ライフサイエンスコーパス: cell generation

1 e-mediated Parkin depletion attenuates CD44H cell generation.

2 o stimulate T-helper cell 1/T-helper cell 17 cell generation.

3 lls from apoptosis and thereby promotes Treg cell generation.

4 , transcription factors programming effector-cell generation.

5 actors necessary for amacrine and horizontal cell generation.

6 IL-17 production but is dispensable for Th17 cell generation.

7 of transcription factors required for plasma cell generation.

8 -specific T-cell priming as well as memory T-cell generation.

9 cells and must be silenced to allow bipolar cell generation.

10 analogous to T-cell effector cell and memory cell generation.

11 thymus is the primary vertebrate organ for T-cell generation.

12 creased Erk1/2 activity promotes gammadeltaT cell generation.

13 ce of RasGRP1 is compatible with gammadeltaT cell generation.

14 injuries, is shown to be inhibitory on Th17 cell generation.

15 te cellular potentials: stem cell vs. cancer cell generation.

16 ed T(H)17 development while promoting T(reg) cell generation.

17 ligand (ICOSL), a molecule required for Tfh cell generation.

18 impaired trafficking promotes local effector cell generation.

19 paracrine IL-2-mediated suppression of Th17 cell generation.

20 g thymic atrophy positively influences tTreg cell generation.

21 because TCR stimulation is required for Treg cell generation.

22 sm may shed light on the improvements of iPS cell generation.

23 s a chemical factor capable of promoting iPS cell generation.

24 Rgammat) and enhanced RORgammat-induced Th17 cell generation.

25 ntiation (CD) 4+ thymic regulatory T (tTreg) cell generation.

26 e capable of enhancing the efficiency of iPS cell generation.

27 cells resulting in overall decreased memory cell generation.

28 the reciprocal regulatory and inflammatory T cell generation.

29 new insight into the process of memory CD8 T cell generation.

30 lls were used to track allospecific memory T-cell generation.

31 at Bcl6 is required for programming of T(FH) cell generation.

32 oregulatory capacities may impair effector T cell generation.

33 cyte-derived DC, 3 relevant molecules for Th-cell generation.

34 th markedly more IFN-gamma(+) and IL-17(+) T cell generation.

35 editing, germinal center reaction and plasma cell generation.

36 ransient results at times equal to that of a cell generation.

37 ing Treg generation and promoting effector T cell generation.

38 et distributions, or regulatory/suppressor T cell generation.

39 lopment of Th17 cells at the expense of Treg cell generation.

40 nal thymic tissue and a decline in de novo T cell generation.

41 locus at the earliest stages of progenitor B cell generation.

42 re-TCR increased the efficacy of alphabeta T cell generation.

43 T cell subset differentiation, and memory T cell generation.

44 to erythroid fate, and increased endothelial cell generation.

45 of future vaccine strategies to maximize MEM cell generation.

46 tely expressed as mutations per day than per cell generation.

47 spleen, inducing FDC development and plasma cell generation.

48 cell receptor stimulation on CD4 effector T cell generation.

49 pears to result from cumulative defects of T cell generation.

50 y onset of CD19 expression acts to enhance B cell generation.

51 e resulted in suppression of effector CD8+ T cell generation.

52 development, 2 days after the onset of hair cell generation.

53 t this effect is independent of IL-5 and Th2 cell generation.

54 ropriate balance of effector/memory CD8(+) T cell generation.

55 t contains sufficient resources for daughter cell generation.

56 l proliferation, differentiation, and plasma cell generation.

57 of an extrafollicular pathway for effector T cell generation.

58 ligoclonality but also interfere with memory cell generation.

59 ory T cell generation, led to autoreactive T cell generation.

60 cetyl cysteine (NAC) treatment restored Th17 cell generation.

61 4 to suppress T cell proliferation and T reg cell generation.

62 V a powerful tool for inducible regulatory T cell generation.

63 nuclear IkappaBNS is crucial for murine Th17 cell generation.

64 , which was associated with a defect in Th17 cell generation.

65 transcription factor serves to restrain Tfh cell generation.

66 e approach for deriving specific therapeutic cell generation.

67 T-bet induction and counteracts regulatory T cell generation.

68 Mink1 as a novel negative regulator of Th17 cell generation.

69 cy did not alter the rate of memory CD8(+) T cell generation.

70 croenvironment instructed pDC-driven Th9/Th2 cell generation.

71 tion for ADAP in the suppression of MP CD8 T cell generation.

72 A miR-31, which negatively regulates pT(reg)-cell generation.

73 failed to provide signals necessary for beta-cell generation.

74 ntiation despite the lack of effector CD4+ T cell generation.

75 -mediated autoimmunity, greatly enhances TFH-cell generation.

76 DCs in the spleen are essential for CD8(+) T cell generation.

77 affecting MG dedifferentiation or progenitor cell generation.

78 e, promoted goblet cell and inhibited paneth cell generation.

79 efficiency of induced pluripotent stem (iPS) cell generation.

80 renewal of ESCs and induced pluripotent stem cell generation.

81 ells, the frequency was approximately 10(-7)/cell/generation.

82 requency of LOMs, which was less than 10(-8)/cell/generation.

83 repositioning of Cnp1 nucleosomes throughout cell generations.

84 imate the age of individual tumor lineage in cell generations.

85 y transmitted, undiminished through multiple cell generations.

86 ieved to carry regulatory information across cell generations.

87 nt expression and sustained function over 50 cell generations.

88 evolved in identical environments for 20,000 cell generations.

89 methylation occurs gradually through several cell generations.

90 not necessarily increase with the number of cell generations.

91 amental for accurate genome inheritance over cell generations.

92 ectively silence transcription over multiple cell generations.

93 n the cell and potentially maintained across cell generations.

94 ental CHO cells over the course of three CHO cell generations.

95 he above, we show here that antiviral CD4+ T cell generation after infection is reduced in the absenc

96 e and promotes T cell expansion and effector cell generation after initial activation via TCR signali

97 rovided, being lost at a rate of 2 to 4% per cell generation after removal of selection.

98 lation of blood vessels did not prevent beta-cell generation after severe pancreas injury by partial

99 sue damage, but also late effects in several cell generations after the initial exposure.

100 tic alterations in the progeny of irradiated cells generations after the initial insult.

101 3 (GSK3), previously reported to reduce Th17 cell generation, also alter Th1 cell production or allev

102 n vitro is a novel mechanism of T regulatory cell generation, although questions regarding the role o

103 lpha4beta7(high) subsets enhanced Th1/Th17 T cell generation and accumulation in the intestine, and t

104 ut it exerts different roles for gammadeltaT cell generation and activation.

105 hat underlie inducible/adaptive regulatory T cell generation and airway tolerance are not well unders

106 vating factor that highly accelerated plasma cell generation and antigen-specific antibody production

107 ctivated CD4(+) T cells led to increased Tfh cell generation and B cell priming, whereas KLF2 overexp

108 s immune tolerance by promoting regulatory T cell generation and blocking Th17 differentiation.

109 f intraclonal V(D)J diversification during B-cell generation and define a manipulable model of human

110 and extracellular requirements for memory NK cell generation and describe the emerging evidence for m

111 ocyte accumulation, lipid accumulation, foam cell generation and endothelial cell injury were all inc

112 role of blood vessels to preserve adult beta-cell generation and function, restricting their importan

113 the effect of low-affinity priming on memory cell generation and function, which is particularly impo

114 and with a defect in inducible regulatory T-cell generation and function.

115 xplore the role of DNA replication in immune cell generation and function.

116 receptor (TCR) signaling in CD8(+) memory T-cell generation and homeostasis are poorly defined.

117 In this study, pathways that influence B10 cell generation and IL-10 production were identified and

118 r (ICOS), which in turn was required for TFR cell generation and inhibition of antibody responses.

119 a1-producing T cell subset required for Th17 cell generation and its cellular mechanism of action rem

120 he receptor TNFRSF14 (HVEM), can support TH2 cell generation and longevity and promote airway remodel

121 he critical role of Glis3 in pancreatic beta-cell generation and maintenance, the elevated Glis3 expr

122 (BAFF; also termed BLyS) is essential for B cell generation and maintenance.

123 asion, and dissemination, and increased stem cell generation and mammosphere formation, dependent upo

124 In the case of NK and NK/T cell generation and maturation, expression of IL-15 and

125 ed an activation cascade leading to memory B-cell generation and particularly IgG1, but also IgA, IgG

126 ation, and inhibition of LFA-1 abolished Tfh cell generation and prevented protective humoral immunit

127 here to the present dogma regarding memory T cell generation and provide a means for identifying fact

128 r MyD88 is required for optimal memory CD8 T-cell generation and responses after lymphocytic choriome

129 e the isoform-selective effects of GSK3 on T cell generation and the therapeutic effects of GSK3 inhi

130 suggest a role for IP-10 in both effector T cell generation and trafficking in vivo.

131 n implicated in coordinating both effector T cell generation and trafficking.

132 We provide an integrated model of cell generation and turnover in the human heart.

133 ic choice at RAMA elements was stable across cell generations and bookmarked through mitosis.

134 ersists in differentiated cells through many cell generations and changes in transcriptional state.

135 tracing vital stain that is retained through cell generations and effectively reads out migration rel

136 g-term maintenance of memory for at least 90 cell generations and the ability to interrogate the stat

137 o electroporation in mice, enhanced memory T-cell generation, and elicited 140-fold higher gene expre

138 oduce inflammatory cytokines, stimulate Th17 cell generation, and fail to secrete IFN-alpha on Toll-l

139 g implications about neonatal immunity, Treg cell generation, and tolerance establishment early in li

140 erminal center (GC) B cell phenotype, plasma cell generation, and virus-specific Ab responses.

141 r acquisition of GC B cell phenotype, plasma cell generation, and virus-specific neutralizing Ab resp

142 expansion of memory B cells and Ab-secreting cell generation are inhibited.

143 er, the molecular mechanisms governing taste cell generation are not well understood.

144 These 2 pathways for memory T cell generation are quite distinct.

145 The mechanisms of human outer radial glial cell generation are unknown, but are proposed to involve

146 ated Smo cannot overcome impaired cerebellar cell generation, arguing for an epistatic role of Pals1

147 n multipotential progenitor cells directed B cell generation at the expense of myeloid cell fates.

148 or pharmacological interference with IgA(+) cell generation attenuates liver carcinogenesis and indu

149 ists not only inhibits Th1 and Th17 effector cell generation but also promotes the generation of Foxp

150 division revealed that CsA allowed multiple cell generations but suppressed the numbers of cells in

151 Such extensive and rapid mature CNS cell generation by a relatively small number of transpla

152 sity compromises the mechanisms regulating T-cell generation by inducing premature thymic involution.

153 ys a critical role in promoting memory CD4 T cell generation by providing survival signals, which all

154 In this study, we manipulated the number of cell generations by varying the rate at which cultures o

155 Il21 and less Il2 and exhibit enhanced Th17 cell generation compared with T cells from NOD.Idd3 cong

156 insufficient TCR signaling improved T-CD4 T-cell generation, consistent with rescue from negative se

157 mber and size after a lag period of about 10 cell generations, consistent with the attrition of telom

158 Grid cell generation depends upon theta rhythm, a 6-10 Hz ele

159 ertion at the epsG target site (2.7 x 10(-7)/cell/generation), determined by quantitative PCR, is 4 t

160 cidation of the mechanisms that regulate Tfh cell generation, differentiation and function should rev

161 MEK1 phosphorylates ERK1/2 and regulates T cell generation, differentiation, and function.

162 nsion and stochastic variability in effector cell generation due to an initially small naive repertoi

163 receptor (ER) signaling for stimulating beta-cell generation during embryonic development and in the

164 t DC subsets to effector and memory CD8(+) T cell generation during infection and the mechanism by wh

165 labeling have provided novel insights on B1a-cell generation during ontogeny.

166 ll self-renewal and induced pluripotent stem cell generation during the final stage of reprogramming.

167 faithfully propagated and maintained through cell generations even after the suppression of the expre

168 tional repression gradually increase for 3-5 cell generations, even though the intracellular level of

169 ion about the basic mechanisms of blood stem cell generation, expansion, and migration.

170 ar, quantitative examination of memory CD8 T cell generation following infection during pregnancy rem

171 edulla, a site that nurtures self-tolerant T-cell generation following positive selection events that

172 7-CD70 pathway was not required for pre-Treg cell generation, Foxp3 induction, or mature Treg cell fu

173 The linear model for memory T-cell generation from differentiated effector cells has b

174 CpG DNA dramatically increased plasma cell generation from GC B cells.

175 ver, CpG DNA did not have effect on memory B cell generation from GC B cells.

176 constitution of CD4 T cell pool depends on T cell generation from hematopoietic stem cells (T-lymphop

177 We recently reported efficient iPS cell generation from human fibroblasts using synthetic m

178 epresents a self-regulatory mechanism of Th2 cell generation from naive CD4 cells, in which the postt

179 ce of Th1 responses and may also inhibit Th2 cell generation from naive CD4 T cell precursors, it has

180 Substantial suppression of Foxp3(+) T(reg) cell generation from retinoic acid receptor-related orph

181 With age, T-cell generation from the thymus is much reduced, yet a s

182 Importantly, this ability of Treg cell generation gradually diminishes within 2 wk of birt

183 Although Smad4 was dispensable for T cell generation, homeostasis, and effector function, it

184 ls (TECs) are crucial for thymopoiesis and T cell generation, how TEC development and function are co

185 thropoiesis is distinct from basal red blood cell generation; however, neither the cellular nor the m

186 ibited stimulation indices and CD4CD25 FOXP3 cell generation in both human leukocyte antigen DR-match

187 tiation, but has a prominent role in iT(reg) cell generation in gut-associated lymphoid tissues.

188 hown to be inhibitory on CAg-stimulated Th17 cell generation in healthy donor PBMC cultures; however,

189 tial signals via isoforms may control plasma-cell generation in humans.

190 al use of IL-7 for enhancing de novo naive T-cell generation in immunocompromised patients.

191 finding, together with normal or enhanced B cell generation in mice deficient for BCMA or TACI, resp

192 These findings suggest that compromised TR B cell generation in NOD mice yields relaxed TR selection,

193 of thymocytes may be as essential as T(reg) cell generation in preventing autoimmune diseases such a

194 proliferation, effector function, and memory cell generation in response to infection with lymphocyti

195 approach we showed that extensive Ab-forming cell generation in spleen, accompanied by somatic hyperm

196 tic drug metformin restored FAO and CD8 T(M)-cell generation in the absence of TRAF6.

197 ation suggests a potential route to new hair cell generation in the adult cochlea.

198 We mechanistically studied tTreg cell generation in the atrophied thymus by utilizing bot

199 lls resulted in a marked impairment in pro-B cell generation in the bone marrow.

200 h17 cells in intestinal mucosa, blocked Th17 cell generation in the lung after Francisella tularensis

201 In addition to butyrate, de novo Treg-cell generation in the periphery was potentiated by prop

202 n mice that lacked this X-linked gene, T reg cell generation in the thymus was intrinsically favored,

203 rfered with IL-15 signaling to suppress iNKT cell generation in the thymus.

204 ture T cell production and specifically iNKT cell generation in the thymus.

205 eptides blocked TGF-beta activation and Th17 cell generation in vitro and protected mice from EAE.

206 A modest defect in plasma cell generation in vitro was documented, which correlate

207 tokine rescues antibody responses and plasma cell generation in vitro.

208 lls, allowing those cells to assist FOXP3+ T cell generation in vitro.

209 Thymic regulatory T (Treg) cell generation in vivo was directly correlated with in

210 3, but not IL12RB1 or TYK2, also reduced Tfh cell generation in vivo, evidenced by decreased circulat

211 fferentiation upon virus infection, and Treg cell generation in vivo.

212 ew 'intersecting pathway' model for memory T-cell generation in which antigen-driven effector differe

213 the data support a model of memory CD8(+) T cell generation in which the chemokine-directed localiza

214 s depends on IL-6 to support pathologic Th17 cell generation in wild-type mice.

215 cell reprogramming to induce specific target cell generation including stem cells, brain cells and ca

216 ity of CD4+ T cells to promote memory CD8+ T-cell generation, indicating that an orchestrated series

217 eprogramming during induced pluripotent stem cell generation is accompanied by changes in DNA methyla

218 nsufficient evidence regarding whether tTreg cell generation is also impaired.

219 However, iPS cell generation is asynchronous and slow (2-3 weeks), th

220 ta mediates these contrasting effects on Th1 cell generation is at least in part by differentially re

221 Identifying pathways for beta-cell generation is essential for cell therapy in diabete

222 Thus, RS cell generation is related neither to cell fusion of unr

223 Radial glial cell generation is significantly impaired in NRG mutants

224 original size, and normal steady-state blood cell generation is sustained with <10% of normal LT-HSC

225 of self-reactivity that elicits thymic Treg cell generation is tuned to secure peripheral tolerance

226 Continued DNA damage for 40 cell generations is reproducibly associated with loss of

227 ssential for pTreg but dispensable for tTreg cell generation, is present only in placental mammals.

228 nsgene rescued DN1 survival and improved DN2 cell generation, it did not restore DN3 differentiation.

229 raded manner to regulate macrophage versus B cell generation; its higher concentration favors the mac

230 on of Aire rather than impaired regulatory T cell generation, led to autoreactive T cell generation.

231 l EML cell subsets generated during multiple cell generations maintain their distinct phenotypic and

232 Finally, T-cell generation, maintenance, and apoptosis depend upon

233 nalyze signaling mechanisms for memory CD4 T cell generation, maintenance, and homeostasis.

234 hen compared two hypotheses of CD4+ memory T cell generation: maturation from activated naive to effe

235 inuous and rapidly renewing system involving cell generation, migration, and differentiation.

236 ies, but not latex beads, stimulated Kupffer cell generation of death ligands, including Fas ligand,

237 S1P decreased CD4 T cell generation of IFN-gamma and IL-4, without affecting

238 ce is characterized by excessive endothelial cell generation of potentially cytotoxic concentrations

239 The cell generation of reactive oxygen species (ROS), howeve

240 ntigens thought to identify tumor initiating cells, generation of 3D aggregates when grown as adheren

241 percentages of both CD4+ and CD8+ splenic T cells, generation of a greater number of IOE-specific, g

242 angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and special

243 events occur several times in each cell and cell generation on average.

244 Short-term memory persists within one cell generation or in postmitotic cells, while long-term

245 ostimulation was not needed for memory CD8 T cell generation or the ability to mount a recall respons

246 whether the lack of IL-10 modulated memory T cell generation or the protective function of cells.

247 1 cells, being lost at a rate of only 8% per cell generation over 24 days posttransfection.

248 out affecting other perfusion events such as cell generation, patterning, differentiation, and adhesi

249 T cells involves an ongoing balance of new T cell generation, peripheral expansion, and turnover.

250 gesting that mechanisms of the CD4+ memory T cell generation play a crucial role in maintaining immun

251 lts newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functio

252 hough RasGRP1 is dispensable for gammadeltaT cell generation, RasGRP1-deficient gammadeltaT cells are

253 in aged individuals, coupled with falling B-cell generation rates and life-long homeostatic competit

254 Herein, CD4+ T cell generation required engagement of CD83, a surface m

255 Suppression of Treg cell generation required proteases and TLR-mediated sign

256 ing of CD28 costimulation showed that T(reg) cell generation requires a motif that binds the tyrosine

257 ical mechanisms essential for successful iPS cell generation requires both accurate capture of cells

258 Th17 cell generation requires exposure of naive T cells to th

259 Peripherally derived regulatory T (pT(reg)) cell generation requires T-cell receptor (TCR) signallin

260 fic roles for Bach2 in favoring regulatory T cell generation, restraining effector T cell differentia

261 Hair cell generation resulted from an increase in the level o

262 system unambiguously demonstrated that hair cell generation resulted from transdifferentiation of su

263 n acute psychosocial stressor at the time of cell generation resulted in a decreased number of newly

264 modulating the process of hematopoietic stem cell generation, specification, and differentiation has

265 et Gprc5a as critical regulators for pT(reg)-cell generation, suggesting a previously unrecognized ep

266 ays involved in CD4 help for memory CD8(+) T cell generation that are independent of TRAIL, and it pr

267 a stochastic computer model of CD4+ memory T cell generation that can simulate and track 10(1)-10(8)

268 el of circumsporozoite-specific memory CD8 T cell generation that protects mice against multiple P. b

269 Even so, through many cell generations the pro-T cells remain uncommitted to t

270 After 40 cell generations the pX-expressing polyploid cultures ex

271 a phosphomutant form of Ngn3 increases alpha cell generation, the earliest endocrine cell type to be

272 f DHA in reciprocally regulating Th and Treg cell generation through the modulating mTOR pathway.

273 tations on invertase secretion are additive, cell generation time is increased 60%, and cells become

274 r for applications ranging from ex vivo stem cell generation to in vivo gene therapy.

275 ective negative selection by enhancing tTreg cell generation to maintain central T-cell tolerance in

276 The contribution of cell generation to physiological heart growth and mainte

277 can transmit epigenetic information from one cell generation to the next.

278 herefore an epigenetic signal passed between cell generations to ensure that replication-associated t

279 n carcinogenesis, and by increased number of cell generations to the development of cancer.

280 During CD44H cell generation, transformed keratinocytes display evide

281 c diet highlighted DC efficacy in effector T-cell generation under hypercholesterolemic conditions.

282 duced polyploid cultures in the course of 70 cell generations undergo progressively increasing DNA da

283 cantly increases the efficiency of mouse iPS cell generation using the transcription factors Oct4, So

284 , we are able to enhance skin-specific tTreg cell generation using three approaches.

285 Light-cell generation was inhibited by 1 mM bumetanide during

286 We found that the capacity of tTreg cell generation was not impaired compared to CD4+ thymic

287 ctivity, NO synthesis and induce endothelial cell generation was reduced.

288 Tfh cell generation was regulated by ICOS ligand (ICOSL) exp

289 Memory cell generation was transiently increased in IL-10(-/-)

290 ll compartment in CLL as it relates to CAR T-cell generation, we examined the phenotype and function

291 tely analyze the effect of DMXAA on CD8(+) T-cell generation, we treated mice bearing tumors derived

292 Furthermore, adiponectin failed to block fat cell generation when bone marrow cells were derived from

293 Fyn, and PKCtheta were essential for T-CD4 T cell generation, whereas mutations in the Ly108 receptor

294 quency was increased to approximately 10(-5)/cell/generation, whereas in Rb+/- ES cells, the frequenc

295 ugh MVA induced accelerated central memory T cell generation, which could be efficiently boosted by s

296 at OX40 can concomitantly promote effector T cell generation while antagonizing the differentiation o

297 y control the expression of a gene over many cell generations with quantitative accuracy.

298 er expression is highly stable over multiple cell generations, with fluctuations within cycles confin

299 py episomal stability of the vector for >100 cell generations without selection.

300 egans embryos, which can survive for several cell generations without transcription, we found that ta