ライフサイエンスコーパス: cell function

1 ces in markers of insulin secretion and beta-cell function.

2 se mice likely due to a loss of regulatory T cell function.

3 me with host cells will result in changes in cell function.

4 ecules, and the consequences for KIR2DS1+ NK-cell function.

5 ediated ATP production is essential for mast cell function.

6 erapeutically targeted to restore effector T-cell function.

7 ntricate mechanisms regulating Treg and Teff cell function.

8 ferentially required for the control of mast cell function.

9 d with lenalidomide develop compromised beta-cell function.

10 d found that anti-TIM-3 treatment enhances T cell function.

11 , extending the classical view of horizontal cell function.

12 f retained islet mass despite decreased beta-cell function.

13 hich these miRNAs modify cervical epithelial cell function.

14 (O2) acts as a potent upstream regulator of cell function.

15 ts due to their critical roles in regulating cell function.

16 ether Prdm16 is also required for adult stem cell function.

17 D62L cleavage and potentially impairs immune-cell function.

18 abetes through direct effects on SI and beta-cell function.

19 n of sustained Ca(2+) signaling to murine NK cell function.

20 ct of non-canonically prenylated proteins on cell function.

21 ression of factors implicated in neural stem cell function.

22 on of proteins or SUMOylation ensures normal cell function.

23 sk by regulating myeloid gene expression and cell function.

24 sociated with the metabolic balance and stem cell function.

25 crucial for cellular homeostasis and normal cell function.

26 ion, mechanotransduction, transcription, and cell function.

27 egulation of key genes responsible for alpha cell function.

28 al cell growth, proliferation and intestinal cell function.

29 size is specific to each species and impacts cell function.

30 proteins and noncoding RNAs to alter target cell function.

31 sustained elimination leads to impaired beta-cell function.

32 which are known to antagonize peripheral Tfh cell function.

33 eutic approach for improving pancreatic beta-cell function.

34 L1, and PD-L2, molecules that might limit NK cell function.

35 duced beta-cell secretory capacity and alpha-cell function.

36 eins, which ultimately interfere with normal cell function.

37 absence of data relating to adaptive immune cell function.

38 nally distinct chromatin states for accurate cell function.

39 diversity and specificity for optimal T reg cell function.

40 ions is heavily dependent on helper CD4(+) T cell function.

41 DH emerges as an important regulator of mast cell function.

42 e that PSGL-1 can also negatively regulate T cell function.

43 l quality control necessary for optimal beta-cell function.

44 ne inhibitory ligands to inhibit antitumor T cell function.

45 ture hematopoietic cells regulate BM stromal-cell function.

46 in pancreatic pericytes is required for beta-cell function.

47 y roles (CTLA-4, PD-1, BTLA, and TIGIT) in T-cell function.

48 e allergic responses through effects on mast cell function.

49 tors, and may be related to a preserved beta-cell function.

50 survival shape tumor progression and immune cell function.

51 er expression, lifespan, and Th/regulatory T cell function.

52 epeated cell divisions and aging impair stem cell function.

53 tudy, we investigated the role of ROS in NKT cell function.

54 s multiple effects on signaling pathways and cell function.

55 ns unclear how T cell-derived CD70 affects T cell function.

56 hanism by which folate regulates trophoblast cell function.

57 tion imparts a durable inhibitory imprint on cell function.

58 agents that neutralize MDSCs yet preserve T-cell function.

59 ontext specific manner to give rise to whole cell function.

60 and expression of the genes required for Tr1 cell function.

61 y receptor expression depending on the CD4 T cell function.

62 beta-cell development, and adult islet beta-cell function.

63 onstrate the essential role of GATA6 in beta-cell function.

64 ion, and combined synergistically to control cell function.

65 ng the long-term consequences of sepsis on T cell function.

66 y circuit that relevantly modulate pituitary cell-function.

67 pacity for protein secretion, altering vital cell functions.

68 ternative to in vivo models for evaluating T-cell functions.

69 les in mechanotransduction and other crucial cell functions.

70 lin (Ig)-related syndromes due to aberrant B-cell functions.

71 ks for predictive modeling of emergent whole cell functions.

72 ament assembly and disassembly are vital for cell functions.

73 tion on immune cell homeostasis and CD4(+) T cell functions.

74 ay that regulate cell proliferation and stem cell functions.

75 lls, allowing the bacterium to modulate host cell functions.

76 toplasmic Esrp1 in maintenance of epithelial cell functions.

77 beta) signals in safe-guarding specific Treg cell functions.

78 cytotoxicity of NK-92 cells and other NK-92 cell functions.

79 of how SCPs together can give rise to whole cell functions.

80 in basic and clinical research studies of B cell functions.

81 s), however, MAPK activity is required for T cells function.

82 ene expression profiles and consequently the cell functioning.

83 similarly modulate the degree of cytotoxic T-cell function and activity in the tumour microenvironmen

84 athway in lymphocytes and is essential for T cell function and adaptive immunity.

85 steine (NAC) is known to promote endothelial cell function and angiogenesis and may have therapeutic

86 B7-related molecules and CD40, blockade of B cell function and B cell survival factors, and disruptio

87 of Prxs by urate hydroperoxide might affect cell function and be partially responsible for the pro-o

88 licated in cellular growth/apoptosis, immune cell function and bone-resorbing osteoclast formation, t

89 immune responses that interfere with neural cell function and communication without affecting their

90 lted in the suppression of tumor-propagating cell function and correlated with increased histone H3 l

91 T2 patients have increased incretin and beta-cell function and decreased alpha-cell function, and thu

92 of the human genome was believed to regulate cell function and development.

93 vestigates the effect of EMPs on endothelial cell function and dysfunction in a model of free fatty a

94 egulating neurotransmission, pancreatic beta-cell function and energy homeostasis.

95 ketosis that were attributed to loss of beta cell function and expansion of alpha cells.

96 le T reg cell TCR, we demonstrate that T reg cell function and gene expression can be partially uncou

97 o characterizations, demonstrating that beta cell function and glucose tolerance were impaired within

98 ed glucose tolerance due to compromised beta-cell function and glucose-stimulated insulin secretion.

99 ovel mechanism of glucose regulation of beta-cell function and growth by repressing stress-induced mi

100 a plays an important role controlling immune cell function and has therefore been identified as a pot

101 the coactivators could be important for beta-cell function and health in vivo.

102 ion in offspring predisposed to altered beta-cell function and hyperglycemia and place it as a critic

103 eta cell genes, thus maintaining mature beta cell function and identity.

104 s of transcriptome reprogramming that define cell function and identity.

105 catalytic and regulatory subunits in normal cell function and in disease.

106 tic beta-cells has been shown to reduce beta-cell function and increase beta-cell apoptosis.

107 nterferons, which interfered with effector T cell function and increased the expression of several pr

108 ung microenvironment can significantly alter cell function and injury and demonstrate the importance

109 shown to be deleterious for pancreatic beta-cell function and insulin release.

110 d diabetes mellitus (DM) impairs endothelial cell function and integrity of BSCS.

111 enerate human knockout cell lines to examine cell function and interrogate the proteome.

112 These findings provide evidence that Paneth cell function and intestinal dysbiosis are involved in v

113 ail is a crucial factor controlling CD8(+) T-cell function and is a potential target to improve cytot

114 a homeostasis that, if disrupted, can impair cell function and lead to disease.

115 the transcription factor ruling regulatory T cell function and maintenance of peripheral immune toler

116 ancreatic histopathology, impairment of beta-cell function and mass, islet inflammation (i.e., insuli

117 paired expression of genes required for beta-cell function and maturity in isolated islets.

118 er, its role as a dual modulator of CD4(+) T cell function and metabolism has not been defined.

119 chanism linking Pb exposure with neural stem cell function and neurodevelopment in children.

120 evelopment of new strategies to improve stem cell function and optimize tissue repair processes.

121 pecific SGs are sufficient to disrupt normal cell function and point to a possible role for SGs in ca

122 The sealer biocompatibility was measured by cell function and proliferation assays of elutions.

123 genetic ablation of innervation preserved NK cell function and restrained post-stroke infection.

124 pathways that modulate context-specific Treg cell function and stability.

125 tify Batf as critical to tissue regulatory T cell function and suggest that polymorphisms that impact

126 Metabolic constraints to cell function and survival shape tumor progression and i

127 f immune activation and preservation of beta-cell function and survival.

128 ion, a process critical for normal red blood cell function and survival.

129 use of the critical role of folate in normal cell function and the wide range of disorders, including

130 pha axis may also promote antigen-presenting cell function and thereby stimulate adaptive T cell-medi

131 ormation about the influence of obesity on B cell function and underlying factors that modulate B cel

132 he phenotype was accompanied by deficient NK cell function and was stable over time.

133 y network within the cell that is crucial to cell functioning and human health.

134 ated mutations and determine how they affect cell functions and contribute to pathogenesis.

135 the regulation of intratumoral gammadeltaT17-cell functions and in the development of primary breast

136 nction, enhancing MQC importance to maintain cell functions and indicating in OPA1 an attractive pote

137 re critical for enhancing antigen-presenting cell functions and influencing T cell responses during m

138 .2 alpha1 in mouse and human TH2 but not TH1 cell functions and showed that knocking down Cav1 alpha1

139 ITK and suboptimal TCR signaling on CD8(+) T cell function, and how these may contribute to phenotype

140 d memory cell differentiation, compromised B cell function, and hypergammaglobulinemia.

141 sterol on metastasis requires myeloid immune cell function, and it was found that this oxysterol incr

142 rker expression, restored HIV-specific CD8 T cell function, and led to decreased viral replication.

143 l measures of insulin sensitivity (SI), beta-cell function, and obesity in children at high risk for

144 vation is crucial in regulating pulmonary NK cell function, and suggest that NK cells serve to limit

145 n and beta-cell function and decreased alpha-cell function, and thus lower glucose levels.

146 odulates cell adhesion and signaling, immune cell function, and tumor metastasis, it is of interest t

147 nd proteins is required to understand normal cell function, and ultimately, elucidate the mechanism o

148 cytokine concentrations and cell phenotypes, cell functions, and post-AMI cardiac function were deter

149 xamined the effects of BNN27 on neural/glial cell function, apoptosis, and inflammation in the experi

150 Moreover, these defects in Cdk5(-/-) T-cell function are associated with altered CCR7 signaling

151 However, the molecular mechanisms of EC cell function are poorly understood.

152 aracterize herein how human primary CD4(+) T cell functions are affected by stiffness within the phys

153 obial infections and cancers, where CD8(+) T cell functions are crucial.

154 iated allergic reactions, whereas other mast cell functions are poorly defined.

155 , particularly in untreated patients whose T cells functions are profoundly impaired.

156 Thus, our findings point out at T cell function as a key determinant of EVD progress and o

157 onse, which has implications for both normal cell function as well as disease.

158 e show that the majority of terminal end bud cells function as highly proliferative, lineage-committe

159 For specialized cell function, as well as active cell behaviors such as

160 the way toward a better understanding of how cells function at the molecular level.

161 To study molecularly defined cell functions, biologically inspired materials that mim

162 binoid) system modulates neuronal and immune cell function, both of which play key roles in pain, the

163 not caused primarily by impairments in CD4 T cell function but result from defects in innate immune c

164 inducible knockdown rats impairs selective T cell functions but not thymocyte development.

165 of the expression of genes involved in beta cell function, but also continual repression of closely

166 ough Orai1 channels is crucial for several T cell functions, but a role in regulating basal cellular

167 ic reticulum (SR) regulate cardiac pacemaker cell function by activation of electrogenic Na/Ca exchan

168 s common and unique aspects of Treg and Teff cell function by differentially regulating gene expressi

169 Instead, modulation of cell function by effector domains may depend on which ot

170 rrent study evaluated effects of ANP on beta-cell function by the use of a beta-cell-specific knockou

171 However, how living cell functions can be modulated via opsins by modifying

172 ay link the systemic inflammation and poor T cell function characteristic of lentiviral infections.

173 ain barrier), ATPase activity and astrocytic cell functions contribute to MDD and suicide, and identi

174 s precipitates defects in hematopoietic stem cell function, contributing to extramedullary hematopoie

175 cell research, including regulation of mast cell functions, differentiation, survival, and novel mou

176 nces in Jak-STAT biology, focusing on immune cell function, disease etiology and therapeutic interven

177 FOS exerts its disruptive effects on Sertoli cell function downstream through Akt1/2.

178 ment as a potential strategy to protect beta-cell function during diabetes progression.

179 is considered to be important in maintaining cell function during growth and development.

180 n of Tpl2 to Th17 differentiation and immune cell function during infection with an extracellular pat

181 myocardial region-specific heterogeneity in cell function emerges during early development and how s

182 NO2 exposure negatively affected beta-cell function, evidenced by a faster decline in disposit

183 To modulate T-cell function for cancer therapy, one challenge is to se

184 ocytes, cytokines, mediators, and epithelial cell function for these asthma subgroups.

185 ures of fasting insulin sensitivity and beta-cell function, for time spent in slow-wave sleep, and fo

186 nables us to describe the emergence of whole cell functions from interacting SCPs.

187 val are necessary for normal pancreatic beta-cell function, glucose homeostasis, and prevention of di

188 teostasis) as fundamental regulators of stem cell function has emerged.

189 However, the role of PDH in mast cell function has not been described.

190 Heterogeneity in cell function has presented a significant hurdle to the

191 Subtypes of CD associated with Paneth cell function have been observed even among patients fro

192 ce) and homeostasis model assessment of beta cell function (HOMA-B) were measured after a mean +/- SD

193 66; betaPFOA=0.64; 95% CI: 0.34, 0.94], beta-cell function (HOMA-beta) (betaPFOS=9.62; 95% CI: 1.55,

194 ton, cell growth, stress response, or immune cell function; however, the molecular functionality of C

195 feeding improved glucose tolerance and beta-cell function in a mouse model of diabetes that incorpor

196 Mechanisms underlying altered beta-cell function in aging are poorly understood in mouse an

197 egulate PD-1 expression can enhance CD8(+) T-cell function in cancer therapy to a similar degree as P

198 egulate PD-1 expression can enhance CD8(+) T-cell function in cancer therapy to a similar degree as P

199 rming growth factor beta) restored CD4+ Th17 cell function in cells from IP children to levels measur

200 from possibly contributing to the control of cell function in general, the changes proved to be pivot

201 e assessed the importance of GPR119 for beta-cell function in Gpr119(-/-) mice and in newly generated

202 A (rs7426056) affects CD28 expression and T cell function in healthy individuals (n = 14 AA, n = 14

203 els of IL-18 and a complete abrogation of NK cell function in HSV-2 infection.

204 buted to islet inflammation and loss of beta-cell function in islet grafts.

205 gs and drug-like molecules can modulate MAIT cell function in mammals.

206 +) T cells that has been shown to regulate T cell function in models of viral infection and autoimmun

207 transcriptional regulator required for stem cell function in multiple fetal and neonatal tissues, in

208 ll growth but is involved in regulating beta-cell function in normal and diabetogenic conditions.

209 We sought to investigate NK cell function in patients with STAT1 GOF mutations.

210 nding the water-activity limit for microbial cell function in relation to temporal constraints and lo

211 vaccination either suppresses or enhances T cell function in response to melanoma antigens, dependin

212 plasma glucose (FPG) concentration and beta-cell function in subjects with impaired fasting glucose

213 acid abundance, would positively impact beta-cell function in the diabetic state.

214 docrine differentiation and to maintain beta cell function in the presence of pro-proliferation cues

215 Assessment of stem cell function in vitro as well as in vivo established th

216 xpression and the corresponding effects on T cell function in vivo.

217 olite levels in normal tissues regulate stem-cell function in vivo.

218 of immunological synapses and in resulting T cell functions in autoimmunity.

219 unities for therapeutic intervention of mast cell functions in inflammatory diseases.

220 tiple sclerosis, yet little is known about T cell functions in remyelination.

221 T cells and Tregs and represses the CD8(+) T cell functions in vitro.

222 ously produced exosomes in regulating immune cell functions in vivo are just beginning to be identifi

223 Mechanistically, Treg cells function in a critical temporal window to impede p

224 roduction, whereas pathogen-specific Vgamma4 cells function in adaptive immunological memory against

225 on of secreted factors shown to promote beta-cell function, including bone morphogenetic protein 4 (B

226 th excitatory cell loss and deficits in grid cell function, including destabilized grid fields and re

227 levels of several transcripts involved in PV cell function, including PV, are lower in the disease.

228 ific HIFs are crucial for aspects of myeloid cell function, including their ability to migrate into i

229 nitric oxide (NO), mediate many endothelial cell functions, including angiogenesis and vascular perm

230 The chemokine CXCL12 regulates multiple cell functions, including angiogenesis, mainly through i

231 inct mechanisms, thereby inhibiting critical cell functions, including cellular proliferation.

232 ygen species also regulate multiple vascular cell functions, including endothelial and smooth muscle

233 ed enhanced pathology was mediated by immune cell function independent of mesenchymal cell Hox5 famil

234 demonstrated that GPR119 also regulates beta-cell function indirectly through incretin hormone secret

235 beta-Cell function (Insulin Secretion Sensitivity Index-2) wa

236 d gastric emptying, glucose absorption, beta-cell function, insulin sensitivity and clearance, and th

237 lecular link between folate availability and cell function involving PCFT and mTOR signalling.

238 Ionotropic Receptors (IRs) required for dry cell function: IR25a, IR93a and IR40a.

239 redisposed to the failure of pancreatic beta-cell function is a major concern for the pharmacologic i

240 based bio-logic system capable of regulating cell function is developed using sortase A (SrtA), a pep

241 Microglial cell function is implicated in the etiology of Alzheimer

242 Vcc system, show that the HCV-specific CD8 T-cell function is modulated by antigen expression levels,

243 r, its role in regulation of pancreatic beta-cell function is not known.

244 mportant role of vesicles in many aspects of cell function is well-recognized, but only recently have

245 Selective suppression of effector CD4(+) T cell functions is necessary to prevent immune cell-media

246 F subunit linked to stem cell and progenitor cell function, is frequently co-amplified and highly exp

247 As p53 is central to hematopoietic stem cell functions, its aberrations affect AML evolution, bi

248 H exposure appears to directly affect Leydig cell function, likely causing premature aging of the tes

249 indicated that, from the standpoint of islet cell function, linagliptin would be more effective in tr

250 pportive effects of PD-1:28 engineering on T-cell function make it an attractive tool for ATT.

251 Thus, beta-cell function measured with the insulin secretion/insuli

252 athways, including cytokines that regulate T-cell function (MIG and IP10) and anti-microbial peptides

253 We sought to investigate the effect on B-cell function of TACI A181E heterozygosity in reportedly

254 We examined glucose homeostasis and beta-cell function of these mice fed a control chow or high-f

255 Empagliflozin enhanced beta-cell function only in subjects with IFG.

256 asma glucose concentration and improves beta-cell function only in subjects with IFG.

257 Reduced pancreatic beta-cell function or mass is the critical problem in develop

258 Sensitivities of NK-cell function, perforin mean channel fluorescence (MCF),

259 ecent evidence shows that early loss of beta-cell function plays an important role in the pathogenesi

260 ting enzymes, coupled with bioassay of guard cell function) plus modeling lead us to propose that pol

261 ) from epithelial cells, tailored effector T cell function, promoting increases in gingival Th17 cell

262 (PIs) are phospholipids that perform crucial cell functions, ranging from cell migration and signalin

263 tigated whole-body lipolysis, ATIS, and beta-cell function relative to ATIS (adipose disposition inde

264 lucose metabolism reflected in impaired beta-cell function relative to peripheral insulin resistance.

265 e tissue insulin sensitivity (ATIS) and beta-cell function remains unknown.

266 aling at multiple cellular sites to regulate cell function, shape, and growth.

267 cilia architecture that is critical for hair cell function.SIGNIFICANCE STATEMENT Two missense mutati

268 Models of cell function that assign a variable to each gene freque

269 The progressive decline in beta-cell function that begins in individuals with NGT is ass

270 on of CD200 (OX2), a negative regulator of T-cell function that binds CD200 receptor (CD200R), is com

271 a "dual effect" on both neuronal and myeloid cell function that could explain a shared propensity for

272 es as developmental regulators of Th2 immune cell function that demonstrates a redeployment of mesenc

273 ammation as a result of defects in dendritic cell function that were associated with abnormal accumul

274 ile mitophagy is critical to pancreatic beta-cell function, the posttranslational signals governing b

275 Epac pathways in the effects of ANP on beta-cell function; the latter seems to prevail.

276 The toxins perturb host cell function through a multistep process of receptor bi

277 c islet EPA abundance improves diabetic beta-cell function through both direct and indirect mechanism

278 ogene family, protein B, which promotes beta-cell function through IL-6-induced GLP-1 production in a

279 ffset of the critical period by promoting PV-cell function throughout the lifetime.

280 The gut microbiota regulates T cell functions throughout the body.

281 tive role of linagliptin in modulating alpha cell function to restore normoglycemia.

282 suggesting that action potentials in granule cells function to coordinate GABA release at relatively

283 nd HIF2alpha are dispensable for muscle stem cell function under normoxia but are required for mainta

284 Inadequate pancreatic beta cell function underlies type 1 and type 2 diabetes melli

285 studies have shown linagliptin improves beta cell function using animal models and isolated islets fr

286 The effect of PDH inhibition on mast cell function was examined.

287 FPG concentration and beta-cell function was measured with a nine-step hyperglycemi

288 tegrated) in circulating CD4(+) cells and NK cell function was observed.

289 omain extraterminal (BET) inhibitors on Th17 cell function was studied in a mouse model of EAU in viv

290 sociated with pancreas development and islet cell function, we analyzed how an endogenous deletion mu

291 ins Galphai2 and Galphai3 in thymocyte and T cell function, we developed several mouse models.

292 lonotypes in differential antiviral CD8(+) T-cell function, we performed detailed functional and mass

293 ptide presented by MHC (self-pMHC) impacts T cell function, we sought to determine whether altered th

294 n of p65, and regulation of target genes and cell function were investigated after different modes of

295 nce of other T-cell subsets or even when TH2 cell functions were severely compromised.

296 tone H2A and an epigenetic regulator of stem-cell function, where it promotes differentiation and, co

297 also operate as critical regulators of stem-cell functions (which are collectively termed 'stemness'

298 ght the role of polar reinforcement in guard cell function, which simultaneously improves our underst

299 roRNAs (miRs) play a vital role in governing cell function, with their levels tightly controlled at t

300 glucose intolerance due to a defect in beta-cell function without alterations in beta-cell mass with