ライフサイエンスコーパス: cell cycle protein

1 her functions have been associated with this cell cycle protein.

2 of the CCNE1 gene, which encodes cyclin E, a cell-cycle protein.

3 duced mTORC1 signaling and altered levels of cell cycle proteins.

4 by phosphorylating transcription factors and cell cycle proteins.

5 ites and cease to proliferate by influencing cell cycle proteins.

6 lator of the cell cycle, may be modulated by cell cycle proteins.

7 d, disease-free controls for the presence of cell cycle proteins.

8 et MDSC population via downstream effects on cell cycle proteins.

9 ne homologue B1, AKT, B-cell lymphoma 2, and cell cycle proteins.

10 requires activation of a defined pathway of cell cycle proteins.

11 e noncycling cells surprisingly express many cell cycle proteins.

12 hat modulates the expression and activity of cell cycle proteins.

13 e cell cycle by mediating the degradation of cell cycle proteins.

14 ar signal-regulated kinase and altered other cell cycle proteins.

15 human microRNAs (miRNAs) directly regulating cell-cycle proteins.

16 s, such as changes in glycolytic enzymes and cell-cycle proteins.

17 rned by the availability and activity of key cell-cycle proteins.

18 and decreased phosphorylation of G2-related cell-cycle proteins.

19 mediating ubiquitination and degradation of cell-cycle proteins.

20 The expression of cyclin D1 and downstream cell cycle proteins after partial hepatectomy was inhibi

21 ause any significant change in the levels of cell cycle proteins analyzed.

22 inoid anticancer compound, SHetA2, regulates cell cycle proteins and cell cycle progression in ovaria

23 mpounds had minimal effects on expression of cell cycle proteins and did not induce caveolin-1 in HCT

24 cell cycle control we examined expression of cell cycle proteins and growth of fibroblasts reversibly

25 d the correlation between C/EBPalpha levels, cell cycle proteins and hepatocyte proliferation in old

26 r plant and animal F-box proteins, including cell cycle proteins and hormone receptors.

27 to favor viral replication by dysregulating cell cycle proteins and kinases.

28 /- and E2f1+/- animals were found to express cell cycle proteins and replicate their DNA.

29 o investigate whether reactivation of the G1 cell cycle proteins and S phase entry was linked with ap

30 simplex virus scavenges the cell for useful cell cycle proteins and subverts them for its own use.

31 phages, suggesting a link between changes in cell cycle proteins and the presence of activated macrop

32 Dysregulated behavior of cell cycle proteins and their control by ubiquitin E3 li

33 f neurodegeneration involved reexpression of cell-cycle proteins and DNA synthesis, indicating that n

34 rentiated, non-cycling neutrophils repurpose cell-cycle proteins and pathways to form NETs.

35 facilitate robust and long-term depletion of cell-cycle proteins and reveals insights into the requir

36 its tumor suppressor function by regulating cell-cycle proteins and Six1 transcriptional targets c-m

37 Cell-cycle proteins and transcriptional regulators such

38 st a possible cooperation of growth factors, cell cycle proteins, and transcription factors during th

39 and contains a motif found in ankyrins, some cell cycle proteins, and transcription factors.

40 We show that several cell cycle proteins are expressed in different models of

41 gression and the regulated expression of key cell cycle proteins are independent of Jak3/common gamma

42 ion factors, which mediate the expression of cell cycle proteins as well as death-inducing genes.

43 trum of insulin resistance and points to the cell-cycle protein as a potential therapeutic target tha

44 ormed to evaluate the overexpression of this cell-cycle protein as one of the putative downstream eff

45 ells was evidenced by enhanced expression of cell cycle proteins, as determined by RT-PCR.

46 , the extent to which TOPgal cells coexpress cell cycle proteins, basic helix-loop-helix (bHLH) trans

47 Up-regulation of cell cycle proteins by EGF is blocked by inhibition of p

48 proliferating cell nuclear antigen (PCNA), a cell cycle protein, by immunohistochemistry.

49 Hence, human Speedy is a novel cell cycle protein capable of promoting cell proliferati

50 ion defect, as well as reduced levels of the cell cycle protein Cdc2.

51 lian protein that shows high homology to the cell cycle proteins Cdc20p of Saccharomyces cerevisiae a

52 The cell-cycle protein Cdc7 regulates S phase by promoting D

53 in Drosophila males, transcript for the core cell cycle protein Cyclin B1 (CycB) is expressed in sper

54 s associated with DNA damage, repair and the cell cycle protein Cyclin D1 in the contused brain sugge

55 to directly explore the significance of the cell cycle protein cyclin D2 in the expansion of beta-ce

56 tosis and markedly reduced expression of the cell cycle protein cyclin D2.

57 from G1 phase by decreasing the G1-specific cell cycle protein cyclin E and increasing the cyclin-Cd

58 The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequen

59 zyme inhibitor protein (AZI), as well as the cell-cycle protein cyclin D1.

60 -regulated promoter of the gene encoding the cell-cycle protein cyclin E.

61 ation as well as expression of the late G1/S cell-cycle proteins cyclin E and cyclin-dependent kinase

62 3, Bax, MDM2, Gadd45), DNA repair (PCNA) and cell cycle proteins (cyclin A, cyclin D, cdk2, cdk4) in

63 ns in serum enzymes and the induction of key cell cycle proteins (cyclin D, cyclin E, and Stat3) and

64 air (p53, Bax, MDM2, WAF1, Gadd45, PCNA) and cell cycle protein, Cyclin D1, in male Wistar rats 48 h

65 eal a cell cycle-independent role for a core cell cycle protein, cyclin E, in synapse function and me

66 t data showing that BRCA1 ubiquitinates G2/M cell cycle proteins, cyclin B and Cdc25C, leading to the

67 gene promoter and levels of the AR-regulated cell cycle proteins, cyclin D1 and hyperphosphorylated R

68 arises from down-regulation of the essential cell-cycle proteins CyclinA, CKS1 and CDK1.

69 NA ligase I, NDH II, Topo I and Topo II) and cell cycle proteins (Cyclins A, B1, D1, D2, D3, E, CDK2,

70 nzyme inhibitors had no measurable effect on cell cycle protein degradation.

71 3 ubiquitin ligase responsible for targeting cell cycle proteins during G1 phase.

72 potential role of Bmi1 as a key regulator of cell cycle proteins during neuronal apoptosis.

73 plication-coupled destruction of a cohort of cell cycle proteins ensures efficient and precise genome

74 transcription factor regulates expression of cell cycle proteins essential for hepatocyte entry into

75 we made a sequential study of alterations in cell cycle protein expression and complex formation amon

76 Rb in postmitotic neurons results in ectopic cell cycle protein expression and neuronal loss without

77 These data are consistent with cell cycle protein expression during podocyte maturation

78 current study was to identify differences in cell cycle protein expression in human and rabbit endoth

79 s demonstrated normal entry into S phase and cell cycle protein expression in the absence of essentia

80 indings demonstrated that MCL has a distinct cell cycle protein expression similar to that of high-gr

81 ive astrocytes from WT mice showed increased cell cycle protein expression that was significantly red

82 ventricular zone (VZ) through modulation of cell cycle protein expression, in particular cyclin D1 a

83 biquitin protein ligase complex that targets cell cycle proteins for degradation by the ubiquitin pro

84 15) show that these adaptors can also target cell cycle proteins for destruction through a second ubi

85 s an essential ubiquitin ligase that targets cell cycle proteins for proteasome-mediated degradation

86 tes cell cycle progression by ubiquitinating cell cycle proteins for proteolysis by the proteasome.

87 ex that targets nuclear p27 among many other cell-cycle proteins for proteosomal degradation.

88 les), were elucidated to identify changes in cell cycle protein function over different phylogenetic

89 gical tools and illustrate the redundancy of cell cycle protein function that can occur in cancer cel

90 Although several cell cycle proteins have been implicated in cell cycle-r

91 Previous reports describing manipulation of cell cycle proteins have not shown induction of cardiomy

92 onproliferative postmitotic roles that these cell cycle proteins have recently been reported to play,

93 ings reveal an unexpected function of a core cell cycle protein in DNA repair and suggest that target

94 ptotic effector of Abeta and of dysregulated cell cycle proteins in AD and identify both Bim and cell

95 eries are normally linked, and expression of cell cycle proteins in developing T cells contributes to

96 ng as well as the expression and activity of cell cycle proteins in FGF2-stimulated intimal smooth mu

97 he expression levels of Cdk2 and its related cell cycle proteins in MCF-7 E cells showed that after E

98 hesion-growth factor control of these two G1 cell cycle proteins in melanomas.

99 Studies of cell cycle proteins in other models of neuronal death pr

100 suggests that inappropriate re-activation of cell cycle proteins in post-mitotic neurons may be respo

101 cytochemistry, we found the re-expression of cell cycle proteins in Purkinje cells and striatal neuro

102 tes distinct CARMA1-dependent control of key cell cycle proteins in T cells.

103 nase activity, cyclin E, cyclin A, and other cell cycle proteins in transgenic CD4(+)CD8(+) thymocyte

104 dentify several unexpected patterns for core cell-cycle proteins in actively proliferating (CDK2-incr

105 on to determine the temporal dynamics of key cell-cycle proteins in asynchronously cycling human cell

106 ese results reveal an unexpected function of cell-cycle proteins in controlling apoptosis in normal c

107 Cell-cycle proteins in cyclin D1(+) cells were not modul

108 creased expression and activation of various cell-cycle proteins in neuronal cell death.

109 To determine the role of cell-cycle proteins in regulating pathological renal hyp

110 Inappropriate activation of cell cycle proteins, in particular cyclin D/Cdk4, is imp

111 anges correlated with modulation of G1 phase cell cycle proteins including decreased cyclin D1, cycli

112 hich mediates the S-phase degradation of key cell cycle proteins, including Cdt1, PR-Set7, and p21.

113 evel and subcellular localization of several cell cycle proteins, including cyclin-D1, -E, -A, and -B

114 KFB3 increased the expression of several key cell cycle proteins, including cyclin-dependent kinase (

115 parallel, immunohistochemical assessment of cell cycle proteins, including cyclins A, B1, E, and Cdk

116 optosis, and altered the expression of other cell cycle proteins, including survivin and Aurora-A.

117 and the phosphorylation state of fundamental cell cycle proteins, including the retinoblastoma protei

118 sing proliferation by altering expression of cell cycle proteins, including up-regulation of p27(Kip1

119 Targeted disruption of various cell-cycle proteins, including Rb, p27(kip1) (p27), and

120 Cyclin D2 is the first cell cycle protein induced following stimulation through

121 he cell cycle inhibitor flavopiridol reduced cell cycle protein induction and significantly improved

122 Of the cell cycle proteins investigated, CDK2, CDK4 and CDK5 we

123 liferation in liver regeneration by inducing cell cycle proteins involved in mitotic progression, inc

124 trachomatis infection destabilizes specific cell cycle proteins involved in the G2/M transition.

125 ice, PHX induces robust up-regulation of key cell-cycle proteins involved in mitotic progression, inc

126 abnormal up-regulation of these important G1 cell cycle proteins is a relatively early event in intes

127 Proteolytic control of Caulobacter cell cycle proteins is primarily executed by ClpXP, a dy

128 cyclin D gene transcription, and accumulated cell cycle proteins known as calpain substrates.

129 atio on the activation threshold of critical cell cycle proteins, leading to the size-sensing checkpo

130 apalogs prevent cap-dependent translation of cell-cycle proteins like c-myc, continuing tumor cell gr

131 ne, and olomoucine) reduced up-regulation of cell cycle proteins, limited neuronal cell death after e

132 me2-dependent phosphorylation of a subset of cell-cycle proteins limits the effects of Cdc14 in meios

133 n interactions, reproduction, DNA metabolism/cell cycle, protein metabolism, and neuronal function.

134 ns is required in vivo for the modulation of cell cycle proteins observed in cells infected with wild

135 Since changes in other cell cycle proteins occur at a later time during TGFbeta

136 These findings suggest that changes in cell cycle proteins occur in both HIVE and the simian mo

137 At least one major control point for the cell cycle proteins occurred between "start" and early S

138 Up-regulation of cell cycle proteins occurs in both neurons and glia afte

139 Cdc25C is a cell cycle protein of the dual specificity phosphatase f

140 sor cells which bears affinity for the yeast cell cycle protein p13sucl and which undergoes rapid tyr

141 of caspase-3 and affecting the expression of cell cycle proteins p21 and CDK2.

142 imulate expression of the TGF-beta-regulated cell cycle protein p27 in the HP75 human pituitary adeno

143 Increased association of cell-cycle proteins p27(kip) and cyclin-dependent kinase

144 regulate expression of the gene encoding the cell cycle protein p55Cdc by using cDNA array technique.

145 of ligand activation on cell proliferation, cell cycle protein phosphorylation, and capillary tube f

146 d INS1 cells display striking differences in cell cycle protein profiles; 3) phosphorylation of pRb i

147 Cell cycle proteins regulate processes as diverse as cel

148 s25/-)mice; and expression of Cdc25A and the cell-cycle proteins regulated by Cdc25A.

149 f the p27 CDK inhibitor, and other G1-acting cell cycle proteins, remained unaffected.

150 Analysis of some critical cell cycle proteins revealed a specific increase in expr

151 The analysis of critical E2- and TAM-related cell cycle proteins revealed an increase of both the exp

152 Instead, immunohistochemical quantitation of cell cycle proteins reveals that MKK4-expressing cells f

153 Cell cycle proteins showed an increased expression 24 ho

154 Analysis of several cell cycle proteins shows normal down-regulation of p27

155 Reexpression of cell cycle proteins such as cyclin-dependent kinases (CD

156 ories including regulation of transcription, cell cycle, protein synthesis, and apoptosis.

157 rts showed increased levels of RNAs encoding cell-cycle proteins, Tgf-beta, periostin, and other prof

158 es, we identify Bora as a previously unknown cell cycle protein that interacts with the Plk1 kinase a

159 nal role of p53 in the regulation of PRC1, a cell cycle protein that plays important roles during cyt

160 nucleotides (ONs) targeted against two human cell cycle proteins that are aberrantly expressed in bre

161 We identify distinct sets of cell cycle proteins that specifically associate with dif

162 tara encodes a conserved cell-cycle protein that contains a Cyclin A (CycA)-bindi

163 Geminin is an essential cell-cycle protein that is only present from S phase to

164 The Atm and Atr proteins are mitotic cell-cycle proteins that also associate with chromatin d

165 These effects were accompanied by changes in cell-cycle proteins that suggest possible mechanisms for

166 in the regulation of the expression of this cell cycle protein, the methylation patterns of p27 in n

167 Herpesviruses are known to interact with cell cycle proteins; thus, the antiviral effects of Rosc

168 uses often modulate the function of critical cell cycle proteins to maximize the efficiency of virus

169 factor couples the coordinate expression of cell cycle proteins to their appropriate transition poin

170 lpha-factor and hydroxyurea, we assigned the cell cycle proteins to two classes: proteins in class I

171 ubiquitin-dependent proteolysis of specific cell-cycle proteins to coordinate chromosome segregation

172 SCI caused cell cycle protein up-regulation associated with neurona

173 a potential pathway involved, expression of cell cycle proteins was assessed.

174 emokines, inflammatory, stress response, and cell cycle proteins was evident in wild-type mice.

175 the effect of E2F97 on expression of various cell cycle proteins was examined.

176 The effect of activated human K-ras on cell cycle proteins was studied by use of a stable MCF-7

177 Association of Cdc42 with cell-cycle proteins was identified by immunoprecipitatio

178 he AKT client molecule p27kip, an inhibitory cell cycle protein, was reduced, whereas cyclin E, which

179 equences of acute and chronic elimination of cell-cycle proteins, we generated and characterized indu

180 Although we found that Crk II bound to the cell cycle protein Wee1, expression of GFP-Crk-nuc did n

181 ut or with RAPA (10 ng/ml) and G1-associated cell cycle proteins were analyzed by immunoblot and dens

182 (ATRA) on cell proliferation, apoptosis, and cell cycle proteins were examined in SEB-1 sebocytes and

183 DNA repair proteins and cell cycle proteins were preferentially expressed within

184 low cytometry, and analysis of signaling and cell-cycle proteins were established.

185 pho-Bad (Ser112) and histone H3 (Ser10), and cell-cycle proteins were unaffected by SGI-1776, suggest

186 Plk1 (Polo-like kinase 1) and other M-phase cell-cycle proteins, which may underlie AI PCa growth.

187 hat ultimately converge on the regulation of cell cycle proteins whose expression and activity are ab

188 e was progressive loss of expression of both cell cycle proteins with increasing tumor grade and path