ライフサイエンスコーパス: cell fate specification

1 erful system to study the molecular basis of cell fate specification.

2 EAD4 in blastomeres dictates first mammalian cell fate specification.

3 constraints, cell proliferation dynamics and cell fate specification.

4 nd nuclear factors in the establishment of T-cell fate specification.

5 te inner ear morphogenesis without affecting cell fate specification.

6 g convergent extension movements or mesoderm cell fate specification.

7 ranscriptional control mechanisms underlying cell fate specification.

8 stem has been most studied in the context of cell fate specification.

9 is a central regulator required for aleurone cell fate specification.

10 study gene regulatory networks that control cell fate specification.

11 ctor that participates in embryonic neuronal cell fate specification.

12 candidate regulators of hypothalamic neural cell fate specification.

13 yet generates different outcomes in daughter cell fate specification.

14 chanism that generates asymmetry in daughter cell fate specification.

15 germline stem cell totipotency and embryonic cell fate specification.

16 al stem cell self-renewal and neuronal/glial cell fate specification.

17 n of radial glial cell division and daughter cell fate specification.

18 ng aspects of dorsal neural tube closure and cell fate specification.

19 hat loss of plasticity can be uncoupled from cell fate specification.

20 an excellent model system to study epidermal cell fate specification.

21 standing gene regulation and the dynamics of cell fate specification.

22 sis, auditory hair cell differentiation, and cell fate specification.

23 nts and inductive tissue interactions during cell fate specification.

24 spacing rule, reflecting the coordination of cell fate specification.

25 lable for the investigation of photoreceptor cell fate specification.

26 SCARECROW (SCR) control root patterning and cell fate specification.

27 tinogenic potential of progenitor cells, and cell fate specification.

28 ly, and this asymmetry is crucial for proper cell fate specification.

29 n mother cells (PMCs), suggesting defects in cell fate specification.

30 eogenic, and block chondrogenic, programs of cell fate specification.

31 lular morphogenesis, signal transduction and cell fate specification.

32 e anterior localization of Numb and daughter cell fate specification.

33 way may mediate Numb signaling in asymmetric cell fate specification.

34 on and a substantial alteration in CD4-CD8 T cell fate specification.

35 nner to regulate both cell proliferation and cell fate specification.

36 pport an inhibitory role for Kremen1 in hair cell fate specification.

37 aling pathway, to negatively regulate vulval cell fate specification.

38 gonad development as well as P12 descendant cell fate specification.

39 movements within defined regions but not for cell fate specification.

40 te specification, gonad development, and P12 cell fate specification.

41 rategy for overcoming epigenetic barriers to cell fate specification.

42 results in disrupted cell proliferation and cell fate specification.

43 regulatory networks to control photoreceptor cell fate specification.

44 s an excellent system to study mechanisms of cell fate specification.

45 d establish an important function for APA in cell fate specification.

46 luences and the interplay between the two in cell fate specification.

47 ct of posttranscriptional regulation in stem cell fate specification.

48 ired for FSC maintenance and polar and stalk cell fate specification.

49 ls entered a cell cycle arrest that preceded cell fate specification.

50 pound eye are a classical model for studying cell fate specification.

51 y be a general mechanism to control terminal cell-fate specification.

52 tone modifications over the course of neural cell-fate specification.

53 -1 causes reciprocal defects in Wnt-mediated cell-fate specification.

54 re we report that ACBD3 is a Numb partner in cell-fate specification.

55 1 and met-2 as negative regulators of vulval cell-fate specification.

56 scription factors plays fundamental roles in cell-fate specification.

57 e programming of cellular age in parallel to cell-fate specification.

58 re inherent to gene expression and can drive cell-fate specification.

59 non-coding RNA epigenetic regulation during cell fate specifications.

60 al regulates patterns of gene expression and cell fate specification along the dorsal-ventral axis.

61 le, the midline cells are involved in neural cell fate specification along the dorso-ventral axis but

62 TRIC LEAVES2 (AS2) gene, which promotes leaf cell fate specification and adaxial polarity.

63 ediating the abilities of the BMPs to direct cell fate specification and axon outgrowth.

64 Wnt signaling is critical for cell fate specification and cell differentiation in many

65 gene regulatory network involved in aleurone cell fate specification and cell differentiation.

66 upstream regulatory events and helps program cell fate specification and cell invasion.

67 However, we also found genes with cell fate specification and cell proliferation phenotype

68 However, its molecular functions in B cell fate specification and commitment have remained elu

69 nt, but its molecular function(s) in early B cell fate specification and commitment is unknown.

70 elopment, but its molecular function(s) in B cell fate specification and commitment is unknown.

71 lysis of genetic networks, which orchestrate cell fate specification and commitment.

72 ysis of regulatory circuits that orchestrate cell fate specification and commitment.

73 signals in the ectoderm in order to regulate cell fate specification and competence prior to the onse

74 that is heavily compromised in DS, but also cell fate specification and dendritic maturation.

75 stone modifications accompany the process of cell fate specification and determination.

76 netic mechanism by which yki plays a role in cell fate specification and differentiation - a novel as

77 autonomous factors required redundantly for cell fate specification and differentiation during inner

78 The mechanisms of photoreceptor cell fate specification and differentiation have been ex

79 RNA-binding proteins (RBPs) coordinate cell fate specification and differentiation in a variety

80 astoma protein (Rb) regulates proliferation, cell fate specification and differentiation in the devel

81 n UNC-62 plays essential roles in regulating cell fate specification and differentiation in the M lin

82 ch signaling pathway, which is important for cell fate specification and differentiation in various s

83 e first week after loss of miRNA expression, cell fate specification and differentiation were not mar

84 of basic developmental mechanisms, including cell fate specification and differentiation, axial patte

85 Wnt signaling mediate critical functions in cell fate specification and differentiation, but specifi

86 leolar size was reduced significantly during cell fate specification and differentiation, predominant

87 nt are the underlying mechanisms controlling cell fate specification and differentiation.

88 ncreatic acinar cells and critical to acinar cell fate specification and differentiation.

89 ption factors, which have been implicated in cell fate specification and differentiation.

90 of morphogenetic movements with progressive cell fate specification and differentiation.

91 s that accompanies developmental competence, cell fate specification and differentiation.

92 a conserved use of closely related bHLHs for cell fate specification and differentiation.

93 tes neural progenitor cell proliferation and cell fate specification and differentiation.

94 llular events, including cell proliferation, cell fate specification and differentiation.

95 system for studying molecular mechanisms of cell fate specification and differentiation.

96 ch and upstream of EYA to regulate main body cell fate specification and differentiation.

97 identifying regulatory parallels between P12 cell fate specification and egl-5 transcriptional regula

98 pment have illuminated mechanisms underlying cell fate specification and elucidated intercellular sig

99 RL) is an essential transcription factor for cell fate specification and functional maintenance of ro

100 ever, how cells differentially transduce the cell fate specification and guidance activities of morph

101 well as during organ patterning, migration, cell fate specification and hair cell regeneration.

102 to examine the effects of ADAM10 deletion on cell fate specification and intestinal stem cell mainten

103 erved Notch signaling pathway is involved in cell fate specification and mediated by molecular intera

104 chback genes may include temporal control of cell fate specification and microRNA-mediated regulation

105 Signaling events that control cell fate specification and molecular differentiation of

106 nals relayed by NF-kappaB critically control cell fate specification and molecular differentiation of

107 Notch is required for many aspects of cell fate specification and morphogenesis during develop

108 l events in the vertebrate embryo, affecting cell fate specification and morphogenesis.

109 two other model systems widely used to study cell fate specification and morphogenesis: the pre-impla

110 ion of the gastrula organizer and regulating cell fate specification and morphogenetic processes in p

111 The transcription factor TLX1 controls cell fate specification and organ expansion during splee

112 n in the meristem is closely integrated with cell fate specification and organ formation.

113 but is a target for regulation by Ral during cell fate specification and pattern formation.

114 During organogenesis, cell fate specification and patterning are regulated by

115 Ea/Ep ingression depends on correct cell fate specification and polarization, apical myosin

116 The coordination of cell fate specification and proliferation is particularl

117 ural tube is a source of signals that direct cell fate specification and proliferation.

118 netic modification with an important role in cell fate specification and reprogramming.

119 is balance is important for axis elongation, cell fate specification and somitogenesis.

120 initial target of Prox1 during the lymphatic cell fate specification and that FGF signaling may play

121 abruptly after germinal and initial somatic cell fate specification and then diminish, whereas 24-nt

122 d applicability in directed differentiation, cell fate specification and therapeutic applications.

123 phogen gradients provide positional cues for cell fate specification and tissue patterning during emb

124 ly conserved signaling pathway that controls cell fate specification and tissue patterning in the emb

125 ens act as graded positional cues to dictate cell fate specification and tissue patterning.

126 To better understand anther cell fate specification and to provide a resource for th

127 es in the embryo and the adult, ranging from cell-fate specification and cell polarity to social beha

128 ution and represent a mechanism for coupling cell-fate specification and cell-cycle progression.

129 tial and temporal mechanisms governing their cell-fate specification and differential integration int

130 These findings forge new links between cell-fate specification and morphogenesis, and they repr

131 LIM homeodomain transcriptional code confers cell-fate specification and neurotransmitter identity in

132 regulatory networks that define neural-crest cell-fate specification and subsequent mesoderm cell lin

133 cyte meiotic maturation/ovulation, male germ cell fate specification, and a nonessential function of

134 itioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division.

135 he other elements, impacting eve expression, cell fate specification, and cardiac function.

136 on between neighboring cells that results in cell fate specification, and CSL is the universal transc

137 o aberrant cell proliferation, inappropriate cell fate specification, and excessive Ras pathway activ

138 role of enhancers in controlling patterning, cell fate specification, and morphogenesis during develo

139 by influencing in addition to proliferation, cell fate specification, and neurite development.

140 uencing neural precursor cell proliferation, cell fate specification, and neuronal maturation.

141 , proliferation, apoptosis, differentiation, cell fate specification, and oncogenesis.

142 sses associated with intestinal development, cell fate specification, and the maintenance of intestin

143 this system, the effects on cell signaling, cell fate specification, and tissue differentiation are

144 TZFs) play pivotal roles in gene expression, cell fate specification, and various developmental proce

145 rdinated program of lineage diversification, cell-fate specification, and morphogenetic movements est

146 of pathways involved in tissue self-renewal, cell-fate specification, and regeneration.

147 exhibited broader and shorter body axis but cell fate specification appeared normal.

148 Among the genes required for male cell fate specification are Wnt/beta-catenin pathway mem

149 Therefore, miRNA172 likely acts in cell-fate specification as a translational repressor of

150 downstream of or parallel to lin-12 in AC/VU cell fate specification at an early developmental stage,

151 spatiotemporally complex manner, completing cell-fate specification at the periphery by Hamburger an

152 essential developmental processes, including cell fate specification, axon guidance and anteroposteri

153 Brg1 was not required for cell fate specification but was required for photorecept

154 ession did not appear to alter photoreceptor cell fate specification, but it inhibited subsequent dif

155 SHR is also essential for BS cell-fate specification, but it is expressed in the cent

156 ly in the BS cells and act redundantly in BS cell-fate specification, but their expression pattern an

157 These results highlight the complexity of cell fate specification by cell-cell interactions in a r

158 a transcriptional regulator that can affect cell fate specification by controlling Achaete levels.

159 ural plate border, prdm1a acts explicitly on cell fate specification by counteracting olig4 expressio

160 n multiple Wnt-mediated processes, including cell fate specification by vulval precursor cells (VPCs)

161 e use of canonical Notch signaling for early cell fate specifications by lower organisms may represen

162 homeodomain proteins play essential roles in cell fate specification, cell differentiation, migration

163 and spatial coordination of cell cycle exit, cell fate specification, cell migration and differentiat

164 uires precise regulation and coordination of cell fate specification, cell proliferation and differen

165 scence microscopy to study processes such as cell-fate specification, cell death, and transdifferenti

166 le exit and differentiation is essential for cell-fate specification, cell survival, and proper wirin

167 (ERK) signaling governs multiple aspects of cell fate specification, cellular transitions, and growt

168 e this with the RTK/N signaling to provide a cell fate specification code that entails both extrinsic

169 4), a receptor kinase implicated in aleurone cell fate specification, colocalized to plasma membrane

170 family of transcription factors orchestrates cell-fate specification, commitment and differentiation

171 m proliferating progenitor cells to terminal cell fate specification, contemporary with regulation of

172 odel organism studies have demonstrated that cell fate specification decisions play an important role

173 Cell-fate specification decisions are critical for norma

174 Proper cell-fate specification decisions are critical to achiev

175 data identify Ptf1a as a major regulator of cell-fate specification decisions in the developing brai

176 In plants, cell fate specification depends primarily on position ra

177 After cell fate specification, differentiating cells must ampl

178 provide important data on the proliferation, cell fate specification, differentiation and survival of

179 ficance of differences in the proliferation, cell fate specification, differentiation of survival of

180 N-myc is not required for retinal cell fate specification, differentiation, or survival.

181 hat is a critical modulator of Ras-dependent cell fate specification during C. elegans development.

182 nc-finger RNA-binding proteins that regulate cell fate specification during C. elegans embryogenesis.

183 family of receptors plays important roles in cell fate specification during development and in adult

184 Sox2 plays critical roles in cell fate specification during development and in stem c

185 Cell proliferation must be coordinated with cell fate specification during development, yet interact

186 ot only normal growth and apoptosis but also cell fate specification during development.

187 egans muscle excess 3 (MEX-3) is involved in cell fate specification during early embryonic developme

188 of genes from this spatial network underlies cell fate specification during early embryonic developme

189 es in cell proliferation, morphogenesis, and cell fate specification during embryonic development.

190 tered levels of Amun function interfere with cell fate specification during eye and sensory organ dev

191 t growth factor (FGF) pathways both regulate cell fate specification during mammalian neural developm

192 f mitotic spindle orientation is crucial for cell fate specification during mammalian neurogenesis.

193 ell signaling pathway is used extensively in cell fate specification during metazoan development.

194 unction in the nucleus that is important for cell fate specification during primary neurogenesis.

195 tercellular signaling events that coordinate cell fate specification during stomatal development.

196 rol genes critical for pattern formation and cell fate specification during the development of multic

197 onal elongation is central to the process of cell fate specification during this critical stage of em

198 However, the mechanism of cell fate specification during this process is unknown.

199 l Notch signaling is essential for different cell fate specifications during early embryogenesis or t

200 onarily conserved pathway essential for many cell fate specification events during metazoan developme

201 signaling pathway required for a variety of cell fate specification events in many organisms.

202 A functional egg-laying system requires cell fate specification events in the epithelial cells o

203 Notch signaling controls numerous cell-fate specification events in multicellular organism

204 mic transformation but are dispensable for T-cell fate specification from a multipotential precursor.

205 l-2 functions with Wnt pathways to control T cell fate specification, gonad development, and P12 cell

206 he Notch pathway is a versatile regulator of cell fate specification, growth, differentiation, and pa

207 Many of the genes and pathways that promote cell fate specification have been elucidated.

208 onflicting verbal models of vulval precursor cell fate specification have been proposed: sequential i

209 It is generally believed that cell fate specification in C. elegans is mainly mediated

210 Cell fate specification in development requires transcri

211 lar events in diverse processes ranging from cell fate specification in development to immune suppres

212 r maintaining stem cell pluripotency and for cell fate specification in development.

213 HLH-2 has been implicated in cell fate specification in different neural lineages and

214 maternal mRNAs, which is crucial for correct cell fate specification in early C. elegans embryos, is

215 s act as graded positional cues that control cell fate specification in many developing tissues.

216 gulation of gene expression is essential for cell fate specification in metazoans.

217 To identify genes affecting cell fate specification in neural crest, we performed a

218 Cell fate specification in the CNS is controlled by the

219 ab-9, a T-box gene known to be important for cell fate specification in the developing C. elegans hin

220 Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila win

221 al role in mediating Hedgehog (Hh)-dependent cell fate specification in the developing spinal cord; h

222 o construct a unified model of photoreceptor cell fate specification in the developing vertebrate ret

223 e exhibit normal stem cell proliferation and cell fate specification in the DG but show impaired diff

224 s study, nucleolus size was monitored during cell fate specification in the Drosophila eye imaginal d

225 Cell fate specification in the early C. elegans embryo r

226 mls-2 also affects cleavage orientation and cell fate specification in the M lineage.

227 he derepression model of gene regulation and cell fate specification in the neural tube, as well as e

228 Our data suggest that cell fate specification in the O/P equivalence group is

229 Cell fate specification in this region depends on sonic

230 These data suggest a model for aleurone cell fate specification in which DEK1 perceives and/or t

231 CTOR2 (PDF2) are indispensable for epidermal cell-fate specification in Arabidopsis embryos.

232 result from an overt defect in patterning or cell-fate specification in Gbx2 mutants.

233 centration-dependent positional and temporal cell-fate specification in solid tissues.

234 ty in the CNS, but the mechanisms regulating cell-fate specification in the developing brainstem are

235 ignalling, and that this crosstalk regulates cell-fate specification in vivo during Xenopus developme

236 gulator of pancreatic development and acinar cell fate specification, induced the expression of endoc

237 A derepression mode of cell-fate specification involving the transcriptional re

238 eveals that this "master regulator" of glial cell fate specification is also required (gasp!) to gene

239 What controls Hippo pathway activity during cell fate specification is incompletely understood.

240 The role of microRNAs in embryonic cell fate specification is largely unknown.

241 Cell fate specification is mediated primarily through th

242 The dynamic process of cell fate specification is regulated by networks of regu

243 the mechanisms underlying prdm1a function in cell fate specification is unknown.

244 Neural cell fate specification is well understood in the embryo

245 sting that this developmental pathway for BS cell-fate specification is likely to be evolutionarily c

246 n of neural progenitors in proliferation and cell fate specification, is largely unknown.

247 t mixed-lineage states are obligatory during cell-fate specification, manifest differing frequencies

248 mbly of gene regulatory networks involved in cell fate specification may facilitate the efficient and

249 ans) is an ideal model organism to study the cell fate specification mechanisms during embryogenesis.

250 a systematic and comprehensive analysis from cell fate specification, migration, and connectivity, to

251 velopment has been used extensively to study cell fate specification, migration, proliferation, survi

252 oan origin of a beta-catenin-mediated binary cell-fate specification module.

253 The genetic control of cell fate specification, morphogenesis and expansion of

254 g aspects of human NC development, including cell fate specification, multipotency and cell migration

255 In larval imaginal discs, growth and cell fate specification occur normally in mutant cells,

256 en though cardiac cell migration and initial cell fate specification occur normally.

257 fluorescence markers, we show that aleurone cell fate specification occurs exclusively in response t

258 ndicates that prdm1 functions to promote the cell fate specification of both neural crest cells and R

259 hods for regulating self-renewal and initial cell fate specification of hESCs.

260 roles for these molecules: an early role in cell fate specification of multiple neural progenitors a

261 These proteins influence cell fate specification of neural lineages and different

262 4/MKK5 or MPK3/MPK6 disrupts the coordinated cell fate specification of stomata versus pavement cells

263 The cell fate specification of subcutaneous preadipocytes by

264 n of SMADs 2 and 3 at the floor plate, while cell fate specification of the notochord and the floor p

265 that the cell-cell interactions involved in cell fate specification of the O/P equivalence group dif

266 the transcriptional networks that govern the cell fate specification of these progenitors are incompl

267 elegans where CeTwist is required to direct cell fate specifications of a subset of mesodermal cells

268 uration of newborn neurons without affecting cell-fate specification of neural stem cells/neural prog

269 ila eye, Frizzled (Fz)/PCP signaling induces cell-fate specification of the R3/R4 photoreceptors thro

270 lls hyperproliferative, and caused defective cell fate specification or differentiation both in vitro

271 out a screen for genes that affect follicle cell fate specification or differentiation.

272 ling is not required in mammals for earliest cell fate specifications or for formation of the three g

273 cal processes, including cell proliferation, cell fate specification, organogenesis, and epithelial-m

274 The far reach of cell fate specification pathways makes it particularly c

275 gration of Wnt-dependent and Wnt-independent cell fate specification pathways within the Caenorhabdit

276 different Wnt pathways converge on the same cell fate specification process, our data suggest they m

277 ng the irreversibility of the patterning and cell fate specification process.

278 Wnt signaling affects cell-fate specification processes throughout embryonic d

279 he relationships among cell types in diverse cell-fate specification processes.

280 B signaling is essential in vivo for Schwann cell fate specification, proliferation, survival, migrat

281 the BS cells, but the molecular basis of BS cell-fate specification remains unclear.

282 This binary cell fate specification requires input from both the Wnt

283 Cell fate specification requires precise coordination of

284 on of asymmetric cell divisions and stomatal cell fate specification, resulting in a lack of stomatal

285 , convergent extension of the cochlear duct, cell fate specification, synaptogenesis, and the establi

286 ional organ requires coordinated programs of cell fate specification, terminal differentiation and mo

287 Ras pathway also functions in cell survival, cell-fate specification, terminal differentiation, and p

288 nally, by controlling the timing and pace of cell fate specification, the embryo temporally modulates

289 erall tempo of retinogenesis, by integrating cell fate specification, the wave of neurogenesis and th

290 nsic transcription factor Ngn2 cooperate for cell fate specification through their synergistic activi

291 encodes a transcription factor that governs cell fate specification throughout development and tissu

292 totic precision fundamentally contributes to cell fate specification, tissue development and homeosta

293 conserved Notch pathway regulates asymmetric cell fate specification to daughters of ganglion mother

294 rocesses ranging from cell proliferation and cell fate specification to differentiation over embryoni

295 has been difficult to assign later roles in cell fate specification to specific BMP ligands.

296 B size could be an important parameter in ES cell fate specification via differential gene expression

297 TGF-beta ligands control cell fate specification via Smad-mediated signaling.

298 and expansion of pavement cells and stomata cell fate specification; we also observed severe alterat

299 gregates known as embryoid bodies (EBs), yet cell fate specification within EBs is generally consider

300 Mechanisms that govern cell-fate specification within developing epithelia have