ライフサイエンスコーパス: cell degeneration

1 which lacks auditory responses and has hair-cell degeneration.

2 s characterized by progressive photoreceptor cell degeneration.

3 xpression leads to photoreceptor and bipolar cell degeneration.

4 ssion of normal opsin leads to photoreceptor cell degeneration.

5 pture could be a direct trigger for the hair cell degeneration.

6 , atypical nuclei, perinuclear clearing, and cell degeneration.

7 of Bmp8b causes male infertility due to germ cell degeneration.

8 lear inclusion (NI) formation and late-onset cell degeneration.

9 ds gene mutations resulting in photoreceptor cell degeneration.

10 ed by ibogaine mediates excitotoxic Purkinje cell degeneration.

11 -onset, and relentless form of photoreceptor cell degeneration.

12 ormer being associated with evidence of beta-cell degeneration.

13 bogaine displayed clear evidence of Purkinje cell degeneration.

14 eless sufficient to induce bilateral granule cell degeneration.

15 be controlled with small molecules to reduce cell degeneration.

16 gical symptom onset and more severe Purkinje cell degeneration.

17 ted males demonstrated RPE and photoreceptor cell degeneration.

18 otoxic stress response, contributing to hair cell degeneration.

19 Iron-containing microglia showed signs of cell degeneration.

20 t contributes to aminoglycoside-induced hair cell degeneration.

21 mossy-fiber sprouting 5-6 weeks after mossy cell degeneration.

22 chromophore showed accelerated photoreceptor cell degeneration.

23 s of CCP1 in mice causes cerebellar Purkinje cell degeneration.

24 With time this causes cone cell degeneration.

25 ults from retinal pigmented epithelium (RPE) cell degeneration.

26 m of SCA17 transgenic mice prior to Purkinje cell degeneration.

27 F3A loss results in very rapid photoreceptor cell degeneration.

28 dysmorphic stereocilia and progressive hair cell degeneration.

29 response to MPP+ treatment, which led to the cell degeneration.

30 VH infusion did not induce dopaminergic cell degeneration.

31 el abolished the RD-associated photoreceptor cell degeneration.

32 asilar papilla at the earliest signs of hair cell degeneration.

33 ve a therapeutic role in human photoreceptor cell degenerations.

34 -) mice lose hearing and manifest outer hair cell degeneration after systemic cisplatin treatment.

35 y is characterized by vascular smooth muscle cell degeneration and accumulation of diagnostic granula

36 Rapid and progressive postnatal acinar cell degeneration and acinar-to-ductal metaplasia occur,

37 entiviral knockdown of EZH2 rescued Purkinje cell degeneration and behavioral abnormalities in Atm(-/

38 etes mellitus at 30+ weeks of age, when beta-cell degeneration and both amorphous and amyloid deposit

39 Significant levels of cell degeneration and cell debris, characteristic of nec

40 1 in mice causes severe ataxia with Purkinje cell degeneration and cerebellar atrophy, partially rese

41 e mutant channels, leading over time to hair-cell degeneration and contributing to their deafness.

42 ysiological potentials likely underlies hair cell degeneration and deafness in Va and Va(J) mice.

43 echanism for the terminal phases of neuronal cell degeneration and death in human neurodegenerative d

44 activation of this receptor induces neuronal cell degeneration and death via stimulation of caspases.

45 -finger transcription factors, leads to germ cell degeneration and defective sperm production in adul

46 retinas against light-induced photoreceptor cell degeneration and inhibited photoreceptor apoptosis.

47 Mechanisms underlying this NK cell degeneration and its biological significance are no

48 Histopathological findings revealed beta-cell degeneration and loss consistent with the drop in t

49 or and an abnormal gait, as well as Purkinje cell degeneration and photoreceptor cell loss.

50 ntually hyperexcitability gives rise to dark cell degeneration and reduced cerebellar output.

51 ounding the SG neurons, leading to satellite cell degeneration and subsequent SG degeneration with a

52 gene expression is synchronal with nucellar cell degeneration and thus, nucellin may be involved wit

53 ly sufficient to delay the onset of Purkinje cell degeneration and to correct the ataxia.

54 which disruptions in NMNAT1 lead to retinal cell degeneration and would provide a resource for testi

55 ral defects in the retina (e.g. dopaminergic cell degeneration and/or lack of regeneration).

56 d extracellular matrix, medial smooth muscle cell degeneration, and adventitial fibrosis.

57 sing loss of conventional MET currents, hair cell degeneration, and deafness in mice.

58 sing into large vacuoles preceding satellite cell degeneration, and followed by SG degeneration.

59 l protein frataxin causes neural and cardiac cell degeneration, and Friedreich's ataxia.

60 ity that glial dysfunction leads to Purkinje cell degeneration, and generated mice that express ataxi

61 ine nucleus migration defects, cochlear hair cell degeneration, and profound hearing loss.

62 as knocked out leading to postnatal Purkinje cell degeneration, and standard delay eyeblink condition

63 GSIS, suggest a molecular mechanism for beta-cell degeneration as a consequence of Ide deficiency, an

64 g a 6-OHDA lesion, it is evident that nigral cell degeneration begins much earlier.

65 overlapping phenotypes arising from Purkinje cell degeneration, cerebellar atrophy and varying degree

66 of Purkinje cells revealed findings of dark cell degeneration consistent with excitotoxic injury.

67 tion of sodium influx to development of dark cell degeneration (DCD) in Purkinje neurons (PNs) follow

68 -induced delayed neurotoxicity known as dark cell degeneration (DCD) that is expressed as cytoplasmic

69 days old), AMPA produced in addition to dark cell degeneration (DCD), an edematous type of toxicity (

70 erker, a recessive mutation that causes hair cell degeneration, deafness, and vestibular dysfunction.

71 bal Npc1 null mice, suggesting that Purkinje cell degeneration does not underlie these phenotypes.

72 Additional neurons undergoing dark cell degeneration exhibited none of these apoptotic feat

73 mild fatty degeneration and inflammation to cell degeneration, fibrosis, and cirrhosis with or witho

74 wever, their involvement in cochlear sensory cell degeneration following acoustic trauma is unknown.

75 Photoreceptor cell degeneration follows a radial gradient, more severe

76 ial activation may be involved in the nigral cell degeneration in 6-OHDA induced parkinsonian mice.

77 urkinje cells, we documented severe Purkinje cell degeneration in 92Q SCA7 transgenic mice.

78 Cell degeneration in Alzheimer's disease is mediated by

79 The polygenic basis of outer hair cell degeneration in Beethoven mice provides a model sys

80 or comparable transneuronal retinal ganglion cell degeneration in both primate species and show that

81 t alter either clinical symptoms or Purkinje cell degeneration in Dpl transgenic mice.

82 ivatives (13n and 36a) caused adrenocortical cell degeneration in guinea pigs treated with these inhi

83 and potentially moderating progressive hair cell degeneration in hearing loss more generally.

84 such as presbycusis, that involve outer hair cell degeneration in humans.

85 Hair cell degeneration in mambo mice precedes endocochlear po

86 causes profound hearing loss and outer hair cell degeneration in mice.

87 pathogenesis of the disease and progressive cell degeneration in MLIV patients.

88 ms of PNH that include toxins, anterior horn cell degeneration in motor neurone disease and genetic d

89 e non-cell-autonomous nature of the Purkinje cell degeneration in our SCA7 mouse model indicates that

90 ntributes to the cascade leading to dopamine cell degeneration in Parkinson's disease (PD).

91 ia nigra and the specific patterns of nigral cell degeneration in Parkinson's disease.

92 al dysfunction in the pathogenesis of nigral cell degeneration in Parkinson's disease.

93 immune/inflammatory factors in dopaminergic cell degeneration in parkinsonian substantia nigra, we a

94 fied as a candidate gene to explain Purkinje cell degeneration in pcd mice, but its function remains

95 n, but unlike Nna1, neither rescues Purkinje cell degeneration in pcd mice, indicating that they do n

96 action contributes to the selective Purkinje cell degeneration in SCA1.

97 unctional changes that characterize ganglion cell degeneration in the glaucomatous eye, and following

98 to 4.2mm posterior to the bregma to examine cell degeneration in the retrosplenial and piriform regi

99 y occasional necrotic cells and no extensive cell degeneration in the same brain regions.

100 Such rats showed no signs of neuronal cell degeneration in the striatum, but did show signific

101 causes a late onset of retinal dopaminergic cell degeneration in zebrafish.

102 t a novel signaling pathway for dopaminergic cell degeneration, in which MPP+ induces the up-regulati

103 due primarily to a late-onset photoreceptor cell degeneration involving initially the rods but event

104 Hearing loss resulting from hair cell degeneration is a common disease that affects milli

105 Photoreceptor cell degeneration is a feature common to these diseases,

106 In rats, TD-induced cell degeneration is accompanied by an accumulation of a

107 However, germ cell degeneration is observed in 47% of adult homozygous

108 ze that the slowly progressive photoreceptor cell degeneration is secondary to abnormal function of t

109 By 12-14 months, retinal ganglion cell degeneration is usually very severe and essentially

110 Atg7(Deltapan) mice exhibit severe acinar cell degeneration, leading to pancreatic inflammation an

111 a (SNpc), a brain region where dopamine (DA) cell degeneration leads to Parkinson's disease (PD), exp

112 iably exhibit embryonic or larval lethality, cell degenerations, malformation of the posterior body,

113 Thus, NK cell degeneration may serve as a means evolved by the im

114 ses (CCP1-6) and is mutated in pcd (Purkinje cell degeneration) mice.

115 ion mutants, and light-induced photoreceptor cell degeneration models), the use of Tb(3+) or Eu(3+) d

116 re implanted into the cerebellum of Purkinje cell degeneration mutant mice (pcd/pcd), a model of adul

117 In RT-treated rats, progressive dopaminergic cell degeneration occurred in the SNc.

118 Progressive base-apex hair cell degeneration occurs at older ages, corresponding wi

119 live ablation produced little or no Purkinje cell degeneration or glial activation.

120 ns in patients who suffer from photoreceptor cell degeneration or related retinal diseases.

121 nerve transection (ONTx) to induce ganglion cell degeneration, or in combination with an ionotropic

122 protected from glaucomatous retinal ganglion cell degeneration out to 14 months of age (oldest assess

123 We report that Purkinje cell degeneration (pcd) mice exhibit a profound impairme

124 Purkinje cell degeneration (pcd) mice have a mutation within the

125 Analysis of visibly ataxic Purkinje cell degeneration (pcd) mice reveals that while differen

126 The Purkinje cell degeneration (pcd) mouse has a disruption in the ge

127 The Purkinje cell degeneration (pcd) mouse is a recessive model of ne

128 ses, and its mutation underlies the Purkinje cell degeneration (pcd) mouse.

129 These animals, the so-called Purkinje Cell Degeneration (PCD) mutant mice, suffer from a progr

130 The Purkinje cell degeneration (pcd) mutant mouse is characterized by

131 ne have been shown to be related to Purkinje cell degeneration (pcd) phenotypes including ataxia in m

132 e classical recessive mouse mutant, Purkinje cell degeneration (pcd), exhibits adult-onset degenerati

133 autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), was first identified through it

134 s have previously demonstrated that Purkinje cell-degeneration (pcd) mutant mice are impaired in eyeb

135 neurons, causes the same pattern of Purkinje cell degeneration, providing a clue to the mechanism of

136 s pathogenesis and mechanisms governing beta-cell degeneration/regeneration.

137 y which this mutation leads to photoreceptor cell degeneration remains unknown.

138 to its decreased expression following nigral cell degeneration suggests that it may play an important

139 ermine whether sustained waking causes brain cell degeneration, three parallel strategies were used.

140 rapid, marked by type I alveolar epithelial cell degeneration, type II alveolar epithelial cell hype

141 ANF ameliorates mutant TBP-mediated Purkinje cell degeneration via protein kinase C (PKC)-dependent s

142 The cell degeneration was associated with an accumulation of

143 after intense-light treatment, photoreceptor cell degeneration was estimated by determining the level

144 Purkinje cell degeneration was evaluated with a Fink-Heimer II st

145 We show that NK cell degeneration was mediated by IL-21 derived from aut

146 scopic observations demonstrated morphologic cell degeneration well before lactate dehydrogenase rele

147 Cell degeneration, when present, extends transneuronally

148 lastoma cells resulted in vacuologenesis and cell degeneration, whereas ES treatment after FIG4-small

149 s exhibiting cerebellar atrophy and Purkinje cell degeneration whose subtypes arise from 31 distinct

150 ession and aggregation of hA might link beta-cell degeneration with diabetes onset and progression, b

151 llar autopsy material showed severe Purkinje cell degeneration, with abnormal intracellular accumulat