ライフサイエンスコーパス: cell cycle regulator

1 re instead caused by aggregation of the Whi3 cell cycle regulator.

2 ents are required to fully activate this key cell cycle regulator.

3 esis may be independent of its function as a cell cycle regulator.

4 hese studies identified KDM8 as an important cell cycle regulator.

5 that express small amounts of this essential cell cycle regulator.

6 ession of both geminin and cyclin A, another cell cycle regulator.

7 The E2F transcription factor is a key cell cycle regulator.

8 CMV replication by targeting Cdc25a, a vital cell cycle regulator.

9 genes are targets of the c-myc oncogene and cell-cycle regulator.

10 p between a connexin molecule and a critical cell-cycle regulator.

11 cells [LSCs]) that exceeds its function as a cell-cycle regulator.

12 xpression of regenerative growth factors and cell cycle regulators.

13 of MALAT1 impaired the expression of various cell cycle regulators.

14 ific degradation beyond degradation of known cell cycle regulators.

15 , cell cycle distribution, and expression of cell cycle regulators.

16 cle progression through its interaction with cell cycle regulators.

17 which have not been previously described as cell cycle regulators.

18 loid divisions, despite normal expression of cell cycle regulators.

19 coordinated activity of differentiation and cell cycle regulators.

20 tein synthesis of cyclin E, as well as other cell cycle regulators.

21 level induced changes in abundance of these cell cycle regulators.

22 enes encoding tumor suppressors and negative cell cycle regulators.

23 budding yeast Swe1p (Wee1) and Mih1p (Cdc25) cell cycle regulators.

24 sphorylation in mitosis including many known cell cycle regulators.

25 equired signalling events for the control of cell cycle regulators.

26 E2 Factor 1 (E2F-1) and E2 Factor 4 (E2F-4) cell cycle regulators.

27 ed by the up-regulation of numerous positive cell cycle regulators.

28 trated deregulated expression of a number of cell cycle regulators.

29 R-mediated induction of c-Myc and additional cell cycle regulators.

30 , including many cytoskeletal components and cell cycle regulators.

31 g up-regulation of both the p21 and p19(ARF) cell-cycle regulators.

32 by controlling the transcription of multiple cell-cycle regulators.

33 methyltransferase CcrM is one of five master cell-cycle regulators.

34 er cells through the upregulation of several cell-cycle regulators.

35 factor contributing to efficient splicing of cell-cycle regulators.

36 transcriptional repression of genes encoding cell-cycle regulators.

37 cell cycle by coordinating the activities of cell-cycle regulators.

38 This study demonstrates that canonical cell-cycle regulators also play important noncanonical r

39 uced growth arrest as well as changes in the cell cycle regulators, although they effectively blocked

40 logy analysis highlighted a preponderance of cell cycle regulators among the 1121 genes perturbed upo

41 Response gene to complement (RGC)-32 is a cell cycle regulator and a downstream target of TGF-beta

42 Despite its well-documented role as a cell cycle regulator and as a tumor suppressor, the func

43 APC/Cdh1 is a major cell cycle regulator and its function has been implicate

44 -21 while increasing the levels of Cdc25a, a cell cycle regulator and known target of miR-21.

45 hese tumors, we identified JARID2/Jumonji, a cell cycle regulator and part of a histone methyltransfe

46 ow that CRIF1, a protein previously known as cell cycle regulator and transcription cofactor, is also

47 oblastoma tumor suppressor (RB) is a central cell cycle regulator and tumor suppressor.

48 t progenitors exhibit aberrant expression of cell cycle regulators and delayed G(1)/S transition, esp

49 Y chromosome and its X-homologue, TSPX, are cell cycle regulators and function as a proto-oncogene a

50 ng, but is accompanied by alterations in key cell cycle regulators and is linked to an hTERT-catalyze

51 in instability of many tumor suppressors and cell cycle regulators and is therefore a novel target in

52 A-2 regulates a wide set of genes, including cell cycle regulators and megakaryocyte-specific genes.

53 Here, we characterize cell cycle regulators and signaling pathways underlying

54 KDM5-activated genes include a large set of cell cycle regulators and that the KDM5s are necessary f

55 le interactions of HCV-encoded proteins with cell cycle regulators and tumor suppressor proteins, rai

56 ctions between HCV-encoded proteins and host cell cycle regulators and tumor suppressor proteins, the

57 e enriched with transcription factors and/or cell cycle regulators and were unrelated to duration of

58 cally, we show that VentX regulates critical cell cycle regulators and Wnt downstream genes previousl

59 CTGF treatment upregulates positive cell-cycle regulators and factors involved in beta-cell

60 e a novel mechanistic role for HIRA (histone cell cycle regulator) and proteasomal degradation-associ

61 l role and mechanism for FOXD3 as a negative cell cycle regulator, and have implications for the repr

62 the cyclin-dependent kinase (Cdk1), a major cell cycle regulator, and the metabolic regulator protei

63 APC substrates are typically cell cycle regulators, and consistent with this, the los

64 regulated transcripts, including several key cell cycle regulators, and genes involved in motility, a

65 cation are Wnt/beta-catenin pathway members, cell cycle regulators, and genes required for mitotic sp

66 tightly controls both positive and negative cell cycle regulators, and indicate that the PI3K/Akt pa

67 in the essentiality of divJ and divK spatial cell cycle regulators, and non-essentiality of the highl

68 actors (including Tcf7), effector molecules, cell cycle regulators, and proteins that regulate fatty

69 Last, the data mechanistically link E2A, cell cycle regulators, and the maintenance of the HSC po

70 eristems by activating the expression of key cell cycle regulators, and therefore, promoting G2 to M

71 p63 regulates the expression of cell cycle regulators, and we determined that cyclin A,

72 al components, AHSP, heme synthesis enzymes, cell-cycle regulators, and blood group antigens.

73 genes encoding DNA-damage response factors, cell-cycle regulators, and chemokine receptors.

74 ription factors, impairment of the CDKN2A/2B cell-cycle regulators, and hyperactive NOTCH1 signaling

75 Furthermore, genomic profiling shows that cell cycle regulators are altered in the majority of EGF

76 We discovered that cell cycle regulators are expressed hours before the act

77 ercle; however, transcriptional levels of G1 cell cycle regulators are reduced.

78 and colorectal cancer risk by the status of cell-cycle regulators are lacking.

79 and -2, either alone or in combination with cell cycle regulators, are recruited near the DSB, where

80 cer and activator of transcription 3 and the cell cycle regulator aryl hydrocarbon receptor, the data

81 interacts with Hsp90, implicating this major cell cycle regulator as a novel Hsp90 client protein in

82 ative PCR array analyses identified multiple cell cycle regulators as potential ZNF24 downstream targ

83 ce, we detected a reduction in proliferative cell cycle regulators as well as an increase in the cell

84 with mammalian apoptosis the involvement of cell-cycle regulators as signaling components.

85 s preferentially modulate expression of host cell cycle regulators, as well as antiviral response fac

86 rest, and that differences in the balance of cell cycle regulators between 129/SvJ and C57BL/6 might

87 ack of protein expression of the key meiotic cell cycle regulators Boule and Cyclin B.

88 ly, flavopiridol inhibited mRNAs of multiple cell cycle regulators, but with uniform increases in bcl

89 NQO1 expression attenuated the reduction of cell cycle regulators by 17-AAG treatment in AhR overexp

90 the expressions of markers of DNA damage and cell-cycle regulators by immunoblotting and performed si

91 itin ligase that promotes the degradation of cell-cycle regulators by the 26S proteasome.

92 it, induces transcriptional up-regulation of cell cycle regulators, bypasses the need for S-phase cel

93 red biphasic regulation of expression of the cell-cycle regulator c-Myc that involved its transient i

94 nd, ultimately, proliferation induced by the cell-cycle regulator c-Myc.

95 es cellular SCF(Fbw7) targets, including the cell-cycle regulators c-Myc and cyclin E.

96 on using a breast cancer model in which this cell-cycle regulator can be genetically ablated prior to

97 us, the paradigm that RBR genes are negative cell cycle regulators cannot be considered universal.

98 This dominantly acting cell cycle regulator causes mitotic arrest and, thereby,

99 target was Ccnd1 mRNA, which encodes the key cell cycle regulator CCND1 (Cyclin D1).

100 ion of oncogenes FOS, JUN, NFKB, and MYC and cell cycle regulators CCND1, CCNE1, and CDK4/6, along wi

101 by altered expression of the c-Myc-targeted cell cycle regulators CCND1, CDKN1A and CDKN2D in a time

102 rk that is responsible for activation of the cell-cycle regulator Cdc14p in Saccharomyces cerevisiae.

103 ysis combined with bioinformatics identified cell cycle regulator Cdc25A as a miR-21 target.

104 se accumulation, and decreased levels of the cell cycle regulator Cdc25a, suggesting altered cell cyc

105 iR-424(322)/503 reduce the expression of the cell cycle regulator CDC25A.

106 tes cell cycle arrest and degradation of the cell cycle regulator Cdc25A.

107 This results in increased expression of the cell-cycle regulator Cdc25A, which is a direct target of

108 e coupled to upregulation of its target--the cell cycle regulator, Cdc25A.

109 e insulin receptor substrate (IRS)-2 and the cell-cycle regulator CDC25b.

110 sis is coordinately controlled by the master cell cycle regulator Cdk together with its counteracting

111 We also find that the cell cycle regulators cdk-1 and cyb-3 and the spindle/cy

112 morphogenesis checkpoint regulator, and the cell cycle regulator Cdk1 play key roles in these morpho

113 CYC6 is a functional homologue of the major cell cycle regulator CDK1, yet definitive genetic eviden

114 denocarcinoma cells, and downregulates a key cell cycle regulator, CDK2.

115 is issue of Blood, Placke et al identify the cell-cycle regulator CDK6 as a promising new target in m

116 by MLL-AF9 are exceptionally reliant on the cell-cycle regulator CDK6, but not its functional homolo

117 ates at specific enhancer regions of the key cell cycle regulator Cdkn1a and the stem cell regulator

118 of Notch2, there were elevated levels of the cell cycle regulators Cdkn1a (p21Cip1), Ccnd2 (CyclinD2)

119 osttranslational modification of the central cell-cycle regulators CDKN1A, retinoblastoma protein, an

120 s of chromosome 9p21 are known to target the cell cycle regulators CDKN2A and CDKN2B.

121 ly through up-regulation of the let-7 target cell cycle regulators cell division cycle 34 (Cdc34) and

122 ociated with upregulation of its target, the cell-cycle regulator cell division cycle 25A (Cdc25A).

123 teraction with host cell factor-1 (HCF-1), a cell-cycle regulator composed of HCF-1N and HCF-1C, is c

124 Unexpectedly, most classic cell-cycle regulators conserved in T. gondii were not de

125 -controlled and co-conserved with the global cell cycle regulator CtrA in the alpha-proteobacteria.

126 ly in other Rhizobiaceae species, the master cell cycle regulator CtrA may recognize an expanded moti

127 ycle progression, and also act on the master cell cycle regulator CtrA.

128 lerosis through, at least in part, targeting cell cycle regulator cyclin A and connective tissue grow

129 eviously identified the aberrantly expressed cell cycle regulator cyclin B1 as a tumor antigen recogn

130 Increased nuclear Yap and the cell cycle regulator cyclin D1 accompanied cardiomyocyte

131 Cyclin D1b is a splice variant of the cell cycle regulator cyclin D1 and is known to harbor di

132 anied by increases in mRNA expression of the cell cycle regulator cyclin D1 and/or glioma-associated

133 tination and degradation of the prooncogenic cell cycle regulator cyclin D1, and also down-regulates

134 f Sox2-positive cells may be mediated by the cell cycle regulator cyclin D1.

135 argeting the stem cell regulator TLX and the cell cycle regulator cyclin D1.

136 ST6Gal-I also potentiates expression of the cell cycle regulator cyclin D2, leading to increased pho

137 hesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1

138 Cell cycle regulators cyclin D1 and cyclin D2 were decre

139 1 stimulation, resulting in induction of the cell cycle regulators cyclin D1 and p21(WAF1/CIP1) PREX1

140 filing and functional studies identified the cell cycle regulators cyclin D1 and USP44 as primary KLF

141 Here, we demonstrate that cell cycle regulators Cyclin D1-3 control cell fate deci

142 The cell-cycle regulator cyclin D1 is expressed in the liver

143 ocytic differentiation via regulation of the cell-cycle regulator cyclin D1.

144 These mechanisms are governed by the cell-cycle regulators cyclin D1-3 that control different

145 ction of transcription factors (OCT4 and T), cell cycle regulators (cyclin D family members) and epig

146 Here, we show that the cell cycle regulator, cyclin-dependent kinase 2 (CDK2),

147 udy, we describe an evolutionarily conserved cell-cycle regulator, cyclin-dependent kinase inhibitor

148 Here, we show that the master cell-cycle regulators, cyclin-dependent kinase (Cdk) and

149 y the timing of gene expression for critical cell cycle regulators cyclins D, A2, and B2 and cyclin-d

150 ces growth arrest, accompanied by changes in cell cycle regulators (decreased retinoblastoma phosphor

151 ted by CcrM and co-regulated by other global cell cycle regulators, demonstrating an extensive cross

152 hat the F-box protein FBL17 acts as a master cell cycle regulator during the diploid sporophyte phase

153 of the cell cycle and reduced expression of cell cycle regulators during the initiation stage of rep

154 We show that differential expression of cell-cycle regulators during development may be responsi

155 e proteasome, thereby driving degradation of cell-cycle regulators during early mitosis.

156 ase (CDK) inhibitor 1A, p21/Cip1, is a vital cell cycle regulator, dysregulation of which has been as

157 its central role in the degradation of many cell-cycle regulators, e.g., Cdt1, p21, and Pr-Set7/Set8

158 egulatory elements targeted by the ancestral cell cycle regulator E2F, much like extant viral oncogen

159 CPR5 to cause overactivation of another core cell-cycle regulator, E2F.

160 The cell cycle regulators E2F1, MYC, MYBL2 (B-Myb) and FOXM1

161 predicted miR-31 gene targets including the cell cycle regulator E2F2.

162 rgeting the pluripotency factor Sox2 and the cell-cycle regulator E2F3 in neural stem/progenitor cell

163 acting through CK and the CK-inducible CYCD3 cell cycle regulators, establishing a mechanistic link t

164 ic exit and G1/S transition by targeting key cell-cycle regulators for destruction.

165 tes mitosis and G1 by sequentially targeting cell-cycle regulators for ubiquitination and proteasomal

166 ed a role for FOXM1 and identified two novel cell cycle regulators, FOXJ3 and FOXK1.

167 Here, we found that the essential cell cycle regulator GcrA in Caulobacter crescentus acti

168 e of the Hox homeodomain in complex with the cell-cycle regulator, Geminin, which inhibits Hox transc

169 genomic network connecting loci enriched in cell cycle regulator genes to nuclear lamina that mediat

170 that ClpXP and Lon each degrade an important cell cycle regulator, helping to trigger the onset of S

171 timing of Yen1 activation, governed by core cell-cycle regulators, helps coordinate DNA repair with

172 The human histone cell cycle regulator (HIRA) complex composed of HIRA, ub

173 haperone HIRA complex, consisting of histone cell cycle regulator (HIRA), Ubinuclein1 (UBN1), and cal

174 acts as a protease in the maturation of the cell cycle regulator host cell factor 1 (HCF-1) and serv

175 GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it

176 ly impacted by proteolytic activation of the cell cycle regulator, host cell factor-1.

177 of Ajuba controls the expression of multiple cell cycle regulators; however, it does not affect Hippo

178 Whereas many established cell-cycle regulators impact NPC proliferation, other si

179 Polo-like kinase 1 (PLK1) is a key cell cycle regulator implicated in the development of va

180 tion factor specificity protein 2 (Sp2) as a cell cycle regulator in two temporally and spatially dis

181 tly, expression of the Gonium retinoblastoma cell cycle regulator in unicellular Chlamydomonas causes

182 In contrast to murine ESCs, most of the cell cycle regulators in hESCs show cell cycle-dependent

183 eficient mice and analyzed the expression of cell cycle regulators in liver samples taken at differen

184 ish this feat, viruses often target critical cell cycle regulators in order to have maximal effect wi

185 However, genetic manipulation of cell cycle regulators in the germ lines of mice results

186 ections between the extracellular matrix and cell cycle regulators in the regulation of hematopoiesis

187 the formin cdc12p participates downstream of cell-cycle regulators in a network that drives the initi

188 systematically isolate and annotate the core cell-cycle regulators in the moth orchid Phalaenopsis ap

189 ar regulation and functional significance of cell-cycle regulators in the pathogenesis and developmen

190 e the retinoblastoma protein (Rb), a crucial cell cycle regulator, in two subtypes of postmitotic SCs

191 However, the role of c-Myc, a key cell-cycle regulator, in this process has been questione

192 Therefore, like many critical cell cycle regulators including p21 and Cdt1, we uncover

193 cs1 facilitates transcriptional silencing of cell cycle regulators including RB/E2F target genes, lik

194 In addition, miR-31 suppressed cell-cycle regulators including E2F1, E2F2, EXO1, FOXM1,

195 ed to suppress the expression of several key cell-cycle regulators including E2F2, and chromatin immu

196 oliferation through regulating expression of cell cycle regulators (including CCND1, CCND2, and ID2)

197 Cell cycle regulators, including cyclin D1 and survivin,

198 Combinations of cell cycle regulators, including E2f1 and CyclinD, delay

199 accompanied by reduced expression of several cell cycle regulators, including Mad2.

200 A3C facilitates degradation of several vital cell cycle regulators, including the retinoblastoma (pRb

201 Expression of critical cell-cycle regulators, including ctrA, and cell division

202 Several cell-cycle regulators, including p53 and p27Kip1, are de

203 this happens in a manner independent of the cell-cycle regulators Ink4a and Arf, which play a major

204 The 14-3-3sigma (Stratifin; Sfn) is a cell cycle regulator intimately involved in the program

205 In particular, disruption of the CDKN2A/B cell cycle regulator is associated with approximately 30

206 for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells

207 The compartmentalization of cell cycle regulators is a common mechanism to ensure th

208 Increasing evidence suggests that Plk1, a cell cycle regulator, is also involved in cellular event

209 It is likely that p53, a well-known cell cycle regulator, is involved in regulating the gene

210 Cut, a linker between Notch signaling and cell-cycle regulators, is specifically downregulated by

211 Vasculature proliferation also involves the cell cycle regulator KIP-RELATED PROTEIN2 and ABERRANT L

212 The cell cycle regulator KRP6 partially represses GA-depende

213 t irrevocable proteolytic degradation of key cell-cycle regulators makes cell-cycle transitions irrev

214 hways linking abortive ribosome synthesis to cell-cycle regulators may all contribute to disease hete

215 with MLL-rearranged AML, and underscore that cell-cycle regulators may have distinct, noncanonical, a

216 Here we show that CYREN (cell cycle regulator of NHEJ) is a cell-cycle-specific i

217 2-associated Protein 1 (CDK2AP1) is one such cell-cycle regulator, originally identified as a growth

218 wth control, including the repression of the cell cycle regulators p14 and p21.

219 the CDKN2A and CDKN2B genes which encode the cell cycle regulators p16(INK4a), p14(ARF) and p15(INK4b

220 aining limited transcription of the negative cell cycle regulators p16Ink4a and p19Arf from the Cdkn2

221 n the transcription factor E47 and the major cell cycle regulator p21 in controlling LT-HSC integrity

222 o MutSbeta, an effect that is blocked by the cell cycle regulator p21(CIP1).

223 ased expression of CDKN1A, which encodes the cell cycle regulator p21(WAF1), as well as the pro-apopt

224 hway and inhibition of the expression of the cell cycle regulator p21.

225 ed proliferation and increased levels of the cell cycle regulator p21/WAF/CDKN1A and disrupts TGF-bet

226 Here, we report that overexpression of the cell-cycle regulator p21 is a critical feature of liver

227 be blocked competitively by the PCNA-binding cell-cycle regulator p21(cip1/waf1).

228 lpha, the translation regulator HuR, and the cell-cycle regulators p21 and survivin.

229 betaMHC) mRNA was increased whereas negative cell-cycle regulators (p21, Meis1) were decreased in Tbx

230 Here, we exploited the cell cycle regulator p27(Kip1) (p27) as a model system t

231 Our studies ascribe a novel role for the cell cycle regulator p27(Kip1) as a prominent negative r

232 cent computational and experimental study of cell-cycle regulator p27 demonstrated that long-range el

233 In contrast, cell-cycle regulator p27(KIP1), caspase activity as well

234 ll-related genes and pathways, including the cell-cycle regulator p27, are lower in parous women with

235 plete silencing of Cdkn1c, encoding negative cell-cycle regulator p57-Kip2.

236 ion by regulating expression and activity of cell cycle regulators, particularly at the G1/S checkpoi

237 Yata et al. show that the mitotic kinase and cell-cycle regulator Plk1 can directly stimulate the DNA

238 In addition, we revealed that a cell cycle regulator, Plk1, switches the balance between

239 es previously associated with LCH, including cell-cycle regulators, proinflammatory cytokines, and ch

240 Hdac1/2 leads to increased expression of the cell-cycle regulators Rb1, p21/Cdkn1a, and p16/Ink4a, re

241 The retinoblastoma (pRB) family of cell cycle regulators, Rb1, Rbl1 (p107), and Rbl2 (p130)

242 by RNAi can mimic the effect of GPC1 on the cell cycle regulators related to the loop.

243 ion represses expression of proproliferative cell cycle regulators required for DNA replication and D

244 zation and downstream phosphorylation of the cell cycle regulator retinoblastoma protein (Rb).

245 staining, protein expression profiles of key cell cycle regulators (retinoblastoma protein, p53, p21(

246 and UAS4 also contain binding sites for the cell cycle regulator SBF (an Swi4-Swi6 heterodimer), whi

247 Here, we show that another critical cell cycle regulator, SciP, is also degraded during the

248 These "core" cell cycle regulators serve diverse postmitotic function

249 sential process, some core animal and fungal cell cycle regulators share no more sequence identity th

250 inetics, telomere lengths, and expression of cell cycle regulators showed significant variation betwe

251 erentiation through its interaction with the cell cycle regulator Stratifin.

252 Thus, like other cell cycle regulators such as Aurkb and survivin, Aurka

253 Cell-size-dependent accumulation of limiting cell cycle regulators such as CDKG1 is a potentially gen

254 cription of AP-1-element containing G1-phase cell cycle regulators such as Myc and Ccnd1 to promote N

255 ression had significant effects on classical cell cycle regulators such as p21/WAF1 or retinoblastoma

256 is occurs without the apparent activation of cell-cycle regulators such as polo kinase or the septati

257 of DNA safeguard mechanisms by targeting of cell-cycle regulators such as WEE1.

258 is implicated in the degradation of several cell cycle regulators, such as p21(Cip1), p27(Kip1), p57

259 is possible that HCV interactions with host cell cycle regulators, such as Rb, have evolved to modif

260 variability of essentiality was observed in cell cycle regulators, suggesting regulatory mechanisms

261 e otherwise highly conserved fizzy family of cell-cycle regulators, suggesting that it probably regul

262 apoptosis and vitamin metabolic pathways and cell cycle regulators, suggestive of loss of cellular ho

263 We propose that cell-cycle regulators target TTBK2 to the basal body, wh

264 intricate gene regulatory network involving cell-cycle regulators, TGFbeta effectors and oncogenic m

265 We propose that Mad2 is an important meiotic cell cycle regulator that ensures the timely degradation

266 Thus, our study suggests PPP1R3B as a new cell cycle regulator that functions by governing Gwl dep

267 Cyclin D1 (CCND1) is an important cell cycle regulator that is considered to be a downstre

268 th an increased expression of p21cip1/waf, a cell cycle regulator that is involved in the differentia

269 Cdc5/Polo kinase is an important upstream cell cycle regulator that suppresses Cdc42 activity.

270 dt2 (CRL4(Cdt2)) is emerging as an important cell cycle regulator that targets numerous proteins for

271 Schlafen (SLFN) family of genes, a group of cell cycle regulators that mediate growth-inhibitory res

272 Rb1 encodes a cell-cycle regulator that is functionally disrupted in m

273 e Plasmodium-specific kinase PfCRK4 is a key cell-cycle regulator that orchestrates multiple rounds o

274 ct in the nucleus via repression of 2 potent cell-cycle regulators that are encoded by the Ink4a/Arf

275 egeneration by controlling the expression of cell-cycle regulators that drive M phase progression.

276 es a mechanism for the selective disposal of cell-cycle regulators that have fulfilled their mitotic

277 ore, suppressor analysis showed that another cell cycle regulator, the methyltransferase CcrM, is sim

278 intermediates, signal transduction pathways, cell cycle regulators, the organelle/protein recycling m

279 -independent developmental role for a master cell-cycle regulator, the anaphase-promoting complex or

280 ensive work on gene knockout mouse models of cell-cycle regulators, the classical model of cell-cycle

281 each centrality ranking contained well-known cell cycle regulators, there was little agreement and no

282 tides, including actin, tubulin, and several cell cycle regulators; therefore, CCT plays an important

283 dering the important role of p19(ink4d) as a cell cycle regulator, these results provide evidence for

284 ich controls cell division by ubiquitinating cell cycle regulators to drive their timely degradation.

285 modeling complex that collaborates with core cell-cycle regulators to promote cell-cycle exit and ter

286 translational suppression of mRNAs encoding cell-cycle regulators via the mTORC1/eukaryotic translat

287 In OVCAR3, an induction of cell cycle regulators was further shown.

288 Based on its role as a cell cycle regulator, we predicted that an Aurka deficie

289 In a screen for cell-cycle regulators, we identified a Drosophila matern

290 Similar effects on proliferation and cell-cycle regulators were observed in human prostate ca

291 -Raf/MKK/ERK showed highest association with cell-cycle regulators, whereas genes downregulated were

292 oma tumor suppressor protein (Rb), a central cell cycle regulator which is also targeted by oncoprote

293 Cyclin E is a cell cycle regulator which is critical for driving G1/S

294 ly transcribed genes, including Myc and Pim1 cell-cycle regulators, which associate with an entirely

295 Z/YAP promote SC proliferation by activating cell cycle regulators, while targeting critical differen

296 We conclude that LMO4 is a novel cell cycle regulator with a key role in mediating ErbB2-

297 Posttranslational modification of cell-cycle regulators with ubiquitin chains is essential

298 ession of a large number of genes, including cell cycle regulators, with concomitant increased cellul

299 to undergo growth arrest and to control the cell cycle regulators without affecting c-Myc and morpho

300 Cyclins are key cell cycle regulators, yet few analyses test their role