ライフサイエンスコーパス: cell depletion

1 , and 28 d postinfection even after CD4(+) T cell depletion.

2 ion, chronic immune activation, and CD4(+) T cell depletion.

3 tissue (LT) fibrosis, which causes CD4(+) T-cell depletion.

4 o AA rupture, which was attenuated by CD8+ T cell depletion.

5 t these B cells are resistant to alphaCD20 B-cell depletion.

6 n largely manifests itself in vivo as CD4+ T cell depletion.

7 lls forming hepatic metastases after myeloid cell depletion.

8 fibroblasts, all of which were reduced by B cell depletion.

9 ccessfully treated with anti-CD20-mediated B-cell depletion.

10 rmline defects such as hypogonadism and germ cell depletion.

11 ed B cell recovery after antibody-mediated B cell depletion.

12 y up-regulated in cancer cells after myeloid cell depletion.

13 nor (D-) transplants and is exacerbated by T-cell depletion.

14 erived from studies of patients treated by B-cell depletion.

15 nd a failure of disease to recur after CD3 T cell depletion.

16 with chronic immune activation and CD4(+) T cell depletion.

17 of the early steps of HIV-1 infection and T cell depletion.

18 enewal capacity, myeloid skewing, and immune cell depletion.

19 r concerted effect in inducing resting CD4 T cell depletion.

20 te of ongoing viral replication and CD4(+) T cell depletion.

21 and can induce peripheral and systemic CD4 T cell depletion.

22 therapeutic efficacy were lost after Kupffer cell depletion.

23 sms (SNPs) in the ZNRD1 region with CD4(+) T-cell depletion.

24 nt of CAV but inhibited the effect of CD25 T cell depletion.

25 gm function was also unaffected by satellite cell depletion.

26 g/mouse) was much less efficient in lymphoma cell depletion.

27 se and apoptosis, which correlated with stem cell depletion.

28 tant was controlled in lungs despite CD4/CD8 cell depletion.

29 ce of Tlr11(-/-) mice is lost upon pDC or NK cell depletion.

30 ion was suppressed by plasmacytoid dendritic cell depletion.

31 ation of the inflammasome resulting in CD4 T cell depletion.

32 to achieve simultaneous DC expansion and NK cell depletion.

33 macaques for years after sustained memory B cell depletion.

34 of these, 129 (64.5%) received an in vivo T-cell depletion.

35 of B cells and investigated mechanisms of B-cell depletion.

36 iral infections due to combined T cell and B cell depletion.

37 ators, consequently slowing down muscle stem cell depletion.

38 mportance of abortive infection in driving T cell depletion.

39 ystrophic phenotype due to rapid muscle stem cell depletion.

40 s of cGVHD, they increased after anti-CD20 B-cell depletion.

41 ed with HBV after antibody-mediated CD4(+) T-cell depletion.

42 d were largely refractory to systemic immune cell depletion.

43 ecropsy, and no virus emerged after CD8(+) T cell depletion.

44 ongoing EAE, which was abrogated by CD8(+) T cell depletion.

45 dampening of autoimmune processes through B cell depletion.

46 Specific natural killer cell depletion 24 hours pre-acute myocardial infarction

47 stinal atrophy featuring stem and progenitor cell depletion, a phenotype unexpected from the previous

48 bers of effector T cells in the tumor, and T cell depletion abolished the reduced tumor growth observ

49 d and brain tissue was attenuated by myeloid cell depletion after TBI.

50 Finally, CD4 T cell depletion alone did not prevent or accelerate devel

51 ed the codepletion of NK and CD4 T cells, NK cells depletion alone eliminated CAV at 3 weeks.

52 NK cell depletion also led to decreased production of IL-22

53 hallmarks of HIV-1 pathogenesis are CD4(+) T cell depletion and abnormal cellular activation.

54 Cell depletion and adoptive transfer studies showed that

55 cell maintenance are key to preventing stem cell depletion and aging.

56 evels, and ultimately caused marked CD4(+) T cell depletion and AIDS-defining conditions.

57 ion is characterized by progressive CD4(+) T-cell depletion and CD8(+) T-cell expansion, and CD4(+) T

58 By combining epithelial cell depletion and cell culture in media with high conce

59 two signature events in HIV infection-CD4 T-cell depletion and chronic inflammation-and creates a pa

60 Lung CD4(+) T-cell depletion and dysfunction, CD8(+) T-cell alveolitis

61 y removed the pericardial AT and performed B-cell depletion and granulocyte-macrophage colony-stimula

62 TD)/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during a

63 aimed to determine mechanisms of human Treg cell depletion and reconstitution after anti-CD25 monocl

64 rotein kinase inactivation as well as cancer cell depletion and show that mast cells in the tumor mic

65 oHSV therapy was sufficient to phenocopy NK-cell depletion and suppress tumor growth and prolong sur

66 IL-15 complexes in response to Ab-mediated T cell depletion and TBI, suggesting products of cell deat

67 ng experiences severe and sustained CD4(+) T cell depletion and tissue disruption.

68 anded in an IL-2-dependent manner upon T reg cell depletion and were able to give rise to mature NK c

69 ior to depletion, during the nadir of CD8(+) cell depletion, and after CD8(+) lymphocyte numbers had

70 e evidence of ongoing inflammation, CD4(+) T cell depletion, and perhaps even inflammation-associated

71 sistant to previous medications, including B-cell depletion, and who switched to tocilizumab (6-8 mg/

72 Immunohistochemical analyses and a cell-depletion approach indicated neutrophils as the maj

73 Using genetic and cell depletion approaches, we generated iNKT cell-defici

74 umour necrosis factor (TNF) inhibition and B-cell depletion are highly effective treatments for activ

75 ation exposure, light skin color, sex, and T-cell depletion are risk factors for cutaneous malignant

76 NK-cell depletion as well as TRAIL and NKG2D pathway blocka

77 BI), cyclophosphamide, or Thy1 Ab-mediated T cell depletion, as well as in RAG(-/-) mice; interesting

78 induced by memory helper T cells, and CD8 T cell depletion at the time of transplantation or depleti

79 h established cGVHD resulted in peripheral B-cell depletion, B cells remained in the lung, and BOS wa

80 Here, we show that chronic B cell depletion (Baffr deficiency) significantly reduces

81 employing costimulation blockade-based or T-cell depletion-based conditioning with 1 or 3 Gy total b

82 graft survival during the time than other T-cell depletion-based protocols.

83 Here, we investigated the outcome of B-cell depletion (Bdep) therapy on CD8(+) T-cell-mediated

84 B-cell depletion before HDM challenge in HDM-sensitized mi

85 tein-specific Ab responses, and gammadelta T cell depletion before infectious challenge did not ablat

86 Mice were also subject to transient Treg cell depletion before sensitization with OVA plus SEA.

87 spheres with stunted folia, profound granule cell depletion, Bergmann gliosis, and signs of Purkinje

88 -TCRgammadelta antibody-induced gammadelta T-cell depletion blunted Ang II-induced SBP rise and endot

89 Anti-CD3 administration induces transient T cell depletion both in preclinical and in clinical studi

90 reventing myonuclear accretion via satellite cell depletion, both the number of transcriptionally act

91 ed immune tolerance does not seem to involve cell depletion, but rather a specific expansion of IL-10

92 antiatherogenic effects are unrelated to NK-cell depletion, but to CD8(+) T and NKT cells.

93 capacity for self-renewal, resulting in germ cell depletion by 2 mo of age.

94 patients show anti-tumor activity through B-cell depletion by anti-CD20 antibody.

95 fect of enriching for tBregs suggests that B-cell depletion by anti-CD20 may not be beneficial at all

96 In monkeys, assessment of safety and target cell depletion by the high- and low-affinity TDBs reveal

97 Such subsets likely explain why B cell depletion can either ameliorate or exacerbate infla

98 T cell depletion can prevent hypertension in experimental

99 bitory KIR showed weak activation and target cell depletion capacity when incubated with rituximab an

100 d mutagenesis that shows sterility with germ cell depletion caused by defective proliferation of prim

101 -IL-7 receptor blocking antibody following T cell depletion, combined with the mammalian target of ra

102 Regulatory T cell depletion completely reverses this immune downmodul

103 ptor alpha (IL-7Ralpha) alone or following T cell depletion confers an advantage for allograft surviv

104 reduced infectious ZIKV levels, and CD8(+) T cell depletions confirmed that CD8(+) T cells mediated t

105 enhanced anti-FVIII antibody formation, MZ B-cell depletion continued to display similar effectivenes

106 Peripheral CD4(+) T-cell depletion correlated with granulomas that contained

107 Peripheral CD4(+) T-cell depletion correlated with increased M. tuberculosis

108 However, CD8(+) T-cell depletion decreased chemokine (CC-motif) ligand ser

109 We further evidenced that CD8(+) T-cell depletion decreased levels of mature monocytes and

110 Satellite cell depletion did not alter diaphragm mean fibre cross-

111 ponse to B cell-derived exosomal proteins, B cell depletion did not alter the exosome-induced CTL res

112 ne (CXC-motif) ligand 1 expression, CD8(+) T-cell depletion did not directly affect monocyte recruitm

113 control, because 2B4 blockade after CD8(+) T-cell depletion did not further aggravate symptoms of EBV

114 The kinetic of Treg cell depletion did not parallel the disappearance of CD2

115 y antibody response, demonstrating that MZ B-cell depletion did not result in FVIII tolerance.

116 leukin-10 (IL-10), although in vivo CD8(+) T cell depletion did not significantly alter Mtb burden.

117 , LM-Kras, alone or in combination with Treg cell depletion, did not increase survival time or slow P

118 KEY POINTS: Satellite cell depletion does not affect diaphragm adaptations to

119 Progressive T cell depletion during chronic human immunodeficiency vir

120 t pathway that plays a central role in CD4 T cell depletion during disease progression to AIDS.

121 ve understanding of the mechanisms driving T cell depletion during HIV infection.IMPORTANCE In HIV-in

122 spite similar viral replication and CD4(+) T cell depletion during primary SIV infection, CD4(+) T ce

123 NK cell depletion during reinfection attenuated weight loss

124 Despite complete CD20-cell depletion during rituximab therapy, the median annu

125 ring the first few days of infection, but NK cell depletion during those early time points can enable

126 Satellite cell depletion early in life (4 months of age) has minim

127 Anti-CD20 B cell depletion effectively reduces disease activity in M

128 show that PD-L1 blockade together with CD4 T cell depletion effectively rescued deeply exhausted CD8

129 Although Treg cell depletion enhances tumor rejection, the ensuing aut

130 chronic inflammation and Ag exposure, CD4 T-cell depletion, etc., alone does not cause poly- and aut

131 Interestingly, NK cell depletion experiments demonstrated a critical cutof

132 Adoptive transfer of serum and T-cell depletion experiments demonstrated a dominant role

133 alreticulin, prophylactic immunization and T-cell depletion experiments showed that melphalan adminis

134 T-cell depletion experiments suggested that T cells were r

135 endritic cells were each implicated based on cell depletion experiments.

136 Parallel cell-depletion experiments demonstrated that Ly6C(hi) in

137 evealed by bone marrow chimera and dendritic cell-depletion experiments, with colon epithelial cells

138 New strategies including naive T-cell depletion, focused cytokine and chemokine inhibitio

139 Rituximab-mediated B-cell depletion followed by adoptive transfer of B cells

140 Chronic B cell depletion for 6 mo in aged naive mice resulted in a

141 rbed doses with experimental measurements of cell depletion for platelets, progenitors, and precursor

142 le of B cells could explain the success of B-cell depletion for remission of AIH despite its classifi

143 NK cell depletion from PBMCs prior to their intrasplenic in

144 because it was eliminated by local CD4(+) T cell depletion from the cornea.

145 By contrast, CD8(+) T cell depletion had no apparent impact on osteoblast abla

146 B cell depletion had no effect on established memory popul

147 l deficit in two ischemia models, whereas NK cell depletion had no effect.

148 otocols use unmanipulated (without ex vivo T-cell depletion) haploidentical grafts combined with enha

149 data suggest that IL-7R blockade following T cell depletion has potential as a robust, immunosuppress

150 seminiferous tubule niche, resulting in germ cell depletion, hypofertility, intratubular germ cell ne

151 However, M96 caused NK cell depletion if given 4 d prior to septic challenge an

152 Despite the preferential Th22 cell depletion, IL-22 production by innate lymphoid cell

153 ed cytotoxic activity (Prf1 mutation) nor NK cell depletion (Il2rg mutation) has any influence on the

154 ks of human HIV infection including CD4(+) T-cell depletion, immune activation, and development of HI

155 and redox state are associated with CD4(+) T cell depletion, immune activation, and inflammation.

156 zation are associated with generalized CD4 T-cell depletion, impaired antigen-specific proliferation,

157 he significance of this finding, a week of B cell depletion in 4-mo-old mice was followed by acute vi

158 conditioning was used in 80%, and in vivo T-cell depletion in 81%, of cases.

159 ges underlying the AIH remission caused by B-cell depletion in an experimental model of AIH.

160 CD8(+) T cell depletion in animals with controlled viremia caused

161 The possible therapeutic benefits of B-cell depletion in combating tumoral immune escape have b

162 Our results indicate that muscle stem cell depletion in dKO muscle is related to upregulation

163 Acute B cell depletion in either 2- or 4-mo-old mice significant

164 Antibody-mediated CD4(+) T-cell depletion in HF mice (starting 4 weeks after ligati

165 Antibody-mediated CD8(+) T-cell depletion in high-fat diet-fed Ldlr(-/-) mice decre

166 Rituximab-induced B cell depletion in IgG4-RD leads to rapid clinical and hi

167 NK cell depletion in MCMV-infected transplants also improve

168 ecruited macrophages, and less smooth muscle cell depletion in PLTP-deficient than in wild-type mice,

169 Viremia remained undetectable after CD8(+) T-cell depletion in seven vaccinated animals that had supp

170 ering viral distribution or burden, and that cell depletion in SiglecH-DTR-Tg mice encompasses more t

171 efficacy of anti-CD20 (rituximab)-mediated B cell depletion in systemic lupus erythematosus may be re

172 Generalised T-cell depletion in the absence of specific depletion of e

173 ccessful use of costimulatory blockade and B-cell depletion in the clinic has revealed that the adapt

174 Prolonged satellite cell depletion in the diaphragm does not result in exces

175 g of HIV/SIV pathogenesis and implicate MAIT cell depletion in the disease process.

176 we have observed a rapid occurrence of stem cell depletion in the dystrophin/utrophin double knockou

177 CD8(+) T cell depletion in the effector phase of disease attenuat

178 myloid polypeptide (IAPP) is responsible for cell depletion in the pancreatic islets of Langherans, a

179 T-cell depletion in the R+/D- setting may actually, theref

180 ected humans, our data suggest that CD4(+) T cell depletion in the setting of HIV disease may reflect

181 ms have been invoked to account for CD4(+) T cell depletion in this setting, but the quantitative con

182 B cell depletion in thyroids of mice given anti-CD20 was m

183 nt mechanism underlying progressive CD4(+) T cell depletion in vivo.

184 Furthermore, T-cell depletion in wild-type mice after transverse aortic

185 gulation of Pax3 mRNA+ cells after satellite cell depletion in young and aged mice suggests that Pax3

186 In vitro, CD14(pos)- and CD15(pos)-cell depletion increased T-cell proliferation in patient

187 rotection was significantly reduced by CD8 T cell depletion, indicating a critical role for CD8 T cel

188 However, B cell depletion inhibited alloantibody generation and sig

189 Myeloid cell depletion inhibited metastatic growth with a marked

190 ential new therapeutics, centered on naive T-cell depletion, interleukin-17/21 inhibition, kinase inh

191 T cell depletion is commonly used in organ transplantation

192 lood transplantation (CBT) without in vivo T-cell depletion is increasingly used to treat high-risk h

193 on and CD8(+) T-cell expansion, and CD4(+) T-cell depletion is linked directly to the risk for opport

194 ent, and (iii) rebounding virus after CD8(+) cell depletion is replication competent and genetically

195 eration rates increased in TA-TLSs upon Treg cell depletion, leading to tumor destruction.

196 During disseminating virus infection, B cell depletion led to sustained weight loss and function

197 ioning regimen consisting of pretransplant T cell depletion, low-dose total body irradiation and post

198 following anti-CD4- and anti-CD8-mediated T cell depletion markedly prolonged skin allograft surviva

199 These results suggest that prolonged B cell depletion may alter the PC survival niche in the ki

200 B-cell depletion may impair vaccine responses and increase

201 understanding tolerance induction and how B cell depletion may prevent tolerance.

202 In vivo T-cell depletion might contribute to the delayed immune re

203 Using a cell-depletion model, we determined that heart regenerat

204 Progression to AIDS is driven by CD4 T cell depletion, mostly involving pyroptosis elicited by

205 Whether satellite cell depletion negatively impacts diaphragm quantitative

206 Acute T cell depletion occurred in the ATG group, with slow reco

207 mphoma cells outside the B-cell nodules or B-cell depletion of the microenvironment.

208 In mouse cells, depletion of ER luminal FKBP10 was almost as pote

209 effector/memory conversion of Ag-specific T cells, depletion of peripheral CD4(+) T cells in hematol

210 In HEp-2 cells, depletion of STING by shRNA results in a decrease

211 In these cells, depletion of STING results in higher yields of bo

212 Of importance, in human cells, depletion of TRAPPC11, but not other TRAPP compon

213 In mesenchymal precursor cells, depletion of WTX and TRIM28 resulted in analogous

214 This enhancing effect of delayed NK cell depletion on antiviral immunity, in contrast to ear

215 els of GVHD to evaluate the effect of CD4+ T cell depletion on GVL versus GVHD and revealed that depl

216 The positive effects of NK cell depletion on T cell responses only occurred when NK

217 Natural killer cell depletion or codepletion of CD4(+) and CD8(+) cells

218 dependent Ab response, without evidence of T cell depletion or cytokine release.

219 B-cell depletion or granulocyte-macrophage colony-stimulat

220 B-cell depletion or IL-10 deficiency in B cells prevented

221 More importantly, B-cell depletion or TNFalpha neutralization can restore th

222 treatment in vivo, CXCR3 blockade, CD8(+) T cell depletion, or IFN-gamma neutralization each inhibit

223 ynamics of acute viral replication, CD4(+) T cell depletion, or preinfection levels of microbial tran

224 and treatment with costimulation blockade, T-cell depletion, or rapamycin.

225 Analogous to myeloid cell depletion, overexpression of ANGPTL7 in cancer cell

226 Unlike B cell depletion, pan-T cell aplasia is prohibitively toxi

227 ut not in germ cells, results in a mild germ cell depletion phenotype.

228 Although it has been speculated that stem cell depletion plays a role in the rapid progression of

229 on, although short-term (3-d) local CD4(+) T cell depletion postinfection did not influence chemokine

230 viral replication and the nadir of CD4(+) T cell depletion predominantly in lamina propria leukocyte

231 B-cell depletion prevented costimulatory blockade-induced

232 ponses during the sensitization phase or Tfh cell depletion prevented Th2 cell-mediated responses fol

233 Although B-cell depletion prevents alloantibody formation, nonhumor

234 ts with LRBA deficiency revealed marked Treg cell depletion; profoundly decreased expression of canon

235 l integration has a central role in CD4(+) T-cell depletion, raising the possibility that integrase i

236 effects of CD79-targeted mAbs do not require cell depletion; rather, they act by inducing an anergic-

237 While CD11c+ cell depletion reduced IL-6, IL-1beta, CXCL1, CXCL2 and

238 The combination of LM-Kras and Treg cell depletion reduced numbers of Foxp3(+)CD4(+) T cells

239 secreting beta cells following targeted beta cell depletion, regenerating the form and function of th

240 and cellular mechanisms responsible for stem cell depletion remain poorly understood.

241 ate that haplo-HSCT after alphabeta T- and B-cell depletion represents a competitive alternative for

242 Antifungal treatment or autoreactive CD4 T cell depletion rescues, whereas oral fungal administrati

243 lyzing individual granulomas revealed that B cell depletion resulted in altered local T cell and cyto

244 either spontaneous nor experimental CD4(+) T cell depletion results in substantial levels of in vivo

245 Lineage-specific cell depletion revealed that Tregs promote HF regenerati

246 In addition to B-cell depletion, rituximab can modulate the immune respon

247 T-cell depletion significantly increased renal calcificati

248 ers had significant LT fibrosis and CD4(+) T-cell depletion, similar to noncontrollers, but the so-ca

249 s significantly reduced by systemic CD4(+) T cell depletion starting before infection, although short

250 Subsequent T-cell depletion stimulates a 3- to 5-log increase in the

251 Specific in vivo cell depletion strategies have allowed us to demonstrate

252 g therapeutic approach but experience with B-cell depletion strategies remains limited.

253 ese studies will facilitate development of T-cell depletion strategies to augment the feasibility of

254 Using adoptive transfer and B cell depletion strategies, we determined that optimal pr

255 cently described hamster model, along with T-cell depletion strategies, we show that CD4(+) T cells a

256 By using various cell-depletion strategies, we find that, whereas lymphoc

257 Using cell-depletion strategies, we show that regeneration is

258 Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8(

259 Immune cell depletion studies demonstrated that CD4(+) and CD8(

260 vo cannot account for the extent of CD4(+) T cell depletion, suggesting indirect or bystander mechani

261 how that MRV infects the thymus and causes T-cell depletion, suggesting that other roseoloviruses may

262 rmore, IL-7 inhibition in combination with T cell depletion synergized with either CTLA-4Ig administr

263 tential therapeutic approaches focusing on B-cell depletion that could be used to translate experimen

264 viral pathways perturbed by in vivo CD8(+) T cell depletion that may contribute to noncytolytic contr

265 Their resistance to in vivo B-cell depletion, that is, their independency from supply

266 mmune complexes suppressed antibody-mediated cell depletion, therapeutic antibody-killing of LCMV inf

267 abdominal aortic aneurysm (AAA) receiving B-cell depletion therapy highlight the importance of under

268 The efficacy of B cell depletion therapy in multiple sclerosis indicates t

269 T-cell depletion therapy is associated with diminished int

270 that the addition of oral anti-CD3 to the B-cell depletion therapy synergistically enhances the supp

271 numbers decrease after rituximab-mediated B-cell depletion therapy; this loss correlates with diseas

272 sis, in part as a result of the success of B cell-depletion therapy.

273 NK cell depletion through treatment with anti-IL-15 monoclo

274 Anti-oxidant treatment, Kupffer cell depletion, Tnfr1 deletion, or JNK inhibition reduce

275 The effects of B cell depletion varied among granulomas in an individual

276 evidence for profound lung mucosal CD4(+) T-cell depletion via a Fas-dependent activation-induced ce

277 ated with mAb against BLyS or APRIL, where B cell depletion via withdrawal of essential survival cyto

278 of tolerance induction by CD3 mAb-mediated T-cell depletion, warranting caution in their use for the

279 Mechanistically, Treg-cell depletion was associated with M1-like macrophage po

280 ory KIR expression, and efficiency of target cell depletion was not negatively affected by KIR/HLA in

281 antiviral immunity, in contrast to early NK cell depletion, was not associated with increased morbid

282 induction, T-cell stimulation, regulatory T cell depletion-was observed at all dose levels.

283 SIV replication, dissemination, and CD4(+) T cell depletion, we profiled miRNA expression in colon fo

284 donor type (mother) and GVHD prophylaxis (T-cell depletion) were also significant predictors of aGVH

285 his attenuation was partially reversed by NK cell depletion, whereas the simultaneous depletion of mo

286 the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumo

287 Here, TMEV infection induced splenic T cell depletion, which was associated with lower anti-vir

288 Systemic myeloid cell depletion with anti-Gr-1 antibody blocked the impro

289 omized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG; fo

290 Recipient conditioning consisted of T cell depletion with CD3-immunotoxin, and 100 cGy total b

291 Antecedent Kupffer cell depletion with clodronate liposomes (0.5 mg/kg).

292 However, Kupffer cell depletion with clodronate liposomes resulted in gre

293 rved in nontransplanted mice and after CD8 T cell depletion with mAb instead of mATG.

294 We hypothesized that CAR T-cell depletion with optimal timing after AML eradication

295 sed SIV reservoir size and accelerated CD4 T-cell depletion with progression to AIDS despite decrease

296 ) individuals demonstrated profound CD4(+) T-cell depletion with reduced CD4/CD8 T-cell ratios in bro

297 IMPORTANCE B-cell depletion with the anti-CD20 antibody rituximab is

298 B-cell depletion with the anti-CD20 antibody, rituximab, f

299 revealed that Treg loss was primarily due to cell depletion, with minimal evidence of Treg conversion

300 administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to t