ライフサイエンスコーパス: cell cycle control

1 ruptive effect of the E2F-ETS interaction on cell cycle control.

2 in-associated transcriptional regulation and cell cycle control.

3 r the Golgi as a ubiquitylation platform for cell cycle control.

4 d exhibited downstream effects distinct from cell cycle control.

5 mmalian tissues such as immune responses and cell cycle control.

6 a candidate oncogene involved in Rb-mediated cell cycle control.

7 ffecting a link between hypoxia pathways and cell cycle control.

8 ular proteins in genomic DNA replication and cell cycle control.

9 rucial roles in transcription modulation and cell cycle control.

10 tic stimulus, steroid metabolic process, and cell cycle control.

11 and can be dissociated from its function in cell cycle control.

12 s with a fundamental requirement for precise cell cycle control.

13 through regulation of targets distinct from cell cycle control.

14 t plays pivotal roles in gene regulation and cell cycle control.

15 s in the cellular response to DNA damage and cell cycle control.

16 n the beta-cell has no discernible effect on cell cycle control.

17 arding miRNA function and their influence on cell cycle control.

18 n, suggesting an obligatory role for TRF1 in cell cycle control.

19 sistance to oxidative stress, DNA repair and cell cycle control.

20 is a disease that results from inappropriate cell cycle control.

21 th a parallel redundancy in their effects on cell cycle control.

22 some biogenesis, chromosome segregation, and cell cycle control.

23 stigated whether this enzyme plays a role in cell cycle control.

24 dence linking nucleocytoplasmic transport to cell cycle control.

25 lular signaling, DNA topological change, and cell cycle control.

26 and repair, transcriptional regulation, and cell cycle control.

27 events and are involved in several facets of cell cycle control.

28 atase, these proteins are likely involved in cell cycle control.

29 s that have previously not been connected to cell cycle control.

30 e-TCR and IL-7 signaling with DNA damage and cell cycle control.

31 n ligase APC/C-Cdh1 is central to eukaryotic cell cycle control.

32 which have not previously been connected to cell cycle control.

33 elf-renewal is intrinsically associated with cell cycle control.

34 Xenopus laevis oocytes, suggesting a role in cell cycle control.

35 deubiquitylase USP11, which is itself under cell cycle control.

36 ell-supported consensus model for eukaryotic cell cycle control.

37 ddition to their well-characterized roles in cell cycle control.

38 gi reassembly, transcription activation, and cell cycle control.

39 CycC, the cognate cyclin partner of Cdk8, in cell cycle control.

40 moting acetylation, leading to disruption of cell cycle control.

41 likely to apply to signaling pathways beyond cell-cycle control.

42 res c-Kit, notch signaling, and p27-mediated cell-cycle control.

43 al molecular link between oxygen sensing and cell-cycle control.

44 aberrations, rather than simply by affecting cell-cycle control.

45 erium Caulobacter crescentus, a paradigm for cell-cycle control.

46 d in brain and involved in DNA synthesis and cell-cycle control.

47 cluding inflammation, immune regulation, and cell-cycle control.

48 umulation of DNA damage secondary to loss of cell-cycle control.

49 upon parasite virulence, differentiation and cell-cycle control.

50 sponse and are likely to be also involved in cell-cycle control.

51 or CHD4 in the DNA-damage response (DDR) and cell-cycle control.

52 or the structure and evolution of eukaryotic cell-cycle control.

53 o mechanisms of epithelial cell polarity and cell-cycle control.

54 pecificity and efficiency required for tight cell-cycle control.

55 A replication increase the robustness of the cell-cycle control.

56 progression mechanism driven by failures in cell-cycle control.

57 op a systems-level perspective of eukaryotic cell cycle controls.

58 to-S transition, and this process is tightly cell cycle controlled.

59 n conjunction with additional alterations of cell cycle control, a situation that might be reminiscen

60 The major cell cycle control acting at the G2 to mitosis transitio

61 es suggest that JNKs may also play a role in cell cycle control, although the underlying mechanisms a

62 s preliminary analysis, 12 genes involved in cell cycle control and 9 genes involved in apoptosis wer

63 n revealed upregulated genes associated with cell cycle control and activation of the Wingless and in

64 ulator of transcription networks that govern cell cycle control and apoptosis throughout development.

65 act as a transcription factor affecting both cell cycle control and apoptosis, and we have previously

66 SMC phenotype in vitro, linked to changes in cell cycle control and bone morphogenic protein receptor

67 t a passive marker, but actively changed the cell cycle control and cell death process motifs of T ce

68 Network analysis of these data revealed that cell cycle control and cell death were the most altered

69 ates the transformation process by impairing cell cycle control and cellular response to DNA damage.

70 at Skp2, an E3 ubiquitin ligase that affects cell cycle control and death, plays a critical role in t

71 ily of pocket proteins play central roles in cell cycle control and development, and the regulatory n

72 ion showed upregulation of genes involved in cell cycle control and development.

73 subfamily, which are known to be involved in cell cycle control and DNA repair, among other functions

74 cellular processes such as gene activation, cell cycle control and DNA repair.

75 tional strategies for metabolic programming, cell cycle control and functional polarization following

76 o up-regulation of several genes involved in cell cycle control and genes in the Foxo family.

77 ts of all metazoan body plans, and comprises cell cycle control and growth, development, somatic- and

78 stigated the coordinate impact of RB-loss on cell cycle control and immune function in the liver.

79 errant miR expression results in deregulated cell cycle control and impaired apoptotic responses, and

80 recise regulation of the ATF4 dosage impacts cell cycle control and impinges on neurogenesis.

81 a demonstrate a novel function of APC beyond cell cycle control and implicate critical role of ubiqui

82 factors involved in histone methylation and cell cycle control and include Ash2L, RbBP5, WDR5, HCF-1

83 -CDK6 conjugation constitutes a mechanism of cell cycle control and inhibition of this SUMOylation pa

84 odes a transcriptional regulator involved in cell cycle control and mother-daughter cell separation.

85 genesis by regulating genes involved in both cell cycle control and neuronal differentiation.

86 ble for regulation of many genes involved in cell cycle control and proliferation, and it has recentl

87 regulation via miRNAs-confers robustness to cell cycle control and provides a molecular basis to und

88 inhibitors, which play critical roles in the cell cycle control and regulation of cell transcription.

89 o human, pescadillo homologs are involved in cell cycle control and ribosome biogenesis, and are esse

90 en the hypothesis that BRCA1 plays a role in cell cycle control and show that BRCA1 is a marker of cl

91 tes the expression of many genes involved in cell cycle control and that a mutation which disrupts th

92 HV genes regulated by CTCF-cohesin are under cell cycle control and that mutation of the CTCF binding

93 We propose that the p63 C-terminus links cell cycle control and the proliferative potential of ep

94 ons related to inflammation, haematopoiesis, cell cycle control and tumour susceptibility.

95 SciP is cell cycle-controlled and co-conserved with the global c

96 dely studied as they are integral players in cell-cycle control and apoptosis.

97 etwork of cellular processes that integrates cell-cycle control and DNA repair or apoptosis, which se

98 osmotic, and other stimuli to mechanisms of cell-cycle control and epithelial cell polarity.

99 cellular processes including transcription, cell-cycle control and immune response.

100 oss of these hypoxia-driven lncRNAs impaired cell-cycle control and inhibited capillary formation.

101 ppression of DNA damage signaling is key for cell-cycle control and needed for normal development.

102 signaling and p27 expression, which restored cell-cycle control and rescued hemogenic endothelial cel

103 pression analysis revealed downregulation of cell-cycle control and survival pathways and upregulatio

104 portance of pRB's LxCxE-interacting motif in cell-cycle control and tumor suppression, we generated m

105 solved how HPV-infected keratinocytes escape cell-cycle control and whether their cross-talk with imm

106 ression of a cdc12p fragment bypasses normal cell-cycle controls and induces contractile ring assembl

107 tor tyrosine kinase signalling pathways, and cell cycle control) and emerging (for example, histone,

108 tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase

109 functions including centrosomal duplication, cell cycle control, and apoptosis.

110 molecules that play key roles in metastasis, cell cycle control, and apoptosis.

111 ha were associated with cancer pathogenesis, cell cycle control, and cell proliferation.

112 the AR to maintain AR activity, AR-dependent cell cycle control, and continued cell proliferation.

113 ss, impaired checkpoint signaling, defective cell cycle control, and genomic instability, which was r

114 with enhanced expression of DNA replication, cell cycle control, and liver-specific genes, indicating

115 at are involved in pigmentation, DNA repair, cell cycle control, and melanocyte proliferation pathway

116 4L, we characterized B cell differentiation, cell cycle control, and mitotic gene expression in GON4L

117 in stress responses, development, apoptosis, cell cycle control, and neuronal function.

118 functions in ribosome biogenesis and export, cell cycle control, and response to stress stimuli.

119 transcription, translation, DNA replication, cell cycle control, and signal transduction, to name but

120 onal profiles of immune response, apoptosis, cell cycle control, and stress.

121 se results confirm that B-Myb is involved in cell cycle control, and that its dysregulation may contr

122 t-harvesting complexes, nitrogen metabolism, cell cycle control, and the circadian clock.

123 hat functions in transcriptional regulation, cell cycle control, and transformation.

124 ent of proteins involved in DNA replication, cell-cycle control, and DNA repair.

125 ssociated with pathways of Wnt signaling and cell-cycle control, and most were conserved between mous

126 ved in cell invasion, metastasis, apoptosis, cell-cycle control, and tumor-related angiogenesis.

127 pression could dysregulate the expression of cell cycle control- and metastasis-related molecules by

128 cellular pathways involved in DNA repair and cell cycle control are disrupted.

129 SCs, and how p53 activity contributes to HSC cell cycle control, are poorly understood.

130 tory proteins, leading to the loss of normal cell-cycle control, are a hallmark of many cancers, incl

131 determines its ability to bind DNA and exert cell cycle control as well as its subcellular localizati

132 The SPB component Cut12 is linked to cell cycle control, as dominant cut12.s11 mutations supp

133 y sub-dynamics that are essential for viable cell cycle control, as well as identifying the sub-dynam

134 between autophagy components, apoptosis and cell cycle control at different stages of autophagic ves

135 relationship between mitochondrial form and cell cycle control at the G(1)-S boundary.

136 d 87 deletions related to diverse aspects of cell cycle control based on GO annotations.

137 Current models of cell-cycle control, based on classic studies of fused ce

138 mphasize differences in the cytoskeleton and cell cycle control between two life cycle stages of the

139 Thus, the cell cycle-controlled breakdown and reassembly of the nu

140 of mitotic gene expression is a key issue in cell cycle control but is poorly understood in most orga

141 Resection is thus under cell cycle control, but additionally regulated by chroma

142 ssive functions of RB that are distinct from cell cycle control, but also demonstrate that the molecu

143 diated protein degradation is fundamental to cell cycle control, but the precise degradation order at

144 ally-derived SBF may have initially hijacked cell cycle control by activating transcription via the c

145 Thus, deregulation of p53-mediated cell cycle control by E1B-55K probably underlies sensiti

146 BCR-ABL is proposed to impair cell-cycle control by disabling p27, a tumor suppressor

147 onic fibroblasts, and osteoblasts shows that cell-cycle control by matrix stiffness is widely conserv

148 al regulator of the cell cycle, and abnormal cell-cycle control can lead to oncogenesis, aberrancies

149 y of mRNA transcribed from genes involved in cell-cycle control, cell proliferation, and apoptosis ha

150 B and p53 were revealed; their loss affected cell cycle control, checkpoint response, and genome stab

151 about similarities and differences in plant cell-cycle control, compared with this model.

152 sregulation of multiple genes that influence cell cycle control (cyclin b1 and p21), apoptosis (Bcl-2

153 Most knowledge on human beta-cell cycle control derives from immunoblots of whole hum

154 ys that underlie higher order events such as cell cycle control, development, innate immune response

155 rphase chromosome-LINC contacts constitute a cell-cycle control device linking nucleoplasmic and cyto

156 phosphorylates RAD50 and NBS1, important for cell cycle control, DNA repair and cell survival.

157 pates in multiple cellular functions such as cell cycle control, DNA repair and regulation of gene tr

158 r cellular growth and has been implicated in cell cycle control, DNA replication, and gene rearrangem

159 lved in sensitive cellular processes such as cell cycle control, DNA replication, control of gene exp

160 ctions as a transcription factor involved in cell-cycle control, DNA repair, apoptosis and cellular s

161 veral canonical signalling pathways, such as cell-cycle control, DNA-damage and -repair responses, p5

162 (Cdk5) contributes to neuronal migration and cell cycle control during embryogenesis, and to the diff

163 et cells, we examined the role of Neurog3 in cell cycle control during this process.

164 and provides insights into the importance of cell-cycle control during host-pathogen interactions.

165 In current models of mammalian cell cycle control, E2f activators (E2f1, E2f2, and E2f3

166 Transcripts involved in cell signaling, cell cycle control, energy production/metabolism, microt

167 Cell cycle controls ensure that DNA replication (S phase

168 complex structures and processes, including cell cycle control, flagella and basal bodies, ribosome

169 Diet also impacted immune regulation, cell cycle control/gene expression, cell motility, and v

170 Deletions of key B-cell differentiation and cell cycle control genes are highly prevalent but vary i

171 causes concerted upregulation of a cadre of cell cycle control genes, including those encoding cycli

172 ating the transcription of a large number of cell cycle-controlled genes.

173 Although genetic variations in cell-cycle control genes have been previously linked to

174 Cell-cycle control genes were inhibited after LA exposur

175 systematic evaluation of the association of cell-cycle control genes with endometrial cancer risk.

176 n in cancer cells results in a disruption of cell cycle control, genetic instability, enhanced cell m

177 thesis, which may contribute to its roles in cell cycle control, genomic maintenance, and tumor suppr

178 f p53 in cellular metabolism, apoptosis, and cell cycle control has led to increasing interest in def

179 The cell-cycle control has a cyclical genetic circuit compos

180 er G2-M transition, and its contributions to cell cycle control have been modeled based on studies us

181 se of the feedback-first motif in eukaryotic cell-cycle control, implemented by nonorthologous protei

182 levels in dDP-deficient fat bodies restores cell-cycle control, improves tissue morphology, and exte

183 gesting common mechanisms of miRNA-regulated cell cycle control in ES cells and cancers.

184 f caspase activity, cell differentiation and cell cycle control in non-type A patients.

185 dings in the context of broader knowledge of cell cycle control in normal and abnormal development.

186 way, which may be explored to restore proper cell cycle control in p53-deficient tumors via p21.

187 and important dimension to the robustness of cell cycle control in particular and to biological signa

188 rt, this reflects a lack of understanding of cell cycle control in the human beta-cell.

189 flowering time and suggest an involvement of cell cycle control in the timing of reproductive transit

190 ve imaging to assess mitotic progression and cell cycle control in these cells, yielding new insights

191 sential cell functions such as apoptosis and cell-cycle control in addition to their role as efficien

192 tinct governing principles for cell size and cell-cycle control in bacteria.

193 Although current textbook explanations of cell-cycle control in eukaryotes emphasize the periodic

194 formation, the role for SOX10 in maintaining cell-cycle control in melanocytes suggests a rational ne

195 We begin with an overview of cell-cycle control in the well-studied yeast and animal

196 n enforcing fate commitment over its role in cell-cycle control in this developmental context.

197 ese findings provide a global perspective on cell-cycle control in vivo, and they highlight a critica

198 ts closer and closer to a realistic model of cell-cycle control in yeast.

199 the tumor suppressor function of pRb during cell cycle control, in part by creating a better substra

200 nate vesicular trafficking, cytokinesis, and cell cycle control independent of GTPase-activating prot

201 Although cell cycle control is an ancient, conserved, and essenti

202 The importance of PINK1 for cell cycle control is further supported by results showi

203 l established, whereas their contribution to cell cycle control is only beginning to be understood.

204 Loss of cell cycle controls is a hallmark of cancer and has a we

205 Loss of cell-cycle control is a hallmark of human cancer.

206 Precise cell-cycle control is critical for plant development and

207 helial cell development and demonstrate that cell-cycle control is required for this process.

208 lysis of the digital circuit showed that the cell-cycle control is robust to intrinsic stochastic var

209 ch occurs in cancers as a result of aberrant cell cycle control, is sufficient to cause PCS and gross

210 ses various diseases associated with loss of cell cycle control, leading to uncontrolled cell prolife

211 ganization and mitotic progress by intricate cell cycle control machinery.

212 In addition, NVP-HSP990 disrupted cell-cycle control mechanism by decreasing CDK2 and CDK4

213 The spindle checkpoint is the prime cell-cycle control mechanism that ensures sister chromat

214 stemic perturbation for mutations within the cell cycle control mechanisms (G2 to mitosis transition)

215 Cell cycle control mechanisms are key in both the impair

216 Cell proliferation and cell cycle control mechanisms are thought to play centra

217 hins provide an excellent model for studying cell cycle control mechanisms governing DNA replication

218 we show this is the result of cooperation of cell cycle control mechanisms that limit E2F-CycE positi

219 eslin is a key positive-regulatory target of cell-cycle control mechanisms; activation of Treslin by

220 luding epigenetic regulation, DNA damage and cell cycle control, microRNA silencing, signal transduct

221 Significant alterations of genes involved in cell cycle control, mitotic checkpoints, and DNA repair

222 allows unbiased integration of the consensus cell cycle control model with innovations specific to th

223 reveals that almost all of the critical G1/S cell cycle control molecules are located in the cytoplas

224 icative of telomere dysfunction and abnormal cell-cycle control, namely dysregulated G1-to-S-phase tr

225 on of single isogenic cells reveals that the cell cycle control network of this bacterium generates a

226 eukaryotic cell divisions before the current cell-cycle control network evolved in all its complexity

227 during DNA licensing, with implications for cell cycle control of DNA replication and genome stabili

228 Our study establishes a mechanism for direct cell cycle control of ECM remodeling during cytokinesis.

229 actor P (HiNF-P; gene symbol Hinfp) mediates cell cycle control of histone H4 gene expression to supp

230 Interestingly, cell cycle control of IPCs by Sox2-mediated expression o

231 during latency and that failure to maintain cell cycle control of latent transcripts inhibits host c

232 kinase 2 (CDK2) is a known regulator in the cell cycle control of the G1/S and S/G2 transitions.

233 We infer that cell cycle control of the V(D)J recombinase limits the p

234 plex plays a critical role in regulating the cell cycle control of viral gene expression during laten

235 These results reveal that cell-cycle control of apical nuclear migration occurs by

236 y the two key targets sufficient to maintain cell-cycle control of CENP-A assembly.

237 gs therefore provide a mechanistic basis for cell-cycle control of DSB repair and highlight the impor

238 Here we establish that cell-cycle control of DSB resection in Saccharomyces cer

239 The mechanisms responsible for cell-cycle control of this behavior are unknown.

240 ole of ATM and its downstream targets in the cell-cycle control of V(D)J recombination in vivo.

241 ired for hemogenic specification, as well as cell-cycle control, of endothelium during embryogenesis.

242 n of genes associated with proliferation and cell cycle control only in the acute liver-specific Hnf4

243 erogeneity represents distinct mechanisms of cell-cycle control or whether a common mechanism can acc

244 ns involved in replication licensing (CDT1), cell cycle control (p21), and chromatin modification (SE

245 y altered gene and protein expression in key cell cycle control pathways.

246 ced proliferative fitness and stably rewired cell cycle control pathways.

247 gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metfor

248 We propose a cell-cycle control principle based on natural variation,

249 In the quantitative model of cell-cycle control, progression from G1 through S phase

250 s been solidly implicated in disturbances of cell cycle control, proliferation, and apoptosis.

251 Human papillomavirus disrupts normal cell-cycle control, promoting uncontrolled cell division

252 The dominant model for eukaryotic cell cycle control proposes that cell cycle progression

253 3' UTR, and inhibited cytokeratin 8 via the cell cycle control protein cyclin D1.

254 phosphorylated Cx43 forms complexes with the cell cycle control proteins cyclin E and cyclin-dependen

255 ng pathway and down-regulates several G(2)-M cell cycle control proteins, resulting in enhanced G(2)-

256 itically involved in processes as diverse as cell cycle control, protooncogene expression, cellular d

257 actors (E2Fs) have a clearly defined role in cell cycle control, recent work has uncovered new functi

258 r the transcriptional regulation of multiple cell cycle control-related genes, including E2F-responsi

259 E2 and TopBP1 would allow E2 to bypass this cell cycle control, resulting in DNA replication more th

260 Targeted analysis of genes involved in cell cycle control revealed a marked increase in p21(WAF

261 p53-dependent cell cycle control, senescence, and apoptosis functions

262 ion of a variety of target genes involved in cell cycle control, senescence, and apoptosis in respons

263 rs that are involved in generic processes of cell-cycle control, signal transduction, and stress resp

264 enomena as diverse as circadian rhythmicity, cell cycle control, stress and damage responses, and ste

265 uiescent state include factors essential for cell cycle control, stress response and survival pathway

266 n translation, global transcription control, cell-cycle control, stress response, DNA topology, DNA r

267 enes participate in chromatin regulation and cell cycle control, supporting the concept that the esta

268 The proteins of the Caulobacter cell cycle control system and its internal organization

269 The Caulobacter cell cycle control system has been exquisitely optimized

270 is an important component of the eukaryotic cell cycle control system.

271 We report a hybrid simulation of the coupled cell-cycle control system, including asymmetric cell div

272 key regulatory pathways involved, including cell cycle control, Tgf-beta signaling, Pten/Akt signali

273 E2F axis is an important pathway involved in cell-cycle control that is deregulated in a number of ca

274 downstream effector of the Hippo pathway of cell-cycle control that plays important roles in tumorig

275 port the reciprocal relationship-that of the cell cycle controlling the miR-16 family.

276 Here we report that the cell cycle controls the interaction of BRCA1 with PALB2-

277 Despite the well established role of RB in cell cycle control, the deletion of RB had no impact on

278 In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) func

279 n structure of a key regulatory interface in cell-cycle control: the destruction box sequence bound t

280 Re-establishing cell cycle control through cyclin-dependent kinase (CDK)

281 s regulating diverse cellular processes from cell cycle control to developmental fate, deregulation o

282 AMPK integrates growth factor signaling with cell cycle control to regulate brain development.

283 The viral Vpr and Vpx proteins target cell cycle controls to counter innate immunity.

284 veal an alternative splicing network linking cell-cycle control to apoptosis.

285 proposed to link circadian transcription and cell-cycle control to tumorigenesis.

286 eir importance to critical functions such as cell cycle control, transcription, and translation, as w

287 es the evolutionarily conserved processes of cell cycle control, transcription, DNA replication and m

288 P1 and E2Fs, which result in the assembly of cell cycle-controlled transcriptional complexes.

289 functions of the BAF57 subunit of SWI/SNF in cell cycle control via transcriptional regulation of cel

290 The EYA1 phosphatase regulates cell-cycle control via transcriptional complex formation

291 A function for AP-2gamma in cell cycle control was verified using flow cytometry: AP

292 n keeping with its previous association with cell cycle control, we demonstrate that FOXM1 binds and

293 central role in the DNA damage response and cell cycle control, we directly tested the hypothesis th

294 Despite a potential role for Geminin in cell cycle control, we found no evidence of proliferatio

295 To explore the mechanisms and evolution of cell-cycle control, we analyzed the position and conserv

296 gulators, establishing a mechanistic link to cell cycle control which provides sustained mitotic acti

297 sistent with defects in proliferation and/or cell cycle control while accumulating higher levels of r

298 but the mechanisms coupling cell growth and cell cycle control with cell size regulation are poorly

299 let-7/miR-98 family play a critical role in cell cycle control with respect to differentiation and t

300 sh a link that intertwines the mechanisms of cell-cycle control with the mechanisms underlying the ac