ライフサイエンスコーパス: cell cycle gene

1 , whereas miR-294 suppresses, the phasing of cell cycle genes.

2 ctors to discriminate cell cycle against non-cell cycle genes.

3 ll cycle by controlling the transcription of cell cycle genes.

4 s characterized by the altered regulation of cell cycle genes.

5 BrdU uptake in vivo and actively transcribed cell cycle genes.

6 rm cells through translational regulation of cell cycle genes.

7 and does not govern expression of canonical cell cycle genes.

8 ing E2F1 binding to the promoters of various cell cycle genes.

9 ntiation and activation of pro-proliferative cell cycle genes.

10 tion, as well as E2F-dependent expression of cell cycle genes.

11 feration by coordinately regulating numerous cell cycle genes.

12 ption factors, reversing their repression of cell cycle genes.

13 ic coregulator complexes to the promoters of cell cycle genes.

14 l mechanism by which nuclear IRS-1 activates cell cycle genes.

15 sion presumably through the control of early cell cycle genes.

16 and represses transcription of E2F-regulated cell cycle genes.

17 modulating the periodic expression of early cell cycle genes.

18 of expression exhibited by these three G(1) cell cycle genes.

19 on of at least a subset of pro-proliferative cell cycle genes.

20 ation of PKC and modulation of cell survival/cell cycle genes.

21 ion and mitosis by stimulating expression of cell cycle genes.

22 eins required for transcription of essential cell cycle genes.

23 a direct role for brlA in the regulation of cell cycle genes.

24 tations in cyclin A, string (cdc25), and new cell cycle genes.

25 minant inhibitory effect on transcription of cell cycle genes.

26 into activator and repressor E2Fs, regulates cell cycle genes.

27 al network able to control the expression of cell cycle genes.

28 e full function of NF-Y in activation of the cell cycle genes.

29 in MYC binding to the promoters of selected cell cycle genes.

30 are underrepresented in both early and late cell cycle genes.

31 t role in transcriptional regulation of late cell cycle genes.

32 inger (ZF) transcriptional regulator of many cell cycle genes.

33 ents have several limitations in identifying cell cycle genes.

34 endent repression of important E2F-dependent cell-cycle genes.

35 sitory surge of pro-apoptotic components and cell-cycle genes.

36 lf-renewal, such as stem cell fate genes and cell-cycle genes.

37 ted to the expression of immune response and cell-cycle genes.

38 feration with concomitant modulation of some cell cycle genes, (2) augmented the NRF2-mediated antiox

39 ession pattern almost entirely consisting of cell cycle genes (5-year odds ratio of metastasis, 24.0;

40 B1-like) genes and the reduced expression of cell cycle genes also indicate bud dormancy in tin.

41 fter RNAi showed a significant enrichment of cell cycle genes among the genes down-regulated after MI

42 nhibitor CR8 after SCI significantly reduced cell cycle gene and protein expression, microglial activ

43 The relatively small number of cell cycle genes and growing molecular genetic toolkit p

44 e abnormalities, we observe dysregulation of cell cycle genes and increased apoptosis in neural crest

45 enhances the E2f-mediated transactivation of cell cycle genes and initiates the activation of low bin

46 hylase PHF8 transcriptionally regulates many cell cycle genes and is therefore predicted to play key

47 pression analysis reveals a dysregulation of cell cycle genes and markers of differentiation in the C

48 l pro-tumorigenic genetic programs including cell cycle genes and Myc-regulated genes before the indu

49 In addition, derepression of cell cycle genes and signalling via the cAMP-PKA pathway

50 oral expression of fliQ, ccrM, and other key cell cycle genes and ultimately the regulation of the ce

51 F2A or -D also resulted in the activation of cell-cycle genes and down-regulation of markers of termi

52 nalysis demonstrated that miR-34a suppresses cell-cycle genes and induces several neural-related gene

53 Furthermore, microarray analysis of cell-cycle genes and real-time reverse transcription-PCR

54 pression was associated with upregulation of cell-cycling genes and co-downregulation of genes implic

55 nd the cis- motif features are predictive of cell cycle genes, and a combination of the two types of

56 BR pathway, does not have a direct effect on cell cycle genes, and promoter analysis suggests a disti

57 H is required for the expression of multiple cell cycle genes, and the gene expression signature resu

58 ion and margins are associated with the late cell-cycle genes, and a metagene that represents the EGF

59 ed cell proliferation, altered expression of cell-cycle genes, and decreased amounts of nuclear, but

60 ave altered expression of a select number of cell-cycle genes, and we identified the mRNA of cyclin-d

61 Cell cycle genes are also activated during the initiatio

62 e sequencing has revealed many C. crescentus cell cycle genes are conserved in other Alphaproteobacte

63 Cell cycle genes are enriched for Celf1 binding sites su

64 R431C in anillin (ANLN), an F-actin binding cell cycle gene, as a cause of FSGS.

65 A limited set of core cell cycle genes associated with cell cycle reentry, lat

66 analysis of p53-dependent repression of the cell cycle genes B-MYB (MYBL2), BUB1, CCNA2, CCNB1, CHEK

67 opose a computational model to predict human cell cycle genes based on transcription factor (TF) bind

68 We identify CHR elements in most late cell cycle genes binding DREAM, MMB, or FOXM1-MuvB.

69 ough inhibition of neointimal hyperplasia by cell cycle gene blockade therapy results in improved end

70 RBR1 regulates not only cell cycle genes, but also, independent of the cell cycl

71 x controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly

72 -LIP releases E2F.Rb-dependent repression of cell cycle genes by a disruption of E2F1.Rb complexes an

73 WT1 proteins facilitate expression of these cell cycle genes by antagonizing transcriptional repress

74 hat Rb can actively repress transcription of cell cycle genes by binding and inactivating transcripti

75 lement in transcriptional regulation of late cell cycle genes by DREAM, MMB and FOXM1-MuvB.

76 keletal genes keratin-18 and beta-actin, the cell cycle gene C-MOS, and housekeeping genes GAPDH and

77 Subsequent to its activation, hundreds of cell-cycle genes can then be expressed, including the cy

78 pathways by up-regulating the expression of cell cycle genes cdc2, PRC1 and PCNA, and the transcript

79 The expression of cell cycle genes, cdc2, PRC1 and PCNA and one of transcr

80 gene Nkx 3.1, the AR coactivator ARA-70, and cell cycle genes Cdk1 and Cdk2 were androgen regulated i

81 , including WNT/beta-catenin alterations and cell-cycle-gene (CDK4 and CDK6) mutations.

82 by a constitutive downregulation of the key cell cycle gene CDKA;1.

83 hose expression was altered by GLI1 included cell cycle genes, cell adhesion genes, signal transducti

84 We find that cell cycle genes cluster into two major waves of express

85 es the detection of previously characterized cell-cycle genes compared to approaches that do not acco

86 d by AGN194,204 required PPARalpha including cell-cycle genes, consistent with AGN-induced hepatocyte

87 can also repress transcription of endogenous cell cycle genes containing E2F sites through recruitmen

88 ed cytokines and the downregulation of tumor cell-cycle genes correlated with NCR2 expression and gre

89 strate that FoxM1 regulates transcription of cell cycle genes critical for progression into S-phase a

90 ort on the transcriptional regulation of the cell cycle gene cyclin D2 by the IL-2R.

91 , the auxin transporter PIN-FORMED1, and the cell cycle genes CYCLIN A2;1 and PROLIFERATING CELL NUCL

92 Expression of NF-YA1 and the G2/M transition cell cycle genes Cyclin B and Cell Division Cycle2 was r

93 Expression levels of the cell cycle genes cyclin D1 and cyclin E1 as well as the

94 mma deregulates expression of STAT5-mediated cell-cycle genes cyclin D1 and p57.

95 The unique plant cell cycle gene, cyclin-dependent kinase B1;1 may have e

96 odulation of the beta-catenin/TCF responsive cell cycle genes, cyclin D1 and p21, we inhibited beta-c

97 dimerizing partner, DP1 and E2F-upregulated cell cycle genes (cyclins E, A, B and D3) and enhanced t

98 enhanced the expression of E2F-downregulated cell cycle genes (cyclins G(2) and I).

99 MOS1 and TCP15 both affect the expression of cell-cycle genes D-type CYCLIN 3;1 (CYCD3;1), which may

100 -phase TFs decreases expression of many late cell cycle genes, delays mitotic progression, and reduce

101 entification and characterization of a novel cell cycle gene, designated Speedy (Spy1).

102 olled in Total Therapy II, overexpression of cell cycle genes distinguished CA from no CA, especially

103 sing antisense oligodeoxynucleotides against cell cycle genes, double-stranded oligodeoxynucleotides

104 to promote a state of deepened repression at cell cycle genes during differentiation.

105 with loss of chromatin accessibility around cell cycle genes during postnatal maturation.

106 The DREAM complex represses cell cycle genes during quiescence through scaffolding M

107 proapototic (BMF, BIM), adrenergic (TH), and cell-cycle genes (e.g., CDC25A, CDK1).

108 iates the transcription of antiapoptotic and cell cycling genes, e.g., Bcl-x(L) and cyclin D1.

109 Applying this method to the cell-cycle gene Emi1, we find strong overall repression

110 rtaken a genome-wide characterization of the cell cycle genes encoded by Chlamydomonas reinhardtii, a

111 Our studies demonstrate that two other G(1) cell cycle genes, encoding cyclin D and CDK4/6, have sim

112 of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8,

113 transcription factor regulates expression of cell cycle genes essential for DNA replication and mitos

114 ident, Win, or MPP2) regulates expression of cell cycle genes essential for progression into DNA repl

115 progenitors on a defined niche coupled with cell cycle gene expression analysis.

116 tions, irrespective of type, associates with cell cycle gene expression and adverse outcome, whereas

117 lysine 14 (H3K14ac) and is required for key cell cycle gene expression and cancer cell proliferation

118 chanism for E2F factors in the regulation of cell cycle gene expression and cell cycle progression un

119 n recruiting B-Myb and FoxM1 to promote late cell cycle gene expression and in regulating cell cycle

120 ors required for DNA replication, while late cell cycle gene expression begins during G2 to prepare f

121 by clustering the yeast genes based on their cell cycle gene expression data and the human genes base

122 ranscription factor binding site (TFBS), and cell cycle gene expression data.

123 y, an application of our method to different cell cycle gene expression datasets suggests that our me

124 cell cycle gene expression and in regulating cell cycle gene expression from quiescence through mitos

125 with the importance of stromal response and cell cycle gene expression in colon tumor recurrence.

126 he effect of all-trans-retinoic acid (RA) on cell cycle gene expression in RA sensitive CA-OV3 and RA

127 lished an MLL-E2F axis in orchestrating core cell cycle gene expression including Cyclins.

128 Strict temporal control of cell cycle gene expression is essential for all eukaryot

129 Early cell cycle gene expression occurs during G1/S to generat

130 analysis was used to determine how the yeast cell cycle gene expression program is regulated by each

131 signaling on progenitor cell regulation and cell cycle gene expression, and loss of epithelial Pygo2

132 ative assay integrating stromal response and cell cycle gene expression, in tumor specimens from pati

133 F1R, appears to have an amplifying effect on cell cycle gene expression, thus providing a molecular e

134 plex remains bound to FoxM1 during peak late cell cycle gene expression, while B-Myb binding is lost

135 distinct transcription complexes to regulate cell cycle gene expression.

136 ons and leads to a dramatic dysregulation of cell cycle gene expression.

137 ellular and physiologic processes, including cell cycle, gene expression, cell viability, stress resp

138 sion patterns resulting from manipulation of cell-cycle gene expression alter the physiology of the o

139 can achieve sequence-specific inhibition of cell-cycle gene expression and DNA replication.

140 d alpha6(hi)beta1(hi)CD34(hi) CSCs differ in cell-cycle gene expression and proliferation characteris

141 s on two public datasets: the Stanford yeast cell-cycle gene expression data, and a gene expression d

142 We consider yeast cell-cycle gene expression data, and show that the propo

143 o determine whether the observed patterns in cell-cycle gene expression in Clock mutants resulted in

144 low-error-rate classification for both yeast cell-cycle gene expression profiles and Dictyostelium ce

145 roliferation, regulation of an E2F-dependent cell-cycle gene expression program, and estrogen-depende

146 f AIF-1 results in increased VSMC growth and cell-cycle gene expression.

147 n neuronal gene expression and a decrease in cell-cycle gene expression.

148 experiments on the Schizosaccharomyces pombe cell-cycle gene expression.

149 cellular architecture resulting from altered cell-cycle gene expression.

150 logy is illustrated by applying it to a HeLa cell-cycle gene-expression data.

151 Using the cell-cycle gene-expression profiles for Saccharomyces ce

152 to specific phases of the cell when studying cell-cycle gene expressions.

153 Although altered expression of cell-cycle genes frequently leads to altered organ growt

154 ession profiling studies suggested that core cell-cycle genes functioning during the G1/S, S, and G2/

155 ell cycle-dependent elements (CDEs), and one cell cycle gene homology region (CHR), typically found i

156 ical, Sp1-like, cell cycle-dependent element/cell cycle gene homology region, and p53-binding sites.

157 LIN54, which directs the complex to promoter cell cycle genes homology region (CHR) elements.

158 The cell cycle genes homology region (CHR) has been identifi

159 g motifs, FOXM1 binding is directed via CHR (cell cycle genes homology region) elements.

160 ified CDE-CHR (Cell cycle-Dependent Elements-Cell cycle genes Homology Region) region of cyclin A pro

161 uencing in mouse and rat OPCs, we identified cell cycle genes (i.e., Cdc2) and chromatin components (

162 Among the cell cycle genes identified as targets, the G1 cyclin D2

163 critical developmental regulatory genes and cell cycle genes in A.nidulans.

164 gulated expression of both developmental and cell cycle genes in A.nidulans.

165 ssociated with significant downregulation of cell cycle genes in both OE21 (P<0.0001) and OE33 (P=0.0

166 to improve the identification of the set of cell cycle genes in budding yeast and humans.

167 To explore the mechanism of repression of cell cycle genes in cervical carcinoma cells following E

168 n contrast, expression was lower in 40 of 44 cell cycle genes in eNOS-KO mice, in association with im

169 Finally, we showed that histone and cell cycle genes in general are exempt from Rtt109-depen

170 ost likely via transcriptional repression of cell cycle genes in response to stress.

171 and the transcriptional regulation of early cell cycle genes in Saccharomyces cerevisiae.

172 rofluidic device, we tracked the dynamics of cell cycle genes in single yeast with subminute exposure

173 the expression of several growth factors and cell cycle genes in the aromatase transgenic mammary gla

174 in transcript abundance of cell division and cell cycle genes in the drought-stressed ovary only.

175 y promoting and repressing the expression of cell cycle genes in the leaf mesophyll.

176 rough transcriptional regulation of specific cell-cycle genes in a cell-type- and developmental-stage

177 nt cells, AR selectively upregulates M-phase cell-cycle genes in androgen-independent cells, includin

178 at Lola represses neural stem cell genes and cell-cycle genes in postmitotic neurons.

179 In a screen for new cell-cycle genes in Schizosaccharomyces pombe we have is

180 ing genes, there was increased expression of cell cycle genes including an A-type cyclin and a subuni

181 ma cells in the levels of expression of many cell cycle genes including cyclin A, B and E, cdk 2,4 an

182 -195 regulates the expression of a number of cell cycle genes, including checkpoint kinase 1 (Chek1),

183 88 target the upstream regions especially of cell cycle genes, including cyclins, cyclin-dependent ki

184 nfection results in dysregulation of several cell cycle genes, including inhibition of cyclin A trans

185 amming in this setting activated a subset of cell-cycle genes, including CENPE, a centromere binding

186 ces and identified many negatively regulated cell-cycle genes, including Cyclins and Cdks.

187 ered expression of developmental factors and cell cycle genes is associated with a higher degree of e

188 The ability of Gata4 to transactivate cell cycle genes is impaired by Hopx/Hdac2-mediated deac

189 ivity, although expression of checkpoint and cell cycle genes is not greatly affected.

190 Expression of these late cell cycle genes is regulated by cyclin-dependent kinase

191 ndividual REST target ribosome biogenesis or cell cycle genes is sufficient to induce activation of Q

192 t increase and the expression of an array of cell cycle genes is virtually unchanged in Dp1-deficient

193 t while Chd8 stimulates the transcription of cell cycle genes, it also precludes the induction of neu

194 revealed downregulation of ion transport and cell cycle genes, leading to altered calcium handling an

195 arly G2 had increased RNA levels, while core cell cycle genes linked to early G1 and late G2 had redu

196 selectively regulating H3K9 demethylation at cell cycle gene loci, thereby representing a key player

197 D1 is essential for H3K9me2 demethylation at cell cycle gene loci.

198 LL1 epigenetic control over proproliferative cell cycle genes: MLL1 inhibition represses expression o

199 By coopting the E2f regulation of cell cycle genes, Multicilin drives massive centriole as

200 ne expression studies point to regulation of cell cycle genes, muscle myosins, NotchR and Wnt pathway

201 y number alterations in MYC/MYCN (n = 6) and cell cycle genes (n = 11).

202 he KEN box as a template, we have identified cell cycle genes Nek2 and B99 as additional Cdh1-APC sub

203 e release of E2F-mediated transrepression of cell cycle genes, not transactivation by E2F.

204 oot development through direct repression of cell cycle genes, particularly CYCD6;1.

205 is encoded within the promoter region of the cell cycle gene POLR3D in the antisense orientation.

206 ow broadly CMV alters the regulation of host cell cycle gene products and highlight the establishment

207 immortalized rat-1 fibroblasts by monitoring cell-cycle gene promoter-driven luciferase activity.

208 kdown, p107 compensated for p130 loss at all cell cycle gene promoters examined, allowing cells to re

209 r the DREAM complex finds that a set of core cell cycle genes regulated in both U2OS and HeLa cells a

210 quired for centriole biogenesis, while other cell cycle genes remain off.

211 FoxM1 activates expression of the cell cycle genes required for both S and M phase progres

212 is critical for regulating the expression of cell cycle genes required for hepatocyte proliferation.

213 DREAM, MMB and FOXM1-MuvB complexes to late cell cycle genes requires CHR elements.

214 Cell cycle genes responded similarly to Shh inactivation

215 hanges in alternative polyadenylation (APA), cell cycle genes showed mostly alternative splicing (AS)

216 gous neonatal hearts identified a network of cell cycle genes significantly up-regulated and down-reg

217 nd that, rapidly after BET displacement, key cell-cycle genes (SKP2, ERK1, and c-MYC) were downregula

218 d epigenetically regulates the expression of cell cycle genes such as CCND1, CCNA1, and WEE1.

219 inhibited the E2-induced expression of early cell cycle genes such as cyclins D1, D3, E1, E2, and B2.

220 ding p38 MAPK-regulated or ERK-1/2-regulated cell-cycle genes such as FOS, MAPK8, MYC, various cyclin

221 of the type-A ARRs and several meristem and cell cycle genes, such as CycD3.

222 n DPSCs was measured by BrdU immunoassay and cell-cycle gene SuperArray.

223 er many cells), some, but not all, canonical cell cycle genes tend to be co-expressed in groups in si

224 genes tested, but zero of six E2F-regulated cell cycle genes tested.

225 xpression of a distinct and larger subset of cell cycle genes than that observed in HPV(-) HNC.

226 right ventricle, and we identified numerous cell cycle genes that are dependent on Gata4 by microarr

227 n of transcriptional, signalling, growth and cell cycle genes that probably play a role in the atroph

228 patocyte proliferation through expression of cell cycle genes that stimulate cyclin-dependent kinase

229 DBF2 belongs to a group of budding yeast cell cycle genes that when mutated prevent cyclin degrad

230 s transcription of the CCNB2, KIF23 and PLK4 cell cycle genes through the recently discovered p53-p21

231 rmly expresses KRT5, P-Cad, EGFR, KRT14, and cell cycle genes throughout the tumor parenchyma.

232 of expression of transcriptionally regulated cell cycle genes to an accuracy of 2 min (approximately

233 g hepatocyte proliferation and expression of cell cycle genes to levels found in young regenerating m

234 density array that tiles the promoters of 56 cell-cycle genes to interrogate 108 samples representing

235 e promoters, interfering with progression of cell cycle, gene transcription, initiation of apoptotic

236 It has recently been discovered that cell-cycle gene transcription is regulated by a core com

237 eta/SMAD signaling, which directly regulates cell-cycle gene transcription to control a reversible G1

238 d expression of the androgen receptor-driven cell-cycle gene UBE2C.

239 oherence of the relative activation times of cell-cycling genes under different experimental conditio

240 any individual cell must be the same for all cell-cycle genes, varies randomly across cells.

241 ation with concomitant regulation in mitotic cell-cycle genes via a VGLCC mechanism.

242 ed expression of miR-221, expression of many cell cycle genes was altered and pathways promoting epit

243 our data showed that expression of the core cell-cycle genes was coordinately regulated during polli

244 For a given cell-cycle gene, we model its expression in each cell in

245 wed a decrease in total heterochromatin, and cell cycle genes were derepressed, leading to proliferat

246 Although some progenitor genes and cell cycle genes were epigenetically silenced during ret

247 onfirmed at the protein level, revealed that cell cycle genes were upregulated in trkB.T1(+/+) but no

248 GSIS), and expression of differentiation and cell-cycle genes were analyzed in human islets transduce

249 feration, survival, and induction of several cell cycle genes, whereas expression of antisense TR3 ab

250 fibroblasts and decreased binding to target cell cycle genes, while a phosphomimetic substitution (S

251 only a practical tool for identifying novel cell cycle genes with high accuracy, but also new insigh

252 a distinct expression signature enriched for cell-cycle genes without requiring the presence of AR-FL

253 Spy1 is 40% homologous to the Xenopus cell cycle gene, X-Spy1.