoints and DNA repair pathways, collecti

94 hat sense stalled replication forks activate cell cycle checkpoints and DNA repair processes, which m

95 Their study has merged with that of cell cycle checkpoints and DNA repair, and common fragil

96 osphorylate downstream targets important for cell cycle checkpoints and DNA repair.

97 RAD9 participates in DNA damage-induced cell cycle checkpoints and DNA repair.

98 pathway that regulates cell cycle arrest at cell cycle checkpoints and facilitates the repair of dsD

99 1 (Chk1) is an essential kinase required for cell cycle checkpoints and for coordination of DNA synth

100 polyomaviruses in primary cells with intact cell cycle checkpoints and how the activation might be l

101 CML progenitors demonstrated active cell cycle checkpoints and increased nonhomologous end j

102 le regulators, bypasses the need for S-phase cell cycle checkpoints and predisposes to genomic instab

103 , and to determine if nuclear Crk II affects cell cycle checkpoints and promotes apoptosis.

104 intenance of genomic integrity by activating cell cycle checkpoints and promoting repair of DNA doubl

105 ibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient canc

106 hibitor Pif1 resulted in the inactivation of cell cycle checkpoints and the subsequent rescue of temp

107 responses to DNA damage caused by defective cell cycle checkpoints and/or DNA repair.

108 ioresistance and that combined inhibition of cell-cycle checkpoint and DNA repair targets provides th

109 ivities results in inefficient p53-dependent cell-cycle checkpoint and exit responses.

110 bed as a tumor suppressor with proapoptotic, cell-cycle checkpoint and mitotic functions.

111 tivation of signal transducers that regulate cell-cycle checkpoints and cell survival.

112 ptional programs known primarily to regulate cell-cycle checkpoints and cell survival.

113 ine protein kinase, is centrally involved in cell-cycle checkpoints and cellular response to DNA dama

114 multiple pathways, including DDR signaling, cell-cycle checkpoints and damage repair, ESC differenti

115 ATM activates multiple cell-cycle checkpoints and DNA repair after DNA damage,

116 concepts emerged around kinases involved in cell-cycle checkpoints and DNA-damage repair.

117 eregulated cell-cycle progression, bypass of cell-cycle checkpoints and genome instability.

118 ATR is a key regulator of cell-cycle checkpoints and homologous recombination (HR)

119 rolling cell proliferation processes such as cell-cycle checkpoints and inducing apoptosis.

120 at orchestrate chromatin structural changes, cell-cycle checkpoints and multiple enzymatic activities

121 suppression at the cross-roads of apoptosis, cell cycle checkpoint, and NF-kappaB pathways.

122 age, propagate injury DNA messages, regulate cell cycle checkpoints, and alter the microenvironment.

123 signaling kinase that regulates DNA repair, cell cycle checkpoints, and apoptosis.

124 of genes involved in the apoptotic response, cell cycle checkpoints, and cellular metabolism.

125 d cellular gene expression, activates G(2)-M cell cycle checkpoints, and is essential for viral sprea

126 yc) expression alters DNA repair mechanisms, cell cycle checkpoints, and karyotypic stability, and th

127 n origin firing, replication-fork stability, cell-cycle checkpoints, and DNA repair.

128 enes, by leading to the induction of various cell cycle checkpoints, apoptosis or cellular senescence

129 excision repair (NER) and the ATR-dependent cell cycle checkpoint are the major pathways responsible

130 p53-dependent G(1) and G(2) cell cycle checkpoints are activated in response DNA dam

131 Cell cycle checkpoints are evolutionarily conserved sign

132 , is crisis, the state that cells reach when cell cycle checkpoints are impaired and cells can no lon

133 Cell cycle checkpoints are implemented to safeguard the

134 In p53-mutant tumors, cell cycle checkpoints are rewired, leading to dependenc

135 Cell-cycle checkpoints are essential for maintaining gen

136 ismatch repair (MMR) triggers prolonged G(2) cell cycle checkpoint arrest after alkylation damage fro

137 nal DNA mismatch repair (MMR) stimulate G(2) cell cycle checkpoint arrest and apoptosis in response t

138 omplexes of protein interactions that govern cell cycle checkpoint arrest and repair of the DNA lesio

139 However, recovery from cell cycle checkpoint arrest when the DSB is repaired by

140 they are highly reliant on the Chk1-mediated cell cycle checkpoint arrest, indicating that HR repair

141 has on DDR proteins and signals that enforce cell cycle checkpoint arrest.

142 gative feedback regulation of damage-induced cell-cycle checkpoint arrest.

143 cle progression, focusing on the G1 and G2/M cell cycle checkpoints, as well as on related essential

144 igger a characteristic 'VSG synthesis block' cell-cycle checkpoint, as some cells reinitiated S phase

145 es typically lead to progression through the cell-cycle checkpoints, as well as increased cell migrat

146 ion mutants, the latter of which affects the cell cycle checkpoint ATAXIA TELANGIECTASIA-MUTATED AND

147 her than erasing their signalling history at cell-cycle checkpoints before mitosis, mother cells tran

148 ability of ATR inhibition to abrogate the G2 cell cycle checkpoint both contributed to the synergisti

149 dl922-947 can override multiple cell cycle checkpoints but induces cell death by a non-a

150 s, replication inhibitors did not activate a cell cycle checkpoint, but they did activate a process t

151 s predominantly engaged in the regulation of cell cycle checkpoints by p21Cip1 and does not trigger a

152 ic expression of miR-421 resulted in S-phase cell cycle checkpoint changes and an increased sensitivi

153 ts with the hRad17 subunit of the hRad17-RFC cell cycle checkpoint clamp loader, and with each of the

154 2IP-deficient cells enforced a robust G(2)-M cell cycle checkpoint compared with control cells.

155 The Rad9-Rad1-Hus1 (9-1-1) cell cycle checkpoint complex plays a key role in the DN

156 f transcription, cell cycle lengthening, and cell cycle checkpoints comprise the midblastula transiti

157 n ligase activity and plays central roles in cell cycle checkpoint control and DNA repair.

158 r to MRL mice, providing a firm link between cell cycle checkpoint control and tissue regeneration.

159 f MK2 in inflammation, Hsp27 regulation, and cell cycle checkpoint control with a focus on brain path

160 le cellular functions such as DNA repair and cell cycle checkpoint control.

161 in the DNA damage response, participating in cell cycle checkpoint control.

162 he DNA damage response comprises DNA repair, cell-cycle checkpoint control, and DNA damage-induced ap

163 es BCL6-mediated repression of p53 and other cell cycle checkpoint-control genes.

164 s of p53 function is well known to influence cell cycle checkpoint controls and apoptosis.

165 and conveys that information to the parasite cell cycle checkpoint controls.

166 n of ATM function resulted in characteristic cell cycle checkpoint defects.

167 copy BRCA1 loss in centrosome amplification, cell-cycle checkpoint defects, DNA damage and genomic in

168 ancer predisposition, radiation sensitivity, cell-cycle checkpoint defects, immunodeficiency, and gon

169 but not all, of the proteins contributing to cell cycle checkpoint deficiencies in RA T cells, via a

170 nation of multiple cellular events including cell cycle checkpoint, DNA repair, transcription, and ap

171 1 may affect chemosensitivity by controlling cell cycle checkpoints, DNA repair, and genomic stabilit

172 ys that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitinati

173 with increased genetic load, which included cell-cycle checkpoints, DNA damage and apoptosis.

174 The DNA damage response triggers cell-cycle checkpoints, DNA repair and apoptosis using m

175 modifiers as molecular switches to regulate cell-cycle checkpoints, DNA repair, cellular senescence,

176 ing to apoptotic resistance and induction of cell cycle checkpoint/DNA repair.

177 YC2 in controlling a G1-to-S light-dependent cell cycle checkpoint, dsCYC2 silencing decreases the ra

178 Cell cycle checkpoints ensure genome integrity and are f

179 Cell cycle checkpoints ensure that proliferation occurs

180 ant, als3-1, resulted in identification of a cell cycle checkpoint factor, ALUMINUM TOLERANT2 (ALT2),

181 CKOalpha mice displayed keratinocyte cell cycle checkpoint failure in vivo in response to UVB

182 rexpress oncogenes that specifically perturb cell-cycle checkpoints (for example, E7 from human papil

183 ATR-deficient CGNPs had impaired cell cycle checkpoint function and continued to prolifer

184 Thus, we hypothesize that ATM performs a cell cycle checkpoint function to protect post-mitotic n

185 ir that is mechanistically distinct from its cell cycle checkpoint function.

186 NA repair, tumor suppression, apoptosis, and cell cycle checkpoint function.

187 -TA strains are not completely deficient for cell-cycle checkpoint functions, indicating that the mut

188 molecular level, NONO bound to the p16-Ink4A cell cycle checkpoint gene and potentiated its circadian

189 s from this mouse pointed to the role of the cell cycle checkpoint gene CDKN1a, or p21(cip1/waf1).

190 Targeted disruption of the mouse Hus1 cell cycle checkpoint gene results in embryonic lethalit

191 Mutations in grp, a cell cycle checkpoint gene, and puc, a negative regulato

192 ilar to the loss-of-function mutants for the cell cycle checkpoint genes ATAXIA TELANGIECTASIA AND RA

193 provides additional insight into the role of cell-cycle checkpoint genes in neurodevelopmental disord

194 ive signals, based in part on derangement of cell cycle checkpoints governed by cilia and centrosomes

195 gene and protein expression that reestablish cell cycle checkpoints, halt protein translation, and pr

196 Overriding cell cycle checkpoint in combination with the inhibition

197 the apical protein kinase that initiates the cell cycle checkpoint in response to DNA damage and repl

198 e part of a signaling cascade that induces a cell cycle checkpoint in response to ROS-induced DNA dam

199 d Skp2 expression may overcome p53-dependent cell cycle checkpoints in melanoma cells and highlight S

200 tive in appropriate downstream signaling and cell cycle checkpoints in response to DNA damage.

201 in phosphatase 2C (PP2C) family and controls cell cycle checkpoints in response to DNA damage.

202 on of G arrest by p18 bypasses a homeostatic cell-cycle checkpoint in iPCs for PC differentiation.

203 s, mechanisms that attenuate DDR and disrupt cell-cycle checkpoints in sporadic cancers are not well

204 ng to the target gene or by maintenance of a cell cycle checkpoint induced by the MSSO itself.

205 ion of HPV1 E4 in cells is known to activate cell cycle checkpoints, inhibiting G(2)-to-M transition

206 trial, by itself and in combination with the cell-cycle checkpoint inhibitor AZD7762.

207 our findings show a rationale for combining cell-cycle checkpoint inhibitors with the novel non-CPT

208 ive regulator of p53 stability when the G(1) cell cycle checkpoint is activated and provides an expla

209 ponse to UV irradiation, suggesting that the cell cycle checkpoint is intact in these cells.

210 The G(2)/M cell cycle checkpoint is regulated by a multitude of sig

211 Understanding the regulatory principles of cell cycle checkpoints is important because loss of chec

212 ransition but their role in regulating other cell cycle checkpoints is incompletely defined.

213 cytotoxicity when depleted, with loss of the cell cycle checkpoint kinase 1 (CHK1/CHEK1) being the mo

214 enes identified 23 candidates, including the cell cycle checkpoint kinase ATM.

215 The cell cycle checkpoint kinase ATR is required for the eff

216 Particularly CHEK1, which encodes for the cell cycle checkpoint kinase CHK1, is significantly over

217 trate that phosphorylation at Thr-288 by the cell cycle checkpoint kinase CHK2 is involved in this pr

218 The cell cycle checkpoint kinase Chk2 was activated by H(2)O

219 P-1, Ser-473, which is phosphorylated by the cell cycle checkpoint kinase Chk2.

220 CRAF pS338 recruits CHK2, a cell cycle checkpoint kinase involved in DNA repair, and

221 The Wee1 cell cycle checkpoint kinase prevents premature mitotic

222 The cell cycle checkpoint kinase, Chk2, was only weakly phos

223 ed DNA, and the ATR targets RPA2 and Chk1, a cell cycle checkpoint kinase, were not phosphorylated.

224 ficacy evoked by targeting the overexpressed cell-cycle checkpoint kinase CHK1 in SCLC.

225 Combining cell-cycle checkpoint kinase inhibitors with the DNA-dam

226 ayor players in the DNA damage response: the cell cycle checkpoint kinases ATR and ATM.

227 matin alterations recruit the DNA repair and cell cycle checkpoint machinery to restore genome integr

228 of PKCdelta in the DNA damage-induced G(2)/M cell cycle checkpoint may be a critical component of its

229 nding of how DHL-7 cells abrogate the G(2)-M cell cycle checkpoint may help identify targets to incre

230 These results suggest that a p53-dependent cell cycle checkpoint monitors changes of cellular NS le

231 atory cytokine mRNA decay, AUF1 destabilizes cell-cycle checkpoint mRNAs, preventing cellular senesce

232 ordinate cell-signaling pathways involved in cell-cycle checkpoints, nuclear localization, gene trans

233 umerous tumor cell lines by inducing the ATM cell cycle checkpoint pathway.

234 which show an induction of the p53-dependent cell cycle checkpoint pathway.

235 ed response including several DNA repair and cell cycle checkpoint pathways is activated to ensure fa

236 damage response, including highly conserved cell cycle checkpoint pathways that prevent cells with D

237 tenance mechanisms, involving DNA repair and cell-cycle checkpoint pathways, initiate genetic instabi

238 ar homeostasis in addition to DNA repair and cell-cycle checkpoint pathways.

239 ation and coordinates diverse DNA repair and cell-cycle checkpoint pathways.

240 is heterogeneity may reflect a relaxation of cell cycle checkpoints, possibly increasing the ability

241 implicate a novel mechanism by which loss of cell cycle checkpoints promotes BRCA1-associated tumorig

242 igh expression levels of both mutant p53 and cell cycle checkpoint protein p21, but not the apoptotic

243 The cell cycle checkpoint protein Rad9-Rad1-Hus1 (the 9-1-1

244 In addition, deletion of Ku80 along with the cell cycle checkpoint protein, p53, dramatically increas

245 A damage due to downregulated 14-3-3sigma, a cell cycle checkpoint protein.

246 stabilizes quadruplex mRNA that encodes the cell-cycle checkpoint protein kinase Aurora A to a great

247 ntified CDK2-interacting protein (CINP) as a cell-cycle checkpoint protein.

248 vealed that pathways involved in cell cycle, cell cycle checkpoints, protein-ubiquitination, and apop

249 nd BRCT domain of the tandem BRCT repeats of cell cycle checkpoint proteins MDC1 (mediator of DNA dam

250 Because cell cycle checkpoint proteins stabilize the genome, the

251 gamma-H2AX stabilizes cell-cycle checkpoint proteins and DNA repair factors at

252 ermore, SpHst4 interacts with SpMyh1 and the cell cycle checkpoint Rad9-Rad1-Hus1 (9-1-1) complex.

253 esults in relaxed chromatin structure, rapid cell-cycle checkpoint recovery and enhanced survival aft

254 migration, differentiation and survival, and cell cycle checkpoint regulation via the ataxia telangie

255 To confirm the role of Ppp5 in cell cycle checkpoint regulation, we generated Ppp5-defi

256 Inhibition of ATM had dual effects on cell-cycle checkpoint regulation and DNA repair that wer

257 The WEE1 kinase is an essential cell cycle checkpoint regulator in Arabidopsis thaliana

258 CHEK2 is a cell cycle checkpoint regulator, and the CHEK2*1100delC

259 f numerous proteins, including helicases and cell cycle checkpoint regulators.

260 Moreover, RAs control the expression of cell-cycle checkpoint regulators such as p27(Kip1), p57(

261 sults in an almost complete loss of a G(2)-M cell cycle checkpoint response induced by 6-TG.

262 Activation of a cell cycle checkpoint response was evidenced by autophos

263 acts with CHK1, a key effector kinase in the cell cycle checkpoint response, and regulates its phosph

264 ting of CycG2 attenuates doxorubicin-induced cell cycle checkpoint responses in multiple cell lines.

265 chromosome stability and in the induction of cell cycle checkpoint responses.

266 A damage and a failure to efficiently invoke cell-cycle checkpoint responses.

267 ed through into mitosis because of defective cell cycle checkpoints, resulting in cell death by mitot

268 ation (IR)-induced DNA damage, activation of cell cycle checkpoints results in cell cycle arrest, all

269 Cell-cycle checkpoints safeguard cells from such catastr

270 generate regions of ssDNA that then trigger cell cycle checkpoint signaling and DSB repair by homolo

271 pon which to build additional aspects of the cell cycle checkpoint signaling network, including those

272 RCT) domains, present in many DNA repair and cell cycle checkpoint signaling proteins, are phosphopro

273 e essential for telomere length maintenance, cell cycle checkpoint signaling, meiotic recombination,

274 Thus targeting DNA replication and G2-M cell cycle checkpoint simultaneously by cisplatin and WE

275 aled that rtel1 mutant plants show activated cell cycle checkpoints, specific sensitivity to DNA cros

276 egulates cellulose production independent of cell cycle checkpoint systems that are controlled by div

277 ain reaction was used to identify changes in cell cycle checkpoint target genes.

278 utive activation of pathways converging on a cell cycle checkpoint that acts as the major rate-limiti

279 f miR-221 and miR-222 is tightly linked to a cell cycle checkpoint that ensures cell survival by coor

280 her increase in E2F7, which induces a second cell cycle checkpoint that prevents unconstrained cell d

281 ion could predict the efficacy of DNA damage cell cycle checkpoints that arrest growth and suppress g

282 th the diminished ability of p53 to regulate cell cycle checkpoints that ultimately leads to transfor

283 DRP-1-mediated mitotic fission is a cell-cycle checkpoint that can be therapeutically target

284 plays a well-characterized role in the major cell-cycle checkpoint that regulates chromosome segregat

285 oliferation and may also compromise multiple cell-cycle checkpoints that maintain genomic integrity,

286 ich mediates relaxation of the intra-S phase cell-cycle checkpoint; this facilitates viral oncogene-d

287 Active p38 MAP kinase promotes a G2/M cell cycle checkpoint through the phosphorylation and ac

288 inase (MK2) and simultaneously controls both cell cycle checkpoints through distinct target mRNAs, bu

289 to simultaneously control the G1/S and G2/M cell cycle checkpoints through transcriptional induction

290 ge checkpoint control, particularly the G(1) cell cycle checkpoint, thus revealing protein ubiquityla

291 ty of Cre-LoxP conditional disruption of the cell cycle checkpoint tumor-suppressor genes Trp53 and R

292 We showed here that E7 abrogated the G1 cell cycle checkpoint under hypoxia and analyzed key cel

293 Abrogation of these cell-cycle checkpoints using Chk1 inhibitors results in

294 ure of MYH activity is its coordination with cell cycle checkpoint via interaction with the Rad9-Rad1

295 s, where it functions in repair and triggers cell-cycle checkpoints via activation of the ataxia-tela

296 53 (via inhibition of MDM2) or impairment of cell cycle checkpoints (via inhibition of CHK1/2 or WEE1

297 ons in the proteins that regulate the G(1)-S cell cycle checkpoint, we exposed non-neoplastic Barrett

298 lung cancer cells displayed a defective G1/S cell cycle checkpoint, were unable to resolve DNA damage

299 Perturbed DNA replication either activates a cell cycle checkpoint, which halts DNA replication, or d

300 Cyclin-dependent kinases (CDKs) coordinate cell cycle checkpoints with DNA repair mechanisms that t