ライフサイエンスコーパス: cell cycle machinery

1 proteins that can modulate components of the cell cycle machinery.

2 e promoted without activation of the mitotic cell cycle machinery.

3 not yet clear how these signals contact the cell cycle machinery.

4 mal receptor signaling events to more distal cell cycle machinery.

5 ne and growth factor receptors to downstream cell cycle machinery.

6 links between cell environment and the core cell cycle machinery.

7 , genetically controlled, and independent of cell cycle machinery.

8 s D1, D2, and D3) are components of the core cell cycle machinery.

9 neling of specific signaling pathways to the cell cycle machinery.

10 wth by regulating specific components of the cell cycle machinery.

11 in integrating the signals from BCR with the cell cycle machinery.

12 k between the ETS family of proteins and the cell cycle machinery.

13 ring mitosis appears to be controlled by the cell cycle machinery.

14 ing networks that ultimately converge on the cell cycle machinery.

15 es very well with a number of changes in the cell cycle machinery.

16 between cytosolic signal transducers and the cell cycle machinery.

17 on of growth control pathways with the basic cell cycle machinery.

18 control, we examined various aspects of the cell cycle machinery.

19 ecular mechanism(s) of PF4 interference with cell cycle machinery.

20 ween cell surface signaling cascades and the cell cycle machinery.

21 a profound effect on several aspects of the cell cycle machinery.

22 ablishing a direct link between Mek1 and the cell cycle machinery.

23 iated in part through modulation of the host cell cycle machinery.

24 iated link between the IL-2 teceptor and the cell cycle machinery.

25 sma membrane with the proteins that form the cell cycle machinery.

26 eton that is itself under the control of the cell cycle machinery.

27 rovide a link between growth factors and the cell cycle machinery.

28 the transmission of mitogenic stimuli to the cell cycle machinery.

29 tritional cues with the activity of the core cell cycle machinery.

30 leting and exiting mitosis and resetting the cell cycle machinery.

31 D-cyclins represent components of cell cycle machinery.

32 Cyclin D1 is a component of the core cell cycle machinery.

33 LP1 facilitates ER signaling cross talk with cell cycle machinery.

34 -mammalian target of rapamycin signaling and cell cycle machinery.

35 Many of these genes are components of the cell cycle machinery.

36 sting a new link between cell growth and the cell cycle machinery.

37 cumulation and engagement with the canonical cell cycle machinery.

38 ilize or otherwise deregulate the coresident cell cycle machinery.

39 r and linking extracellular signaling to the cell cycle machinery.

40 ight link developmental controls to the core cell cycle machinery.

41 P2 serves to link Notch1 activation with the cell cycle machinery.

42 n the Cyclin-Cdk complexes that comprise the cell cycle machinery.

43 se mechanism between mitogen stimulation and cell cycle machinery.

44 vents depend on local regulators that impact cell cycle machinery.

45 vide a link between estrogen, c-Myc, and the cell cycle machinery.

46 es in vitro growth and does not obstruct the cell-cycle machinery.

47 erexpress cyclin D1, a component of the core cell-cycle machinery.

48 use of changes in expression and activity of cell-cycle machinery.

49 causes inappropriate activation of neuronal cell-cycle machinery.

50 , the Chk1 protein couples DNA repair to the cell-cycle machinery.

51 stablish a direct link between HIF-1 and the cell-cycle machinery.

52 onnections between development and the basic cell-cycle machinery.

53 )], PI3K signaling [18.1% (80/442)], and the cell-cycle machinery [10.4% (46/442)].

54 expression and activity of components of the cell cycle machinery after culture in RA.

55 ctly regulate the G2/M component of the host cell cycle machinery, allowing for the release of the ch

56 sistently, pharmacological inhibition of the cell cycle machinery also blocked differentiation in viv

57 point, and linkage of mitogenic signaling to cell cycle machinery, also implicates one of these cell-

58 Whether stem cells have unique cell cycle machineries and how they integrate with niche

59 S phase event and provide a link between the cell cycle machinery and activation of histone gene tran

60 levels of major components of the molecular cell cycle machinery and alter the levels of several tum

61 These observations link the cell cycle machinery and angiogenesis and reveal the pre

62 whereas normal cells maintain an integrated cell cycle machinery and are subject to cell cycle check

63 rowth in part by suppressing elements of the cell cycle machinery and bud-autonomous IAA biosynthesis

64 nk between transcriptional regulation of the cell cycle machinery and cell differentiation.

65 regulated at the initiation step by both the cell cycle machinery and checkpoint pathways.

66 in enhances mESCs self-renewal by regulating cell cycle machinery and core pluripotency transcription

67 istinguish between ZM's effects on the basic cell cycle machinery and its effects on checkpoints.

68 ce, the precise molecular interplays between cell cycle machinery and master regulators of cell fate

69 cytoskeletal signaling pathways and the core cell cycle machinery and may represent a general mechani

70 results show that Ca(2+) modulates both the cell cycle machinery and nuclear maturation during meios

71 titumor agents; effects of FTIs and GGTIs on cell cycle machinery and progression and potential mecha

72 RB serves as a transducer between the cell cycle machinery and promoter-specific transcription

73 rating oncogenic signaling pathways with the cell cycle machinery and promoting optimal cell cycle pr

74 involved in DNA replication, transcription, cell cycle machinery and regulation of its own expressio

75 understanding of HCMV's interaction with the cell cycle machinery and reveal a new cellular pattern o

76 t that ECT2 is an important link between the cell cycle machinery and Rho signaling pathways involved

77 horylation of pRb2/p130 is controlled by the cell cycle machinery and that pRb2/p130 may indeed be an

78 utilizes multiple pathways to signal to the cell cycle machinery and that these pathways synergize t

79 The links between the cell cycle machinery and the cytoskeletal proteins contr

80 Expression of components of the cell cycle machinery and the Notch pathway, as well as o

81 Mechanistic changes in regulation of the cell-cycle machinery and Akt-mTOR signaling were consist

82 tients who have driving abnormalities in the cell-cycle machinery and are thus more likely to respond

83 ic and muscarinic receptors may regulate the cell-cycle machinery and consequently the expansion of t

84 indicate disrupted coordination between the cell-cycle machinery and cytoskeletal function.

85 nsport and demonstrate a direct link between cell-cycle machinery and dynein pathway activity.

86 and D3) are components of the mammalian core cell-cycle machinery and function to drive cell prolifer

87 Cyclin D1 is a component of the core cell-cycle machinery and is frequently overexpressed in

88 ental regulators, specific components of the cell-cycle machinery and organ patterning.

89 te decisions are tightly associated with the cell-cycle machinery and reveal insights in the mechanis

90 bject to the regulatory controls of both the cell-cycle machinery and the Ran-signaling pathway.

91 significant reorganization of the canonical cell-cycle machinery and the use of meiosis-specific cel

92 mines cell fate is through regulation of the cell cycle machinery, and as such the cellular consequen

93 then influence differential gene expression, cell cycle machinery, and cytoskeletal organization of G

94 and are regulated by, core components of the cell cycle machinery, and focus our attention on the sol

95 Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation b

96 Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed

97 h much evidence suggests that alterations in cell cycle machinery are implicated in the carcinogenic

98 Critical parts of the cell cycle machinery are the cyclin-dependent kinases (C

99 e lacking cyclin D3, a component of the core cell cycle machinery, are refractory to stimulation by t

100 he cell-cycle arrest validates the bacterial cell-cycle machinery as an effective target for antimicr

101 f the computed molecular predictors with the cell cycle machinery, as well as the identification of h

102 ne the proliferation index and status of the cell cycle machinery at discrete stages of hematopoietic

103 wth regulation by coupling cell shape to the cell-cycle machinery at the level of signal transduction

104 th inhibition accounted for by disruption of cell cycle machinery; (b) is growth inhibition accompani

105 through cyclin D1, while Myc can impact the cell cycle machinery by transcriptionally upregulating c

106 lls, the Neu-Ras pathway is connected to the cell-cycle machinery by cyclin D1, explaining the absolu

107 y couples the nutritional environment to the cell-cycle machinery by regulating the activity of PP2A.

108 ulation of mass) and cell proliferation (the cell cycle machinery) by independent pathways.

109 Components of cell cycle machinery can play a key role in regulating s

110 ivity can be regulated coordinately with the cell cycle machinery (CDK2 and CDK4) and/or coordinately

111 layers of regulation imposed on core mitotic cell cycle machinery components by the program of germ c

112 oliferative cells, whether components of the cell cycle machinery contribute to its metabolic action

113 re components of the DNA damage response and cell cycle machinery cooperate to help enforce IgH and T

114 f an alternative cell death modality and the cell cycle machinery could have a transformative impact

115 These findings reveal that the cell-cycle machinery directly regulates the Ran-signalin

116 rrent understanding of the regulation of the cell cycle machinery especially as it relates to vascula

117 in ligases target numerous components of the cell cycle machinery for destruction.

118 d evolved mechanisms to manipulate the plant cell cycle machinery for DNA replication, and to optimiz

119 sms that link growth factor signaling to the cell cycle machinery have not been established.

120 ways through which these proteins impact the cell cycle machinery have not been explicitly determined

121 activity is regulated coordinately with the cell cycle machinery in bone cells.

122 y alleviating the negative constraint on the cell cycle machinery in cardiac myocytes.

123 ecently discovered that the nucleoli contain cell cycle machinery in close proximity to nascent ribos

124 entation 1 (HEF1; NEDD9) links PGE(2) to the cell cycle machinery in colorectal cancer cells.

125 ctural integrity of the microtubules and the cell cycle machinery in interphase cells.

126 yclins D1, D2, and D3) are key components of cell cycle machinery in mammalian cells.

127 that pre-mRNA splicing may be linked to the cell cycle machinery in mammalian cells.

128 (D1, D2, and D3) are components of the core cell cycle machinery in mammalian cells.

129 HCMV lytic infection subverts the host cell cycle machinery in multiple ways.

130 Consequently, an ectopic activation of the cell cycle machinery in neurons has emerged as a potenti

131 ngs show that insulin uses components of the cell cycle machinery in post-mitotic cells to control gl

132 odegeneration involves the activation of the cell cycle machinery in postmitotic neurons.

133 w these mitogenic signals are coupled to the cell cycle machinery in primary T cells is not clear.

134 kinase ultimately leads to activation of the cell cycle machinery in response to FGF-2.

135 t that FADD is involved in the regulation of cell cycle machinery in T lymphocytes.

136 We propose that N-myc lies upstream of the cell cycle machinery in the developing mouse retina and

137 Strategies targeting the cell cycle machinery in the heart and vasculature offer

138 To determine the potential roles of the cell cycle machinery in the regulation of the terminal d

139 he way CD28 signaling is coupled to the core cell cycle machinery in these two T cell subsets.

140 stimuli, whereas prevalent disruption of the cell cycle machinery in tumor cells often confers resist

141 We report here that components of the cell cycle machinery in yeast, specifically the cell cyc

142 f Cks/Suc1, a highly conserved member of the cell-cycle machinery in eukaryotes [1,2].

143 RhoA, conveys the "cell shape signal" to the cell-cycle machinery in human capillary endothelial cell

144 is known about the overall importance of the cell-cycle machinery in maintaining ES cell identity.

145 e Polycomb system of cellular memory and the cell-cycle machinery in mammals.

146 ish a fundamental framework for study of the cell-cycle machinery in Phalaenopsis orchids.

147 We found that miR-34/449 suppresses the cell-cycle machinery in vivo and promotes cell-cycle exi

148 endently regulate multiple components of the cell cycle machinery, including expression of p21(Cip1)

149 cycle regulation in these cells and how the cell cycle machinery influences hESCs properties.

150 phogenesis, the mechanisms through which the cell cycle machinery integrates with differentiation sig

151 Deregulation of the cell cycle machinery is a hallmark of cancer.

152 this study we determined to what extent the cell cycle machinery is altered during epidermal prolife

153 Dysregulation of cell cycle machinery is implicated in a number of neuron

154 How the cell cycle machinery is modified to transform a mitotic

155 l cycle position, how it is regulated by the cell cycle machinery is not known.

156 An essential part of the cell cycle machinery is the cyclin-dependent kinases (CD

157 is [1] [2], but the link between Ras and the cell-cycle machinery is not clear.

158 scriptional regulator of some members of the cell cycle machinery, is not induced following sIgM cros

159 the subsequent cell growth response, such as cell cycle machinery, is regulated in cardiac hypertroph

160 combination triggers a dual blockade of the cell cycle machinery, leading to apoptosis, and providin

161 Ca(2+)-dependent negative regulation of the cell cycle machinery (MAPK-MPF cascade) is due to Ca(2+)

162 alysis of common components of apoptotic and cell cycle machinery may provide insight into the coordi

163 Our findings support a model whereby the cell cycle machinery not only controls cell division but

164 findings demonstrate that IL-4 regulates the cell cycle machinery of astroglial cells via a p27Kip1 b

165 These viruses need the cell cycle machinery of the host cell to complete their

166 and suggest that additional elements of the cell cycle machinery participate in this mechanism.

167 Because the cell cycle machinery participates in Saccharomyces cerev

168 vity, in part, by multifaceted regulation of cell cycle machinery, possibly via concomitant changes i

169 ated cyclin D1 and subsequent alterations in cell cycle machinery provides keratinocytes the ability

170 At the level of the cell cycle machinery, RAF and AKT cooperated to induce c

171 How cell cycle machinery regulates extracellular matrix (ECM

172 -Myc interacts with the intrinsic cyclin/Cdk cell cycle machinery remain undefined.

173 The model identified known components of the cell-cycle machinery, such as CCND1, CCNE2, and CDC25A,

174 nd cellular targets linking GR activation to cell cycle machinery suggest two distinct regulatory mec

175 s (CDK4 and CDK6) are components of the core cell cycle machinery that drives cell proliferation.

176 way required for activation of the canonical cell cycle machinery that is inhibited by P4.

177 a novel link between the transcriptional and cell cycle machinery that may be relevant to the pathoge

178 evels of cyclin D1 [2-5], a component of the cell cycle machinery that operates during G1 phase by ac

179 s been made in identifying components of the cell-cycle machinery that are impacted by the checkpoint

180 rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its a

181 2+ influx is essential for activation of the cell cycle machinery, the processes that regulate Ca2+ i

182 ults explain the temporal specificity of the cell-cycle machinery, thereby providing a biochemical me

183 he Ras and Myc oncogenes can impact the core cell cycle machinery through all three D-cyclins.

184 S595 phosphorylation may globally couple the cell cycle machinery to regulatory pathways that impact

185 K and provides a novel mechanism linking the cell cycle machinery to translational control.

186 , so is not a consequence of feedback by the cell-cycle machinery to maintain cell-cycle length.

187 A hallmark of cancer is the deregulation of cell-cycle machinery, ultimately facilitating aberrant p

188 Strikingly, the major alterations in the cell cycle machinery underlying cervical carcinogenesis

189 c transcription factor communicates with the cell cycle machinery via cyclins D1 and D2, but not D3,

190 link environmental mitogenic stimuli to the cell cycle machinery via modulation of G1 cyclin express

191 Further investigation revealed that the cell cycle machinery was activated by FcgammaR cross-lin

192 link the signal transduction pathway and the cell cycle machinery, we developed a selection strategy

193 viously unknown small molecules that inhibit cell cycle machinery, we performed a chemical genetic sc

194 genous TGF-beta effects on the modulation of cell cycle machinery were analyzed previously.

195 3-regulated cell proliferation by modulating cell cycle machinery, while hyperactivation of RhoA furt

196 formative divisions rely first of all on the cell cycle machinery with centrally acting cyclin-depend

197 e is an integral component of the eukaryotic cell cycle machinery, yet very few centrosomal proteins